Projects per year
Personal profile
Biography
Dr. Laird studies the pathogenesis of movement disorders with a particular focus on identifying and testing potential disease treatments. Her group has been successful at producing and characterising the world’s first zebrafish model of spinocerebellar ataxia type-3 (also known as Machado Joseph Disease, MJD). They are currently testing the effect of various drugs on these zebrafish with the aim of identifying a treatment for the disease.
Dr. Laird's full CV, with all grants and activities, can be accessed here.
Research interests
- Developing transgenic zebrafish models of neurodegenerative diseases such as spinocerebellar ataxia-3 and motor neuron disease
- Role of proteolytic cleavage in the pathogenesis of spinocerebellar ataxia-3
- Potential of autophagy induction for the treatment of spinocerebellar ataxia-3
- Role of glutamate induced excitotoxicity in the pathogenesis of spinocerebellar ataxia-3
External positions
Senior Research Scientist, ANZAC Research Institute
Jan 2010 → Feb 2016Postdoctoral Fellow, University of Leuven
May 2008 → Oct 2010Casual Admin/Research Assistant, The University of New South Wales
Jan 2002 → Jan 2007Fingerprint
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Projects
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Modulating actin dynamics in ALS/MND as a novel therapeutic approach
Atkin, J., Woodruff, T. M., Karl, T., Craik, D., Guillemin, G. & Laird, A.
4/01/21 → 3/01/24
Project: Research
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CMNDR: Macquarie University Centre for Motor Neuron Disease Research
Atkin, J., Blair, I., Rowe, D., Atkin, J., Chung, R., Guillemin, G., Laird, A., Lee, A., Morsch, M., Shi, B., Williams, K. & Yang, S.
1/01/20 → 31/12/22
Project: Other
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Snow Foundation Co-funded Fellow: Evaluating potential MND therapeutics in zebrafish models
27/07/18 → 26/07/21
Project: Research
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Calpeptin, and related candidates, for the treatment of Machado Joseph disease
Laird, A., Nicholson, G., Walker, A. K., Cole, N., Lee, A., Morsch, M., Davis, R., Guillemin, G., Atkin, J. & Ooi, L.
1/01/18 → 31/12/21
Project: Research
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Novel therapeutics targeting neuronal transport pathways in MND
Atkin, J., Walker, A. K., Laird, A., Jonathan, B. & Abbott, B.
28/04/17 → …
Project: Research
Research Outputs
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Flow cytometry allows rapid detection of protein aggregates in cell culture and zebrafish models of spinocerebellar ataxia-3
Robinson, K. J., Tym, M. C., Hogan, A., Watchon, M., Yuan, K. C., Plenderleith, S. K., Don, E. K. & Laird, A. S., 10 Mar 2021, (Submitted) In: bioRxiv.Research output: Contribution to journal › Article
File1 Downloads (Pure) -
In vivo validation of bimolecular fluorescence complementation (BiFC) to investigate aggregate formation in amyotrophic lateral sclerosis (ALS)
Don, E. K., Maschirow, A., Radford, R. A. W., Scherer, N. M., Vidal-Itriago, A., Hogan, A., Maurel, C., Formella, I., Stoddart, J. J., Hall, T. E., Lee, A., Shi, B., Cole, N. J., Laird, A. S., Badrock, A. P., Chung, R. S. & Morsch, M., May 2021, In: Molecular Neurobiology. 58, 5, p. 2061-2074 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Sodium valproate increases activity of the sirtuin pathway resulting in beneficial effects for spinocerebellar ataxia-3 in vivo
Watchon, M., Luu, L., Robinson, K. J., Yuan, K. C., De Luca, A., Suddull, H. J., Tym, M. C., Guillemin, G. J., Cole, N. J., Nicholson, G. A., Chung, R. S., Lee, A. & Laird, A. S., 9 Mar 2021, (Submitted) In: bioRxiv.Research output: Contribution to journal › Article
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Unbiased label-free quantitative proteomics of cells expressing amyotrophic lateral sclerosis (ALS) mutations in CCNF reveals activation of the apoptosis pathway: a workflow to screen pathogenic gene mutations
Cheng, F., Luca, A. D., Hogan, A. L., Rayner, S. L., Davidson, J. M., Watchon, M., Stevens, C. H., Muñoz, S. S., Ooi, L., Yerbury, J. J., Don, E. K., Fifita, J. A., Villalva, M. D., Suddull, H., Chapman, T. R., Hedl, T. J., Walker, A. K., Yang, S., Morsch, M., Shi, B. & 4 others, , Apr 2021, In: Frontiers in Molecular Neuroscience. 14, p. 1-18 18 p., 627740.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Aberrant cerebellar circuitry in the spinocerebellar ataxias
Robinson, K. J., Watchon, M. & Laird, A. S., 16 Jul 2020, In: Frontiers in Neuroscience. 14, p. 1-27 27 p., 707.Research output: Contribution to journal › Review article › peer-review
Open AccessFile13 Downloads (Pure)
Prizes
Activities
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Invited speaker at Australian Proteostasis Conference
Angela Laird (Speaker)
2019Activity: Talk or presentation › Invited talk
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Invited Plenary Speaker International Machado Joseph Disease Conference
Angela Laird (Speaker)
2019Activity: Talk or presentation › Invited talk
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Key note speaker at MND Gala dinner
Angela Laird (Speaker)
2019Activity: Talk or presentation › Invited talk
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Invited Speaker at MQ Women Shaping the Future Symposium
Angela Laird (Speaker)
2019Activity: Talk or presentation › Invited talk
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Australian and New Zealand Zebrafish Conference
Angela Laird (Participant)
2018Activity: Participating in or organising an event › Participating in a conference, workshop or event series
Press / Media
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Macquarie University Top 10 Researchers to Watch on Twitter (2018)
1/02/18
1 Media contribution
Press/Media: Public Engagement Activities
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Zebrafish study offers hope to MJD sufferers, The Australian
8/08/17
1 item of Media coverage
Press/Media: Other
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Invited Expert Panel Member for Machado Joseph disease Film Event
23/02/17
1 Media contribution
Press/Media: Public Engagement Activities
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