Projects per year
Personal profile
Biography
I finished my ophthalmology training in Russia in 1985, and set up a large independent diagnostic centre. Since then I have specialized in clinical electrophysiology of vision. In 1992 I migrated to Australia. I completed my PhD in UNSW (Sydney) in 1996. During last several years my research has expanded into area of neurological diseases, particularly multiple sclerosis (MS). Thus, in 2008 I performed world’s first study of structure/function interaction in visual system of optic neuritis patients. I also initiated and, in collaboration with the REEH (Melbourne), have conducted studies of optic nerve remyelination, which are now considered a benchmark for trials of MS therapies (2009). I have became an expert in structural techniques such as Optical Coherence Tomography and Magnetic Resonance Imaging of the visual system, which is reflected in frequent requests to review papers submitted to ophthalmic and neurology journals. My collaboration with Macquarie University produced one of the world first algorithms for retinal segmentation of OCT images (2009) and helped to develop an animal model of optic nerve demyelination (2010), while collaboration with Hebrew University (Israel) and BMRI (Sydney) resulted in development of a special methodology to analyse the posterior part of the visual pathway in MS patients (2011).
My work resulted in several invitations for review papers and more then 70 publications in leading ophthalmological and neurological journals. Results of my studies were published in Annals of Neurology, NeuroImage, Neurology, Ophthalmology, Journal of Neurology, Neurosurgery and Psychiatry, Multiple Sclerosis and others.I have been involved in five international clinical trials both as an investigator and a study designer. I have been CIA on 3 NHMRC grants, I have also been CIA on grants from the American MS Society, the Australian MS Society, ORIA and others with total amount of funding exceeding $4.5m ($3m in last 5 years). I was awarded a Sydney Medical Foundation Fellowship continuously from 1999 to 2013. My most recent achievement is securing (as CIA) a $1.2m grant from National MS Society (USA) and matching grant from Sydney University Medical Foundation ($1.2 m) to conduct longitudinal study of visual system in MS. This work, which commenced in 2014, involves collaborating with leading MS research centers in Italy, Spain, Israel, Germany and Canada.
I have initiated close collaboration between ophthalmology and neurology Departments and Brain and Mind Center, which led to the development of my current research program. Furthermore, as part of the research program I established close collaboration with several leading international institutions such as:
- University Hospital, Düsseldorf (Germany),
- Clinical Neuroimmunology Group NeuroCure Clinical Research Center Charité - Universitätsmedizin Berlin (Germany),
- Institute of Computer Vision and Robotics, University of Girona (Spain),
- Tel Aviv university (Israel),
- San Raffaele hospital, Milan (Italy),
- Departments of Clinical Neurosciences and Surgery, University of Calgary (Canada)
- Hadassah medical center (Israel).
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Collaborations and top research areas from the last five years
Projects
- 10 Finished
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Investigating the role of demyelination in anterograde transsynaptic degeneration in MS
1/04/20 → 31/03/24
Project: Research
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Mechanisms for the neuroprotective effects of Siponimod - Is there neuroprotection beyond S1P receptors?
Graham, S. L., Klistorner, A., Gupta, V. & Mirzaei, M.
13/07/18 → 31/10/20
Project: Other
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Validating biomarkers of myelination and axonal loss in visual system of MS patients.
1/01/16 → 1/06/20
Project: Research
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Neuroprotective role of FTY720 in congenital mouse model of Glaucoma
Graham, S. L., Klistorner, A., Gupta, V. & You, Y.
1/08/14 → 30/09/16
Project: Research
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Mechanisms of transsynaptic degeneration in the aging brain
Wall, R. V., Basavarajappa, D., Klistorner, A., Graham, S. & You, Y., 1 Oct 2024, In: Aging and Disease. 15, 5, p. 2149-2167 19 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile25 Downloads (Pure) -
Anti-inflammatory effects of siponimod in a mouse model of excitotoxicity-induced retinal injury
Basavarajappa, D., Gupta, V., Chitranshi, N., Viswanathan, D., Gupta, V., Vander Wall, R., Palanivel, V., Mirzaei, M., You, Y., Klistorner, A. & Graham, S. L., Dec 2023, In: Molecular Neurobiology. 60, 12, p. 7222-7237 16 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile8 Citations (Scopus)48 Downloads (Pure) -
A real-world clinical validation for AI-based MRI monitoring in multiple sclerosis
Barnett, M., Wang, D., Beadnall, H., Bischof, A., Brunacci, D., Butzkueven, H., Brown, J. W. L., Cabezas, M., Das, T., Dugal, T., Guilfoyle, D., Klistorner, A., Krieger, S., Kyle, K., Ly, L., Masters, L., Shieh, A., Tang, Z., van der Walt, A., Ward, K., & 5 others , 19 Oct 2023, In: npj Digital Medicine. 6, 1, p. 1-9 9 p., 196.Research output: Contribution to journal › Article › peer-review
Open AccessFile10 Citations (Scopus)51 Downloads (Pure) -
S1PR1 signaling attenuates apoptosis of retinal ganglion cells via modulation of cJun/Bim cascade and Bad phosphorylation in a mouse model of glaucoma
Basavarajappa, D., Gupta, V., Vander Wall, R., Gupta, V., Chitranshi, N., Mirshahvaladi, S. S. O., Palanivel, V., You, Y., Mirzaei, M., Klistorner, A. & Graham, S. L., Jan 2023, In: FASEB Journal. 37, 1, p. 1-16 16 p., e22710.Research output: Contribution to journal › Article › peer-review
Open AccessFile9 Citations (Scopus)120 Downloads (Pure) -
Siponimod exerts neuroprotective effects on the retina and higher visual pathway through neuronal S1PR1 in experimental glaucoma
Basavarajappa, D., Gupta, V., Chitranshi, N., Wall, R. V., Rajput, R., Pushpitha, K., Sharma, S., Mirzaei, M., Klistorner, A. & Graham, S. L., Apr 2023, In: Neural Regeneration Research. 18, 4, p. 840-848 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile10 Citations (Scopus)43 Downloads (Pure)