• 1130 Citations
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20002020
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Research Outputs 2000 2019

2019

Bipolenins K-N: new sesquiterpenoids from the fungal plant pathogen Bipolaris sorokiniana

Phan, C-S., Li, H., Kessler, S., Solomon, P. S., Piggott, A. M. & Chooi, Y-H., 26 Aug 2019, In : Beilstein Journal of Organic Chemistry. 15, p. 2020-2028 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Pathogens
Biological Products
Seed
sativene

Discovery and heterologous biosynthesis of the burnettramic acids: rare PKS-NRPS-derived bolaamphiphilic pyrrolizidinediones from an Australian fungus, Aspergillus burnettii

Li, H., Gilchrist, C. L. M., Lacey, H. J., Crombie, A., Vuong, D., Pitt, J. I., Lacey, E., Chooi, Y-H. & Piggott, A. M., 8 Feb 2019, In : Organic Letters. 21, 5, p. 1287-1291 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Aspergillus
Aspergillus nidulans
biosynthesis
fungi
Biosynthesis

Heterologous biosynthesis of elsinochrome A sheds light on the formation of the photosensitive perylenequinone system

Hu, J., Sarrami, F., Li, H., Zhang, G., Stubbs, K. A., Lacey, E., Stewart, S. G., Karton, A., Piggott, A. M. & Chooi, Y-H., 7 Feb 2019, In : Chemical Science. 10, 5, p. 1457-1465 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Biosynthesis
Oxidoreductases
Genes
Chromosomes
Yeast

Predicting blood–brain barrier permeability of marine-derived kinase inhibitors using ensemble classifiers reveals potential hits for neurodegenerative disorders

Plisson, F. & Piggott, A. M., Feb 2019, In : Marine Drugs. 17, 2, 23 p., 81.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Blood-Brain Barrier
Neurodegenerative Diseases
Permeability
Phosphotransferases
Central Nervous System Diseases

The structure of testacein, a new hybrid polyketide-sesquiterpene metabolite from the lichen Notoparmelia testacea

Elix, J. A., Liao, L., Barrow, R. A. & Piggott, A. M., Jul 2019, In : Australasian Lichenology. 85, p. 34-39 6 p.

Research output: Contribution to journalArticleResearch

Open Access
File
Polyketides
Sesquiterpenes
Metabolites
Nuclear magnetic resonance spectroscopy
Mass spectrometry
2018

A26771B: a forgotten antibiotic

Cowled, M. S., Lacey, E. & Piggott, A. M., 2018, Organic18 RACI Organic Division National Conference: conference program. p. 114 1 p. PT24

Research output: Chapter in Book/Report/Conference proceedingConference abstractResearch

Anti-Bacterial Agents
A26771B

A study of the chemical diversity of macroalgae from South Eastern Australia

Vuong, D., Kaplan, M., Lacey, H. J., Crombie, A., Lacey, E. & Piggott, A. M., Apr 2018, In : Fitoterapia. 126, p. 53-64 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Seaweed
South Australia
Phaeophyta
Agrochemicals
Rhodophyta

Banksialactones and banksiamarins: isochromanones and isocoumarins from an Australian fungus, Aspergillus banksianus

Chaudhary, N. K., Pitt, J. I., Lacey, E., Crombie, A., Vuong, D., Piggott, A. M. & Karuso, P., Jul 2018, In : Journal of Natural Products. 81, 7, p. 1517-1526 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Isocoumarins
Aspergillus
Metabolites
Fungi
Acids

Chemical ecogenomics-guided discovery of phytotoxic α-pyrones from the fungal wheat pathogen Parastagonospora nodorum

Li, H., Hu, J., Wei, H., Solomon, P. S., Vuong, D., Lacey, E., Stubbs, K. A., Piggott, A. M. & Chooi, Y. H., 5 Oct 2018, In : Organic Letters. 20, 19, p. 6148–6152 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Pyrones
Polyketide Synthases
Polyketides
Oxygenases
wheat

Expanding antibiotic chemical space around the nidulin pharmacophore

Morshed, M. T., Vuong, D., Crombie, A., Lacey, A. E., Karuso, P., Lacey, E. & Piggott, A. M., 28 Apr 2018, In : Organic and Biomolecular Chemistry. 16, 16, p. 3038-3051 14 p.

