Andreia Vaqueirinho de Pinho

Dr

  • 3466 Citations
  • 14 h-Index
20112020
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Research Outputs 2011 2019

  • 3466 Citations
  • 14 h-Index
  • 18 Article
  • 3 Review article
  • 1 Chapter
  • 1 Meeting abstract
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Article
2018

ROBO2 is a stroma suppressor gene in the pancreas and acts via TGF-β signalling

Pinho, A. V., Van Bulck, M., Chantrill, L., Arshi, M., Sklyarova, T., Herrmann, D., Vennin, C., Gallego-Ortega, D., Mawson, A., Giry-Laterriere, M., Magenau, A., Leuckx, G., Baeyens, L., Gill, A. J., Phillips, P., Timpson, P., Biankin, A. V., Wu, J. & Rooman, I., 1 Dec 2018, In : Nature Communications. 9, 1, p. 1-14 14 p., 5083.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Suppressor Genes
suppressors
pancreas
Transforming Growth Factor beta
genes
2017

Hypermutation in pancreatic cancer

Humphris, J. L., Patch, A. M., Nones, K., Bailey, P. J., Johns, A. L., McKay, S., Chang, D. K., Miller, D. K., Pajic, M., Kassahn, K. S., Quinn, M. C. J., Bruxner, T. J. C., Christ, A. N., Harliwong, I., Idrisoglu, S., Manning, S., Nourse, C., Nourbakhsh, E., Stone, A., Wilson, P. J. & 66 othersAnderson, M., Fink, J. L., Holmes, O., Kazakoff, S., Leonard, C., Newell, F., Waddell, N., Wood, S., Mead, R. S., Xu, Q., Wu, J., Pinese, M., Cowley, M. J., Jones, M. D., Nagrial, A. M., Chin, V. T., Chantrill, L. A., Mawson, A., Chou, A., Scarlett, C. J., Pinho, A. V., Rooman, I., Giry-Laterriere, M., Samra, J. S., Kench, J. G., Merrett, N. D., Toon, C. W., Epari, K., Nguyen, N. Q., Barbour, A., Zeps, N., Jamieson, N. B., McKay, C. J., Carter, C. R., Dickson, E. J., Graham, J. S., Duthie, F., Oien, K., Hair, J., Morton, J. P., Sansom, O. J., Grützmann, R., Hruban, R. H., Maitra, A., Iacobuzio-Donahue, C. A., Schulick, R. D., Wolfgang, C. L., Morgan, R. A., Lawlor, R. T., Rusev, B., Corbo, V., Salvia, R., Cataldo, I., Tortora, G., Tempero, M. A., Australian Pancreatic Cancer Genome Initiative, Hofmann, O., Eshleman, J. R., Pilarsky, C., Scarpa, A., Musgrove, E. A., Gill, A. J., Pearson, J. V., Grimmond, S. M., Waddell, N. & Biankin, A. V., Jan 2017, In : Gastroenterology. 152, 1, p. 68-74.e2 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Pancreatic Neoplasms
DNA Repair
Mutation
Immunotherapy
Patient Selection

Identification of unique neoantigen qualities in long-term survivors of pancreatic cancer

Balachandran, V. P., Luksza, M., Zhao, J. N., Makarov, V., Moral, J. A., Remark, R., Herbst, B., Askan, G., Bhanot, U., Senbabaoglu, Y., Wells, D. K., Cary, C. I. O., Grbovic-Huezo, O., Attiyeh, M., Medina, B., Zhang, J., Loo, J., Saglimbeni, J., Abu-Akeel, M., Zappasodi, R. & 19 othersRiaz, N., Smoragiewicz, M., Kelley, Z. L., Basturk, O., Australian Pancreatic Cancer Genome Initiative, Goenen, M., Levine, A. J., Allen, P. J., Fearon, D. T., Merad, M., Gnjatic, S., Iacobuzio-Donahue, C. A., Wolchok, J. D., DeMatteo, R. P., Chan, T. A., Greenbaum, B. D., Merghoub, T., Leach, S. D. & Bassi, C., 23 Nov 2017, In : Nature. 551, 7681, p. 512-516 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Lost in translation: returning germline genetic results in genome-scale cancer research

