Projects per year
Personal profile
Biography
Dr. Laird studies the pathogenesis of movement disorders with a particular focus on identifying and testing potential disease treatments. Her group has been successful at producing and characterising the world’s first zebrafish model of spinocerebellar ataxia type-3 (also known as Machado Joseph Disease, MJD). They are currently testing the effect of various drugs on these zebrafish with the aim of identifying a treatment for the disease.
Dr. Laird's full CV, with all grants and activities, can be accessed here.
Research interests
- Developing transgenic zebrafish models of neurodegenerative diseases such as spinocerebellar ataxia-3 and motor neuron disease
- Role of proteolytic cleavage in the pathogenesis of spinocerebellar ataxia-3
- Potential of autophagy induction for the treatment of spinocerebellar ataxia-3
- Role of glutamate induced excitotoxicity in the pathogenesis of spinocerebellar ataxia-3
External positions
Senior Research Scientist, ANZAC Research Institute
Jan 2010 → Feb 2016
Postdoctoral Fellow, University of Leuven
May 2008 → Oct 2010
Casual Admin/Research Assistant, The University of New South Wales
Jan 2002 → Jan 2007
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Quinolinones as a Novel Therapeutic Strategy in ALS
Atkin, J., Abbott, B. M. & Laird, A.
1/09/22 → 31/08/25
Project: Research
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Testing drugs that induce autophagy for the treatment of Machado Joseph disease
Laird, A., Nicholson, G. & Chung, R.
1/03/17 → …
Project: Research
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A laser platform to undertake single-cell-resolution experiments in zebrafish
Chung, R., Morsch, M., Laird, A. & Cole, N.
1/01/17 → …
Project: Research
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Testing drugs for the treatment of Machado Joseph disease
Laird, A., Shi, B., Cole, N., Ooi, L. & Nicholson, G.
1/01/17 → …
Project: Research
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Butyrate as a potential therapeutic agent for neurodegenerative disorders
Chakraborty, P., Gamage, H. K. A. H. & Laird, A. S., Jun 2024, In: Neurochemistry International. 176, p. 1-15 15 p., 105745.Research output: Contribution to journal › Review article › peer-review
5 Citations (Scopus) -
Spermidine treatment: induction of autophagy but also apoptosis?
Watchon, M., Wright, A. L., Ahel, H. I., Robinson, K. J., Plenderleith, S. K., Kuriakose, A., Yuan, K. C. & Laird, A. S., 5 Mar 2024, In: Molecular Brain. 17, 1, p. 1-15 15 p., 15.Research output: Contribution to journal › Article › peer-review
Open AccessFile31 Downloads (Pure) -
The deubiquitinase function of ataxin-3 and its role in the pathogenesis of Machado-Joseph disease and other diseases
Potapenko, A., Davidson, J. M., Lee, A. & Laird, A. S., 18 Mar 2024, In: Biochemical Journal. 481, 6, p. 461-480 20 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile71 Downloads (Pure) -
Treatment with sodium butyrate induces autophagy resulting in therapeutic benefits for spinocerebellar ataxia type 3
Watchon, M., Robinson, K. J., Luu, L., An, Y., Yuan, K. C., Plenderleith, S. K., Cheng, F., Don, E. K., Nicholson, G. A., Lee, A. & Laird, A. S., 31 Jan 2024, In: FASEB Journal. 38, 2, p. 1-19 19 p., e23429.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)81 Downloads (Pure) -
Autophagy function and benefits of autophagy induction in models of Spinocerebellar ataxia type 3
Watchon, M., Luu, L., Plenderleith, S. K., Yuan, K. C. & Laird, A. S., 14 Mar 2023, In: Cells. 12, 6, p. 1-16 16 p., 893.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)73 Downloads (Pure)
Prizes
Activities
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Invited Plenary Speaker International Machado Joseph Disease Conference
Angela Laird (Speaker)
2019Activity: Talk or presentation › Invited talk
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Invited speaker at Australian Proteostasis Conference
Angela Laird (Speaker)
2019Activity: Talk or presentation › Invited talk
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Key note speaker at MND Gala dinner
Angela Laird (Speaker)
2019Activity: Talk or presentation › Invited talk
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Invited Speaker at MQ Women Shaping the Future Symposium
Angela Laird (Speaker)
2019Activity: Talk or presentation › Invited talk
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Australian and New Zealand Zebrafish Conference
Angela Laird (Participant)
2018Activity: Participating in or organising an event › Participating in a conference, workshop or event series
Press/Media
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Macquarie University Top 10 Researchers to Watch on Twitter (2018)
1/02/18
1 Media contribution
Press/Media: Public Engagement Activities
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Zebrafish study offers hope to MJD sufferers, The Australian
8/08/17
1 item of Media coverage
Press/Media: Other
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Invited Expert Panel Member for Machado Joseph disease Film Event
23/02/17
1 Media contribution
Press/Media: Public Engagement Activities
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