Research output: Contribution to journalArticleResearchpeer-review

antibiotics
analogs
Anti-Bacterial Agents
biosynthesis
fungi

Predicting blood-brain barrier permeability of marine-derived kinase inhibitors

Plisson, F., Piggott, A., Hamilton, N. & Capon, R., 2018. 1 p.

Research output: Contribution to conferencePosterResearch

Taxonomy-guided microbial biodiscovery: finding the low-hanging fruit

Piggott, A. M., 2018, Organic18 RACI Organic Division National Conference: conference program. Royal Australian Chemical Institute, p. 50 1 p.

Research output: Chapter in Book/Report/Conference proceedingConference abstractResearch

taxonomy
microorganisms
polyketides
metabolites
Aspergillus
2017

Aspergillus hancockii sp. Nov., a biosynthetically talented fungus endemic to southeastern Australian soils

Pitt, J. I., Lange, L., Lacey, A. E., Vuong, D., Midgley, D. J., Greenfield, P., Bradbury, M. I., Lacey, E., Busk, P. K., Pilgaard, B., Chooi, Y-H. & Piggott, A. M., 5 Apr 2017, In : PLoS ONE. 12, 4, p. 1-21 21 p., e0170254.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Aspergillus
Metabolites
Fungi
secondary metabolites
Soil

Crellasterones A and B: A-norsterol derivatives from the new caledonian sponge crella incrustans

Ragini, K., Piggott, A. M. & Karuso, P., 15 Jun 2017, In : Marine Drugs. 15, 6, p. 1-10 10 p., 177.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
New Caledonia
Porifera
Circular Dichroism
Biological Products
Nucleosides

Cyclization of linear tetrapeptides containing N-nethylated amino acids by using 1-propanephosphonic acid anhydride

Zhang, S., De Leon Rodriguez, L. M., Lacey, E., Piggott, A. M., Leung, I. K. H. & Brimble, M. A., 3 Jan 2017, In : European Journal of Organic Chemistry. 2017, 1, p. 149-158 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Anhydrides
Cyclization
anhydrides
amino acids
Amino Acids

Enantiodivergence in the biosynthesis of bromotyrosine alkaloids from sponges?

Ragini, K., Fromont, J., Piggott, A. M. & Karuso, P., 27 Jan 2017, In : Journal of Natural Products. 80, 1, p. 215-219 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Expanding antibiotic chemical space through precursor-directed biosynthesis

Morshed, M. T., Vuong, D., Crombie, A., Lacey, E. & Piggott, A., 2017, RACI National Centenary Conference 2017: abstract book. Sydney: ICMS Australasia, p. 507 1 p.

Research output: Chapter in Book/Report/Conference proceedingConference proceeding contributionResearch

Biosynthesis
Anti-Bacterial Agents
Aspergillus
Depsides
Methicillin

Identifying the cellular targets of antibiotics using T7 phage display

Tirunagari, S., Vo, J., Karuso, P. & Piggott, A. M., 3 Apr 2017, p. 21. 1 p.

Research output: Contribution to conferencePosterResearch

Taxonomy-guided microbial biodiscovery

Piggott, A., Pitt, J., Lacey, A., Vuong, D. & Lacey, E., 2017, RACI National Centenary Conference 2017: abstract book. Sydney: ICMS Australasia, p. 354 1 p.

Research output: Chapter in Book/Report/Conference proceedingConference proceeding contributionResearch

secondary metabolites
taxonomy
Aspergillus
forest surveys
phenotype
2016

Aspergillus sydowii marine fungal bloom in Australian coastal waters, its metabolites and potential impact on symbiodinium dinoflagellates

Hayashi, A., Crombie, A., Lacey, E., Richardson, A. J., Vuong, D., Piggott, A. M. & Hallegraeff, G., 16 Mar 2016, In : Marine Drugs. 14, 3, p. 1-14 14 p., 59.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Dinoflagellida
Aspergillus
Dust
Anthozoa
Water

Banksialactones B-L, new isochromanones from Aspergillus banksianus

Chaudhary, N., Lacey, E., Piggott, A. M. & Karuso, P., 2016, The Royal Australian Chemical Institute NSW Organic Chemistry Group: 37th Annual One-Day Symposium : program and book of abstracts. Karuso, P., Try, A. & Piggott, A. (eds.). Melbourne: Royal Australian Chemical Institute, p. 28-28 1 p.

