• 1300 Citations
  • 21 h-Index
20002020

Research output per year

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Personal profile

Biography

Research in my group spans the exciting and challenging interface between chemistry and biology. We are particularly interested in exploring the extraordinary chemical and structural diversity of natural products and using these molecules as new drug leads and as probes to elucidate biochemical and cellular pathways.

Qualifications

BMedScs (Hons) Macq, PhD Macq, MRACI CChem

Employment

2018 -Senior Lecturer, Macquarie University
2014 - 2017ARC Future Fellow, Macquarie University
2012 - 2014Senior Research Officer, IMB, The University of Queensland
2007 - 2012Research Officer, IMB, The University of Queensland
2005 - 2007Postdoctoral Research Fellow, Macquarie University

Research Interests

  • Discovery and development of next-generation antibiotics
  • Natural product mode of action
  • Biodiscovery and structure elucidation
  • Chemical biology using natural product probes

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Projects

Research Outputs

Biosynthesis of a new benzazepine alkaloid nanangelenin A from Aspergillus nanangensis involves an unusual ι-kynurenine-incorporating NRPS catalyzing regioselective lactamization

Li, H., Gilchrist, C. L. M., Phan, C-S., Lacey, H. J., Vuong, D., Moggach, S. A., Lacey, E., Piggott, A. M. & Chooi, Y-H., 15 Apr 2020, In : Journal of the American Chemical Society. 142, 15, p. 7145-7152 8 p.

Research output: Contribution to journalArticle

  • Biosynthesis of a novel benzazepine alkaloid nanangelenin A involves an unprecedented fungal NRPS that incorporates L-kynurenine and catalyzes a regioselective peptide cyclization

    Li, H., Gilchrist, C. L. M., Phan, C., Lacey, H. J., Lacey, E., Piggott, A. & Chooi, Y. H., 13 Jan 2020.

    Research output: Contribution to conferencePoster

  • Comprehensive chemotaxonomic and genomic profiling of a biosynthetically talented Australian fungus, Aspergillus burnettii sp. nov.

    Gilchrist, C. L. M., Lacey, H. J., Vuong, D., Pitt, J. I., Lange, L., Lacey, E., Pilgaard, B., Chooi, Y-H. & Piggott, A. M., Oct 2020, In : Fungal Genetics and Biology. 143, 15 p., 103435.

    Research output: Contribution to journalArticle

  • Conglobatins B–E: cytotoxic analogues of the C2-symmetric macrodiolide conglobatin

    Lacey, H. J., Booth, T. J., Vuong, D., Rutledge, P. J., Lacey, E., Chooi, Y. H. & Piggott, A. M., 17 Jun 2020, In : Journal of Antibiotics. 10 p.

    Research output: Contribution to journalArticle

  • Talauxins: hybrid phenalenone dimers from Talaromyces stipitatus

    Chaudhary, N. K., Crombie, A., Vuong, D., Lacey, E., Piggott, A. M. & Karuso, P., 24 Apr 2020, In : Journal of Natural Products. 83, 4, p. 1051-1060 10 p.

    Research output: Contribution to journalArticle