Research Output 1969 2019

2019

Eddy current-tunneling magneto-resistive sensor for micromotion detection of a tibial orthopaedic implant

Khokle, R. P., Franco, F., de Freitas, S. C., Esselle, K. P., Heimlich, M. C. & Bokor, D. J., 15 Feb 2019, In : IEEE Sensors Journal. 19, 4, p. 1285-1292 8 p.

Research output: Contribution to journalArticleResearchpeer-review

orthopedics
Orthopedics
Eddy currents
eddy currents
sensors

Effect of disinfectant formulation and organic soil on the efficacy of oxidizing disinfectants against biofilms

Chowdhury, D., Rahman, A., Hu, H., Jensen, S. O., Deva, A. K. & Vickery, K., 1 Sep 2019, In : Journal of Hospital Infection. 103, 1, p. e33-e41 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Disinfectants
Biofilms
Soil
Chlorine
Detergents

Effect of extradural constriction on CSF flow in rat spinal cord

Berliner, J. A., Woodcock, T., Najafi, E., Hemley, S. J., Lam, M., Cheng, S., Bilston, L. E. & Stoodley, M. A., 26 Mar 2019, In : Fluids and Barriers of the CNS. 16, 1, 15 p., 7.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Subarachnoid Space
Constriction
Cerebrospinal Fluid
Spinal Cord
Injections

Effects of sphenoid surgery on nasal irrigation delivery

Grayson, J. W., Cavada, M., Wong, E., Lien, B., Duvnjak, M., Campbell, R., Kalish, L., Sacks, R. & Harvey, R. J., Sep 2019, In : International Forum of Allergy and Rhinology. 9, 9, p. 971-976 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Nasal Lavage
Therapeutic Irrigation
Sphenoid Sinus
Endoscopes
Nasal Cavity

Emerging novel therapies in overcoming resistance to targeted therapy

Pinho, A. V., Lee, J. H. & Rizos, H., 2019, Current applications for overcoming resistance to targeted therapies. Szewczuk, M. R., Qorri, B. & Sambi, M. (eds.). Switzerland: Springer, Springer Nature, p. 223-258 36 p. (Resistance to Targeted Anti-Cancer Therapeutics; vol. 20).

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review

Melanoma
Neoplasms
Therapeutics
Physiologic Monitoring
Leukemia, Myelogenous, Chronic, BCR-ABL Positive

Ethical issues across the IDEAL stages of surgical innovation

Rogers, W. A., Hutchison, K. & McNair, A., 1 Feb 2019, In : Annals of surgery. 269, 2, p. 229-233 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Ethics

Evaluation of The Practitioner Online Referral and Treatment Service (PORTS): the first 18 months of a state-wide digital service for adults with anxiety, depression, or substance use problems

Titov, N., Rock, D., Bezuidenhout, G., Webb, N., Kayrouz, R., Nielssen, O., Williams, L., Purtell, C., Dear, B. F. & Staples, L. G., 25 Sep 2019, In : Cognitive Behaviour Therapy. 20 p.

Research output: Contribution to journalArticleResearchpeer-review

Referral and Consultation
Anxiety
Depression
Mental Health Services
Therapeutics

Evidence of Müller glial dysfunction in patients with aquaporin-4 immunoglobulin G–positive neuromyelitis optica spectrum disorder

You, Y., Zhu, L., Zhang, T., Shen, T., Fontes, A., Yiannikas, C., Parratt, J., Barton, J., Schulz, A., Gupta, V., Barnett, M. H., Fraser, C. L., Gillies, M., Graham, S. L. & Klistorner, A., 1 Jun 2019, In : Ophthalmology. 126, 6, p. 801-810 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Aquaporin 4
Neuromyelitis Optica
Neuroglia
Immunoglobulin G
Multiple Sclerosis

Feasibility and safety of lumbar puncture in the Parkinson's disease research participants: Parkinson's Progression Marker Initiative (PPMI)