Research output: Chapter in Book/Report/Conference proceedingOther chapter contributionResearch

Enantiodivergence in the biosynthesis of spiroisoxazoline bromotyrosine alkaloids

Ragini, K., Piggott, A. M. & Karuso, P., 2016, The Royal Australian Chemical Institute NSW Organic Chemistry Group: 37th Annual One-Day Symposium : program and book of abstracts. Karuso, P., Try, A. & Piggott, A. (eds.). Melbourne: Royal Australian Chemical Institute, p. 59-59 1 p.

Research output: Chapter in Book/Report/Conference proceedingOther chapter contributionResearch

Expanding antibiotic chemical space through precursor-directed biosynthesis

Morshed, M., Vuong, D., Crombie, A., Lacey, E. & Piggott, A., 30 Nov 2016, p. 56. 1 p.

Research output: Contribution to conferencePosterResearch

Biosynthesis
Anti-Bacterial Agents
Aspergillus
Depsides
Methicillin

Identifying the cellular targets of antibiotics using T7 phage display

Tirunagari, S., Vo, J., Karuso, P. & Piggott, A. M., 2016, The Royal Australian Chemical Institute NSW Organic Chemistry Group: 37th Annual One-Day Symposium : program and book of abstracts. Karuso, P., Try, A. & Piggott, A. (eds.). Melbourne: Royal Australian Chemical Institute, p. 66-66 1 p.

Research output: Chapter in Book/Report/Conference proceedingOther chapter contributionResearch

Identifying the cellular targets of natural products using T7 phage display

Piggott, A. M. & Karuso, P., 1 May 2016, In : Natural Product Reports. 33, 5, p. 626-636 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Bacteriophage T7
Bacteriophages
Biological Products
Display devices
Molecular biology

Kumbicins A-D: Bis-Indolyl Benzenoids and Benzoquinones from an Australian Soil Fungus, Aspergillus kumbius

Lacey, H. J., Vuong, D., Pitt, J. I., Lacey, E. & Piggott, A. M., 2016, In : Australian Journal of Chemistry. 69, 2, p. 152-160 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Benzoquinones
Aspergillus
Fungi
Soil surveys
Soils

Primary pH degradation products of doramectin

Moore, A. F., Lacey, H. J., Crombie, A., Lacey, E. & Piggott, A. M., 14 Sep 2016, In : Tetrahedron Letters. 57, 37, p. 4224-4227 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Degradation
doramectin
Monosaccharides
Isomerization
2015

Aranciamycins I and J, Antimycobacterial Anthracyclines from an Australian Marine-Derived Streptomyces sp

Khalil, Z. G., Raju, R., Piggott, A. M., Salim, A. A., Blumenthal, A. & Capon, R. J., 24 Apr 2015, In : Journal of Natural Products. 78, 4, p. 949-952 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Anthracyclines
Streptomyces
Inhibitory Concentration 50
Bacteria
Spectroscopic analysis

New phenalenone analogues from a cryptic fungal co-culture leading to the biogenesis of duclauxamides

Chaudhary, N., Lacey, E., Piggott, A. & Karuso, P., 2015, RACI NSW Organic Chemistry Group 36th annual one-day symposium: programme. Melbourne: Royal Australian Chemical Institute, p. 22 1 p.

Research output: Chapter in Book/Report/Conference proceedingOther chapter contributionResearch

New phenalenone dimers and monomer from Talaromyces bacillisporus

Chaudhary, N. K., Lacey, E., Piggott, A. M. & Karuso, P. H., 2015, p. 4. 1 p.

