Macquarie Medical School

Projects

Projects per year 2001 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2030

• 1 Curtailed
• 52 Not started
• 291 Active
• 466 Finished

Projects per year

Search results

• Active

  A Prelude towards transforming adenoid cystic carcinoma into an immune hot tumour

  Chakraborty, R., Packer, N., Shannon, K., Rizos, H., Lee, J., Nasiri, N., Dawes, J., Tay, A. & Surya, V.

  1/01/25 → 30/06/26

  Project: Research

• MRFF 2023: Randomised controlled trial of screening patients with Schizophrenia for obstructive sleep apnea using in-laboratory polysomnography or 3-nights of home oximetry.

  Grunstein, R., Ellender, C., Marshall, N., Siskind, D., Sharma, R., Yee, B., Lappin, J., Fooken, J., Kairaitis, K., Harris, A., Phillips, C., Lawn, S., Lambert, T., Kalucy, M., Parkinson, B. & Lane, A.

  1/01/25 → 31/12/28

  Project: Research

• Development of ALS gene therapies for targeted protein degradation of TDP-43

  Lee, A., Morsch, M., Rayner, S. & Chung, R.

  1/09/24 → 31/08/26

  Project: Research

• CTU: An Open-label, Randomized Phase 3 Study of MK-2870 as a Single Agent and in Combination with Pembrolizumab Versus Treatment of Physician’s Choice in Participants with HR+/HER2-Unresectable Locally Advanced or Metastatic Breast Cancer.

  Sabanathan, D., Chapman, N., Martin, L. & TAIDI, G.

  1/08/24 → 20/05/29

  Project: Research

• CTU: A Phase 3, Randomized, Open-label, Study to Compare the Efficacy and Safety of Adjuvant MK-2870 in Combination with Pembrolizumab (MK-3475) Versus treatment of Physician’s Choice (TPC) in Participants With Triple-Negative Breast Cancer (TNBC) Who Received Neoadjuvant Therapy and Did Not Achieve a Pathological Complete Response (pCR) at Surgery

  Sabanathan, D., Chapman, N., TAIDI, G. & Martin, L.

  1/08/24 → 20/05/29

  Project: Research

• APM002: A Randomised, Double-Blind, Placebo-Controlled, 60 Week, Phase II Clinical Trial of Ambroxol and Doxycycline in Moderate Severity Parkinsons Disease

  Cooper, A. A., Lewis, S., West, S. & Harvey, C.

  25/07/24 → 6/05/29

  Project: Research

• IDEAS 23: TDP-43 nuclear depletion in MND - potential driver of neurodegeneration and therapeutic target

  Hogan, A., Maurel, C., Rayner, S., Morsch, M., Williams, K., Walker, A. K. & Lisowski, L.

  1/07/24 → 30/06/27

  Project: Research

• Research Support - Parkinsons and Dementia

  Lewis, S., Harvey, C. & West, S.

  1/07/24 → 30/06/26

  Project: Research

• CTU: A Phase I Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Clinical Activity of GSK5733584 for Injection in Subjects with Advanced Solid Tumors

  Sabanathan, D., Martin, L., Quinlan, G., Chapman, N., TAIDI, G. & Garcia, M.

  26/06/24 → 17/06/29

  Project: Research

• MNDRA24: Investigating the role of extracellular vesicles (EVs) membrane proteome in MND pathogenesis and clinical application

  Wang, Y., Yang, S., Lee, A., Fath, T. & Ooi, L.

  24/06/24 → 23/06/25

  Project: Research

• Special Project: Dr Magdalena Przybyla - Amyloid-precursor protein (APP) facilitates the spread of tau pathology in Alzheimer's disease models

  Przybyla, M.

  18/06/24 → 30/06/26

  Project: Research

• Usyd led: Synergise, Integrate and Enhance Sleep Research to Transform Brain Ageing (SIESTA)

  Naismith, S., D'Rozario, A., Grunstein, R., Martins, R., Gordon, C., Hoyos, C., Rainey-Smith, S., Anderson, C., Shine, J. M., Bourgeat, P., Coulson, E. J., Trickett, D., Wassing, R., Fripp, J., Postnova, S., Ward, S., Matar, E., Phillips, C., Jacobson, L., Hedner, J. & Eslick, S.

  11/06/24 → 10/06/29

  Project: Research

• MNDRA24: Targeting the nucleus: Is TDP-43 supplementation in the nucleus enough to delay disease progression?

  Morsch, M., Luu, L. & Hogan, A.

