• 422 Citations
  • 10 h-Index
20062022

Research output per year

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Personal profile

Biography

Dr. Laird studies the pathogenesis of movement disorders with a particular focus on identifying and testing potential disease treatments. Her group has been successful at producing and characterising the world’s first zebrafish model of spinocerebellar ataxia type-3 (also known as Machado Joseph Disease, MJD). They are currently testing the effect of various drugs on these zebrafish with the aim of identifying a treatment for the disease.

Dr. Laird's full CV, with all grants and activities, can be accessed here.

Research interests

  • Developing transgenic zebrafish models of neurodegenerative diseases such as spinocerebellar ataxia-3 and motor neuron disease 
  • Role of proteolytic cleavage in the pathogenesis of spinocerebellar ataxia-3 
  • Potential of autophagy induction for the treatment of spinocerebellar ataxia-3 
  • Role of glutamate induced excitotoxicity in the pathogenesis of spinocerebellar ataxia-3

External positions

Senior Research Scientist, ANZAC Research Institute

Jan 2010Feb 2016

Postdoctoral Fellow, University of Leuven

May 2008Oct 2010

Casual Admin/Research Assistant, The University of New South Wales

Jan 2002Jan 2007

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Projects

Research Outputs

  • 422 Citations
  • 10 h-Index
  • 14 Article
  • 1 Chapter
  • 1 Review article

Motor neuron abnormalities correlate with impaired movement in zebrafish that express mutant superoxide dismutase 1

Robinson, K. J., Yuan, K. C., Don, E. K., Hogan, A. L., Winnick, C. G., Tym, M. C., Lucas, C. W., Shahheydari, H., Watchon, M., Blair, I. P., Atkin, J. D., Nicholson, G. A., Cole, N. J. & Laird, A. S., 1 Feb 2019, In : Zebrafish. 16, 1, p. 8-14 7 p.

Research output: Contribution to journalArticle

Open Access
File
  • 1 Citation (Scopus)
    8 Downloads (Pure)
    Open Access
    File
  • 18 Downloads (Pure)

    Neuronal cell culture from transgenic zebrafish models of neurodegenerative disease

    Acosta, J. R., Watchon, M., Yuan, K. C., Fifita, J. A., Svahn, A. J., Don, E. K., Winnick, C. G., Blair, I. P., Nicholson, G. A., Cole, N. J., Goldsbury, C. & Laird, A. S., Oct 2018, In : Biology Open. 7, 10, p. 1-7 7 p., bio036475.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 2 Citations (Scopus)
    14 Downloads (Pure)

    Calpain inhibition is protective in Machado–Joseph disease zebrafish due to induction of autophagy

    Watchon, M., Yuan, K. C., Mackovski, N., Svahn, A. J., Cole, N. J., Goldsbury, C., Rinkwitz, S., Becker, T. S., Nicholson, G. A. & Laird, A. S., 2017, In : Journal of Neuroscience. 37, 32, p. 7782-7794 13 p.

    Research output: Contribution to journalArticle

  • 19 Citations (Scopus)

    Expression of ALS/FTD-linked mutant CCNF in zebrafish leads to increased cell death in the spinal cord and an aberrant motor phenotype

    Hogan, A. L., Don, E. K., Rayner, S. L., Lee, A., Laird, A. S., Watchon, M., Winnick, C., Tarr, I. S., Morsch, M., Fifita, J. A., Gwee, S. S. L., Formella, I., Hortle, E., Yuan, K. C., Molloy, M. P., Williams, K. L., Nicholson, G. A., Chung, R. S., Blair, I. P. & Cole, N. J., 15 Jul 2017, In : Human molecular genetics. 26, 14, p. 2616-2626 11 p.

    Research output: Contribution to journalArticle

  • 10 Citations (Scopus)

    Prizes

    Best Early Career Researcher article

    Angela Laird (Recipient), 2017

    Prize: Honorary award

    Best poster presentation

    Angela Laird (Recipient), 2007

    Prize: Honorary award

    Best Poster Presentation

    Angela Laird (Recipient), 2007

    Prize: Honorary award

    Senior Researcher Travel Award

    Angela Laird (Recipient), 2016

    Prize: Honorary award

    Sir Grafton Elliot-Smith Award

    Angela Laird (Recipient), 2007

    Prize: Honorary award

    Activities

    • 5 Other
    • 1 Participating in a conference, workshop, ...

    Press / Media

    Zebrafish study offers hope to MJD sufferers, The Australian

    Angela Laird

    8/08/17

    1 item of Media coverage

    Press/Media: Other

    Australia Wide, ABC TV

    Angela Laird

    1/10/16

    1 item of Media coverage

    Press/Media: Public Engagement Activities

    Researchers eye zebrafish in bid to cure fatal Machado Joseph Disease

    Angela Laird

    23/04/16

    1 item of Media coverage

    Press/Media: Public Engagement Activities