Prakash, N., Caspell-Garcia, C., Coffey, C., Siderowf, A., Tanner, C. M., Kieburtz, K., Mollenhauer, B., Galasko, D., Merchant, K., Foroud, T., Chahine, L. M., Weintraub, D., Casaceli, C., Dorsey, R., Wilson, R., Herzog, M., Daegele, N., Arnedo, V., Frasier, M., Sherer, T. & 5 othersMarek, K., Frank, S., Jennings, D., Simuni, T. & Parkinson's Progression Markers Initiative, May 2019, In : Parkinsonism and Related Disorders. 62, p. 201-209 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Spinal Puncture
Parkinson Disease
Safety
Research
Needles

Five-year survival outcomes for patients with advanced melanoma treated with pembrolizumab in KEYNOTE-001

Hamid, O., Robert, C., Daud, A., Hodi, F. S., Hwu, W. J., Kefford, R., Wolchok, J. D., Hersey, P., Joseph, R., Weber, J. S., Dronca, R., Mitchell, T. C., Patnaik, A., Zarour, H. M., Joshua, A. M., Zhao, Q., Jensen, E., Ahsan, S., Ibrahim, N. & Ribas, A., 1 Apr 2019, In : Annals of oncology : official journal of the European Society for Medical Oncology. 30, 4, p. 582-588 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Melanoma
Survival
Disease-Free Survival
pembrolizumab
Therapeutics

Functional outcomes and quality of life after microsurgical clipping of unruptured intracranial aneurysms: a prospective cohort study

O'Donnell, J. M., Morgan, M. K. & Manuguerra, M., Jan 2019, In : Journal of Neurosurgery. 130, 1, p. 278-285 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Intracranial Aneurysm
Cohort Studies
Quality of Life
Prospective Studies
Referral and Consultation

Going back

Al Muderis, M. & Weaver, P., 7 Apr 2019, Australia: Allen and Unwin. 298 p.

Research output: Book/ReportBookResearch

Health impairment from nasal airway obstruction and changes in health utility values from septorhinoplasty

Tjahjono, R., Alvarado, R., Kalish, L., Sacks, R., Campbell, R., Marcells, G., Orgain, C. & Harvey, R. J., Mar 2019, In : JAMA Facial Plastic Surgery. 21, 2, p. 146-151 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Nasal Obstruction
Health
Symptom Assessment
Nose
Economics

How I do it: 3D exoscopic endoscope-assisted microvascular decompression

Li Ching Ng, A. & Di Ieva, A., 1 Jul 2019, In : Acta Neurochirurgica. 161, 7, p. 1443-1447 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Microvascular Decompression Surgery
Endoscopes
Hemifacial Spasm
Trigeminal Neuralgia
Safety

Hydrogenation-controlled mechanical properties in graphene helicoids: exceptional distribution-dependent behavior

Sharifian, A., Moshfegh, A., Javadzadegan, A., Hassanzadeh Afrouzi, H., Baghani, M. & Baniassadi, M., 21 Jun 2019, In : Physical Chemistry Chemical Physics. 21, 23, p. 12423-12433 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Graphite
Hydrogenation
hydrogenation
graphene
mechanical properties

Impact of cardiac magnetic resonance imaging on heart failure patients referred to a tertiary advanced heart failure unit: improvements in diagnosis and management

Lum, Y. H., McKenzie, S., Brown, M. & Hamilton-Craig, C., 1 Feb 2019, In : Internal Medicine Journal. 49, 2, p. 203-211 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Heart Failure
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy
Echocardiography
Electronic Health Records

Impact of chronic health conditions and injury on school performance and health outcomes in New South Wales, Australia: a retrospective record linkage study protocol

Mitchell, R., Cameron, C. M., Lystad, R. P., Nielssen, O., McMaugh, A., Herkes, G. K., Schniering, C. & Hng, T-M., 2019, In : BMJ Open Pediatrics. 3, 1, p. 1-6 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
South Australia
New South Wales
School Health Services
Health
Wounds and Injuries