  3/06/24 → 2/06/25

  Project: Research

• MRFF (Monash led): Primary Breathe AUS: A primary care technology-enabled intervention to improve symptom self-management for people with chronic respiratory illness

  Smallwood, N., Sanci, L., Philip, J., Russell, G. M., Mant, J., Willis, K., Chondros, P., Bosnic-Anticevich, S., Manski-Nankervis, J., Spathis, A., Steinfort, D., Khor, Y. H., Osadnik, C., Disler, R., Hancock, K. L. & Holland, A. E.

  3/06/24 → 2/06/29

  Project: Research

• MNDRA24: Examining the Pathogenic Roles of Circular RNAs in Genomic Instability in ALS

  Saravanabavan, S. & Atkin, J.

  1/06/24 → 31/05/25

  Project: Research

• N-PARTI: The National Paediatric Applied Research Translation Initiative (N-PARTI)

  Braithwaite, J., Harrison, R., Mumford, V., Davis, E., de Wet, C., Homaira, N., Mitchell, R., Jaffe, A., Fisher, G., Willcock, S., McMullan, B., Arnolda, G., Zurynski, Y., Woodhead, H. & Hibbert, P.

  1/06/24 → 31/05/29

  Project: Research

• MNDRA24: Probing molecular drivers of TDP-43 phase transition: the influence of lysine modifications.

  Maurel, C., Richter, G. & Morsch, M.

  1/06/24 → 31/05/25

  Project: Research

• CTU: First-in-Human, Phase 1 Study of AMT-676, an Anti-CDH17 Antibody-Drug Conjugate, in Patients with Advanced Solid Tumors

  Park, J., Chapman, N., Martin, L. & TAIDI, G.

  24/05/24 → 30/04/29

  Project: Research

• CTU: A first-in-human, Phase 1/2, open-label, multi-center, dose-escalation, dose-optimization, and dose-expansion study to evaluate the safety; tolerability, pharmacokinetics, pharmacodynamics, and anti-tumor activity of PARP1 selective inhibitor, IMP1734, in patients with advanced solid tumors.

  Sabanathan, D., Chapman, N., Martin, L. & TAIDI, G.

  13/05/24 → 17/04/29

  Project: Research

• NN9541-4945: CTU: Investigation of the safety and efficacy of once weekly NNC0519-0130 administered subcutaneously in participants with type 2 diabetes – a dose finding study

  Preda, V., Chapman, N., TAIDI, G. & Martin, L.

  2/05/24 → 27/03/29

  Project: Research

• SGNDV-005: CTU: A Phase 2 Basket Study of Disitamab Vedotin in Adult Subjects with Previously Treated, Locally-Advanced Unresectable or Metastatic Solid Tumors That Express HER2

  Park, J., Chapman, N., TAIDI, G. & Martin, L.

  1/05/24 → 17/01/29

  Project: Research

• A Phase 1, Randomized, Double Blind, Placebo Controlled, Single and Multiple Dose Escalation Study in Healthy Volunteers and an Expansion cohort in Adult Participants with Amyotrophic Lateral Sclerosis (ALS) to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of SPG302

  Rowe, D., Kalband, B., Delcourt, C., Gan, R. & Bayeh, P.

  1/05/24 → 19/04/29

  Project: Research

• IDEAS 23: Developing novel gene expression control mechanisms for Amyotrophic Lateral Sclerosis gene therapies

  Chung, R., Williams, K. & Lee, A.

  1/05/24 → 30/04/27

  Project: Research

• MNDRA PhD Top-Up Scholarship: Identification and characterisation of RNA-protein interaction in pathological aggregates of TDP-43 in MND

  Cheng, F., Lee, A., Rayner, S., Morsch, M. & Chung, R.

  30/04/24 → 29/04/27

  Project: Research

• Clairleaf: CTU: A randomised, double-blind, parallel group, roll-over study evaluating long-term safety and efficacy of oral doses of BI 1291583 q.d. (Part A) followed by open label long-term safety assessment (Part B) in patients with bronchiectasis (ClairleafTM)

  Morgan, L., Martin, L., TAIDI, G. & Chapman, N.

  28/04/24 → 19/03/29

  Project: Research

• BG-C9074-101: CTU: Phase 1a/1b Study of BG-C9074, an Antibody Drug Conjugate Targeting B7H4, as Monotherapy and in Combination With Tislelizumab in Participants With Advanced Solid Tumors

  Parsonson, A., Chester, C., Chapman, N., TAIDI, G. & Martin, L.

