Projects per year
Personal profile
Biography
Research in my group spans the exciting and challenging interface between chemistry and biology. We are particularly interested in exploring the extraordinary chemical and structural diversity of natural products and using these molecules as new drug leads and as probes to elucidate biochemical and cellular pathways.
Qualifications
BMedScs (Hons) Macq, PhD Macq, MRACI CChem
Employment
2021 - | Associate Professor, Macquarie University |
2018 - 2020 | Senior Lecturer, Macquarie University |
2014 - 2017 | ARC Future Fellow, Macquarie University |
2012 - 2014 | Senior Research Officer, IMB, The University of Queensland |
2007 - 2012 | Research Officer, IMB, The University of Queensland |
2005 - 2007 | Postdoctoral Research Fellow, Macquarie University |
Research Interests
- Discovery and development of next-generation antibiotics
- Natural product mode of action
- Biodiscovery and structure elucidation
- Chemical biology using natural product probes
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Network
Projects
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UWA led: CRISPR-based pathway activation for bioactive molecule discovery in fungi
Chooi, Y. H., Piggott, A. & Keller, N.
11/02/21 → 10/02/24
Project: Research
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Overcoming antibiotic resistance: rapid discovery of new antibacterial drug targets using chemicalproteomics
Piggott, A., MQRES, M., MQRES (International), M. (. & Capon, R.
7/04/14 → …
Project: Research
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Rapid Isolation System
Karuso, P., Taylor, P., Piggott, A., Liu, F., Jamie, J., Park, S. J., Jamie, I., Keaveney, S., Venkatesan, K. & Wong, D.
1/01/20 → 31/12/20
Project: Other
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GRF: Galleria Research Facility: Bringing a Flexible, Accessible and Ethical Animal Model to Macquarie
Cain, A., Short, F., Maselko, M., Paulsen, I., Gillings, M., Parker, L., Wang, Y., Jaschke, P. & Piggott, A.
1/01/20 → 31/12/20
Project: Other
Research Outputs
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Hancockiamides: phenylpropanoid piperazines from Aspergillus hancockii are biosynthesised by a versatile dual single-module NRPS pathway
Li, H., Lacey, A. E., Shu, S., Kalaitzis, J. A., Vuong, D., Crombie, A., Hu, J., Gilchrist, C. L. M., Lacey, E., Piggott, A. M. & Chooi, Y. H., 21 Jan 2021, In: Organic and Biomolecular Chemistry. 19, 3, p. 587-595 9 p.Research output: Contribution to journal › Article › peer-review
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Semisynthesis and biological evaluation of a focused library of unguinol derivatives as next-generation antibiotics
Morshed, M. T., Nguyen, H. T., Vuong, D., Crombie, A., Lacey, E., Ogunniyi, A. D., Page, S. W., Trott, D. J. & Piggott, A. M., 7 Feb 2021, In: Organic and Biomolecular Chemistry. 19, 5, p. 1022-1036 15 p.Research output: Contribution to journal › Article › peer-review
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TriTOX: a novel Trichomonas vaginalis assay platform for high-throughput screening of compound libraries
Lam, A. Y. F., Vuong, D., Jex, A. R., Piggott, A. M., Lacey, E. & Emery-Corbin, S. J., Apr 2021, In: International Journal for Parasitology: Drugs and Drug Resistance. 15, p. 68-80 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Downloads (Pure) -
Biosynthesis of a new benzazepine alkaloid nanangelenin A from Aspergillus nanangensis involves an unusual ι-kynurenine-incorporating NRPS catalyzing regioselective lactamization
Li, H., Gilchrist, C. L. M., Phan, C-S., Lacey, H. J., Vuong, D., Moggach, S. A., Lacey, E., Piggott, A. M. & Chooi, Y-H., 15 Apr 2020, In: Journal of the American Chemical Society. 142, 15, p. 7145-7152 8 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus) -
Biosynthesis of a novel benzazepine alkaloid nanangelenin A involves an unprecedented fungal NRPS that incorporates L-kynurenine and catalyzes a regioselective peptide cyclization
Li, H., Gilchrist, C. L. M., Phan, C., Lacey, H. J., Lacey, E., Piggott, A. & Chooi, Y. H., 13 Jan 2020.Research output: Contribution to conference › Poster
Prizes
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Faculty of Science and Engineering Award for Excellence in Innovative Research Partnership
Piggott, Andrew (Recipient), 6 Dec 2019
Prize