• 862 Citations
  • 13 h-Index
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  • 25 Similar Profiles
Amyotrophic Lateral Sclerosis Medicine & Life Sciences
Endoplasmic Reticulum Stress Medicine & Life Sciences
Protein Disulfide-Isomerases Medicine & Life Sciences
Frontotemporal Lobar Degeneration Medicine & Life Sciences
Pathology Medicine & Life Sciences
DNA-Binding Proteins Medicine & Life Sciences
Motor Neurons Medicine & Life Sciences
Unfolded Protein Response Medicine & Life Sciences

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Projects 2015 2021

Validating the NLRP3 Inflammasome as a Therapeutic Target in Motor Neuron Disease

Atkin, J., Woodruff, T. M., McCombe, P. A., Walker, A., Robertson, A. & Gordon, R.


Project: Research

Novel therapeutics targeting neuronal transport pathways in MND

Atkin, J., Walker, A., Laird, A., Jonathan, B. & Abbott, B.

28/04/17 → …

Project: Research

Therapeutics based on the protective activity of protein disulphide in MND

Atkin, J., Walker, A., Laird, A., Heras, B., Anderson, M., Craik, D. & Bleackley, M.

28/04/17 → …

Project: Research

Research Output 2007 2018

  • 862 Citations
  • 13 h-Index
  • 20 Article
  • 3 Review article
  • 1 Chapter
  • 1 Comment/opinion

ERp57 is protective against mutant SOD1-induced cellular pathology in amyotrophic lateral sclerosis

Parakh, S., Jagaraj, C. J., Vidal, M., Ragagnin, A. M. G., Perri, E. R., Konopka, A., Toth, R. P., Galper, J., Blair, I. P., Thomas, C. J., Walker, A. K., Yang, S., Spencer, D. M. & Atkin, J. D. 15 Apr 2018 In : Human Molecular Genetics. 27, 8, p. 1311-1331 21 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Endoplasmic Reticulum Stress
DNA-Binding Proteins

Pathogenic mutation in the ALS/FTD gene, CCNF, causes elevated Lys48-linked ubiquitylation and defective autophagy

Lee, A. , Rayner, S. L. , Gwee, S. S. L. , De Luca, A. , Shahheydari, H. , Sundaramoorthy, V. , Ragagnin, A. , Morsch, M. , Radford, R. , Galper, J. , Freckleton, S. , Shi, B. , Walker, A. K. , Don, E. K. , Cole, N. J. , Yang, S. , Williams, K. L. , Yerbury, J. J. , Blair, I. P. , Atkin, J. D. & 2 others Molloy, M. P. & Chung, R. S. Jan 2018 In : Cellular and Molecular Life Sciences. 75, 2, p. 335–354 20 p.

Research output: Contribution to journalArticle


Stilbenes from Veratrum maackii Regel protect against ethanol-induced DNA damage in mouse cerebellum and cerebral cortex

Wu, Y., Li, S., Liu, J., Liu, X., Ruan, W., Lu, J., Liu, Y., Lawson, T., Shimoni, O., Lovejoy, D. B., Walker, A. K., Cong, Y. & Shi, B. 18 Jul 2018 In : ACS Chemical Neuroscience. 9, 7, p. 1616-1624 9 p.

Research output: Contribution to journalArticle

Cerebral Cortex
DNA Damage
Open Access
Casein Kinase II
Ubiquitin-Protein Ligases
Open Access
Quality Control
Neurodegenerative Diseases
Endoplasmic Reticulum-Associated Degradation
Molecular Chaperones