  25/04/24 → 17/04/29

  Project: Research

• PROSPERO: CTU: A Phase III, Multicentre, Randomised, Double-Blind, Chronic-dosing, Parallel-group, Placebo-controlled Extension Study to Evaluate the Long-term Efficacy and Safety of Tozorakimab in participants with Chronic Obstructive Pulmonary Disease (COPD) with a History of Exacerbations

  Ing, A., Chester, C., Chapman, N., Martin, L. & TAIDI, G.

  24/04/24 → 17/04/29

  Project: Research

• Investigating biomarkers for Alzheimer's disease

  Martins, R., Garg, M. & Sharmin, T.

  19/04/24 → 19/04/29

  Project: Research

• MK-5684-01A: CTU: A Phase 1/2 Umbrella Substudy of MK-5684-U01 Master Protocol to Evaluate the Safety and Efficacy of MK-5684-based Treatment Combinations or MK-5684 Alone in Participants With Metastatic Castration-resistant Prostate Cancer (mCRPC)

  Zhang, A., Chapman, N., Chester, C., TAIDI, G. & Martin, L.

  12/04/24 → 27/03/29

  Project: Research

• CIBI363A101: CTU: A Phase 1, Open-label, Multicenter Study of IBI363 (PD1-IL2m) in Subjects with Advanced Solid Malignancies or Lymphomas

  Park, J., Chester, C., Chapman, N., TAIDI, G. & Martin, L.

  12/04/24 → 28/02/29

  Project: Research

• DARF: Investigating mechanisms of tau uptake and release in glia

  Genoud, S., Fath, T., Van Eersel, J. & Ittner, L.

  8/04/24 → 8/04/26

  Project: Research

• CIP 2023-01: CTU: Targeted lung denervation (TLD) with the Ryme Medical Lung Denervation System in patients with chronic obstructive pulmonary disease (COPD)

  Ing, A., Chester, C., Chapman, N., Martin, L. & TAIDI, G.

  8/04/24 → 13/03/29

  Project: Research

• DARF: Identifying the effects of the gut microbiome on microglial cells in Alzheimer's disease.

  Manuneedhi Cholan, P., Morsch, M., Martins, R. & Fernando, W. M. A. D. B.

  8/04/24 → 4/08/27

  Project: Research

• D3L-001-100: CTU: A Phase 1, Open-label Dose Escalation and Dose-Expansion Study Evaluating the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Preliminary Efficacy of D3L-001 Monotherapy in Subjects with HER2-Positive Advanced Solid Tumors.

  Park, J., Chester, C., Chapman, N., TAIDI, G. & Martin, L.

  4/04/24 → 19/03/29

  Project: Research

• Predicting, Diagnosing and Treating Synucleinopathies

  Lewis, S.

  1/04/24 → 31/12/25

  Project: Research

• An Open Label Extension Study to Investigate the Long Term Safety, Tolerability And Efficacy of Oral Monepantel in individuals with Motor Neurone Disease Who Previously Completed Study MON-2021-001

  Rowe, D., Kalband, B., Delcourt, C., Gan, R. & Bayeh, P.

  28/03/24 → 27/03/29

  Project: Research

• MQEPS: Indocyanine green (ICG) lymphography in lower limb lymphoedema and the implications for self-management and compression garment prescription.

  Koelmeyer, L. A., Gaitatzis, K. & Blackwell, R.

  28/03/24 → 27/03/25

  Project: Research

• AMT-562-01: CTU: First-in-Human, Phase 1 Study of AMT-562, an Anti-HER3 Antibody-Drug Conjugate, in Patients with Advanced Solid Tumors

  Sabanathan, D., Chapman, N., Chester, C., TAIDI, G. & Martin, L.

  25/03/24 → 26/02/29

  Project: Research

• CTU: Phase I/II Study to Assess the Safety, tolerability, Pharmacokinetics and efficacy of JSKN033 in Patients with Advanced or Metastatic Solid Malignant Tumors

  Park, J., TAIDI, G., Martin, L. & Chapman, N.

  20/03/24 → 15/02/29

  Project: Research

• CONVERT II: CTU: An Evaluation of the AeriSeal System for CONVERTing Collateral Ventilation Status in Patients with Severe Emphysema: The CONVERT II Trial

  Ing, A., Chester, C. & Chapman, N.

  13/03/24 → 29/11/28

  Project: Research

• V940-005: CTU: A Phase 2, Randomized, Double-Blind, Placebo- and Active-Comparator-Controlled Clinical Study of Adjuvant V940 (mRNA-4157) Plus Pembrolizumab Versus Adjuvant Placebo Plus Pembrolizumab in Participants with High-Risk Muscle-Invasive Urothelial Carcinoma Post-Radical Resection

  Zhang, A., Chapman, N. & Chester, C.

