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20002020
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Research Outputs 2000 2019

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Article
2019

A tetrapeptide class of biased analgesics from an Australian fungus targets the μ-opioid receptor

Dekan, Z., Sianati, S., Yousuf, A., Sutcliffe, K. J., Gillis, A., Mallet, C., Singh, P., Jin, A. H., Wang, A. M., Mohammadi, S. A., Stewart, M., Ratnayake, R., Fontaine, F., Lacey, E., Piggott, A. M., Du, Y. P., Canals, M., Sessions, R. B., Kelly, E., Capon, R. J. & 2 othersAlewood, P. F. & Christie, M. J., 29 Oct 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 44, p. 22353-22358 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Opioid Peptides
mu Opioid Receptor
GTP-Binding Proteins
Analgesics
Fungi

Bipolenins K-N: new sesquiterpenoids from the fungal plant pathogen Bipolaris sorokiniana

Phan, C-S., Li, H., Kessler, S., Solomon, P. S., Piggott, A. M. & Chooi, Y-H., 26 Aug 2019, In : Beilstein Journal of Organic Chemistry. 15, p. 2020-2028 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Pathogens
Biological Products
Seed
sativene

Discovery and heterologous biosynthesis of the burnettramic acids: rare PKS-NRPS-derived bolaamphiphilic pyrrolizidinediones from an Australian fungus, Aspergillus burnettii

Li, H., Gilchrist, C. L. M., Lacey, H. J., Crombie, A., Vuong, D., Pitt, J. I., Lacey, E., Chooi, Y-H. & Piggott, A. M., 8 Feb 2019, In : Organic Letters. 21, 5, p. 1287-1291 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Aspergillus
Aspergillus nidulans
biosynthesis
fungi
Biosynthesis

Heterologous biosynthesis of elsinochrome A sheds light on the formation of the photosensitive perylenequinone system

Hu, J., Sarrami, F., Li, H., Zhang, G., Stubbs, K. A., Lacey, E., Stewart, S. G., Karton, A., Piggott, A. M. & Chooi, Y-H., 7 Feb 2019, In : Chemical Science. 10, 5, p. 1457-1465 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Biosynthesis
Oxidoreductases
Genes
Chromosomes
Yeast

Predicting blood–brain barrier permeability of marine-derived kinase inhibitors using ensemble classifiers reveals potential hits for neurodegenerative disorders

Plisson, F. & Piggott, A. M., Feb 2019, In : Marine Drugs. 17, 2, 23 p., 81.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Blood-Brain Barrier
Neurodegenerative Diseases
Permeability
Phosphotransferases
Central Nervous System Diseases

The structure of testacein, a new hybrid polyketide-sesquiterpene metabolite from the lichen Notoparmelia testacea

Elix, J. A., Liao, L., Barrow, R. A. & Piggott, A. M., Jul 2019, In : Australasian Lichenology. 85, p. 34-39 6 p.

Research output: Contribution to journalArticleResearch

Open Access
File
Polyketides
Sesquiterpenes
Metabolites
Nuclear magnetic resonance spectroscopy
Mass spectrometry
2018

A study of the chemical diversity of macroalgae from South Eastern Australia

Vuong, D., Kaplan, M., Lacey, H. J., Crombie, A., Lacey, E. & Piggott, A. M., Apr 2018, In : Fitoterapia. 126, p. 53-64 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Seaweed
South Australia
Phaeophyta
Agrochemicals
Rhodophyta

Banksialactones and banksiamarins: isochromanones and isocoumarins from an Australian fungus, Aspergillus banksianus

Chaudhary, N. K., Pitt, J. I., Lacey, E., Crombie, A., Vuong, D., Piggott, A. M. & Karuso, P., Jul 2018, In : Journal of Natural Products. 81, 7, p. 1517-1526 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Isocoumarins
Aspergillus
Metabolites
Fungi
Acids

Chemical ecogenomics-guided discovery of phytotoxic α-pyrones from the fungal wheat pathogen Parastagonospora nodorum

Li, H., Hu, J., Wei, H., Solomon, P. S., Vuong, D., Lacey, E., Stubbs, K. A., Piggott, A. M. & Chooi, Y. H., 5 Oct 2018, In : Organic Letters. 20, 19, p. 6148–6152 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Pyrones
Polyketide Synthases
Polyketides
Oxygenases
wheat

Expanding antibiotic chemical space around the nidulin pharmacophore

Morshed, M. T., Vuong, D., Crombie, A., Lacey, A. E., Karuso, P., Lacey, E. & Piggott, A. M., 28 Apr 2018, In : Organic and Biomolecular Chemistry. 16, 16, p. 3038-3051 14 p.

