• 862 Citations
  • 13 h-Index
20072021
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Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

  • 25 Similar Profiles
Amyotrophic Lateral Sclerosis Medicine & Life Sciences
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Projects 2015 2021

Validating the NLRP3 Inflammasome as a Therapeutic Target in Motor Neuron Disease

Atkin, J., Woodruff, T. M., McCombe, P. A., Walker, A., Robertson, A. & Gordon, R.

1/01/1831/12/21

Project: Research

Novel therapeutics targeting neuronal transport pathways in MND

Atkin, J., Walker, A., Laird, A., Jonathan, B. & Abbott, B.

28/04/17 → …

Project: Research

Therapeutics based on the protective activity of protein disulphide in MND

Atkin, J., Walker, A., Laird, A., Heras, B., Anderson, M., Craik, D. & Bleackley, M.

28/04/17 → …

Project: Research

Research Output 2007 2018

  • 862 Citations
  • 13 h-Index
  • 20 Article
  • 3 Review article
  • 1 Chapter
  • 1 Comment/opinion

ERp57 is protective against mutant SOD1-induced cellular pathology in amyotrophic lateral sclerosis

Parakh, S., Jagaraj, C. J., Vidal, M., Ragagnin, A. M. G., Perri, E. R., Konopka, A., Toth, R. P., Galper, J., Blair, I. P., Thomas, C. J., Walker, A. K., Yang, S., Spencer, D. M. & Atkin, J. D. 15 Apr 2018 In : Human Molecular Genetics. 27, 8, p. 1311-1331 21 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Endoplasmic Reticulum Stress
Pathology
Apoptosis
DNA-Binding Proteins

Pathogenic mutation in the ALS/FTD gene, CCNF, causes elevated Lys48-linked ubiquitylation and defective autophagy

Lee, A. , Rayner, S. L. , Gwee, S. S. L. , De Luca, A. , Shahheydari, H. , Sundaramoorthy, V. , Ragagnin, A. , Morsch, M. , Radford, R. , Galper, J. , Freckleton, S. , Shi, B. , Walker, A. K. , Don, E. K. , Cole, N. J. , Yang, S. , Williams, K. L. , Yerbury, J. J. , Blair, I. P. , Atkin, J. D. & 2 others Molloy, M. P. & Chung, R. S. Jan 2018 In : Cellular and Molecular Life Sciences. 75, 2, p. 335–354 20 p.

Research output: Contribution to journalArticle

Cyclins
Ubiquitination
Autophagy
Mutation
Genes

Stilbenes from Veratrum maackii Regel protect against ethanol-induced DNA damage in mouse cerebellum and cerebral cortex

Wu, Y., Li, S., Liu, J., Liu, X., Ruan, W., Lu, J., Liu, Y., Lawson, T., Shimoni, O., Lovejoy, D. B., Walker, A. K., Cong, Y. & Shi, B. 18 Jul 2018 In : ACS Chemical Neuroscience. 9, 7, p. 1616-1624 9 p.

Research output: Contribution to journalArticle

Veratrum
Stilbenes
Cerebral Cortex
Cerebellum
DNA Damage
Open Access
File
Casein Kinase II
Phosphorylation
Cyclins
Ubiquitin-Protein Ligases
Ubiquitination
Open Access
File
Quality Control
Proteins
Neurodegenerative Diseases
Endoplasmic Reticulum-Associated Degradation
Molecular Chaperones