Angela Laird

Personal profile

Biography

Dr. Laird studies the pathogenesis of movement disorders with a particular focus on identifying and testing potential disease treatments. Her group has been successful at producing and characterising the world’s first zebrafish model of spinocerebellar ataxia type-3 (also known as Machado Joseph Disease, MJD). They are currently testing the effect of various drugs on these zebrafish with the aim of identifying a treatment for the disease.

Dr. Laird's full CV, with all grants and activities, can be accessed here.

Research interests

Developing transgenic zebrafish models of neurodegenerative diseases such as spinocerebellar ataxia-3 and motor neuron disease
Role of proteolytic cleavage in the pathogenesis of spinocerebellar ataxia-3
Potential of autophagy induction for the treatment of spinocerebellar ataxia-3
Role of glutamate induced excitotoxicity in the pathogenesis of spinocerebellar ataxia-3

External positions

Senior Research Scientist, ANZAC Research Institute

Jan 2010 → Feb 2016

Postdoctoral Fellow, University of Leuven

May 2008 → Oct 2010

Casual Admin/Research Assistant, The University of New South Wales

Jan 2002 → Jan 2007

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Projects

8 Finished
9 Active

CMNDR: Macquarie University Centre for Motor Neuron Disease Research

Atkin, J., Blair, I., Rowe, D., Atkin, J., Chung, R., Guillemin, G., Laird, A., Lee, A., Morsch, M., Shi, B., Williams, K. & Yang, S.

1/01/20 → 31/12/22

Project: Other

Snow Foundation Co-funded Fellow: Evaluating potential MND therapeutics in zebrafish models

Laird, A. & Chung, R.

27/07/18 → 26/07/21

Project: Research

Calpeptin, and related candidates, for the treatment of Machado Joseph disease

Laird, A., Nicholson, G., Walker, A. K., Cole, N., Lee, A., Morsch, M., Davis, R., Guillemin, G., Atkin, J. & Ooi, L.

1/01/18 → 31/12/21

Project: Research

Therapeutics based on the protective activity of protein disulphide in MND

Atkin, J., Walker, A. K., Laird, A., Heras, B., Anderson, M., Craik, D. & Bleackley, M.

28/04/17 → …

Project: Research

Novel therapeutics targeting neuronal transport pathways in MND

Atkin, J., Walker, A. K., Laird, A., Jonathan, B. & Abbott, B.

28/04/17 → …

Project: Research

Research Outputs

448 Citations
10 h-Index
17 Article
2 Review article
1 Chapter
1 Meeting abstract

Aberrant cerebellar circuitry in the spinocerebellar ataxias

Robinson, K. J., Watchon, M. & Laird, A. S., 16 Jul 2020, In : Frontiers in Neuroscience. 14, p. 1-27 27 p., 707.

Research output: Contribution to journal › Review article

Open Access

File

1 Downloads (Pure)

Accelerated loss of hypoxia response in zebrafish with familial Alzheimer's disease-like mutation of Presenilin 1

Newman, M., Nik, H. M., Sutherland, G. T., Hin, N., Kim, W. S., Halliday, G. M., Jayadev, S., Smith, C., Laird, A. S., Lucas, C. W., Kittipassorn, T., Peet, D. J. & Lardelli, M., 15 Jul 2020, In : Human Molecular Genetics. 29, 14, p. 2379–2394 16 p.

Research output: Contribution to journal › Article

The redox activity of protein disulfide isomerase inhibits ALS phenotypes in cellular and zebrafish models

Parakh, S., Shadfar, S., Perri, E. R., Ragagnin, A. M. G., Piattoni, C. V., Fogolín, M. B., Yuan, K. C., Shahheydari, H., Don, E. K., Thomas, C. J., Hong, Y., Comini, M. A., Laird, A. S., Spencer, D. M. & Atkin, J. D., 22 May 2020, In : iScience. 23, 5, p. 1-27 44 p., 101097.

Research output: Contribution to journal › Article

Open Access

File

1 Citation (Scopus)

4 Downloads (Pure)

Exposure of a cryptic Hsp70 binding site determines the cytotoxicity of the ALS-associated SOD1-mutant A4V

Claes, F., Rudyak, S., Laird, A. S., Louros, N., Beerten, J., Debulpaep, M., Michiels, E., van der Kant, R., Van Durme, J., De Baets, G., Houben, B., Ramakers, M., Yuan, K., Gwee, S. S. L., Hernandez, S., Broersen, K., Oliveberg, M., Moahamed, B., Kirstein, J., Robberecht, W. & 2 others, Rousseau, F. & Schymkowitz, J., 31 Dec 2019, In : Protein Engineering, Design and Selection. 32, 10, p. 443-457 15 p.

Research output: Contribution to journal › Article