Impact of MRI protocols on Alzheimer's disease detection

Alam, S., Hamey, L. & Ho-Shon, K., 16 Jan 2019, 2018 International Conference on Digital Image Computing: Techniques and Applications, DICTA 2018. Murshed, M., Paul, M., Asikuzzaman, M., Pickering, M., Natu, A., Robles-Kelly, A., You, S., Zheng, L. & Rahman, A. (eds.). Institute of Electrical and Electronics Engineers (IEEE), 8 p. 8615774

Research output: Chapter in Book/Report/Conference proceedingConference proceeding contributionResearchpeer-review

Magnetic resonance
Atlases
Alzheimer Disease
Magnetic Resonance Imaging
Imaging techniques

Interaction between PLA2R1 and HLA-DQA1 variants contributes to the increased genetic susceptibility to membranous nephropathy in Western China

Wang, W., Fan, S., Li, G., Wang, A. Y., Hong, D., Zhong, X. & Wang, L., Sep 2019, In : Nephrology. 24, 9, p. 919-925 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Membranous Glomerulonephritis
Genetic Predisposition to Disease
China
Odds Ratio
Alleles

Introduction to "A review of breast implant-associated anaplastic large cell lymphoma"

Clemens, M. W. & Deva, A. K., 1 Mar 2019, In : Plastic and reconstructive surgery. 143, 3, p. 5S 1 p.

Research output: Contribution to journalArticleResearchpeer-review

Investigation of nanofluid heat transfer in a microchannel under magnetic field via lattice Boltzmann method: effects of surface hydrophobicity, viscous dissipation, and Joule heating

Alipour Lalami, A., Hassanzadeh Afrouzi, H., Moshfegh, A., Omidi, M. & Javadzadegan, A., 1 Jun 2019, In : Journal of Heat Transfer. 141, 6, p. 1-10 10 p., 062403.

Research output: Contribution to journalArticleResearchpeer-review

Joule heating
Hydrophobicity
hydrophobicity
microchannels
Microchannels

Involvement in compensation litigation and outcome from an online pain management program

Nielssen, O., Staples, L., Titov, N., Gandy, M., Fogliati, R. & Dear, B., Aug 2019, In : Rehabilitation Psychology. 64, 3, p. 263-268 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Jurisprudence
Pain Management
Compensation and Redress
Opioid Analgesics
Pain

Is haematological monitoring actually needed with clozapine treatment?

Nielssen, O., 18 Jun 2019, In : Australian and New Zealand Journal of Psychiatry.

Research output: Contribution to journalComment/opinionResearchpeer-review

Is minimally-invasive surgery an added-value for patients with hepatocellular carcinoma and portal vein hypertension undergoing liver resection? Results of an international multi-institutional analysis

Bagante, F., Ruzzenente, A., Beal, E. W. W., Conci, S., Merath, K., Campagnaro, T., Martel, G., Alexandrescu, S., Popescu, I., Ratti, F., Aldrighetti, L., Soubrane, O., Marques, H. P., Hugh, T. J., Poultsides, G. A., Lam, V., Iacono, C., Guglielmi, A. & Pawlik, T. M., May 2019, In : Gastroenterology. 156, 6 Supplement 1, p. S1431 1 p., 1048.

Research output: Contribution to journalMeeting abstractResearchpeer-review

Laminar wall shear stress in brain arteriovenous malformations: systematic review of literature

Lo Presti, A., Rogers, J. M., Stoodley, M. A., Assaad, N. N. A., Simons, M., Sen, I. & Morgan, M. K., 1 Aug 2019, In : World Neurosurgery. 128, p. e760-e767 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Arteriovenous Malformations
Brain
Arteries
Research
MEDLINE

Lattice-Boltzmann method for analysis of combined forced convection and radiation heat transfer in a channel with sinusoidal distribution on walls

Javadzadegan, A., Motaharpour, S. H., Moshfegh, A., Akbari, O. A., Afrouzi, H. H. & Toghraie, D., 15 Jul 2019, In : Physica A: Statistical Mechanics and its Applications. 526, p. 1-18 18 p., 121066.