Johns, A. L., McKay, S. H., Humphris, J. L., Pinese, M., Chantrill, L. A., Mead, R. S., Tucker, K., Andrews, L., Goodwin, A., Leonard, C., High, H. A., Nones, K., Patch, A. M., Merrett, N. D., Pavlakis, N., Kassahn, K. S., Samra, J. S., Miller, D. K., Chang, D. K., Pajic, M. & 7 othersAustralian Pancreatic Cancer Genome Initiative, Pearson, J. V., Grimmond, S. M., Waddell, N., Zeps, N., Gill, A. J. & Biankin, A. V., 28 Apr 2017, In : Genome Medicine. 9, 1, p. 1-9 9 p., 41.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Genome
Pancreatic Neoplasms
Research
Neoplasms
Genes

ROCK signaling promotes collagen remodeling to facilitate invasive pancreatic ductal adenocarcinoma tumor cell growth

Rath, N., Morton, J. P., Julian, L., Helbig, L., Kadir, S., McGhee, E. J., Anderson, K. I., Kalna, G., Mullin, M., Pinho, A. V., Rooman, I., Samuel, M. S. & Olson, M. F., 1 Feb 2017, In : EMBO Molecular Medicine. 9, 2, p. 198-218 21 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Adenocarcinoma
Collagen
Growth
Neoplasms
Matrix Metalloproteinases

Whole-genome landscape of pancreatic neuroendocrine tumours

Scarpa, A., Chang, D. K., Nones, K., Corbo, V., Patch, A. M., Bailey, P., Lawlor, R. T., Johns, A. L., Miller, D. K., Mafficini, A., Rusev, B., Scardoni, M., Antonello, D., Barbi, S., Cingarlini, S., Vicentini, C., Sikora, K. O., McKay, S., Quinn, M. C. J., Bruxner, T. J. C. & 84 othersChrist, A. N., Harliwong, I., Idrisoglu, S., McLean, S., Nourse, C., Nourbakhsh, E., Wilson, P. J., Anderson, M. J., Fink, J. L., Newell, F., Waddell, N., Holmes, O., Kazakoff, S. H., Leonard, C., Wood, S., Xu, Q., Nagaraj, S. H., Amato, E., Dalai, I., Bersani, S., Cataldo, I., Dei Tos, A. P., Capelli, P., Davì, M. V., Landoni, L., Malpaga, A., Miotto, M., Whitehall, V. L. J., Leggett, B. A., Harris, J. L., Harris, J., Jones, M. D., Humphris, J., Chantrill, L. A., Chin, V., Nagrial, A. M., Pajic, M., Scarlett, C. J., Pinho, A., Rooman, I., Toon, C., Wu, J., Pinese, M., Cowley, M., Barbour, A., Mawson, A., Humphrey, E. S., Colvin, E. K., Chou, A., Lovell, J. A., Jamieson, N. B., Duthie, F., Gingras, M. C., Fisher, W. E., Dagg, R. A., Lau, L. M. S., Lee, M., Pickett, H. A., Reddel, R. R., Samra, J. S., Kench, J. G., Merrett, N. D., Epari, K., Nguyen, N. Q., Zeps, N., Falconi, M., Simbolo, M., Butturini, G., Van Buren, G., Partelli, S., Fassan, M., Australian Pancreatic Cancer Genome Initiative, Khanna, K. K., Gill, A. J., Wheeler, D. A., Gibbs, R. A., Musgrove, E. A., Bassi, C., Tortora, G., Pederzoli, P., Pearson, J. V., Waddell, N., Biankin, A. V. & Grimmond, S. M., 2 Mar 2017, In : Nature. 543, 7643, p. 65-71 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Neuroendocrine Tumors
DNA Repair
Genome
Mutation
Gene Fusion
2016

Ampullary cancers harbor ELF3 tumor suppressor gene mutations and exhibit frequent WNT dysregulation

