Projects per year
Personal profile
Biography
I finished my ophthalmology training in Russia in 1985, and set up a large independent diagnostic centre. Since then I have specialized in clinical electrophysiology of vision. In 1992 I migrated to Australia. I completed my PhD in UNSW (Sydney) in 1996. During last several years my research has expanded into area of neurological diseases, particularly multiple sclerosis (MS). Thus, in 2008 I performed world’s first study of structure/function interaction in visual system of optic neuritis patients. I also initiated and, in collaboration with the REEH (Melbourne), have conducted studies of optic nerve remyelination, which are now considered a benchmark for trials of MS therapies (2009). I have became an expert in structural techniques such as Optical Coherence Tomography and Magnetic Resonance Imaging of the visual system, which is reflected in frequent requests to review papers submitted to ophthalmic and neurology journals. My collaboration with Macquarie University produced one of the world first algorithms for retinal segmentation of OCT images (2009) and helped to develop an animal model of optic nerve demyelination (2010), while collaboration with Hebrew University (Israel) and BMRI (Sydney) resulted in development of a special methodology to analyse the posterior part of the visual pathway in MS patients (2011).
My work resulted in several invitations for review papers and more then 70 publications in leading ophthalmological and neurological journals. Results of my studies were published in Annals of Neurology, NeuroImage, Neurology, Ophthalmology, Journal of Neurology, Neurosurgery and Psychiatry, Multiple Sclerosis and others.I have been involved in five international clinical trials both as an investigator and a study designer. I have been CIA on 3 NHMRC grants, I have also been CIA on grants from the American MS Society, the Australian MS Society, ORIA and others with total amount of funding exceeding $4.5m ($3m in last 5 years). I was awarded a Sydney Medical Foundation Fellowship continuously from 1999 to 2013. My most recent achievement is securing (as CIA) a $1.2m grant from National MS Society (USA) and matching grant from Sydney University Medical Foundation ($1.2 m) to conduct longitudinal study of visual system in MS. This work, which commenced in 2014, involves collaborating with leading MS research centers in Italy, Spain, Israel, Germany and Canada.
I have initiated close collaboration between ophthalmology and neurology Departments and Brain and Mind Center, which led to the development of my current research program. Furthermore, as part of the research program I established close collaboration with several leading international institutions such as:
- University Hospital, Düsseldorf (Germany),
- Clinical Neuroimmunology Group NeuroCure Clinical Research Center Charité - Universitätsmedizin Berlin (Germany),
- Institute of Computer Vision and Robotics, University of Girona (Spain),
- Tel Aviv university (Israel),
- San Raffaele hospital, Milan (Italy),
- Departments of Clinical Neurosciences and Surgery, University of Calgary (Canada)
- Hadassah medical center (Israel).
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Network
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Investigating the role of demyelination in anterograde transsynaptic degeneration in MS
1/04/20 → 31/03/24
Project: Research
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Investigating mechanisms of axonal degeneration in multiple sclerosis
1/07/14 → 1/10/22
Project: Research
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Mechanisms for the neuroprotective effects of Siponimod - Is there neuroprotection beyond S1P receptors?
Graham, S. L., Klistorner, A., Gupta, V. & Mirzaei, M.
13/07/18 → 31/10/20
Project: Other
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Validating biomarkers of myelination and axonal loss in visual system of MS patients.
1/01/16 → 1/06/20
Project: Research
Research Outputs
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Analysis of multifocal visual evoked potentials using artificial intelligence algorithms
Klistorner, S., Eghtedari, M., Graham, S. L. & Klistorner, A., 3 Jan 2022, In: Translational Vision Science and Technology. 11, 1, p. 1-7 7 p., 10.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Expansion of chronic MS lesions is associated with an increase of radial diffusivity in periplaque white matter
Klistorner, S., Barnett, M. H., Yiannikas, C., Barton, J., Parratt, J., You, Y., Graham, S. L. & Klistorner, A., Apr 2022, In: Multiple Sclerosis Journal. 28, 5, p. 697-706 10 p.Research output: Contribution to journal › Article › peer-review
1 Citation (Scopus) -
Long-term effect of permanent demyelination on axonal survival in multiple sclerosis
Klistorner, A., Klistorner, S., You, Y., Graham, S. L., Yiannikas, C., Parratt, J. & Barnett, M., 1 May 2022, In: Neurology: Neuroimmunology and Neuroinflammation. 9, 3, p. 1-9 9 p., 1155.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)2 Downloads (Pure) -
The expansion and severity of chronic MS lesions follows a periventricular gradient
Klistorner, S., Barnett, M. H., Graham, S. L., Wang, C. & Klistorner, A., Sep 2022, In: Multiple Sclerosis Journal. 28, 10, p. 1504-1514 11 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Trans-synaptic degeneration in the visual pathway: neural connectivity, pathophysiology, and clinical implications in neurodegenerative disorders
Sharma, S., Chitranshi, N., Vander Wall, R., Basavarajappa, D., Gupta, V., Mirzaei, M., Graham, S. L., Klistorner, A. & You, Y., Mar 2022, In: Survey of Ophthalmology. 67, 2, p. 411-426 16 p.Research output: Contribution to journal › Review article › peer-review
2 Citations (Scopus)