Research output: Contribution to journalArticleResearchpeer-review

antibiotics
analogs
Anti-Bacterial Agents
biosynthesis
fungi
2017

Aspergillus hancockii sp. Nov., a biosynthetically talented fungus endemic to southeastern Australian soils

Pitt, J. I., Lange, L., Lacey, A. E., Vuong, D., Midgley, D. J., Greenfield, P., Bradbury, M. I., Lacey, E., Busk, P. K., Pilgaard, B., Chooi, Y-H. & Piggott, A. M., 5 Apr 2017, In : PLoS ONE. 12, 4, p. 1-21 21 p., e0170254.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Aspergillus
Metabolites
Fungi
secondary metabolites
Soil

Crellasterones A and B: A-norsterol derivatives from the new caledonian sponge crella incrustans

Ragini, K., Piggott, A. M. & Karuso, P., 15 Jun 2017, In : Marine Drugs. 15, 6, p. 1-10 10 p., 177.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
New Caledonia
Porifera
Circular Dichroism
Biological Products
Nucleosides

Cyclization of linear tetrapeptides containing N-nethylated amino acids by using 1-propanephosphonic acid anhydride

Zhang, S., De Leon Rodriguez, L. M., Lacey, E., Piggott, A. M., Leung, I. K. H. & Brimble, M. A., 3 Jan 2017, In : European Journal of Organic Chemistry. 2017, 1, p. 149-158 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Anhydrides
Cyclization
anhydrides
amino acids
Amino Acids

Enantiodivergence in the biosynthesis of bromotyrosine alkaloids from sponges?

Ragini, K., Fromont, J., Piggott, A. M. & Karuso, P., 27 Jan 2017, In : Journal of Natural Products. 80, 1, p. 215-219 5 p.

Research output: Contribution to journalArticleResearchpeer-review

2016

Aspergillus sydowii marine fungal bloom in Australian coastal waters, its metabolites and potential impact on Symbiodinium dinoflagellates

Hayashi, A., Crombie, A., Lacey, E., Richardson, A. J., Vuong, D., Piggott, A. M. & Hallegraeff, G., 16 Mar 2016, In : Marine Drugs. 14, 3, p. 1-14 14 p., 59.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Dinoflagellida
Aspergillus
Dust
Anthozoa
Water

Identifying the cellular targets of natural products using T7 phage display

Piggott, A. M. & Karuso, P., 1 May 2016, In : Natural Product Reports. 33, 5, p. 626-636 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Bacteriophage T7
Bacteriophages
Biological Products
Display devices
Molecular biology

Kumbicins A-D: Bis-Indolyl Benzenoids and Benzoquinones from an Australian Soil Fungus, Aspergillus kumbius

Lacey, H. J., Vuong, D., Pitt, J. I., Lacey, E. & Piggott, A. M., 2016, In : Australian Journal of Chemistry. 69, 2, p. 152-160 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Benzoquinones
Aspergillus
Fungi
Soil surveys
Soils

Primary pH degradation products of doramectin

Moore, A. F., Lacey, H. J., Crombie, A., Lacey, E. & Piggott, A. M., 14 Sep 2016, In : Tetrahedron Letters. 57, 37, p. 4224-4227 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Degradation
doramectin
Monosaccharides
Isomerization
2015

Aranciamycins I and J, Antimycobacterial Anthracyclines from an Australian Marine-Derived Streptomyces sp

Khalil, Z. G., Raju, R., Piggott, A. M., Salim, A. A., Blumenthal, A. & Capon, R. J., 24 Apr 2015, In : Journal of Natural Products. 78, 4, p. 949-952 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Anthracyclines
Streptomyces
Inhibitory Concentration 50
Bacteria
Spectroscopic analysis
2014

Callyspongisines A-D: Bromopyrrole alkaloids from an Australian marine sponge, Callyspongia sp.

