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Research Outputs 2006 2019

2019

Bioreducible zinc(II)–dipicolylamine functionalized hyaluronic acid mediates safe siRNA delivery and effective glioblastoma RNAi therapy

Zheng, M., Yang, Z., Chen, S., Wu, H., Liu, Y., Wright, A., Lu, J-W., Xia, X., Lee, A., Zhang, J., Yin, H., Wang, Y., Ruan, W. & Liang, X-J., 22 Jan 2019, In : ACS Applied Bio Materials. 2, 1, p. 362-369 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Hyaluronic Acid
Glioblastoma
RNA Interference
Small Interfering RNA
Nanomedicine

Label-free fluorescent poly(amidoamine) dendrimer for traceable and controlled drug delivery

Wang, G., Fu, L., Walker, A., Chen, X., Lovejoy, D. B., Hao, M., Lee, A., Chung, R., Rizos, H., Irvine, M., Zheng, M., Liu, X., Lu, Y. & Shi, B., 13 May 2019, In : Biomacromolecules. 20, 5, p. 2148-2158 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Controlled drug delivery
Dendrimers
Cytotoxicity
Doxorubicin
Labels

Proteomics approaches for biomarker and drug target discovery in ALS and FTD

Hedl, T. J., San Gil, R., Cheng, F., Rayner, S. L., Davidson, J. M., De Luca, A., Villalva, M. D., Ecroyd, H., Walker, A. K. & Lee, A., 11 Jun 2019, In : Frontiers in Neuroscience. 13, p. 1-25 25 p., 548.

Research output: Contribution to journalReview articleResearchpeer-review

Open Access
File
Drug Discovery
Proteomics
Biomarkers
Proteins
Mass Spectrometry
Ligases
Ubiquitin
Neurodegenerative Diseases
Proteomics
Ubiquitin-Protein Ligases
2018

Aurora kinase B regulates axonal outgrowth and regeneration in the spinal motor neurons of developing zebrafish

Gwee, S. S. L., Radford, R. A. W., Chow, S., Syal, M. D., Morsch, M., Formella, I., Lee, A., Don, E. K., Badrock, A. P., Cole, N. J., West, A. K., Cheung, S. N. S. & Chung, R. S., Dec 2018, In : Cellular and molecular life sciences. 75, 23, p. 4269-4285 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Aurora Kinase B
Motor Neurons
Zebrafish
Regeneration
Neurons

DNA nanoclew templated spherical nucleic acids for siRNA delivery

Ruan, W., Zheng, M., An, Y., Liu, Y., Lovejoy, D., Hao, M., Zou, Y., Lee, A., Yang, S., Lu, Y., Morsch, M., Chung, R. & Shi, B., 14 Apr 2018, In : Chemical Engineering Communications. 54, p. 3609-3612 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Nucleic acids
Nucleic Acids
Small Interfering RNA
DNA
Ribonuclease III

Pathogenic mutation in the ALS/FTD gene, CCNF, causes elevated Lys48-linked ubiquitylation and defective autophagy

Lee, A., Rayner, S. L., Gwee, S. S. L., De Luca, A., Shahheydari, H., Sundaramoorthy, V., Ragagnin, A., Morsch, M., Radford, R., Galper, J., Freckleton, S., Shi, B., Walker, A. K., Don, E. K., Cole, N. J., Yang, S., Williams, K. L., Yerbury, J. J., Blair, I. P., Atkin, J. D. & 2 othersMolloy, M. P. & Chung, R. S., Jan 2018, In : Cellular and Molecular Life Sciences. 75, 2, p. 335–354 20 p.

Research output: Contribution to journalArticleResearchpeer-review

Cyclins
Ubiquitination
Autophagy
Mutation
Genes

Real-time visualization of oxidative stress-mediated neurodegeneration of individual spinal motor neurons in vivo

Formella, I., Svahn, A. J., Radford, R. A. W., Don, E. K., Cole, N. J., Hogan, A., Lee, A., Chung, R. S. & Morsch, M., 1 Oct 2018, In : Redox Biology. 19, p. 226-234 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Oxidative stress
Motor Neurons
Neurons
Reactive Oxygen Species
Oxidative Stress
2017

A Versatile upconversion surface evaluation platform for bio-nano surface selection for the nervous system

