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Fingerprint Dive into the research topics where Adam Keith Walker is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 16 Similar Profiles
Amyotrophic Lateral Sclerosis Medicine & Life Sciences
Endoplasmic Reticulum Stress Medicine & Life Sciences
Protein Disulfide-Isomerases Medicine & Life Sciences
Frontotemporal Lobar Degeneration Medicine & Life Sciences
Pathology Medicine & Life Sciences
DNA-Binding Proteins Medicine & Life Sciences
Motor Neurons Medicine & Life Sciences
Unfolded Protein Response Medicine & Life Sciences

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Projects 2015 2021

Validating the NLRP3 Inflammasome as a Therapeutic Target in Motor Neuron Disease

Atkin, J., Woodruff, T. M., McCombe, P. A., Walker, A., Robertson, A. & Gordon, R.

1/01/1831/12/21

Project: Research

Novel therapeutics targeting neuronal transport pathways in MND

Atkin, J., Walker, A., Laird, A., Jonathan, B. & Abbott, B.

28/04/17 → …

Project: Research

Therapeutics based on the protective activity of protein disulphide in MND

Atkin, J., Walker, A., Laird, A., Heras, B., Anderson, M., Craik, D. & Bleackley, M.

28/04/17 → …

Project: Research

Frontotemporal Dementia
Motor Neuron Disease
Queensland

Research Outputs 2007 2019

  • 968 Citations
  • 13 h-Index
  • 23 Article
  • 3 Review article
  • 1 Chapter
  • 1 Comment/opinion

Genetic and immunopathological analysis of CHCHD10 in Australian amyotrophic lateral sclerosis and frontotemporal dementia and transgenic TDP-43 mice

McCann, E. P., Fifita, J. A., Grima, N., Galper, J., Mehta, P., Freckleton, S. E., Zhang, K. Y., Henden, L., Hogan, A. L., Chan Moi Fat, S., Wu, S. S. L., Jagaraj, C. J., Berning, B. A., Williams, K. L., Twine, N. A., Bauer, D., Piguet, O., Hodges, J., Kwok, J. B. J., Halliday, G. M. & 7 othersKiernan, M. C., Atkin, J., Rowe, D. B., Nicholson, G. A., Walker, A. K., Blair, I. P. & Yang, S., 5 Nov 2019, In : Journal of Neurology, Neurosurgery and Psychiatry.

Research output: Contribution to journalArticleResearchpeer-review

Sclerosis
DNA-Binding Proteins
Transgenic Mice
Spinal Cord
Proteins

Label-free fluorescent poly(amidoamine) dendrimer for traceable and controlled drug delivery

Wang, G., Fu, L., Walker, A., Chen, X., Lovejoy, D. B., Hao, M., Lee, A., Chung, R., Rizos, H., Irvine, M., Zheng, M., Liu, X., Lu, Y. & Shi, B., 13 May 2019, In : Biomacromolecules. 20, 5, p. 2148-2158 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Controlled drug delivery
Dendrimers
Cytotoxicity
Doxorubicin
Labels

Proteomics approaches for biomarker and drug target discovery in ALS and FTD

Hedl, T. J., San Gil, R., Cheng, F., Rayner, S. L., Davidson, J. M., De Luca, A., Villalva, M. D., Ecroyd, H., Walker, A. K. & Lee, A., 11 Jun 2019, In : Frontiers in Neuroscience. 13, p. 1-25 25 p., 548.

Research output: Contribution to journalReview articleResearchpeer-review

Open Access
File
Drug Discovery
Proteomics
Biomarkers
Proteins
Mass Spectrometry

ERp57 is protective against mutant SOD1-induced cellular pathology in amyotrophic lateral sclerosis

Parakh, S., Jagaraj, C. J., Vidal, M., Ragagnin, A. M. G., Perri, E. R., Konopka, A., Toth, R. P., Galper, J., Blair, I. P., Thomas, C. J., Walker, A. K., Yang, S., Spencer, D. M. & Atkin, J. D., 15 Apr 2018, In : Human molecular genetics. 27, 8, p. 1311-1331 21 p.

Research output: Contribution to journalArticleResearchpeer-review

Amyotrophic Lateral Sclerosis
Endoplasmic Reticulum Stress
Pathology
Apoptosis
DNA-Binding Proteins

Pathogenic mutation in the ALS/FTD gene, CCNF, causes elevated Lys48-linked ubiquitylation and defective autophagy

Lee, A., Rayner, S. L., Gwee, S. S. L., De Luca, A., Shahheydari, H., Sundaramoorthy, V., Ragagnin, A., Morsch, M., Radford, R., Galper, J., Freckleton, S., Shi, B., Walker, A. K., Don, E. K., Cole, N. J., Yang, S., Williams, K. L., Yerbury, J. J., Blair, I. P., Atkin, J. D. & 2 othersMolloy, M. P. & Chung, R. S., Jan 2018, In : Cellular and Molecular Life Sciences. 75, 2, p. 335–354 20 p.

Research output: Contribution to journalArticleResearchpeer-review

Cyclins
Ubiquitination
Autophagy
Mutation
Genes