Plisson, F., Prasad, P., Xiao, X., Piggott, A. M., Huang, X. C., Khalil, Z. & Capon, R. J., 14 Mar 2014, In : Organic and Biomolecular Chemistry. 12, 10, p. 1579-1584 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Callyspongia
alkaloids
Porifera
Alkaloids
Phosphotransferases

Corymbia phloem phenolics, tannins and terpenoids: Interactions with a cerambycid borer

Hayes, R. A., Piggott, A. M., Smith, T. E. & Nahrung, H. F., 2014, In : Chemoecology. 24, 3, p. 95-103 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Corymbia
Phloem
phloem
Tannins
Terpenes

Mollemycin A: an antimalarial and antibacterial glyco-hexadepsipeptide- polyketide from an Australian marine-derived Streptomyces sp. (CMB-M0244)

Raju, R., Khalil, Z. G., Piggott, A. M., Blumenthal, A., Gardiner, D. L., Skinner-Adams, T. S. & Capon, R. J., 21 Mar 2014, In : Organic Letters. 16, 6, p. 1716-1719 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Polyketides
parasites
Antimalarials
spectroscopic analysis
Streptomyces

Rare Streptomyces sp. polyketides as modulators of K-Ras localisation

Salim, A. A., Xiao, X., Cho, K. J., Piggott, A. M., Lacey, E., Hancock, J. F. & Capon, R. J., 21 Jul 2014, In : Organic and Biomolecular Chemistry. 12, 27, p. 4872-4878 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Polyketides
Streptomyces
Modulators
esters
modulators

Shornephine A: Structure, chemical stability, and P-glycoprotein inhibitory properties of a rare diketomorpholine from an Australian marine-derived Aspergillus sp.

Khalil, Z. G., Huang, X. C., Raju, R., Piggott, A. M. & Capon, R. J., 19 Sep 2014, In : Journal of Organic Chemistry. 79, 18, p. 8700-8705 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Aspergillus
Chemical stability
P-Glycoprotein
Diketopiperazines
Geologic Sediments
2013

Abyssomicins from the South China Sea deep-sea sediment verrucosispora sp. natural thioether michael addition adducts as antitubercular prodrugs

Wang, Q., Song, F., Xiao, X., Huang, P., Li, L., Monte, A., Abdel-Mageed, W. M., Wang, J., Guo, H., He, W., Xie, F., Dai, H., Liu, M., Chen, C., Xu, H., Liu, M., Piggott, A. M., Liu, X., Capon, R. J. & Zhang, L., 21 Jan 2013, In : Angewandte Chemie - International Edition. 52, 4, p. 1231-1234 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Biosynthesis
Prodrugs
Biomimetics
Sulfides
Sediments

Australian marine sponge alkaloids as a new class of glycine-gated chloride channel receptor modulator

Balansa, W., Islam, R., Gilbert, D. F., Fontaine, F., Xiao, X., Zhang, H., Piggott, A. M., Lynch, J. W. & Capon, R. J., 15 Jul 2013, In : Bioorganic and Medicinal Chemistry. 21, 14, p. 4420-4425 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Indole Alkaloids
Chloride Channels
Sesquiterpenes
Porifera
Alkaloids

Nocardiopsins C and D and nocardiopyrone A: New polyketides from an Australian marine-derived Nocardiopsis sp.

Raju, R., Piggott, A. M., Quezada, M. & Capon, R. J., 14 Jan 2013, In : Tetrahedron. 69, 2, p. 692-698 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Polyketides
Pyrones
Polyketide Synthases
Geologic Sediments
Queensland

Sesterterpene glycinyl-lactams: a new class of glycine receptor modulator from Australian marine sponges of the genus Psammocinia

Balansa, W., Islam, R., Fontaine, F., Piggott, A. M., Zhang, H., Xiao, X., Webb, T. I., Gilbert, D. F., Lynch, J. W. & Capon, R. J., 28 Jul 2013, In : Organic and Biomolecular Chemistry. 11, 28, p. 4695-4701 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Sesterterpenes
Glycine Receptors
Lactams
Porifera
glycine

Sydowiols A-C: Mycobacterium tuberculosis protein tyrosine phosphatase inhibitors from an East China Sea marine-derived fungus, Aspergillus sydowii

Liu, X., Song, F., Ma, L., Chen, C., Xiao, X., Ren, B., Liu, X., Dai, H., Piggott, A. M., Av-Gay, Y., Zhang, L. & Capon, R. J., 6 Nov 2013, In : Tetrahedron Letters. 54, 45, p. 6081-6083 3 p.

