Projects per year
Search results
-
Active
Development of ALS gene therapies for targeted protein degradation of TDP-43
Lee, A., Morsch, M., Rayner, S. & Chung, R.
1/09/24 → 31/08/26
Project: Research
-
MNDRA24: Investigating the role of extracellular vesicles (EVs) membrane proteome in MND pathogenesis and clinical application
Wang, Y., Yang, S., Lee, A., Fath, T. & Ooi, L.
24/06/24 → 23/06/25
Project: Research
-
IDEAS 23: Developing novel gene expression control mechanisms for Amyotrophic Lateral Sclerosis gene therapies
Chung, R., Williams, K. & Lee, A.
1/05/24 → 30/04/27
Project: Research
-
FightMND ECRF: Improving the likelihood of translation of novel degrader technology for the treatment of MND
Rayner, S., Lee, A., Chung, R., Halliday, G., Walker, A. K. & Liu, F.
1/10/23 → 30/09/27
Project: Research
-
FightMND Discovery: Deciphering the role of TDP43 regulation of cryptic exons in ALS pathogenesis
Chung, R., Williams, K., Lee, A., Morsch, M., Rayner, S. & Grima, N.
1/10/23 → 30/09/26
Project: Research
-
MND led by UQ: Identifying proteins that control TDP-43 post-translational modification
Walker, A., Pflum, M., Bademosi, A., Ittner, A., Lee, A. & Rosa Fernandes, L.
13/07/23 → 30/06/25
Project: Research
-
Biomolecular Discovery and Design Research Centre
Packer, N., Paulsen, I., Nevalainen, H., Haynes, P., Molloy, M., Atwell, B., Barron, A., Beggs, P., Bergquist, P. L., Brown, L., Cornish, J., Chung, R., De Deene, Y., Garcia-Bennett, A., Gillings, M., Goodchild, A., Guillemin, G., Hallinan, J., Hose, G., Jaschke, P., Mabbutt, B., Raftos, D., Ranganathan, S., Sofronov, G., Sunna, A., Tetu, S., Andersen, M., Willows, R., Ahn, C., Breen, E., Campbell, M., Care, A., Cordina, N., Curach, N., Everest Dass, A., Elbourne, L., Goold, H., Hassan, K., Kautto, L., Krisp, C., Kroukamp, H., Lee, A., Lin, C., Mackie, A., McKay, M., McQuade, L., Mirzaei, M., Mohamedali, A., Ostrowski, M., Parker, L., Pascovici, D., Penesyan, A., Shah, B., Sun, A., Thompson, E. & Williams, T.
1/01/17 → …
Project: Research
-
Advanced protein quantification capability
Walker, A. K., Lee, A., Connor, M., Atkin, J., Lim, E., Baker, M. S., Rizos, H., Phillips, J. K., Yang, S. & Blair, I.
1/01/17 → …
Project: Research
-
Not started
Evaluation of molecular biomarkers for diagnostic and prognostic use in ALS
Chung, R., Lee, A., Morsch, M., Enge, T. G. & Dossetto, A.
Project: Other
-
Finished
MNDRA23: Characterising CHCHD10-induced TDP-43 mitochondria entry in MND
Yang, S., Lee, A., Zou, A. & Blair, I.
30/06/23 → 29/06/24
Project: Research
-
Characterising the interactome of sequestosome-1/(p62) – the peacemaker between protein homeostasis and dysfunction
Davidson, J., Lee, A., Morsch, M., Richter, G., Rea, S. & Di Ieva, A.
14/03/23 → 14/03/24
Project: Research
-
Characterising the interactome of sequestosome-1 (p62) – the peacemaker between protein homeostasis and dysfunction
Davidson, J., Lee, A., Morsch, M., Richter, G., Di Ieva, A. & Rea, S.
1/01/23 → 31/12/23
Project: Research
-
Predicting Motor Neuron Disease (MND) Patient Status by Machine Learning
Lee, A., Liu, S. & Suddull, H.
24/01/21 → 31/12/22
Project: Research
-
Microglia and the inflammation spectrum - not just good or bad
Morsch, M., Lee, A. & Williams, K.
1/01/21 → 31/12/23
Project: Research
-
Development of a TDP43-targeting gene therapy for ALS
Chung, R., Lisowski, L., Walker, A. K., Rogers, M., Lee, A., Morsch, M. & Rayner, S.
1/10/20 → 30/09/23
Project: Research
-
The unexplored posttranslational modification (SUMOylation) of TDP-43 affects aggregate formation and localisation
Morsch, M., Maurel, C., Lee, A., Vourc'H, P. & Chung, R.
1/06/20 → 31/05/21
Project: Research
-
Clearance of TDP-43 by PROteolysis TArgeting Chimera (PROTAC) dual targeting to treat amyotrophic lateral sclerosis (ALS)
Lee, A., Rayner, S., Martin, A., van Hummel, A., Morsch, M., Shi, B., Ke, Y., Ittner, L. & Chung, R.
