Projects per year
Personal profile
Biography
Research in my group spans the exciting and challenging interface between chemistry and biology. We are particularly interested in exploring the extraordinary chemical and structural diversity of natural products and using these molecules as new drug leads and as probes to elucidate biochemical and cellular pathways.
Qualifications
BMedScs (Hons) Macq, PhD Macq, MRACI CChem
Employment
| 2018 - | Senior Lecturer, Macquarie University |
| 2014 - 2017 | ARC Future Fellow, Macquarie University |
| 2012 - 2014 | Senior Research Officer, IMB, The University of Queensland |
| 2007 - 2012 | Research Officer, IMB, The University of Queensland |
| 2005 - 2007 | Postdoctoral Research Fellow, Macquarie University |
Research Interests
- Discovery and development of next-generation antibiotics
- Natural product mode of action
- Biodiscovery and structure elucidation
- Chemical biology using natural product probes
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Network
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Projects
GRF: Galleria Research Facility: Bringing a Flexible, Accessible and Ethical Animal Model to Macquarie
Cain, A., Short, F., Maselko, M., Paulsen, I., Gillings, M., Parker, L., Wang, Y., Jaschke, P. & Piggott, A.
1/01/20 → 31/12/20
Project: Other
Reverse Chemical Proteomics: Harnessing Yeast Display for Drug Discovery
Piggott, A., Karuso, P., Kwon, H. J. & MQRES (International), M. (.
1/01/18 → 31/12/20
Project: Research
Overcoming antibiotic resistance: rapid discovery of new antibacterial drug targets using chemicalproteomics
Piggott, A., MQRES, M., MQRES (International), M. (. & Capon, R.
7/04/14 → …
Project: Research
A high performance liquid chromatography system for use in mass spectrometry-based biomolecular discovery
Haynes, P., Raftos, D., Cornish, J., Piggott, A. & Atwell, B.
1/01/16 → 31/12/16
Project: Research
Yeast display as a platform technology to accelerate antiparasitic drug discovery and development
1/01/15 → 31/12/16
Project: Research
Research Outputs
Biosynthesis of a new benzazepine alkaloid nanangelenin A from Aspergillus nanangensis involves an unusual ι-kynurenine-incorporating NRPS catalyzing regioselective lactamization
Li, H., Gilchrist, C. L. M., Phan, C-S., Lacey, H. J., Vuong, D., Moggach, S. A., Lacey, E., Piggott, A. M. & Chooi, Y-H., 15 Apr 2020, In : Journal of the American Chemical Society. 142, 15, p. 7145-7152 8 p.Research output: Contribution to journal › Article
Biosynthesis of a novel benzazepine alkaloid nanangelenin A involves an unprecedented fungal NRPS that incorporates L-kynurenine and catalyzes a regioselective peptide cyclization
Li, H., Gilchrist, C. L. M., Phan, C., Lacey, H. J., Lacey, E., Piggott, A. & Chooi, Y. H., 13 Jan 2020.Research output: Contribution to conference › Poster
Comprehensive chemotaxonomic and genomic profiling of a biosynthetically talented Australian fungus, Aspergillus burnettii sp. nov.
Gilchrist, C. L. M., Lacey, H. J., Vuong, D., Pitt, J. I., Lange, L., Lacey, E., Pilgaard, B., Chooi, Y-H. & Piggott, A. M., Oct 2020, In : Fungal Genetics and Biology. 143, 15 p., 103435.Research output: Contribution to journal › Article
Conglobatins B–E: cytotoxic analogues of the C2-symmetric macrodiolide conglobatin
Lacey, H. J., Booth, T. J., Vuong, D., Rutledge, P. J., Lacey, E., Chooi, Y. H. & Piggott, A. M., 17 Jun 2020, In : Journal of Antibiotics. 10 p.Research output: Contribution to journal › Article
Talauxins: hybrid phenalenone dimers from Talaromyces stipitatus
Chaudhary, N. K., Crombie, A., Vuong, D., Lacey, E., Piggott, A. M. & Karuso, P., 24 Apr 2020, In : Journal of Natural Products. 83, 4, p. 1051-1060 10 p.Research output: Contribution to journal › Article