Fu, L., Morsch, M., Shi, B., Wang, G., Lee, A., Radford, R., Lu, Y., Jin, D. & Chung, R., 17 Aug 2017, In : Nanoscale. 9, 36, p. 13683-13692 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Neurology
Nanoparticles
Neurodegenerative diseases
Cytotoxicity
Polyethylene glycols

Casein kinase II phosphorylation of cyclin F at serine 621 regulates the Lys48-ubiquitylation E3 ligase activity of the SCF(cyclin F) complex

Lee, A., Rayner, S. L., De Luca, A., Gwee, S. S. L., Morsch, M., Sundaramoorthy, V., Shahheydari, H., Ragagnin, A., Shi, B., Yang, S., Williams, K. L., Don, E. K., Walker, A. K., Zhang, K. Y., Yerbury, J. J., Cole, N. J., Atkin, J. D., Blair, I. P., Molloy, M. P. & Chung, R. S., 2017, In : Open Biology. 7, 10, p. 1-11 11 p., 170058.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Casein Kinase II
Phosphorylation
Cyclins
Ubiquitin-Protein Ligases
Ubiquitination

Cyclin F: a component of an E3 ubiquitin ligase complex with roles in neurodegeneration and cancer

Galper, J., Rayner, S. L., Hogan, A. L., Fifita, J. A., Lee, A., Chung, R. S., Blair, I. P. & Yang, S., 1 Aug 2017, In : International Journal of Biochemistry and Cell Biology. 89, p. 216-220 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Cyclins
Ubiquitin-Protein Ligases
Cell Cycle Checkpoints
Frontotemporal Dementia
Neoplasms

Expression of ALS/FTD-linked mutant CCNF in zebrafish leads to increased cell death in the spinal cord and an aberrant motor phenotype

Hogan, A. L., Don, E. K., Rayner, S. L., Lee, A., Laird, A. S., Watchon, M., Winnick, C., Tarr, I. S., Morsch, M., Fifita, J. A., Gwee, S. S. L., Formella, I., Hortle, E., Yuan, K. C., Molloy, M. P., Williams, K. L., Nicholson, G. A., Chung, R. S., Blair, I. P. & Cole, N. J., 15 Jul 2017, In : Human molecular genetics. 26, 14, p. 2616-2626 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Amyotrophic Lateral Sclerosis
Zebrafish
Spinal Cord
Cell Death
Phenotype

Multifunctional hybrid nanoparticles for traceable drug delivery and intracellular microenvironment-controlled multistage drug-release in neurons

Shi, B., Du, X., Chen, J., Fu, L., Morsch, M., Lee, A., Liu, Y., Cole, N. & Chung, R., 24 May 2017, In : Small. 13, 20, p. 1-10 10 p., 1603966.

Research output: Contribution to journalArticleResearchpeer-review

Drug delivery
Nanoparticles
Neurons
Drug Delivery Systems
Brain Diseases

Plasma biomarker proteins for detection of human growth hormone administration in athletes

Tan, S-H., Lee, A., Pascovici, D., Care, N., Birzniece, V., Ho, K., Molloy, M. P. & Khan, A., 2017, In : Scientific Reports. 7, 1, p. 1-12 12 p., 10039.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Human Growth Hormone
Athletes
Growth Hormone
Blood Proteins
Biomarkers

Triggering cell stress and death using conventional UV laser confocal microscopy

Morsch, M., Radford, R. A. W., Don, E. K., Lee, A., Hortle, E., Cole, N. J. & Chung, R. S., 2 Mar 2017, In : Journal of visualized experiments : JoVE. 2017, 120, p. 1-9 9 p., e54983.