Research output: Contribution to journalArticleResearchpeer-review

Pyrogallol
Protein Tyrosine Phosphatases
Ethers
Aspergillus
Fungi
2012

Brevianamides with antitubercular potential from a marine-derived isolate of aspergillus versicolor

Song, F., Liu, X., Guo, H., Ren, B., Chen, C., Piggott, A. M., Yu, K., Gao, H., Wang, Q., Liu, M., Liu, X., Dai, H., Zhang, L. & Capon, R. J., 21 Sep 2012, In : Organic Letters. 14, 18, p. 4770-4773 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Aspergillus
spectroscopic analysis
China
sediments
drugs

Design and application of in vivo FRET biosensors to identify protein prenylation and nanoclustering inhibitors

Köhnke, M., Schmitt, S., Ariotti, N., Piggott, A. M., Parton, R. G., Lacey, E., Capon, R. J., Alexandrov, K. & Abankwa, D., 27 Jul 2012, In : Chemistry and Biology. 19, 7, p. 866-874 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Protein Prenylation
Prenylation
Biosensing Techniques
Biosensors
Proteolipids

Heronamycin A: a new benzothiazine ansamycin from an Australian marine-derived Streptomyces sp.

Raju, R., Piggott, A. M., Khalil, Z., Bernhardt, P. V. & Capon, R. J., 29 Feb 2012, In : Tetrahedron Letters. 53, 9, p. 1063-1065 3 p.

Research output: Contribution to journalArticleResearchpeer-review

Rifabutin
Queensland
Spectroscopic analysis
X ray crystallography
X Ray Crystallography

Kinase Inhibitor Scaffolds against Neurodegenerative Diseases from a Southern Australian Ascidian, Didemnum sp.

Plisson, F., Conte, M., Khalil, Z., Huang, X. C., Piggott, A. M. & Capon, R. J., Jun 2012, In : ChemMedChem. 7, 6, p. 983-990 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Neurodegenerative diseases
Urochordata
Cyclins
Scaffolds
Neurodegenerative Diseases

Staurosporines disrupt phosphatidylserine trafficking and mislocalize ras proteins

Cho, K. J., Park, J. H., Piggott, A. M., Salim, A. A., Gorfe, A. A., Parton, R. G., Capon, R. J., Lacey, E. & Hancock, J. F., 21 Dec 2012, In : Journal of Biological Chemistry. 287, 52, p. 43573-43584 12 p.

Research output: Contribution to journalArticleResearchpeer-review

ras Proteins
Phosphatidylserines
Cell membranes
Cell Membrane
Staurosporine

Symphyocladins A-G: Bromophenol adducts from a Chinese marine red alga, Symphyocladia latiuscula

Xu, X., Piggott, A. M., Yin, L., Capon, R. J. & Song, F., 18 Apr 2012, In : Tetrahedron Letters. 53, 16, p. 2103-2106 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Aconitic Acid
Rhodophyta
NSC 153174
Military Personnel
Algae
2011

Ikirydinium A: a new indole alkaloid from the seeds of Hunteria umbellata (K. Schum)

Ajala, O. S., Piggott, A. M., Plisson, F., Khalil, Z., Huang, X. C., Adesegun, S. A., Coker, H. A. B. & Capon, R. J., 28 Dec 2011, In : Tetrahedron Letters. 52, 52, p. 7125-7127 3 p.

Research output: Contribution to journalArticleResearchpeer-review

Indole Alkaloids
Vinblastine
Biosynthesis
Bacilli
Nigeria

Nocardioazines: A novel bridged diketopiperazine scaffold from a marine-derived bacterium inhibits p-glycoprotein

Raju, R., Piggott, A. M., Huang, X. C. & Capon, R. J., 20 May 2011, In : Organic Letters. 13, 10, p. 2770-2773 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Diketopiperazines
efflux
reversing
indoles
Scaffolds

Reveromycins revealed: New polyketide spiroketals from Australian marine-derived and terrestrial Streptomyces spp. A case of natural products vs. artifacts

Fremlin, L., Farrugia, M., Piggott, A. M., Khalil, Z., Lacey, E. & Capon, R. J., 21 Feb 2011, In : Organic and Biomolecular Chemistry. 9, 4, p. 1201-1211 11 p.

Research output: Contribution to journalArticleResearchpeer-review

starters
Polyketides
fermentation
biosynthesis
metabolites
2010

9-(5-deoxy-5-thio - D-xylofuranosyl)adenine disulfide from the Southern Australian marine sponge trachycladus laevispirulifer: The first natural occurrence of a nucleoside disulfide

Peng, C., Gunaherath, G. M. K. B., Piggott, A. M., Khalil, Z., Conte, M. & Capon, R. J., 2010, In : Australian Journal of Chemistry. 63, 6, p. 873-876 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Adenine
Nucleosides
Disulfides
Thionucleosides
Spectroscopic analysis

Heronamides A - C, new polyketide macrolactams from an Australian marine-derived Streptomyces sp. A biosynthetic case for synchronized tandem electrocyclization

Raju, R., Piggott, A. M., Conte, M. M. & Capon, R. J., 21 Oct 2010, In : Organic and Biomolecular Chemistry. 8, 20, p. 4682-4689 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Polyketides
biosynthesis
Spectroscopic analysis
Biosynthesis
biomimetics

Heronapyrroles A-C: Farnesylated 2-nitropyrroles from an Australian marine-derived Streptomyces sp.