  12/03/24 → 28/02/29

  Project: Research

• CIBI133A101: CTU: A Multicentre, Open-label, Phase 1/2 Study of IBI133 in Subjects with Unresectable, Locally Advanced or Metastatic Solid Tumours

  Park, J., TAIDI, G., Chester, C., Chapman, N. & Martin, L.

  10/03/24 → 28/02/29

  Project: Research

• MRFF (Usyd led): A primary care multi-disciplinary team care approach, including pulmonary rehabilitation, to improve uptake and outcomes of comprehensive evidence-based care for COPD

  Dennis, S., Zwar, N., McKeough, Z., Alison, J. A., Halcomb, E., Cunich, M., Vagholkar, S., Dobler, C. C., Paul, S. S., Pagano, L., Meharg, D., Ansari, S., Jenkins, C., McNamara, R., Xuan, W., Jennings, M., McDougall, B., Short, K., Herrmann, K. & Kulas, H.

  1/03/24 → 29/02/28

  Project: Research

• FightMND IMPACT: Developing novel gene expression control mechanisms for ALS gene therapies

  Chung, R., Williams, K., Grima, N. & Chapman, T.

  1/03/24 → 1/03/26

  Project: Research

• CTU: AN INTERVENTIONAL, DOUBLE-BLIND, RANDOMIZED, MULTICENTER PHASE 3 STUDY OF PF-07220060 PLUS FULVESTRANT COMPARED TO FULVESTRANT IN PARTICIPANTS OVER 18 YEARS OF AGE WITH HORMONE RECEPTOR-POSITIVE, HER2-NEGATIVE ADVANCED/METASTATIC BREAST CANCER WHOSE DISEASE PROGRESSED AFTER PRIOR CDK 4/6 INHIBITOR BASED THERAPY

  Sabanathan, D., Contacos, C., Chapman, N., Chester, C. & TAIDI, G.

  27/02/24 → 27/02/29

  Project: Research

• SEACRAFT-1: CTU: An open-label study to assess the safety and efficacy of naporafenib (ERAS-254) administered with trametinib in previously treated patients with locally advanced unresectable or metastatic solid tumor malignancies with RAS Q61X mutations [SEACRAFT-1]

  Park, J., Chapman, N. & Chester, C.

  27/02/24 → 26/02/29

  Project: Research

• DYNASTY-Breast02: CTU: A Phase 3, Randomized, Multi-center, Open-label Study of DB-1303 Versus Investigator’s Choice Chemotherapy in Human Epidermal Growth Factor Receptor 2 (HER2)-low, Hormone Receptor Positive (HR+) Metastatic Breast Cancer Patients whose Disease has Progressed on Endocrine Therapy (ET) (DYNASTY-Breast02).

  Sabanathan, D., Contacos, C., Chester, C., Chapman, N., Martin, L. & TAIDI, G.

  20/02/24 → 16/11/28

  Project: Research

• CRE Usyd led: The Centre of Research Excellence for Applied Innovations in Oral Cancer

  Clark, J., Gupta, R., Boyer, M., Rizos, H., Yang, J. Y. H., Palendira, M., Wallace, G. G., Woodruff, M., Crook, J. M., Li, Q., McKenzie, D., Lee, J., Agresta, B., Ashford, B. G., Venchiarutti, R., Pajic, M., Charters, E., Sagnella, S., Dunn, M. & Braithwaite, J.

  20/02/24 → 19/02/29

  Project: Research

• ALUMMINATE RRMM: CTU: A Phase 3, Randomized, Multicenter, Open-label Study to Evaluate the Efficacy and Safety of Alnuctamab Compared to Standard of Care Regimens in Participants with Relapsed or Refractory Multiple Myeloma (RRMM)

  Menzies Wojtowicz, M., Chapman, N., Chester, C., TAIDI, G. & Martin, L.

  15/02/24 → 17/01/29

  Project: Research

• OMAHA-4: CTU A Phase 3, Randomized, Open-label Study of MK-5684 Versus Alternative Abiraterone Acetate or Enzalutamide in Participants with Metastatic Castration-resistant Prostate Cancer (mCRPC) That Progressed On or After Prior Treatment with One Next-generation Hormonal Agent (NHA)

  Zhang, A., Martin, L., Contacos, C., Chester, C., Chapman, N. & TAIDI, G.

  6/02/24 → 18/01/29

  Project: Research