Gingras, M. C., Covington, K. R., Chang, D. K., Donehower, L. A., Gill, A. J., Ittmann, M. M., Creighton, C. J., Johns, A. L., Shinbrot, E., Dewal, N., Fisher, W. E., Pilarsky, C., Grützmann, R., Overman, M. J., Jamieson, N. B., Van Buren, G., Drummond, J., Walker, K., Hampton, O. A., Xi, L. & 158 othersMuzny, D. M., Doddapaneni, H., Lee, S. L., Bellair, M., Hu, J., Han, Y., Dinh, H. H., Dahdouli, M., Samra, J. S., Bailey, P., Waddell, N., Pearson, J. V., Harliwong, I., Wang, H., Aust, D., Oien, K. A., Hruban, R. H., Hodges, S. E., McElhany, A., Saengboonmee, C., Duthie, F. R., Grimmond, S. M., Biankin, A. V., Wheeler, D. A., Gibbs, R. A., Jones, M. D., Mawson, A., Scarlett, C. J., Brancato, M. A. L., Rowe, S. J., Simpson, S. H., Smith Martyn, M., Thomas, M. T., Chantrill, L. A., Chin, V. T., Angela, C., Cowley, M. J., Humphris, J. L., Mead, S., Nagrial, A. M., Pajic, M., Pettit, J., Pinese, M., Rooman, I., Wu, J., Tao, J., DiPietro, R., Watson, C., Steinmann, A., Lee, H. C., Wong, R., Pinho, A. V., Giry-Laterriere, M., Daly, R. J., Musgrove, E. A., Sutherland, R. L., Kassahn, K. S., Miller, D. K., Wilson, P. J., Patch, A. M., Song, S., Idrisoglu, S., Nourse, C., Nourbakhsh, E., Manning, S., Wani, S., Gongora, M., Anderson, M., Holmes, O., Leonard, C., Taylor, D., Wood, S., Xu, C., Nones, K., Fink, L. J., Christ, A., Bruxner, T., Cloonan, N., Newell, F., Quinn, M., Nagaraj, S., Kazakoff, S., Waddell, N., Krisnan, K., Queelly, Wood, D., Pavlakis, N., Guminski, A., Toon, C., Asghari, R., Merrett, N. D., Pavey, D., Das, A., Cosman, P. H., Ismail, K., O'Connnor, C., Lam, V. W., McLeod, D., Pleass, H. C., Richardson, A., James, V., Kench, J. G., Cooper, C. L., Joseph, D., Sandroussi, C., Crawford, M., Gallagher, J., Texler, M., Forest, C., Laycock, A., Epari, K. P., Ballal, M., Fletcher, D. R., Mukhedkar, S., Spry, N. A., DeBoer, B., Chai, M., Zeps, N., Beilin, M., Feeney, K., Nguyen, N. Q., Ruszkiewicz, A. R., Worthley, C., Tan, C. P., Debrencini, T., Chen, J., Brooke-Smith, M. E., Papangelis, V., Tang, H., Barbour, A. P., Clouston, A. D., Martin, P., O'Rourke, T. J., Chiang, A., Fawcett, J. W., Slater, K., Yeung, S., Hatzifotis, M., Hodgkinson, P., Christophi, C., Nikfarjam, M., Mountain, A., Eshleman, J. R., Maitra, A., Iacobuzio-Donahue, C. A., Schulick, R. D., Wolfgang, C. L., Morgan, R. A., Hodgin, M., Scarpa, A., Lawlor, R. T., Beghelli, S., Corbo, V., Scardoni, M., Bassi, C., Tempero, M. A., Glasgow, G. & Graham, J. S., 2 Feb 2016, In : Cell Reports. 14, 4, p. 907-919 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Genetic Suppression
Ports and harbors
Tumor Suppressor Genes
Tumors
Adenocarcinoma