Research output: Contribution to conferencePosterResearch

New small molecule analgesics that target the ALPHA3 glycine receptor

Lynch, J., Talwar, S., Xiao, X., Balansa, W., Islam, R., Fontaine, F., Piggott, A., Zhang, H., Webb, T., Gilbert, D., Vaughan, C. & Capon, R., Aug 2015, In : Journal of Neurochemistry. 134, S1, p. 18 1 p., S06-03.

Research output: Contribution to journalMeeting abstractResearch

Reverse chemical proteomics as a tool in natural product drug discovery

Piggott, A. M., Gotsbacher, M., Kwon, H. & Karuso, P., 2015, p. 16. 1 p.

Research output: Contribution to conferencePosterResearch

Reverse chemical proteomics with natural products for cellular and clinical applications

Karuso, P., Piggott, A. & Gotsbacher, M., 2015.

Research output: Contribution to conferencePaperResearch

2014

Callyspongisines A-D: Bromopyrrole alkaloids from an Australian marine sponge, Callyspongia sp.

Plisson, F., Prasad, P., Xiao, X., Piggott, A. M., Huang, X. C., Khalil, Z. & Capon, R. J., 14 Mar 2014, In : Organic and Biomolecular Chemistry. 12, 10, p. 1579-1584 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Callyspongia
alkaloids
Porifera
Alkaloids
Phosphotransferases

Corymbia phloem phenolics, tannins and terpenoids: Interactions with a cerambycid borer

Hayes, R. A., Piggott, A. M., Smith, T. E. & Nahrung, H. F., 2014, In : Chemoecology. 24, 3, p. 95-103 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Corymbia
Phloem
phloem
Tannins
Terpenes

Mollemycin A: an antimalarial and antibacterial glyco-hexadepsipeptide- polyketide from an Australian marine-derived Streptomyces sp. (CMB-M0244)

Raju, R., Khalil, Z. G., Piggott, A. M., Blumenthal, A., Gardiner, D. L., Skinner-Adams, T. S. & Capon, R. J., 21 Mar 2014, In : Organic Letters. 16, 6, p. 1716-1719 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Polyketides
parasites
Antimalarials
spectroscopic analysis
Streptomyces

Rare Streptomyces sp. polyketides as modulators of K-Ras localisation

Salim, A. A., Xiao, X., Cho, K. J., Piggott, A. M., Lacey, E., Hancock, J. F. & Capon, R. J., 21 Jul 2014, In : Organic and Biomolecular Chemistry. 12, 27, p. 4872-4878 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Polyketides
Streptomyces
Modulators
esters
modulators

Shornephine A: Structure, chemical stability, and P-glycoprotein inhibitory properties of a rare diketomorpholine from an Australian marine-derived Aspergillus sp.

Khalil, Z. G., Huang, X. C., Raju, R., Piggott, A. M. & Capon, R. J., 19 Sep 2014, In : Journal of Organic Chemistry. 79, 18, p. 8700-8705 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Aspergillus
Chemical stability
P-Glycoprotein
Diketopiperazines
Geologic Sediments
2013

Abyssomicins from the South China Sea deep-sea sediment verrucosispora sp. natural thioether michael addition adducts as antitubercular prodrugs

Wang, Q., Song, F., Xiao, X., Huang, P., Li, L., Monte, A., Abdel-Mageed, W. M., Wang, J., Guo, H., He, W., Xie, F., Dai, H., Liu, M., Chen, C., Xu, H., Liu, M., Piggott, A. M., Liu, X., Capon, R. J. & Zhang, L., 21 Jan 2013, In : Angewandte Chemie - International Edition. 52, 4, p. 1231-1234 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Biosynthesis
Prodrugs
Biomimetics
Sulfides
Sediments

Australian marine sponge alkaloids as a new class of glycine-gated chloride channel receptor modulator

Balansa, W., Islam, R., Gilbert, D. F., Fontaine, F., Xiao, X., Zhang, H., Piggott, A. M., Lynch, J. W. & Capon, R. J., 15 Jul 2013, In : Bioorganic and Medicinal Chemistry. 21, 14, p. 4420-4425 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Indole Alkaloids
Chloride Channels
Sesquiterpenes
Porifera
Alkaloids

Nocardiopsins C and D and nocardiopyrone A: New polyketides from an Australian marine-derived Nocardiopsis sp.

