• 355 Citations
  • 7 h-Index
20062021
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Personal profile

Biography

Dr. Laird studies the pathogenesis of movement disorders with a particular focus on identifying and testing potential disease treatments. Her group has been successful at producing and characterising the world’s first zebrafish model of spinocerebellar ataxia type-3 (also known as Machado Joseph Disease, MJD). They are currently testing the effect of various drugs on these zebrafish with the aim of identifying a treatment for the disease.

Dr. Laird's full CV, with all grants and activities, can be accessed here.

Research interests

  • Developing transgenic zebrafish models of neurodegenerative diseases such as spinocerebellar ataxia-3 and motor neuron disease 
  • Role of proteolytic cleavage in the pathogenesis of spinocerebellar ataxia-3 
  • Potential of autophagy induction for the treatment of spinocerebellar ataxia-3 
  • Role of glutamate induced excitotoxicity in the pathogenesis of spinocerebellar ataxia-3

External positions

Senior Research Scientist, ANZAC Research Institute

Jan 2010Feb 2016

Postdoctoral Fellow, University of Leuven

May 2008Oct 2010

Casual Admin/Research Assistant, The University of New South Wales

Jan 2002Jan 2007

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

  • 21 Similar Profiles
Zebrafish Medicine & Life Sciences
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Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2013 2021

Research Output 2006 2018

  • 355 Citations
  • 7 h-Index
  • 12 Article
  • 1 Chapter
  • 1 Review article

Neuronal cell culture from transgenic zebrafish models of neurodegenerative disease

Acosta, J. R., Watchon, M., Yuan, K. C., Fifita, J. A., Svahn, A. J., Don, E. K., Winnick, C. G., Blair, I. P., Nicholson, G. A., Cole, N. J., Goldsbury, C. & Laird, A. S. 1 Jan 2018 In : Biology Open. 7, 10, p. 1-7 7 p., bio036475

Research output: Contribution to journalArticle

Open Access
File
Neurodegenerative diseases
neurodegenerative diseases
Zebrafish
Danio rerio
Cell culture

Calpain inhibition is protective in Machado–Joseph disease zebrafish due to induction of autophagy

Watchon, M., Yuan, K. C., Mackovski, N., Svahn, A. J., Cole, N. J., Goldsbury, C., Rinkwitz, S., Becker, T. S., Nicholson, G. A. & Laird, A. S. 2017 In : Journal of Neuroscience. 37, 32, p. 7782-7794 13 p.

Research output: Contribution to journalArticle

Machado-Joseph Disease
Calpain
Autophagy
Zebrafish
Ataxin-3

Expression of ALS/FTD-linked mutant CCNF in zebrafish leads to increased cell death in the spinal cord and an aberrant motor phenotype

Hogan, A. L., Don, E. K., Rayner, S. L., Lee, A., Laird, A. S., Watchon, M., Winnick, C., Tarr, I. S., Morsch, M., Fifita, J. A., Gwee, S. S. L., Formella, I., Hortle, E., Yuan, K. C., Molloy, M. P., Williams, K. L., Nicholson, G. A., Chung, R. S., Blair, I. P. & Cole, N. J. 15 Jul 2017 In : Human Molecular Genetics. 26, 14, p. 2616-2626 11 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Zebrafish
Spinal Cord
Cell Death
Phenotype

Long polyglutamine tracts impair the autophagy protein quality control pathway

Laird, A. S. Oct 2017 In : Movement Disorders. 32, 10, p. 1376 1 p.

Research output: Contribution to journalReview article

Tissue-specific models of spinal muscular atrophy confirm a critical role of SMN in motor neurons from embryonic to adult stages

Laird, A. S., Mackovski, N., Rinkwitz, S., Becker, T. S. & Giacomotto, J. 1 May 2016 In : Human Molecular Genetics. 25, 9, p. 1728-1738 11 p., ddw044

Research output: Contribution to journalArticle

Spinal Muscular Atrophy
Motor Neurons
Zebrafish
Premature Mortality
Muscular Atrophy

Prizes

Best Early Career Researcher article

Angela Laird (Recipient), 2017

Prize: Honorary award

Best poster presentation

Angela Laird (Recipient), 2007

Prize: Honorary award

Best Poster Presentation

Angela Laird (Recipient), 2007

Prize: Honorary award

Senior Researcher Travel Award

Angela Laird (Recipient), 2016

Prize: Honorary award

Sir Grafton Elliot-Smith Award

Angela Laird (Recipient), 2007

Prize: Honorary award

Activities 2008 2016

  • 5 Other
  • 1 Participating in a conference, workshop, ...

Press / Media

Zebrafish study offers hope to MJD sufferers, The Australian

Angela Laird

8/08/17

1 item of media coverage

Press/Media: Other

Australia Wide, ABC TV

Angela Laird

1/10/16

1 item of media coverage

Press/Media: Public Engagement Activities

Researchers eye zebrafish in bid to cure fatal Machado Joseph Disease

Angela Laird

23/04/16

1 item of media coverage

Press/Media: Public Engagement Activities