Research output: Contribution to journalArticleResearchpeer-review

Confocal microscopy
Ablation
Confocal Microscopy
Cell Death
Laser ablation
2016

CCNF mutations in amyotrophic lateral sclerosis and frontotemporal dementia

Williams, K. L., Topp, S., Yang, S., Smith, B., Fifita, J. A., Warraich, S. T., Zhang, K. Y., Farrawell, N., Vance, C., Hu, X., Chesi, A., Leblond, C. S., Lee, A., Rayner, S. L., Sundaramoorthy, V., Dobson-Stone, C., Molloy, M. P., Van Blitterswijk, M., Dickson, D. W., Petersen, R. C. & 48 othersGraff-Radford, N. R., Boeve, B. F., Murray, M. E., Pottier, C., Don, E., Winnick, C., McCann, E. P., Hogan, A., Daoud, H., Levert, A., Dion, P. A., Mitsui, J., Ishiura, H., Takahashi, Y., Goto, J., Kost, J., Gellera, C., Gkazi, A. S., Miller, J., Stockton, J., Brooks, W. S., Boundy, K., Polak, M., Muñoz-Blanco, J. L., Esteban-Pérez, J., Rábano, A., Hardiman, O., Morrison, K. E., Ticozzi, N., Silani, V., De Belleroche, J., Glass, J. D., Kwok, J. B. J., Guillemin, G. J., Chung, R. S., Tsuji, S., Brown, R. H., García-Redondo, A., Rademakers, R., Landers, J. E., Gitler, A. D., Rouleau, G. A., Cole, N. J., Yerbury, J. J., Atkin, J. D., Shaw, C. E., Nicholson, G. A. & Blair, I. P., 15 Apr 2016, In : Nature Communications. 7, p. 1-8 8 p., 11253.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Ubiquitinated Proteins
mutations
Ubiquitin-Protein Ligase Complexes
proteins
Mutation

Combined Antibody/Lectin enrichment identifies extensive changes in the O-GIcNAc Sub-proteome upon Oxidative stress

Lee, A., Miller, D., Henry, R., Paruchuri, V. D. P., O'Meally, R. N., Boronina, T., Cole, R. N. & Zachara, N. E., 2 Dec 2016, In : Journal of Proteome Research. 15, 12, p. 4318-4336 19 p.

Research output: Contribution to journalArticleResearchpeer-review

Oxidative stress
Proteome
Lectins
Oxidative Stress
Antibodies
2015

In vivo characterization of microglial engulfment of dying neurons in the zebrafish spinal cord

Morsch, M., Radford, R., Lee, A., Don, E. K., Badrock, A. P., Hall, T. E., Cole, N. J. & Chung, R., 31 Aug 2015, In : Frontiers in Cellular Neuroscience. 9, p. 1-11 11 p., 321.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Microglia
Zebrafish
Spinal Cord
Neurons
Central Nervous System

Quantitative phosphoproteomics reveals crosstalk between phosphorylation and O-GlcNAc in the DNA damage response pathway

Zhong, J., Martinez, M., Sengupta, S., Lee, A., Wu, X., Chaerkady, R., Chatterjee, A., O'Meally, R. N., Cole, R. N., Pandey, A. & Zachara, N. E., 1 Jan 2015, In : Proteomics. 15, 2-3, p. 591-607 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Phosphorylation
Crosstalk
DNA Damage
Automatic teller machines
DNA
2014

Characterization of the specificity of O-GlcNAc reactive antibodies under conditions of starvation and stress

Reeves, R. A., Lee, A., Henry, R. & Zachara, N. E., 15 Jul 2014, In : Analytical Biochemistry. 457, p. 8-18 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Starvation
Antibodies
Workflow
Glucose
Phosphorylation

O-GlcNAc regulated arginine methylation: a novel paradigm in survival signaling

Zachara, N., Fahie, K., Henry, R., Miller, D. & Lee, A., Apr 2014, In : FASEB Journal. 28, 1, 1 p., 359.3.

Research output: Contribution to journalMeeting abstractResearch

2013

Dynamic O-GlcNAcylation and its roles in the cellular stress response and homeostasis

Groves, J. A., Lee, A., Yildirir, G. & Zachara, N. E., Sep 2013, In : Cell Stress and Chaperones. 18, 5, p. 535-558 24 p.

Research output: Contribution to journalReview articleResearchpeer-review

Homeostasis
Heat-Shock Proteins
Proteins
Mitochondrial Dynamics
Biological Phenomena

O-GlcNAc regulated arginine methylation: a novel paradigm in survival signaling

Lee, A., Fahie, K., Henry, R., Miller, D. & Zachara, N., Nov 2013, In : Glycobiology. 23, 11, p. 1338-1339 2 p., 27.

Research output: Contribution to journalMeeting abstractResearchpeer-review

Tandem ion exchange fractionation of chicken egg white reveals the presence of proliferative bioactivity

Lee, A., Molloy, M. P., Baker, M. S. & Kapur, A., 1 May 2013, In : Journal of Agricultural and Food Chemistry. 61, 17, p. 4079-4088 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Egg White
chicken eggs
Ion Exchange
ion exchange
egg albumen
2012

Characterization of the specificity of CTD110.6, an O-GlcNAc reactive antibody, under conditions of cellular starvation and stress

Reeves, R. A., Lee, A., Hart, G. & Zachara, N., Nov 2012, In : Glycobiology. 22, 11, p. 1555-1555 1 p., 108.

