• 1146 Citations
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Personal profile


Research in my group spans the exciting and challenging interface between chemistry and biology. We are particularly interested in exploring the extraordinary chemical and structural diversity of natural products and using these molecules as new drug leads and as probes to elucidate biochemical and cellular pathways.


BMedScs (Hons) Macq, PhD Macq, MRACI CChem


2018 -Senior Lecturer, Macquarie University
2014 - 2017ARC Future Fellow, Macquarie University
2012 - 2014Senior Research Officer, IMB, The University of Queensland
2007 - 2012Research Officer, IMB, The University of Queensland
2005 - 2007Postdoctoral Research Fellow, Macquarie University

Research Interests

  • Discovery and development of next-generation antibiotics
  • Natural product mode of action
  • Biodiscovery and structure elucidation
  • Chemical biology using natural product probes

Fingerprint Dive into the research topics where Andrew Piggott is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 2 Similar Profiles
Spectroscopic analysis Chemical Compounds
Aspergillus Chemical Compounds
Polyketides Chemical Compounds
Streptomyces Medicine & Life Sciences
Biosynthesis Chemical Compounds
Metabolites Chemical Compounds
spectroscopic analysis Physics & Astronomy
Porifera Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2013 2020

Research Outputs 2000 2019

A tetrapeptide class of biased analgesics from an Australian fungus targets the μ-opioid receptor

Dekan, Z., Sianati, S., Yousuf, A., Sutcliffe, K. J., Gillis, A., Mallet, C., Singh, P., Jin, A. H., Wang, A. M., Mohammadi, S. A., Stewart, M., Ratnayake, R., Fontaine, F., Lacey, E., Piggott, A. M., Du, Y. P., Canals, M., Sessions, R. B., Kelly, E., Capon, R. J. & 2 othersAlewood, P. F. & Christie, M. J., 29 Oct 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 44, p. 22353-22358 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Opioid Peptides
mu Opioid Receptor
GTP-Binding Proteins

Bipolenins K-N: new sesquiterpenoids from the fungal plant pathogen Bipolaris sorokiniana

Phan, C-S., Li, H., Kessler, S., Solomon, P. S., Piggott, A. M. & Chooi, Y-H., 26 Aug 2019, In : Beilstein Journal of Organic Chemistry. 15, p. 2020-2028 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Biological Products

Discovery and heterologous biosynthesis of the burnettramic acids: rare PKS-NRPS-derived bolaamphiphilic pyrrolizidinediones from an Australian fungus, Aspergillus burnettii

Li, H., Gilchrist, C. L. M., Lacey, H. J., Crombie, A., Vuong, D., Pitt, J. I., Lacey, E., Chooi, Y-H. & Piggott, A. M., 8 Feb 2019, In : Organic Letters. 21, 5, p. 1287-1291 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Aspergillus nidulans

Heterologous biosynthesis of elsinochrome A sheds light on the formation of the photosensitive perylenequinone system

Hu, J., Sarrami, F., Li, H., Zhang, G., Stubbs, K. A., Lacey, E., Stewart, S. G., Karton, A., Piggott, A. M. & Chooi, Y-H., 7 Feb 2019, In : Chemical Science. 10, 5, p. 1457-1465 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Predicting blood–brain barrier permeability of marine-derived kinase inhibitors using ensemble classifiers reveals potential hits for neurodegenerative disorders

Plisson, F. & Piggott, A. M., Feb 2019, In : Marine Drugs. 17, 2, 23 p., 81.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Blood-Brain Barrier
Neurodegenerative Diseases
Central Nervous System Diseases