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Personal profile


I finished my ophthalmology training in Russia in 1985, and set up a large independent diagnostic centre. Since then I have specialized in clinical electrophysiology of vision. In 1992 I migrated to Australia. I completed my PhD in UNSW (Sydney) in 1996. During last several years my research has expanded into area of neurological diseases, particularly multiple sclerosis (MS). Thus, in 2008 I performed world’s first study of structure/function interaction in visual system of optic neuritis patients. I also initiated and, in collaboration with the REEH (Melbourne), have conducted studies of optic nerve remyelination, which are now considered a benchmark for trials of MS therapies (2009). I have became an expert in structural techniques such as Optical Coherence Tomography and Magnetic Resonance Imaging of the visual system, which is reflected in frequent requests to review papers submitted to ophthalmic and neurology journals. My collaboration with Macquarie University produced one of the world first algorithms for retinal segmentation of OCT images (2009) and helped to develop an animal model of optic nerve demyelination (2010), while collaboration with Hebrew University (Israel) and BMRI (Sydney) resulted in development of a special methodology to analyse the posterior part of the visual pathway in MS patients (2011).

My work resulted in several invitations for review papers and more then 70 publications in leading ophthalmological and neurological journals. Results of my studies were published in Annals of Neurology, NeuroImage, Neurology, Ophthalmology, Journal of Neurology, Neurosurgery and Psychiatry, Multiple Sclerosis and others.I have been involved in five international clinical trials both as an investigator and a study designer. I have been CIA on 3 NHMRC grants, I have also been CIA on grants from the American MS Society, the Australian MS Society, ORIA and others with total amount of funding exceeding $4.5m ($3m in last 5 years). I was awarded a Sydney Medical Foundation Fellowship continuously from 1999 to 2013. My most recent achievement is securing (as CIA) a $1.2m grant from National MS Society (USA) and matching grant from Sydney University Medical Foundation ($1.2 m) to conduct longitudinal study of visual system in MS. This work, which commenced in 2014, involves collaborating with leading MS research centers in Italy, Spain, Israel, Germany and Canada.

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  • 7 Similar Profiles
Visual Evoked Potentials Medicine & Life Sciences
Optic Neuritis Medicine & Life Sciences
Multiple Sclerosis Medicine & Life Sciences
Glaucoma Medicine & Life Sciences
Visual Fields Medicine & Life Sciences
Nerve Fibers Medicine & Life Sciences
Optic Nerve Medicine & Life Sciences
Visual Field Tests Medicine & Life Sciences

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Projects 2008 2020

Research Output 1996 2019

Demyelination precedes axonal loss in the transneuronal spread of human neurodegenerative disease

You, Y., Joseph, C., Wang, C., Gupta, V., Liu, S., Yiannikas, C., Chua, B., Chitranshi, N., Shen, T., Dheer, Y., Invernizzi, A., Borotkanics, R., Barnett, M., Graham, S. L. & Klistorner, A., 1 Feb 2019, In : Brain; a journal of neurology. 142, 2, p. 426-442 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Demyelinating Diseases
Neurodegenerative Diseases
Myelin Sheath

Differing structural and functional patterns of optic nerve damage in multiple sclerosis and neuromyelitis optica spectrum disorder

Shen, T., You, Y., Arunachalam, S., Fontes, A., Liu, S., Gupta, V., Parratt, J., Wang, C., Barnett, M., Barton, J., Chitranshi, N., Zhu, L., Fraser, C. L., Graham, S. L., Klistorner, A. & Yiannikas, C., Mar 2019, In : Ophthalmology. 126, 3, p. 445-453 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Neuromyelitis Optica
Optic Nerve
Multiple Sclerosis
Visual Evoked Potentials

Evidence of Müller glial dysfunction in patients with aquaporin-4 immunoglobulin G–positive neuromyelitis optica spectrum disorder

You, Y., Zhu, L., Zhang, T., Shen, T., Fontes, A., Yiannikas, C., Parratt, J., Barton, J., Schulz, A., Gupta, V., Barnett, M. H., Fraser, C. L., Gillies, M., Graham, S. L. & Klistorner, A., 1 Feb 2019, In : Ophthalmology.

Research output: Contribution to journalArticleResearchpeer-review

Aquaporin 4
Neuromyelitis Optica
Immunoglobulin G
Multiple Sclerosis

MS-GAN: GAN-based semantic segmentation of multiple sclerosis lesions in brain magnetic resonance imaging

Zhang, C., Song, Y., Liu, S., Lill, S., Wang, C., Tang, Z., You, Y., Gao, Y., Klistorner, A., Barnett, M. & Cai, W., 16 Jan 2019, 2018 International Conference on Digital Image Computing: Techniques and Applications, DICTA 2018. Murshed, M., Paul, M., Asikuzzaman, M., Pickering, M., Natu, A., Robles-Kelly, A., You, S., Zheng, L. & Rahman, A. (eds.). Institute of Electrical and Electronics Engineers (IEEE), 8 p. 8615771

Research output: Chapter in Book/Report/Conference proceedingConference proceeding contributionResearchpeer-review

Magnetic resonance
Multiple Sclerosis
Magnetic Resonance Imaging

Sex-specific effect of BDNF Val66Met genotypes on the progression of open-angle glaucoma

Shen, T., Gupta, V. K., Klistorner, A., Chitranshi, N., Graham, S. L. & You, Y., 1 Mar 2019, In : Investigative ophthalmology & visual science. 60, 4, p. 1069-1075 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Open Angle Glaucoma
Brain-Derived Neurotrophic Factor
Nerve Fibers