Raju, R., Piggott, A. M., Barrientos Diaz, L. X., Khalil, Z. & Capon, R. J., 19 Nov 2010, In : Organic Letters. 12, 22, p. 5158-5161 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Spectroscopic analysis
beaches
spectroscopic analysis
Streptomyces
Gram-Positive Bacteria

Ircinialactams: Subunit-selective glycine receptor modulators from Australian sponges of the family Irciniidae

Balansa, W., Islam, R., Fontaine, F., Piggott, A. M., Zhang, H., Webb, T. I., Gilbert, D. F., Lynch, J. W. & Capon, R. J., 15 Apr 2010, In : Bioorganic and Medicinal Chemistry. 18, 8, p. 2912-2919 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Glycine Receptors
Porifera
Modulators
Sesterterpenes
Lactams

Nocardiopsins: New FKBP12-binding macrolide polyketides from an Australian marine-derived actinomycete, nocardiopsis sp

Raju, R., Piggott, A. M., Conte, M., Tnimov, Z., Alexandrov, K. & Capon, R. J., 8 Mar 2010, In : Chemistry - A European Journal. 16, 10, p. 3194-3200 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Tacrolimus Binding Protein 1A
Polyketides
Macrolides
Tacrolimus
Sirolimus
2009

Cottoquinazoline A and cotteslosins A and B, metabolites from an Australian marine-derived strain of Aspergillus versicolor

Fremlin, L. J., Piggott, A. M., Lacey, E. & Capon, R. J., 24 Apr 2009, In : Journal of Natural Products. 72, 4, p. 666-670 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Sterigmatocystin
Cellophane
Aspergillus
Phenols
Cytotoxins

Microbial biotransformation as a source of chemical diversity in cane toad steroid toxins

Hayes, R. A., Piggott, A. M., Dalle, K. & Capon, R. J., 15 Mar 2009, In : Bioorganic and Medicinal Chemistry Letters. 19, 6, p. 1790-1792 3 p.

Research output: Contribution to journalArticleResearchpeer-review

Bufanolides
Canes
Biotransformation
Anura
Steroids

Naseseazines A and B: a new dimeric diketopiperazine framework from a marine-derived actinomycete, Streptomyces sp

Raju, R., Piggott, A. M., Conte, M., Aalbersberg, W. G. L., Feussner, K. & Capon, R. J., 3 Sep 2009, In : Organic Letters. 11, 17, p. 3862-3865 4 p.

Research output: Contribution to journalArticleResearchpeer-review

actinomycetes
Diketopiperazines
Geologic Sediments
Spectroscopic analysis
Actinobacteria

Rapid isolation of novel FK506 binding proteins from multiple organisms using gDNA and cDNA T7 phage display

Piggott, A. M., Kriegel, A. M., Willows, R. D. & Karuso, P., 1 Oct 2009, In : Bioorganic and Medicinal Chemistry. 17, 19, p. 6841-6850 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Tacrolimus Binding Proteins
Bacteriophage T7
Bacteriophages
Complementary DNA
Display devices
2008

Bistellettazines A-C and bistellettazole A: new terpenyl-pyrrolizidine and terpenyl-imidazole alkaloids from a southern Australian marine sponge, Stelletta sp

El-Naggar, M., Piggott, A. M. & Capon, R. J., 2008, In : Organic Letters. 10, 19, p. 4247-4250 4 p.

Research output: Contribution to journalArticleResearchpeer-review

alkaloids
Porifera
imidazoles
Alkaloids
Spectroscopic analysis

Rapid identification of a protein binding partner for the marine natural product kahalalide F by using reverse chemical proteomics

Piggott, A. M. & Karuso, P., 3 Mar 2008, In : ChemBioChem. 9, 4, p. 524-530 7 p.

Research output: Contribution to journalArticleResearchpeer-review

2007

Fluorometric assay for the determination of glutathione reductase activity

Piggott, A. M. & Karuso, P., 15 Nov 2007, In : Analytical Chemistry. 79, 22, p. 8769-8773 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Glutathione Reductase
Assays
Dithionitrobenzoic Acid
Sulfhydryl Compounds
Haptens