Since the 80s and 90s HIV/AIDS activism developed networking around issues of sexualities in the transnational space. Over time, HIV/AIDS and sex education, and later issues of sexual orientation and gender identity, were taken up by arms of the UN and other international bodies. Since 2011 there have been direct efforts from the UN, UNESCO and the UNDP around homophobic and transphobic bullying in schools, relationship rights, and the rights of people with intersex variations. This talk considers some of the benefits and problems of global networking and transnational interventions on LGBTI issues; drawing on data from interviews with key informants participating high-level global networking for LGBTI rights from Northern and Southern contexts. It argues that policy provisions have both a usefulness and a potential for to agitate specific harms in certain contexts. It discusses key countries’ roles in this work, and issues for future global networking on LGBTI rights.