Genomic analyses identify molecular subtypes of pancreatic cancer

Bailey, P., Chang, D. K., Nones, K., Johns, A. L., Patch, A. M., Gingras, M. C., Miller, D. K., Christ, A. N., Bruxner, T. J. C., Quinn, M. C., Nourse, C., Murtaugh, L. C., Harliwong, I., Idrisoglu, S., Manning, S., Nourbakhsh, E., Wani, S., Fink, L., Holmes, O., Chin, V. & 83 othersAnderson, M. J., Kazakoff, S., Leonard, C., Newell, F., Waddell, N., Wood, S., Xu, Q., Wilson, P. J., Cloonan, N., Kassahn, K. S., Taylor, D., Quek, K., Robertson, A., Pantano, L., Mincarelli, L., Sanchez, L. N., Evers, L., Wu, J., Pinese, M., Cowley, M. J., Jones, M. D., Colvin, E. K., Nagrial, A. M., Humphrey, E. S., Chantrill, L. A., Mawson, A., Humphris, J., Chou, A., Pajic, M., Scarlett, C. J., Pinho, A. V., Giry-Laterriere, M., Rooman, I., Samra, J. S., Kench, J. G., Lovell, J. A., Merrett, N. D., Toon, C. W., Epari, K., Nguyen, N. Q., Barbour, A., Zeps, N., Moran-Jones, K., Jamieson, N. B., Graham, J. S., Duthie, F., Oien, K., Hair, J., Grützmann, R., Maitra, A., Iacobuzio-Donahue, C. A., Wolfgang, C. L., Morgan, R. A., Lawlor, R. T., Corbo, V., Bassi, C., Rusev, B., Capelli, P., Salvia, R., Tortora, G., Mukhopadhyay, D., Petersen, G. M., Munzy, D. M., Fisher, W. E., Karim, S. A., Eshleman, J. R., Hruban, R. H., Pilarsky, C., Morton, J. P., Sansom, O. J., Scarpa, A., Musgrove, E. A., Bailey, U. M. H., Hofmann, O., Sutherland, R. L., Wheeler, D. A., Gill, A. J., Gibbs, R. A., Pearson, J. V., Waddell, N., Biankin, A. V., Grimmond, S. M. & Australian Pancreatic Cancer Genome Initiative, 3 Mar 2016, In : Nature. 531, 7592, p. 47-52 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Pancreatic Neoplasms
Gene Regulatory Networks
Neoplasms
Up-Regulation
Genes

Sirtuin1 stimulates the proliferation and the expression of glycolysis genes in pancreatic neoplastic lesions

Pinho, A. V., Mawson, A., Gill, A., Arshi, M., Warmerdam, M., Giry-Laterriere, M., Eling, N., Lie, T., Kuster, E., Camargo, S., Biankin, A. V., Wu, J. & Rooman, I., 2016, In : Oncotarget. 7, 46, p. 74768-74778 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Sirtuin 1
Glycolysis
Gene Expression
Adenocarcinoma
Pancreas
2015

Pancreas-specific Sirt1-deficiency in mice compromises beta-cell function without development of hyperglycemia

Pinho, A. V., Bensellam, M., Wauters, E., Rees, M., Giry-Laterriere, M., Mawson, A., Ly, L. Q., Biankin, A. V., Wu, J., Laybutt, D. R. & Rooman, I., 5 Jun 2015, In : PLoS ONE. 10, 6, p. 1-13 13 p., e0128012.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Sirtuin 1
islets of Langerhans
hyperglycemia
pancreas
Hyperglycemia

SOX9 regulates ERBB signalling in pancreatic cancer development

Grimont, A., Pinho, A. V., Cowley, M. J., Augereau, C., Mawson, A., Giry-Laterrière, M., Van Den Steen, G., Waddell, N., Pajic, M., Sempoux, C., Wu, J., Grimmond, S. M., Biankin, A. V., Lemaigre, F. P., Rooman, I. & Jacquemin, P., 1 Nov 2015, In : Gut. 64, 11, p. 1790-1799 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Pancreatic Neoplasms
Adenocarcinoma
Cell Line
SOX9 Transcription Factor
Gene Expression

