Personal profile
Biography
Amy K. Cain is an ARC Future Fellow and Professor of Molecular Biology in the School of Natural Sciences and the ARC Centre of Excellence in Synthetic Biology at Macquarie University, Sydney. She has worked in academic groups, hospital labs and in the pharmaceutical industry across Australia, Cambridge and Oxford in the UK, Malawi (sub-Saharan Africa), and Boston (USA). Her current research focuses on developing new-to-nature antibiotics and uncovering bacterial stress response systems in hospital pathogens using functional genomic techniques. She is the founder and Director of the Galleria Research Facility, an ethical and cost-effective in vivo model for testing pathogenicity of microbes, and toxicity and efficacy of new drugs.
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Collaborations and top research areas from the last five years
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Cellular Senescence and Biofilm–Host Interactions as Drivers of Chronic Wound Healing Failure in the Elderly
Asadnia, M. (Primary Chief Investigator) & Cain, A. (Chief Investigator)
23/09/25 → 31/12/28
Project: Research
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JPIAMR: Revitalising the Antifungal Pipeline with Transition Metals
Cain, A. (Primary Chief Investigator), Frei, A. (Chief Investigator), Bromley, M. (Chief Investigator) & Wenzel, M. (Chief Investigator)
1/05/25 → 29/04/28
Project: Research
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ID24 (Flinders led): The central roles of lipids in bacterial pathogenesis
Eijkelkamp, B. (Chief Investigator), Cain, A. (Primary Chief Investigator), Ponton, F. (Chief Investigator), Miller, S. (Associate Investigator), O'Mara, M. (Associate Investigator), Bihari, S. (Associate Investigator), Snel, M. (Associate Investigator) & Paulsen, I. (Associate Investigator)
1/01/25 → 31/12/27
Project: Research
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Advancing Nanomaterials for Improved Wound Dressings in Chronic Wound Care
Asadnia, M. (Primary Chief Investigator), Cain, A. (Chief Investigator) & Pastras, C. (Chief Investigator)
16/12/24 → 15/12/27
Project: Research
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Head Agreement (Griffith led): Solving Plastic Waste CRC
Chen, C. (Chief Investigator), Gu, T. (Primary Chief Investigator), Singh, A. (Chief Investigator), Sheng, M. (Chief Investigator), Yang, J. (Chief Investigator), Beheshti, A. (Chief Investigator), Wang, Y. (Chief Investigator), Asadnia, M. (Chief Investigator), Bishop, M. (Chief Investigator), Cain, A. (Chief Investigator), Feih, S. (Chief Investigator), Naebe, M. (Chief Investigator), Giurco, D. (Chief Investigator) & Ball, A. (Chief Investigator)
15/09/24 → 15/09/34
Project: Research
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Alkylation-based optimization of antifungal FPPS inhibitors yields a potent, broad-spectrum lipophilic zoledronate derivative
Kane, A., Lai, F., Rothwell, J. G., Dinh, T. T. H., Campbell, L., Cain, A. K., Hibbs, D., Hanrahan, J. & Carter, D., Feb 2026, In: mBio. 17, 2, p. 1-19 19 p., e03199-25.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Link opens in a new tab Citation (Scopus)2 Downloads (Pure) -
Directed evolution of biofilm production using double emulsion droplets
Zhuang, S., Pascoe, D., Nagy, S. S., Li, L., Cain, A. & Inglis, D. W., Jan 2026, In: Biomicrofluidics. 20, 1, p. 1-10 10 p., 014101.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Downloads (Pure) -
Molecular insights into polyurethane biodegradation in Pseudomonas protegens
Semenec, L., Maharjan, R., Rajabal, V., Tay, A. P., Xu, X., Lott, H., Facey, F. S. B., Dinh, H., Tetu, S. G., Williams, T. C., Paulsen, I. T. & Cain, A. K., Feb 2026, In: mBio. 17, 2, p. 1-19 19 p., e03544-25.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Link opens in a new tab Citation (Scopus)3 Downloads (Pure) -
The cyclin dependent kinase (CDK)7 inhibitor BS-181 inhibits pathogenic Cryptococcus species, causing G2/M arrest and a splicing defect
Sethiya, P., Desmarini, D., Bowring, B., Dinh, H., Cain, A. K., Parsania, C., Halliday, C. L., Chen, S. C. A., Hewitt, K. & Djordjevic, J. T., 2026, In: Virulence. 17, 1, p. 1-16 16 p., 2629100.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Downloads (Pure) -
Characterising the multiple-plastic degrading strain of Bacillus subtilis GM_03 From the Galleria mellonella microbiome
Facey, F. S. B., Maharjan, R., Dinh, H., Buchanan, J. S., Connal, L. A., Tay, A. P., Paulsen, I. T. & Cain, A. K., Oct 2025, In: Environmental Microbiology Reports. 17, 5, p. 1-11 11 p., e70216.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Link opens in a new tab Citations (Scopus)5 Downloads (Pure)
Prizes
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Faculty Excellence Award 2020 - Inter-Departmental Collaboration
Cain, A. (Recipient), Fernandez, M. (Recipient), Lustri, C. (Recipient) & Swain, M. (Recipient), 3 Dec 2020
Prize: Other distinction
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Fellowship of the Australian Society for Microbiology.
Cain, A. (Recipient), 5 May 2021
Prize: Honorary award
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Impacts
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JAMSpod (microbiology podcast)
Cain, A. (Participant), Semenec, L. (Participant) & Goold, H. (Participant)
Impact: Society impacts