Research output: Contribution to journalArticleResearchpeer-review

Forced Convection
forced convection
Lattice Boltzmann Method
Heat Transfer
heat transfer

Letter to the Editor Regarding “The Exoscope in Neurosurgery: An Innovative Point of View. A Systematic Review of the Technical, Surgical, and Educational Aspects”

Di Ieva, A. & Tschabitscher, M., 1 Jul 2019, In : World Neurosurgery. 127, p. 652 1 p.

Research output: Contribution to journalComment/opinionResearchpeer-review

Limitations of electromyography in the assessment of abdominal wall muscle contractility following botulinum toxin A injection

Tomazini Martins, R., Elstner, K. E., Skulina, C., Rodriguez-Acevedo, O., Read, J. W., Rowe, D. B. & Ibrahim, N., 9 Apr 2019, In : Frontiers in Surgery. 6, p. 1-8 8 p., 16.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Abdominal Muscles
Type A Botulinum Toxins
Abdominal Wall
Electromyography
Injections

Local specific Immunoglobulin E among patients with nonallergic rhinitis: a systematic review

Hamizan, A. W., Rimmer, J., Husain, S., Alvarado, R., Tatersall, J., Sewell, W., Kalish, L. & Harvey, R. J., 1 Feb 2019, In : Rhinology. 57, 1, p. 10-20 11 p.

Research output: Contribution to journalReview articleResearchpeer-review

Rhinitis
Nose
Immunoglobulin E
Hypersensitivity
Allergens

Long-term azithromycin reduces Haemophilus influenzae and increases antibiotic resistance in severe asthma

Taylor, S. L., Leong, L. E. X., Mobegi, F. M., Choo, J. M., Wesselingh, S., Yang, I. A., Upham, J. W., Reynolds, P. N., Hodge, S., James, A. L., Jenkins, C., Peters, M. J., Baraket, M., Marks, G. B., Gibson, P. G., Rogers, G. B. & Simpson, J. L., 1 Aug 2019, In : American Journal of Respiratory and Critical Care Medicine. 200, 3, p. 309-317 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Azithromycin
Haemophilus influenzae
Microbial Drug Resistance
Asthma
Macrolides

Loss of Shp2 rescues BDNF/TrkB signaling and contributes to improved retinal ganglion cell neuroprotection

Chitranshi, N., Dheer, Y., Mirzaei, M., Wu, Y., Salekdeh, G. H., Abbasi, M., Gupta, V., Vander Wall, R., You, Y., Graham, S. L. & Gupta, V., 6 Feb 2019, In : Molecular Therapy. 27, 2, p. 424-441 18 p.

Research output: Contribution to journalArticleResearchpeer-review

trkB Receptor
Retinal Ganglion Cells
Glaucoma
Endoplasmic Reticulum Stress
Apoptosis

Lung elastic recoil and ventilation heterogeneity of diffusion-dependent airways in older people with asthma and fixed airflow obstruction

Tonga, K. O., Berend, N., Thamrin, C., Farah, C. S., Jetmalani, K., Chapman, D. G. & King, G. G., 1 Mar 2019, In : The European respiratory journal. 53, 3, p. 1-4 4 p., 1801028.

Research output: Contribution to journalLetterResearchpeer-review

Magnetic resonance spectroscopic assessment of isocitrate dehydrogenase status in gliomas: the new frontiers of spectrobiopsy in neurodiagnostics

Di Ieva, A., Magnussen, J. S., McIntosh, J., Mulcahy, M. J., Pardey, M. & Choi, C., 14 Sep 2019, (Accepted/In press) In : World Neurosurgery.