Whole genomes redefine the mutational landscape of pancreatic cancer

Waddell, N., Pajic, M., Patch, A. M., Chang, D. K., Kassahn, K. S., Bailey, P., Johns, A. L., Miller, D., Nones, K., Quek, K., Quinn, M. C. J., Robertson, A. J., Fadlullah, M. Z. H., Bruxner, T. J. C., Christ, A. N., Harliwong, I., Idrisoglu, S., Manning, S., Nourse, C., Nourbakhsh, E. & 70 othersWani, S., Wilson, P. J., Markham, E., Cloonan, N., Anderson, M. J., Fink, J. L., Holmes, O., Kazakoff, S. H., Leonard, C., Newell, F., Poudel, B., Song, S., Taylor, D., Waddell, N., Wood, S., Xu, Q., Wu, J., Pinese, M., Cowley, M. J., Lee, H. C., Jones, M. D., Nagrial, A. M., Humphris, J., Chantrill, L. A., Chin, V., Steinmann, A. M., Mawson, A., Humphrey, E. S., Colvin, E. K., Chou, A., Scarlett, C. J., Pinho, A. V., Giry-Laterriere, M., Rooman, I., Samra, J. S., Kench, J. G., Pettitt, J. A., Merrett, N. D., Toon, C., Epari, K., Nguyen, N. Q., Barbour, A., Zeps, N., Jamieson, N. B., Graham, J. S., Niclou, S. P., Bjerkvig, R., Grützmann, R., Aust, D., Hruban, R. H., Maitra, A., Iacobuzio-Donahue, C. A., Wolfgang, C. L., Morgan, R. A., Lawlor, R. T., Corbo, V., Bassi, C., Falconi, M., Zamboni, G., Tortora, G., Tempero, M. A., Australian Pancreatic Cancer Genome Initiative, Gill, A. J., Eshleman, J. R., Pilarsky, C., Scarpa, A., Musgrove, E. A., Pearson, J. V., Biankin, A. V. & Grimmond, S. M., 26 Feb 2015, In : Nature. 518, 7540, p. 495-501 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Pancreatic Neoplasms
Adenocarcinoma
Maintenance
DNA Repair-Deficiency Disorders
BRCA2 Gene
2013

Amino acid transporters expression in acinar cells is changed during acute pancreatitis

Rooman, I., Lutz, C., Pinho, A. V., Huggel, K., Reding, T., Lahoutte, T., Verrey, F., Graf, R. & Camargo, S. M. R., 1 Jan 2013, In : Pancreatology. 13, 5, p. 475-485 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Amino Acid Transport Systems
Acinar Cells
Pancreatitis
Amino Acids
Pancreas

Histomolecular phenotypes and outcome in adenocarcinoma of the ampulla of vater

Chang, D. K., Jamieson, N. B., Johns, A. L., Scarlett, C. J., Pajic, M., Chou, A., Pinese, M., Humphris, J. L., Jones, M. D., Toon, C., Nagrial, A. M., Chantrill, L. A., Chin, V. T., Pinho, A. V., Rooman, I., Cowley, M. J., Wu, J., Mead, R. S., Colvin, E. K., Samra, J. S. & 19 othersCorbo, V., Bassi, C., Falconi, M., Lawlor, R. T., Crippa, S., Sperandio, N., Bersani, S., Dickson, E. J., Mohamed, M. A. A., Oien, K. A., Foulis, A. K., Musgrove, E. A., Sutherland, R. L., Kench, J. G., Carter, C. R., Gill, A. J., Scarpa, A., McKay, C. J. & Biankin, A. V., 1 Apr 2013, In : Journal of Clinical Oncology. 31, 10, p. 1348-1356 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Ampulla of Vater
Adenocarcinoma
Lymph Nodes
Phenotype
Carcinoma

Sirtuin-1 regulates acinar-to-ductal metaplasia and supports cancer cell viability in pancreatic cancer