Raju, R., Piggott, A. M., Quezada, M. & Capon, R. J., 14 Jan 2013, In : Tetrahedron. 69, 2, p. 692-698 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Polyketides
Pyrones
Polyketide Synthases
Geologic Sediments
Queensland

Sesterterpene glycinyl-lactams: a new class of glycine receptor modulator from Australian marine sponges of the genus Psammocinia

Balansa, W., Islam, R., Fontaine, F., Piggott, A. M., Zhang, H., Xiao, X., Webb, T. I., Gilbert, D. F., Lynch, J. W. & Capon, R. J., 28 Jul 2013, In : Organic and Biomolecular Chemistry. 11, 28, p. 4695-4701 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Sesterterpenes
Glycine Receptors
Lactams
Porifera
glycine

Sydowiols A-C: Mycobacterium tuberculosis protein tyrosine phosphatase inhibitors from an East China Sea marine-derived fungus, Aspergillus sydowii

Liu, X., Song, F., Ma, L., Chen, C., Xiao, X., Ren, B., Liu, X., Dai, H., Piggott, A. M., Av-Gay, Y., Zhang, L. & Capon, R. J., 6 Nov 2013, In : Tetrahedron Letters. 54, 45, p. 6081-6083 3 p.

Research output: Contribution to journalArticleResearchpeer-review

Pyrogallol
Protein Tyrosine Phosphatases
Ethers
Aspergillus
Fungi
2012

Brevianamides with antitubercular potential from a marine-derived isolate of aspergillus versicolor

Song, F., Liu, X., Guo, H., Ren, B., Chen, C., Piggott, A. M., Yu, K., Gao, H., Wang, Q., Liu, M., Liu, X., Dai, H., Zhang, L. & Capon, R. J., 21 Sep 2012, In : Organic Letters. 14, 18, p. 4770-4773 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Aspergillus
spectroscopic analysis
China
sediments
drugs

Design and application of in vivo FRET biosensors to identify protein prenylation and nanoclustering inhibitors

Köhnke, M., Schmitt, S., Ariotti, N., Piggott, A. M., Parton, R. G., Lacey, E., Capon, R. J., Alexandrov, K. & Abankwa, D., 27 Jul 2012, In : Chemistry and Biology. 19, 7, p. 866-874 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Protein Prenylation
Prenylation
Biosensing Techniques
Biosensors
Proteolipids

Heronamycin A: a new benzothiazine ansamycin from an Australian marine-derived Streptomyces sp.

Raju, R., Piggott, A. M., Khalil, Z., Bernhardt, P. V. & Capon, R. J., 29 Feb 2012, In : Tetrahedron Letters. 53, 9, p. 1063-1065 3 p.

Research output: Contribution to journalArticleResearchpeer-review

Rifabutin
Queensland
Spectroscopic analysis
X ray crystallography
X Ray Crystallography

Kinase Inhibitor Scaffolds against Neurodegenerative Diseases from a Southern Australian Ascidian, Didemnum sp.

Plisson, F., Conte, M., Khalil, Z., Huang, X. C., Piggott, A. M. & Capon, R. J., Jun 2012, In : ChemMedChem. 7, 6, p. 983-990 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Neurodegenerative diseases
Urochordata
Cyclins
Scaffolds
Neurodegenerative Diseases

Staurosporines disrupt phosphatidylserine trafficking and mislocalize ras proteins

Cho, K. J., Park, J. H., Piggott, A. M., Salim, A. A., Gorfe, A. A., Parton, R. G., Capon, R. J., Lacey, E. & Hancock, J. F., 21 Dec 2012, In : Journal of Biological Chemistry. 287, 52, p. 43573-43584 12 p.

Research output: Contribution to journalArticleResearchpeer-review

ras Proteins
Phosphatidylserines
Cell membranes
Cell Membrane
Staurosporine