• 1252 Citations
  • 20 h-Index

Research output per year

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Personal profile


Research in my group spans the exciting and challenging interface between chemistry and biology. We are particularly interested in exploring the extraordinary chemical and structural diversity of natural products and using these molecules as new drug leads and as probes to elucidate biochemical and cellular pathways.


BMedScs (Hons) Macq, PhD Macq, MRACI CChem


2018 -Senior Lecturer, Macquarie University
2014 - 2017ARC Future Fellow, Macquarie University
2012 - 2014Senior Research Officer, IMB, The University of Queensland
2007 - 2012Research Officer, IMB, The University of Queensland
2005 - 2007Postdoctoral Research Fellow, Macquarie University

Research Interests

  • Discovery and development of next-generation antibiotics
  • Natural product mode of action
  • Biodiscovery and structure elucidation
  • Chemical biology using natural product probes

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Research Outputs

Biosynthesis of a novel benzazepine alkaloid nanangelenin A involves an unprecedented fungal NRPS that incorporates L-kynurenine and catalyzes a regioselective peptide cyclization

Li, H., Gilchrist, C. L. M., Phan, C., Lacey, H. J., Lacey, E., Piggott, A. & Chooi, Y. H., 13 Jan 2020.

Research output: Contribution to conferencePoster

  • Talauxins: hybrid phenalenone dimers from Talaromyces stipitatus

    Chaudhary, N. K., Crombie, A., Vuong, D., Lacey, E., Piggott, A. M. & Karuso, P., 24 Apr 2020, In : Journal of Natural Products. 83, 4, p. 1051-1060 10 p.

    Research output: Contribution to journalArticle

  • A tetrapeptide class of biased analgesics from an Australian fungus targets the μ-opioid receptor

    Dekan, Z., Sianati, S., Yousuf, A., Sutcliffe, K. J., Gillis, A., Mallet, C., Singh, P., Jin, A. H., Wang, A. M., Mohammadi, S. A., Stewart, M., Ratnayake, R., Fontaine, F., Lacey, E., Piggott, A. M., Du, Y. P., Canals, M., Sessions, R. B., Kelly, E., Capon, R. J. & 2 others, Alewood, P. F. & Christie, M. J., 29 Oct 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 44, p. 22353-22358 6 p.

    Research output: Contribution to journalArticle

    Open Access
  • 4 Citations (Scopus)
    3 Downloads (Pure)

    Bipolenins K-N: new sesquiterpenoids from the fungal plant pathogen Bipolaris sorokiniana

    Phan, C-S., Li, H., Kessler, S., Solomon, P. S., Piggott, A. M. & Chooi, Y-H., 26 Aug 2019, In : Beilstein Journal of Organic Chemistry. 15, p. 2020-2028 9 p.

    Research output: Contribution to journalArticle

    Open Access
  • 1 Citation (Scopus)
    3 Downloads (Pure)

    Bisindole alkaloids from a New Zealand deep-sea marine sponge Lamellomorpha strongylata

    Ragini, K., Piggott, A. M. & Karuso, P., Dec 2019, In : Marine Drugs. 17, 12, p. 1-14 14 p., 683.

    Research output: Contribution to journalArticle

    Open Access
  • 3 Downloads (Pure)