Wauters, E., Sanchez-Arevalo Lobo, V. J., Pinho, A. V., Mawson, A., Herranz, D., Wu, J., Cowley, M. J., Colvin, E. K., Njicop, E. N., Sutherland, R. L., Liu, T., Serrano, M., Bouwens, L., Real, F. X., Biankin, A. V. & Rooman, I., 1 Apr 2013, In : Cancer Research. 73, 7, p. 2357-2367 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Sirtuin 1
Metaplasia
Pancreatic Neoplasms
Cell Survival
Neoplasms
2012

Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes

Biankin, A. V., Waddell, N., Kassahn, K. S., Gingras, M. C., Muthuswamy, L. B., Johns, A. L., Miller, D. K., Wilson, P. J., Patch, A. M., Wu, J., Chang, D. K., Cowley, M. J., Gardiner, B. B., Song, S., Harliwong, I., Idrisoglu, S., Nourse, C., Nourbakhsh, E., Manning, S., Wani, S. & 107 othersGongora, M., Pajic, M., Scarlett, C. J., Gill, A. J., Pinho, A. V., Rooman, I., Anderson, M., Holmes, O., Leonard, C., Taylor, D., Wood, S., Xu, Q., Nones, K., Fink, J. L., Christ, A., Bruxner, T., Cloonan, N., Kolle, G., Newell, F., Pinese, M., Mead, R. S., Humphris, J. L., Kaplan, W., Jones, M. D., Colvin, E. K., Nagrial, A. M., Humphrey, E. S., Chou, A., Chin, V. T., Chantrill, L. A., Mawson, A., Samra, J. S., Kench, J. G., Lovell, J. A., Daly, R. J., Merrett, N. D., Toon, C., Epari, K., Nguyen, N. Q., Barbour, A., Zeps, N., Australian Pancreatic Cancer Genome Initiative, Kakkar, N., Zhao, F., Wu, Y. Q., Wang, M., Muzny, D. M., Fisher, W. E., Brunicardi, F. C., Hodges, S. E., Reid, J. G., Drummond, J., Chang, K., Han, Y., Lewis, L. R., Dinh, H., Buhay, C. J., Beck, T., Timms, L., Sam, M., Begley, K., Brown, A., Pai, D., Panchal, A., Buchner, N., De Borja, R., Denroche, R. E., Yung, C. K., Serra, S., Onetto, N., Mukhopadhyay, D., Tsao, M. S., Shaw, P. A., Petersen, G. M., Gallinger, S., Hruban, R. H., Maitra, A., Iacobuzio-Donahue, C. A., Schulick, R. D., Wolfgang, C. L., Morgan, R. A., Lawlor, R. T., Capelli, P., Corbo, V., Scardoni, M., Tortora, G., Tempero, M. A., Mann, K. M., Jenkins, N. A., Perez-Mancera, P. A., Adams, D. J., Largaespada, D. A., Wessels, L. F. A., Rust, A. G., Stein, L. D., Tuveson, D. A., Copeland, N. G., Musgrove, E. A., Scarpa, A., Eshleman, J. R., Hudson, T. J., Sutherland, R. L., Wheeler, D. A., Pearson, J. V., McPherson, J. D., Gibbs, R. A. & Grimmond, S. M., 15 Nov 2012, In : Nature. 491, 7424, p. 399-405 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Pancreatic Neoplasms
Genome
Genes
Carcinogenesis
Adenocarcinoma
2011

Adult pancreatic acinar cells dedifferentiate to an embryonic progenitor phenotype with concomitant activation of a senescence programme that is present in chronic pancreatitis

Pinho, A. V., Rooman, I., Reichert, M., De Medts, N., Bouwens, L., Rustgi, A. K. & Real, F. X., 1 Jul 2011, In : Gut. 60, 7, p. 958-966 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Acinar Cells
Chronic Pancreatitis
Phenotype
Ceruletide
Suspensions

p53-dependent regulation of growth, epithelial-mesenchymal transition and stemness in normal pancreatic epithelial cells

Pinho, A. V., Rooman, I. & Real, F. X., 15 Apr 2011, In : Cell Cycle. 10, 8, p. 1312-1321 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Epithelial-Mesenchymal Transition
Epithelial Cells
Acinar Cells
Growth
Phenotype