4/05/20 → 3/05/21
Project: Research
-
CMNDR: Macquarie University Centre for Motor Neuron Disease Research
Atkin, J., Blair, I., Rowe, D., Atkin, J., Chung, R., Guillemin, G., Laird, A., Lee, A., Morsch, M., Shi, B., Williams, K. & Yang, S.
1/01/20 → 31/12/22
Project: Other
-
BDRC: Biomolecular Discovery Research Centre
Sunna, A., Packer, N., Paulsen, I., Guillemin, G., Li, M., Sofronov, G., Haynes, P., Mabbutt, B., Tetu, S., Thaysen-Andersen, M., Ponton, F., Garcia-Bennett, A., Wang, Y., Cain, A., Kroukamp, H., Maselko, M., Francis, H., Liquet-Weiland, B., Rodger, A., Lee, A., Connor, M., Inglis, D., Carthey, A. & Asadnia, M.
1/01/20 → 31/12/22
Project: Other
-
Refinement of CCNF gene therapy for MND
Rayner, S., Lee, A. & Chung, R.
1/08/19 → 30/06/20
Project: Research
-
Targeting the nucleo-cytoplasmic transport machinery in sporadic and familial ALS
Morsch, M., Lee, A., Walker, A. K. & Chung, R.
1/06/19 → 31/05/20
Project: Research
-
Revealing the role of protein clearance pathways in sporadic ALS
Chung, R., Lee, A., Rayner, S. & Yang, S.
1/05/19 → 30/04/20
Project: Research
-
Pre-clinical evaluation of novel therapies for clearance of TDP-43 in amyotrophic lateral sclerosis
Chung, R., Walker, A. K., Ittner, L., Lee, A. & Rayner, S.
1/01/19 → 31/12/19
Project: Research
-
Glycoproteomic characterisation of pathogenic gene mutations in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD)
Lee, A., Moh, E., Vidal Robau, M., Chung, R., Atkin, J., Thaysen-Andersen, M. & Packer, N.
1/07/18 → 31/12/18
Project: Research
-
The role of mutant CYLD in frontotemporal dementia and motor neuron disease
Blair, I., Dobson-Stone, C., Kwok, J. B., Atkin, J., Ooi, L., Ittner, A., Lee, A., Mather, K. A., Thompson, E. & Burgio, G.
1/01/18 → 31/12/21
Project: Research
-
Calpeptin, and related candidates, for the treatment of Machado Joseph disease
Laird, A., Nicholson, G., Walker, A. K., Cole, N., Lee, A., Morsch, M., Davis, R., Guillemin, G., Atkin, J. & Ooi, L.
1/01/18 → 31/12/21
Project: Research
-
Establishing an advanced platform for single cell fluorescent imaging and analysis
Morsch, M., Yang, S., Lee, A., Lim, E., Chung, R., Blair, I., Rizos, H. & Atkin, J.
1/01/18 → 31/12/18
Project: Other
-
Macquarie University Centre for Motor Neuron Disease Research
Blair, I., Rowe, D., Guillemin, G., Chung, R., Atkin, J., Cole, N., Laird, A., Lim, E., Williams, K., Yang, S., Morsch, M., Lee, A., Shi, B., Walker, A. K., Lovejoy, D., Furlong, S., Adams, L., Syal, D., Bazzi, R., Svahn, A., Parakh, S., Shahheydari, H., Konopka, A., Ragagnin, A., Mehta, P., Wright, A., Bourbon, L., Sabaretnam, M., Don, E., Hortle, E., De Luca, A., Zhang, K., Tarr, I., Galper, J., Varney, B., Chow, S. & Formella, I.
1/01/17 → 31/12/19
Project: Research
-
New approaches to plasma biomarker studies in MND/ALS.
Chung, R., Molloy, M., Rowe, D., Guillemin, G., Krisp, C. & Lee, A.
10/06/16 → 9/06/17
Project: Research
-
Identifying mechanisms responsible for ubiquitination of TAR DNA-binding protein 43 (TDP-43) in ALS pathogenesis
Lee, A., Chung, R., Blair, I. & Atkin, J.
1/02/16 → 18/02/17
Project: Research
-
Proteomic studies to identify the defects in protein-protein interactions and cellular signalling pathways caused by mutations in a newly identified familial ALS gene
Chung, R., Blair, I., Yerbury, J., Lee, A., Molloy, M. & Atkin, J.
1/06/15 → 31/05/16
Project: Research
-
Live-cell confocal microscope
Atkin, J., Sundaramoorthy, V., Halloran, M., Avolio, A., Butlin, M., Chung, R., Morsch, M., Lee, A., Shi, B., Connor, M., Goodchild, A., Hassan, S., Guillemin, G., Lim, E., Lovejoy, D., Adams, S., Heng, B., McMullan, S., Phillips, J. K., Hildreth, C., Rizos, H., Shahheydari, H., Irvine, M., Lauter, C., Boyd, S. & Vickery, K.
12/02/15 → 31/12/15
Project: Research