Angela Laird

Personal profile

Biography

Dr. Laird studies the pathogenesis of movement disorders with a particular focus on identifying and testing potential disease treatments. Her group has been successful at producing and characterising the world’s first zebrafish model of spinocerebellar ataxia type-3 (also known as Machado Joseph Disease, MJD). They are currently testing the effect of various drugs on these zebrafish with the aim of identifying a treatment for the disease.

Dr. Laird's full CV, with all grants and activities, can be accessed here.

Research interests

Developing transgenic zebrafish models of neurodegenerative diseases such as spinocerebellar ataxia-3 and motor neuron disease
Role of proteolytic cleavage in the pathogenesis of spinocerebellar ataxia-3
Potential of autophagy induction for the treatment of spinocerebellar ataxia-3
Role of glutamate induced excitotoxicity in the pathogenesis of spinocerebellar ataxia-3

External positions

Senior Research Scientist, ANZAC Research Institute

Jan 2010 → Feb 2016

Postdoctoral Fellow, University of Leuven

May 2008 → Oct 2010

Casual Admin/Research Assistant, The University of New South Wales

Jan 2002 → Jan 2007

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Zebrafish Medicine & Life Sciences

Motor Neurons Medicine & Life Sciences

Danio rerio Agriculture & Biology

Autonomic Dysreflexia Medicine & Life Sciences

Spinal Cord Injuries Medicine & Life Sciences

Machado-Joseph Disease Medicine & Life Sciences

Neurodegenerative Diseases Medicine & Life Sciences

Amyotrophic Lateral Sclerosis Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2013 2022

8 Finished
9 Active

CMNDR: Macquarie University Centre for Motor Neuron Disease Research

Atkin, J., Blair, I., Rowe, D., Atkin, J., Chung, R., Guillemin, G., Laird, A., Lee, A., Morsch, M., Shi, B., Williams, K. & Yang, S.

1/01/20 → 31/12/22

Project: Other

Snow Foundation Co-funded Fellow: Evaluating potential MND therapeutics in zebrafish models

Laird, A. & Chung, R.

27/07/18 → 26/07/21

Project: Research

Calpeptin, and related candidates, for the treatment of Machado Joseph disease

Laird, A., Nicholson, G., Walker, A. K., Cole, N., Lee, A., Morsch, M., Davis, R., Guillemin, G., Atkin, J. & Ooi, L.

1/01/18 → 31/12/21

Project: Research

Novel therapeutics targeting neuronal transport pathways in MND

Atkin, J., Walker, A., Laird, A., Jonathan, B. & Abbott, B.

28/04/17 → …

Project: Research

Therapeutics based on the protective activity of protein disulphide in MND

Atkin, J., Walker, A., Laird, A., Heras, B., Anderson, M., Craik, D. & Bleackley, M.

28/04/17 → …

Project: Research

Research Outputs 2006 2019

409 Citations
9 h-Index
14 Article
1 Chapter
1 Review article

Motor neuron abnormalities correlate with impaired movement in zebrafish that express mutant superoxide dismutase 1

Robinson, K. J., Yuan, K. C., Don, E. K., Hogan, A. L., Winnick, C. G., Tym, M. C., Lucas, C. W., Shahheydari, H., Watchon, M., Blair, I. P., Atkin, J. D., Nicholson, G. A., Cole, N. J. & Laird, A. S., 1 Feb 2019, In : Zebrafish. 16, 1, p. 8-14 7 p.

Research output: Contribution to journal › Article › Research › peer-review

Open Access

File

Motor Neurons

Zebrafish

motor neurons

Danio rerio

superoxide dismutase

Constitutive overexpression of the ALS-linked gene CCNF fusions results in cytotoxicity to preclude generation of transgenic zebrafish models

Hogan, A. L., Don, E. K., Fifita, J. A., Williams, K. L., Chung, R. S., Laird, A. S., Blair, I. P. & Cole, N. J., 19 Mar 2018, In : Matters. 2018, p. 1-6 6 p.

Research output: Contribution to journal › Article › Research › peer-review

Open Access

File

Gene Fusion

Zebrafish

Neurodegenerative Diseases

Embryonic Structures

Proteins

Neuronal cell culture from transgenic zebrafish models of neurodegenerative disease

Acosta, J. R., Watchon, M., Yuan, K. C., Fifita, J. A., Svahn, A. J., Don, E. K., Winnick, C. G., Blair, I. P., Nicholson, G. A., Cole, N. J., Goldsbury, C. & Laird, A. S., Oct 2018, In : Biology Open. 7, 10, p. 1-7 7 p., bio036475.

Research output: Contribution to journal › Article › Research › peer-review

Open Access

File

Neurodegenerative diseases

neurodegenerative diseases

Zebrafish

Danio rerio

Cell culture

Calpain inhibition is protective in Machado–Joseph disease zebrafish due to induction of autophagy

Watchon, M., Yuan, K. C., Mackovski, N., Svahn, A. J., Cole, N. J., Goldsbury, C., Rinkwitz, S., Becker, T. S., Nicholson, G. A. & Laird, A. S., 2017, In : Journal of Neuroscience. 37, 32, p. 7782-7794 13 p.

Research output: Contribution to journal › Article › Research › peer-review

Machado-Joseph Disease

Calpain

Autophagy

Zebrafish

Ataxin-3