Projects per year
Personal profile
Biography
I finished my ophthalmology training in Russia in 1985, and set up a large independent diagnostic centre. Since then I have specialized in clinical electrophysiology of vision. In 1992 I migrated to Australia. I completed my PhD in UNSW (Sydney) in 1996. During last several years my research has expanded into area of neurological diseases, particularly multiple sclerosis (MS). Thus, in 2008 I performed world’s first study of structure/function interaction in visual system of optic neuritis patients. I also initiated and, in collaboration with the REEH (Melbourne), have conducted studies of optic nerve remyelination, which are now considered a benchmark for trials of MS therapies (2009). I have became an expert in structural techniques such as Optical Coherence Tomography and Magnetic Resonance Imaging of the visual system, which is reflected in frequent requests to review papers submitted to ophthalmic and neurology journals. My collaboration with Macquarie University produced one of the world first algorithms for retinal segmentation of OCT images (2009) and helped to develop an animal model of optic nerve demyelination (2010), while collaboration with Hebrew University (Israel) and BMRI (Sydney) resulted in development of a special methodology to analyse the posterior part of the visual pathway in MS patients (2011).
My work resulted in several invitations for review papers and more then 70 publications in leading ophthalmological and neurological journals. Results of my studies were published in Annals of Neurology, NeuroImage, Neurology, Ophthalmology, Journal of Neurology, Neurosurgery and Psychiatry, Multiple Sclerosis and others.I have been involved in five international clinical trials both as an investigator and a study designer. I have been CIA on 3 NHMRC grants, I have also been CIA on grants from the American MS Society, the Australian MS Society, ORIA and others with total amount of funding exceeding $4.5m ($3m in last 5 years). I was awarded a Sydney Medical Foundation Fellowship continuously from 1999 to 2013. My most recent achievement is securing (as CIA) a $1.2m grant from National MS Society (USA) and matching grant from Sydney University Medical Foundation ($1.2 m) to conduct longitudinal study of visual system in MS. This work, which commenced in 2014, involves collaborating with leading MS research centers in Italy, Spain, Israel, Germany and Canada.
I have initiated close collaboration between ophthalmology and neurology Departments and Brain and Mind Center, which led to the development of my current research program. Furthermore, as part of the research program I established close collaboration with several leading international institutions such as:
- University Hospital, Düsseldorf (Germany),
- Clinical Neuroimmunology Group NeuroCure Clinical Research Center Charité - Universitätsmedizin Berlin (Germany),
- Institute of Computer Vision and Robotics, University of Girona (Spain),
- Tel Aviv university (Israel),
- San Raffaele hospital, Milan (Italy),
- Departments of Clinical Neurosciences and Surgery, University of Calgary (Canada)
- Hadassah medical center (Israel).
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Collaborations and top research areas from the last five years
Projects
- 10 Finished
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Investigating the role of demyelination in anterograde transsynaptic degeneration in MS
You, Y. (Primary Chief Investigator) & Klistorner, A. (Co-Investigator)
1/04/20 → 31/03/24
Project: Research
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Longitudinal analysis of MS lesions
Klistorner, A. (Primary Chief Investigator)
2/01/19 → 19/12/20
Project: Research
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Mechanisms for the neuroprotective effects of Siponimod - Is there neuroprotection beyond S1P receptors?
Graham, S. L. (Primary Chief Investigator), Klistorner, A. (Chief Investigator), Gupta, V. (Chief Investigator) & Mirzaei, M. (Chief Investigator)
13/07/18 → 31/10/20
Project: Other
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Validating biomarkers of myelination and axonal loss in visual system of MS patients.
Klistorner, A. (Primary Chief Investigator)
1/01/16 → 1/06/20
Project: Research
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Neuroprotective role of FTY720 in congenital mouse model of Glaucoma
Graham, S. L. (Primary Chief Investigator), Klistorner, A. (Chief Investigator), Gupta, V. (Chief Investigator) & You, Y. (Chief Investigator)
1/08/14 → 30/09/16
Project: Research
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Choroid plexus enlargement in secondary progressive MS: phenotype comparison
Klistorner, S., Barnett, M. H., Wang, C., Van Der Walt, A., Butzkueven, H., Gong, Z., Bouhrara, M., Parratt, J., Yiannikas, C. & Klistorner, A., Dec 2025, In: Multiple Sclerosis and Related Disorders. 104, p. 1-10 10 p., 106832.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Link opens in a new tab Citations (Scopus)18 Downloads (Pure) -
Correlations between postmortem quantitative MRI parameters and demyelination, axonal loss and gliosis in multiple sclerosis: a systematic review and meta-analysis
Shen, T., Sheriff, S., Qu, Y., Gupta, V. K., Graham, S. L., Klistorner, A., Jia, H., Sun, X. & You, Y., Apr 2025, In: Brain Imaging and Behavior. 19, 2, p. 323-335 13 p.Research output: Contribution to journal › Article › peer-review
3 Link opens in a new tab Citations (Scopus) -
Dysregulation of the kynurenine pathway in relapsing remitting multiple sclerosis and its correlations with progressive neurodegeneration
Staats Pires, A., Krishnamurthy, S., Sharma, S., Chow, S., Klistorner, S., Guillemin, G. J., Klistorner, A., You, Y. & Heng, B., Mar 2025, In: Neurology: Neuroimmunology and Neuroinflammation. 12, 2, p. 1-12 12 p., e200372.Research output: Contribution to journal › Article › peer-review
Open AccessFile15 Link opens in a new tab Citations (Scopus)82 Downloads (Pure) -
RENEWED: a follow-up study of the opicinumab phase 2 RENEW study in participants with acute optic neuritis
Aktas, O., Ziemssen, F., Ziemssen, T., Klistorner, A., Butzkueven, H., Izquierdo, G., Leocani, L., Balcer, L. J., Galetta, S. L., Castrillo-Viguera, C., Bradley, D. P., Naylor, M. L., Belachew, S., Franchimont, N., Zhu, B., Cheng, W. & RENEWED Investigators, Jan 2025, In: Multiple Sclerosis and Related Disorders. 93, p. 1-9 9 p., 106185.Research output: Contribution to journal › Article › peer-review
Open AccessFile9 Link opens in a new tab Citations (Scopus)8 Downloads (Pure) -
Mechanisms of transsynaptic degeneration in the aging brain
Wall, R. V., Basavarajappa, D., Klistorner, A., Graham, S. & You, Y., 1 Oct 2024, In: Aging and Disease. 15, 5, p. 2149-2167 19 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile6 Link opens in a new tab Citations (Scopus)60 Downloads (Pure)