Projects per year
Personal profile
Biography
Dr. Laird studies the pathogenesis of movement disorders with a particular focus on identifying and testing potential disease treatments. Her group has been successful at producing and characterising the world’s first zebrafish model of spinocerebellar ataxia type-3 (also known as Machado Joseph Disease, MJD). They are currently testing the effect of various drugs on these zebrafish with the aim of identifying a treatment for the disease.
Dr. Laird's full CV, with all grants and activities, can be accessed here.
Research interests
- Developing transgenic zebrafish models of neurodegenerative diseases such as spinocerebellar ataxia-3 and motor neuron disease
- Role of proteolytic cleavage in the pathogenesis of spinocerebellar ataxia-3
- Potential of autophagy induction for the treatment of spinocerebellar ataxia-3
- Role of glutamate induced excitotoxicity in the pathogenesis of spinocerebellar ataxia-3
External positions
Senior Research Scientist, ANZAC Research Institute
Jan 2010 → Feb 2016
Postdoctoral Fellow, University of Leuven
May 2008 → Oct 2010
Casual Admin/Research Assistant, The University of New South Wales
Jan 2002 → Jan 2007
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Modulating actin dynamics in ALS/MND as a novel therapeutic approach
Atkin, J., Woodruff, T. M., Karl, T., Craik, D., Guillemin, G. & Laird, A.
4/01/21 → 3/01/24
Project: Research
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CMNDR: Macquarie University Centre for Motor Neuron Disease Research
Atkin, J., Blair, I., Rowe, D., Atkin, J., Chung, R., Guillemin, G., Laird, A., Lee, A., Morsch, M., Shi, B., Williams, K. & Yang, S.
1/01/20 → 31/12/22
Project: Other
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Novel therapeutics targeting neuronal transport pathways in MND
Atkin, J., Walker, A. K., Laird, A., Jonathan, B. & Abbott, B.
28/04/17 → …
Project: Research
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Therapeutics based on the protective activity of protein disulphide in MND
Atkin, J., Walker, A. K., Laird, A., Heras, B., Anderson, M., Craik, D. & Bleackley, M.
28/04/17 → …
Project: Research
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A novel calpain inhibitor compound has protective effects on a zebrafish model of spinocerebellar ataxia type 3
Robinson, K. J., Yuan, K., Plenderleith, S. K., Watchon, M. & Laird, A., 29 Sep 2021, In: Cells. 10, 10, p. 1-15 15 p., 2592.Research output: Contribution to journal › Article › peer-review
Open AccessFile10 Downloads (Pure) -
Flow cytometry allows rapid detection of protein aggregates in cell culture and zebrafish models of spinocerebellar ataxia-3
Robinson, K. J., Tym, M. C., Hogan, A., Watchon, M., Yuan, K. C., Plenderleith, S. K., Don, E. K. & Laird, A. S., 10 Mar 2021, (Submitted) In: bioRxiv.Research output: Contribution to journal › Article
File10 Downloads (Pure) -
Flow cytometry allows rapid detection of protein aggregates in cellular and zebrafish models of spinocerebellar ataxia 3
Robinson, K. J., Tym, M. C., Hogan, A., Watchon, M., Yuan, K. C., Plenderleith, S. K., Don, E. K. & Laird, A. S., 1 Oct 2021, In: DMM Disease Models and Mechanisms. 14, 10, p. 1-12 12 p., dmm049023.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)5 Downloads (Pure) -
In vivo validation of bimolecular fluorescence complementation (BiFC) to investigate aggregate formation in amyotrophic lateral sclerosis (ALS)
Don, E. K., Maschirow, A., Radford, R. A. W., Scherer, N. M., Vidal-Itriago, A., Hogan, A., Maurel, C., Formella, I., Stoddart, J. J., Hall, T. E., Lee, A., Shi, B., Cole, N. J., Laird, A. S., Badrock, A. P., Chung, R. S. & Morsch, M., May 2021, In: Molecular Neurobiology. 58, 5, p. 2061-2074 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)45 Downloads (Pure) -
Pathophysiological interplay between O-GlcNAc transferase and the Machado-Joseph disease protein ataxin-3
Sena, P. P., Weber, J. J., Watchon, M., Robinson, K. J., Wassouf, Z., Hauser, S., Helm, J., Abeditashi, M., Schmidt, J., Hubener-Schmid, J., Schols, L., Laird, A. S., Riess, O. & Schmidt, T., 23 Nov 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 47, p. 1-12 12 p., e2025810118.Research output: Contribution to journal › Article › peer-review
Open Access
Prizes
Activities
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Invited speaker at Australian Proteostasis Conference
Angela Laird (Speaker)
2019Activity: Talk or presentation › Invited talk
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Key note speaker at MND Gala dinner
Angela Laird (Speaker)
2019Activity: Talk or presentation › Invited talk
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Invited Plenary Speaker International Machado Joseph Disease Conference
Angela Laird (Speaker)
2019Activity: Talk or presentation › Invited talk
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Invited Speaker at MQ Women Shaping the Future Symposium
Angela Laird (Speaker)
2019Activity: Talk or presentation › Invited talk
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Australian and New Zealand Zebrafish Conference
Angela Laird (Participant)
2018Activity: Participating in or organising an event › Participating in a conference, workshop or event series
Press / Media
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Macquarie University Top 10 Researchers to Watch on Twitter (2018)
1/02/18
1 Media contribution
Press/Media: Public Engagement Activities
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Zebrafish study offers hope to MJD sufferers, The Australian
8/08/17
1 item of Media coverage
Press/Media: Other
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Invited Expert Panel Member for Machado Joseph disease Film Event
23/02/17
1 Media contribution
Press/Media: Public Engagement Activities
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