Research output: Contribution to journalArticleResearchpeer-review

Isocitrate Dehydrogenase
Glioma
Magnetic Resonance Spectroscopy
Mutation
Tumor Biomarkers

Management of recurrent haemoptysis in malignancy with combined TISSEEL and intrabronchial valves

Di Michiel, J., Pan, C., Ing, A. & Saghaie, T., 1 Apr 2019, In : Respirology Case Reports. 7, 3, p. 1-3 3 p., e00406.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Hemoptysis
Hemorrhage
Neoplasms
Fibrin Tissue Adhesive
Bronchoscopy

Measuring the effects of bronchial thermoplasty using oscillometry

Langton, D., Ing, A., Sha, J., Bennetts, K., Hersch, N., Kwok, M., Plummer, V., Thien, F. & Farah, C., 1 May 2019, In : Respirology. 24, 5, p. 431-436 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Oscillometry
Spirometry
Asthma
Forced Expiratory Volume
Residual Volume

Mepolizumab improves small airway function in severe eosinophilic asthma

Farah, C. S., Badal, T., Reed, N., Rogers, P. G., King, G. G., Thamrin, C., Peters, M. J. & Seccombe, L. M., 1 Mar 2019, In : Respiratory Medicine. 148, p. 49-53 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Asthma
Spirometry
Lung
Ventilation
Therapeutics
Mitogen-Activated Protein Kinases
Melanoma
Cells
Protein Kinase Inhibitors
Phosphotransferases
Retinoid X Receptors
Molecular Dynamics Simulation
Transcription Factors
Pharmacology
Ligands

Monozygotic twins and triplets discordant for amyotrophic lateral sclerosis display differential methylation and gene expression

Tarr, I. S., McCann, E. P., Benyamin, B., Peters, T. J., Twine, N. A., Zhang, K. Y., Zhao, Q., Zhang, Z-H., Rowe, D. B., Nicholson, G. A., Bauer, D., Clark, S. J., Blair, I. P. & Williams, K. L., 4 Jun 2019, In : Scientific Reports. 9, 1, p. 1-17 17 p., 8254.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Monozygotic Twins
Amyotrophic Lateral Sclerosis
Methylation
Gene Expression
Genes

Myocardial bridging and endothelial dysfunction: computational fluid dynamics study

Javadzadegan, A., Moshfegh, A., Qian, Y., Kritharides, L. & Yong, A. S. C., 6 Mar 2019, In : Journal of Biomechanics. 85, p. 92-100 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Myocardial Bridging
Hydrodynamics
Shear stress
Computational fluid dynamics
Flow patterns

Myocilin gene Gln368Ter variant penetrance and association with glaucoma in population-based and registry-based studies

Han, X., Souzeau, E., Ong, J-S., An, J., Siggs, O. M., Burdon, K. P., Best, S., Goldberg, I., Healey, P. R., Graham, S. L., Ruddle, J. B., Mills, R. A., Landers, J., Galanopoulos, A., White, A. J. R., Casson, R., Mackey, D. A., Hewitt, A. W., Gharahkhani, P., Craig, J. E. & 1 othersMacgregor, S., 1 Jan 2019, In : JAMA Ophthalmology. 137, 1, p. 28-35 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Penetrance
Glaucoma
Registries
Ocular Hypertension
Population

Nasal mucosal brushing as a diagnostic method for allergic rhinitis

Hamizan, A., Alvarado, R., Rimmer, J., Sewell, W. A., Barham, H. P., Kalish, L. & Harvey, R., 1 May 2019, In : Allergy and Asthma Proceedings. 40, 3, p. 167-172 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Nose
Turbinates
Immunoglobulin E
Biopsy
Skin Tests

Neoadjuvant dabrafenib combined with trametinib for resectable, stage IIIB–C, BRAFV600 mutation-positive melanoma (NeoCombi): a single-arm, open-label, single-centre, phase 2 trial