Research output: Contribution to journalMeeting abstractResearchpeer-review

O-GlcNAc-regulated arginine methylation: a new paradigm in survival signaling

Lee, A., Miller, D., Henry, R. & Zachara, N., Nov 2012, In : Glycobiology. 22, 11, p. 1521-1521 1 p., 10.

Research output: Contribution to journalMeeting abstractResearchpeer-review

2011

Less label, more free: Approaches in label-free quantitative mass spectrometry

Neilson, K. A., Ali, N. A., Muralidharan, S., Mirzaei, M., Mariani, M., Assadourian, G., Lee, A., Van Sluyter, S. C. & Haynes, P. A., Feb 2011, In : Proteomics. 11, 4, p. 535-553 19 p.

Research output: Contribution to journalReview articleResearchpeer-review

Proteomics
Mass spectrometry
Labels
Mass Spectrometry
Workflow

Liver membrane proteome glycosylation changes in mice bearing an extra-hepatic tumor

Lee, A., Chick, J. M., Kolarich, D., Haynes, P. A., Robertson, G. R., Tsoli, M., Jankova, L., Clarke, S. J., Packer, N. H. & Baker, M. S., Sep 2011, In : Molecular and Cellular Proteomics. 10, 9, p. 1-18 18 p., M900538-MCP200.

Research output: Contribution to journalArticleResearchpeer-review

Bearings (structural)
Glycosylation
Proteome
Liver
Tumors

Quantitative N-linked glycoproteomics of myocardial ischemia and reperfusion injury reveals early remodeling in the extracellular environment

Parker, B. L., Palmisano, G., Edwards, A. V. G., White, M. Y., Engholm-Keller, K., Lee, A., Scott, N. E., Kolarich, D., Hambly, B. D., Packer, N. H., Larsen, M. R. & Cordwell, S. J., Aug 2011, In : Molecular and Cellular Proteomics. 10, 8, p. 1-13 13 p., M110.006833.

Research output: Contribution to journalArticleResearchpeer-review

Myocardial Reperfusion Injury
Reperfusion Injury
Myocardial Ischemia
Glycopeptides
Peptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine Amidase
2010

The lectin riddle: Glycoproteins fractionated from complex mixtures have similar glycomic profiles

Lee, A., Nakano, M., Hincapie, M., Kolarich, D., Baker, M. S., Hancock, W. S. & Packer, N. H., 1 Aug 2010, In : OMICS A Journal of Integrative Biology. 14, 4, p. 487-499 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Glycomics
Complex Mixtures
Lectins
Glycoproteins
Oligosaccharides
2009

Rat liver membrane glycoproteome: Enrichment by phase partitioning and glycoprotein capture

Lee, A., Kolarich, D., Haynes, P. A., Jensen, P. H., Baker, M. S. & Packer, N. H., Feb 2009, In : Journal of Proteome Research. 8, 2, p. 770-781 12 p.

Research output: Contribution to journalArticleResearchpeer-review

hydrazine
Liver
Rats
Glycoproteins
Membrane Proteins
2007

A comparative study of gel based shotgun proteomic techniques using rat liver membrane protein

Lee, A., Chick, J., Haynes, P. A., Molloy, M., Baker, M. S., Uhlen, K., Hornsten, L., Bjellqvist, B. & Len, A., 2007, p. 54-54. 1 p.

Research output: Contribution to conferenceAbstractResearch

TFF system throughput twice that of other evaluated systems

Kapur, A., Lee, A., Baker, M. S., Hood, B. & Yang, Y., Jan 2007, GE Healthcare. 4 p.

Research output: Book/ReportOther reportResearchpeer-review

proteome
immunoglobulin Y
health services
2006

A comparison of immunodepletion strategies for plasma biomarker discovery

Baker, M. S., Khan, A., Lee, A., Shum, W. -K., Soon, J., Molloy, M. P., Polaskova, V., Tan, S. -H. & Kapur, A., Oct 2006, In : Molecular and Cellular Proteomics. 5, S10, p. S180-S180 1 p.

Research output: Contribution to journalMeeting abstractResearchpeer-review