• 448 Citations
  • 10 h-Index
20062020

Research output per year

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Personal profile

Biography

Dr. Laird studies the pathogenesis of movement disorders with a particular focus on identifying and testing potential disease treatments. Her group has been successful at producing and characterising the world’s first zebrafish model of spinocerebellar ataxia type-3 (also known as Machado Joseph Disease, MJD). They are currently testing the effect of various drugs on these zebrafish with the aim of identifying a treatment for the disease.

Dr. Laird's full CV, with all grants and activities, can be accessed here.

Research interests

  • Developing transgenic zebrafish models of neurodegenerative diseases such as spinocerebellar ataxia-3 and motor neuron disease 
  • Role of proteolytic cleavage in the pathogenesis of spinocerebellar ataxia-3 
  • Potential of autophagy induction for the treatment of spinocerebellar ataxia-3 
  • Role of glutamate induced excitotoxicity in the pathogenesis of spinocerebellar ataxia-3

External positions

Senior Research Scientist, ANZAC Research Institute

Jan 2010Feb 2016

Postdoctoral Fellow, University of Leuven

May 2008Oct 2010

Casual Admin/Research Assistant, The University of New South Wales

Jan 2002Jan 2007

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Projects

Research Outputs

  • 448 Citations
  • 10 h-Index
  • 17 Article
  • 2 Review article
  • 1 Chapter
  • 1 Meeting abstract

Aberrant cerebellar circuitry in the spinocerebellar ataxias

Robinson, K. J., Watchon, M. & Laird, A. S., 16 Jul 2020, In : Frontiers in Neuroscience. 14, p. 1-27 27 p., 707.

Research output: Contribution to journalReview article

Open Access
File
  • 1 Downloads (Pure)

    Accelerated loss of hypoxia response in zebrafish with familial Alzheimer's disease-like mutation of Presenilin 1

    Newman, M., Nik, H. M., Sutherland, G. T., Hin, N., Kim, W. S., Halliday, G. M., Jayadev, S., Smith, C., Laird, A. S., Lucas, C. W., Kittipassorn, T., Peet, D. J. & Lardelli, M., 15 Jul 2020, In : Human Molecular Genetics. 29, 14, p. 2379–2394 16 p.

    Research output: Contribution to journalArticle

  • The redox activity of protein disulfide isomerase inhibits ALS phenotypes in cellular and zebrafish models

    Parakh, S., Shadfar, S., Perri, E. R., Ragagnin, A. M. G., Piattoni, C. V., Fogolín, M. B., Yuan, K. C., Shahheydari, H., Don, E. K., Thomas, C. J., Hong, Y., Comini, M. A., Laird, A. S., Spencer, D. M. & Atkin, J. D., 22 May 2020, In : iScience. 23, 5, p. 1-27 44 p., 101097.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 1 Citation (Scopus)
    4 Downloads (Pure)

    Exposure of a cryptic Hsp70 binding site determines the cytotoxicity of the ALS-associated SOD1-mutant A4V

    Claes, F., Rudyak, S., Laird, A. S., Louros, N., Beerten, J., Debulpaep, M., Michiels, E., van der Kant, R., Van Durme, J., De Baets, G., Houben, B., Ramakers, M., Yuan, K., Gwee, S. S. L., Hernandez, S., Broersen, K., Oliveberg, M., Moahamed, B., Kirstein, J., Robberecht, W. & 2 others, Rousseau, F. & Schymkowitz, J., 31 Dec 2019, In : Protein Engineering, Design and Selection. 32, 10, p. 443-457 15 p.

    Research output: Contribution to journalArticle

  • 1 Citation (Scopus)

    Prizes

    Best Early Career Researcher article

    Angela Laird (Recipient), 2017

    Prize: Honorary award

    Best poster presentation

    Angela Laird (Recipient), 2007

    Prize: Honorary award

    Best Poster Presentation

    Angela Laird (Recipient), 2007

    Prize: Honorary award

    Senior Researcher Travel Award

    Angela Laird (Recipient), 2016

    Prize: Honorary award

    Sir Grafton Elliot-Smith Award

    Angela Laird (Recipient), 2007

    Prize: Honorary award

    Activities

    • 5 Other
    • 1 Participating in a conference, workshop, ...

    Press / Media

    Zebrafish study offers hope to MJD sufferers, The Australian

    Angela Laird

    8/08/17

    1 item of Media coverage

    Press/Media: Other

    Australia Wide, ABC TV

    Angela Laird

    1/10/16

    1 item of Media coverage

    Press/Media: Public Engagement Activities

    Researchers eye zebrafish in bid to cure fatal Machado Joseph Disease

    Angela Laird

    23/04/16

    1 item of Media coverage

    Press/Media: Public Engagement Activities