Long, G. V., Saw, R. P. M., Lo, S., Nieweg, O. E., Shannon, K. F., Gonzalez, M., Guminski, A., Lee, J. H., Lee, H., Ferguson, P. M., Rawson, R. V., Wilmott, J. S., Thompson, J. F., Kefford, R. F., Ch'ng, S., Stretch, J. R., Emmett, L., Kapoor, R., Rizos, H., Spillane, A. J. & 2 othersScolyer, R. A. & Menzies, A. M., 1 Jul 2019, In : The Lancet Oncology. 20, 7, p. 961-971 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Melanoma
Mutation
dabrafenib
trametinib
Neoadjuvant Therapy

New frontiers: extracorporeal vascular reconstruction with robotic renal autotransplantation

Yao, J., Hameed, A., Allen, R., Pleass, H., Lam, V., Leslie, S., Kim, L. & Lau, H., Apr 2019, In : Journal of Urology. 201, 4 Supplement, p. E852 1 p., V08-12.

Research output: Contribution to journalMeeting abstractResearchpeer-review

Non-invasive physiological monitoring

Butlin, M., Tan, I., Barin, E. & Avolio, A. P., Jan 2019, Interventional cardiology and cardiac catheterisation: the essential guide. Boland, J. E. & Muller, D. W. M. (eds.). Second ed. CRC Press, Taylor & Francis Group, p. 11-20 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapterResearch

Physiologic Monitoring
Blood Pressure
Cardiology
Cardiac Output
Aorta

Opioid use before and after completion of an online pain management program

Nielssen, O., Karin, E., Staples, L., Titov, N., Gandy, M., Fogliati, V. J. & Dear, B. F., Oct 2019, In : Journal of consulting and clinical psychology. 87, 10, p. 904-917 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Pain Management
Opioid Analgesics
Pain
Anxiety
Depression

Osteitis in chronic rhinosinusitis

Snidvongs, K., Sacks, R. & Harvey, R. J., 1 May 2019, In : Current Allergy and Asthma Reports. 19, 5, p. 1-10 10 p., 24.

Research output: Contribution to journalReview articleResearchpeer-review

Osteitis
Osteogenesis
Nasal Polyps
Bone Remodeling
Biological Factors

Outcome of serious violent offenders with psychotic illness and cognitive disorder dealt with by the New South Wales criminal justice system

Nielssen, O., Yee, N. Y. L., Dean, K. & Large, M., 1 May 2019, In : Australian and New Zealand Journal of Psychiatry. 53, 5, p. 441-446 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Criminal Law
New South Wales
Psychotic Disorders
Kaplan-Meier Estimate
Survival Analysis

Patient-reported olfaction improves following outside-in Draf III frontal sinus surgery for chronic rhinosinusitis

Wong, E. H., Do, T. Q., Harvey, R. J., Orgain, C. A., Sacks, R. & Kalish, L., 1 Jan 2019, In : Laryngoscope. 129, 1, p. 25-30 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Frontal Sinus
Smell
Medication Adherence
Visual Analog Scale
Nose

Patient-reported outcomes in patients with resected, high-risk melanoma with BRAF V600E or BRAF V600K mutations treated with adjuvant dabrafenib plus trametinib (COMBI-AD): a randomised, placebo-controlled, phase 3 trial

Schadendorf, D., Hauschild, A., Santinami, M., Atkinson, V., Mandalà, M., Chiarion-Sileni, V., Larkin, J., Nyakas, M., Dutriaux, C., Haydon, A., Robert, C., Mortier, L., Lesimple, T., Plummer, R., Schachter, J., Dasgupta, K., Manson, S., Koruth, R., Mookerjee, B., Kefford, R. & 3 othersDummer, R., Kirkwood, J. M. & Long, G. V., 1 May 2019, In : The Lancet Oncology. 20, 5, p. 701-710 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Melanoma
Placebos
Mutation
Recurrence
Quality of Life