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Personal profile

Biography

Dr. Laird studies the pathogenesis of movement disorders with a particular focus on identifying and testing potential disease treatments. Her group has been successful at producing and characterising the world’s first zebrafish model of spinocerebellar ataxia type-3 (also known as Machado Joseph Disease, MJD). They are currently testing the effect of various drugs on these zebrafish with the aim of identifying a treatment for the disease.

Dr. Laird's full CV, with all grants and activities, can be accessed here.

Research interests

  • Developing transgenic zebrafish models of neurodegenerative diseases such as spinocerebellar ataxia-3 and motor neuron disease 
  • Role of proteolytic cleavage in the pathogenesis of spinocerebellar ataxia-3 
  • Potential of autophagy induction for the treatment of spinocerebellar ataxia-3 
  • Role of glutamate induced excitotoxicity in the pathogenesis of spinocerebellar ataxia-3

External positions

Senior Research Scientist, ANZAC Research Institute

Jan 2010Feb 2016

Postdoctoral Fellow, University of Leuven

May 2008Oct 2010

Casual Admin/Research Assistant, The University of New South Wales

Jan 2002Jan 2007

Fingerprint Dive into the research topics where Angela Laird is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 30 Similar Profiles
Zebrafish Medicine & Life Sciences
Motor Neurons Medicine & Life Sciences
Danio rerio Agriculture & Biology
Autonomic Dysreflexia Medicine & Life Sciences
Spinal Cord Injuries Medicine & Life Sciences
Machado-Joseph Disease Medicine & Life Sciences
Neurodegenerative Diseases Medicine & Life Sciences
Amyotrophic Lateral Sclerosis Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2013 2021

Research Outputs 2006 2019

  • 379 Citations
  • 9 h-Index
  • 14 Article
  • 1 Chapter
  • 1 Review article

Motor neuron abnormalities correlate with impaired movement in zebrafish that express mutant superoxide dismutase 1

Robinson, K. J., Yuan, K. C., Don, E. K., Hogan, A. L., Winnick, C. G., Tym, M. C., Lucas, C. W., Shahheydari, H., Watchon, M., Blair, I. P., Atkin, J. D., Nicholson, G. A., Cole, N. J. & Laird, A. S., 1 Feb 2019, In : Zebrafish. 16, 1, p. 8-14 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Motor Neurons
Zebrafish
motor neurons
Danio rerio
superoxide dismutase
Open Access
File
Gene Fusion
Zebrafish
Neurodegenerative Diseases
Embryonic Structures
Proteins

Neuronal cell culture from transgenic zebrafish models of neurodegenerative disease

Acosta, J. R., Watchon, M., Yuan, K. C., Fifita, J. A., Svahn, A. J., Don, E. K., Winnick, C. G., Blair, I. P., Nicholson, G. A., Cole, N. J., Goldsbury, C. & Laird, A. S., Oct 2018, In : Biology Open. 7, 10, p. 1-7 7 p., bio036475.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Neurodegenerative diseases
neurodegenerative diseases
Zebrafish
Danio rerio
Cell culture

Calpain inhibition is protective in Machado–Joseph disease zebrafish due to induction of autophagy

Watchon, M., Yuan, K. C., Mackovski, N., Svahn, A. J., Cole, N. J., Goldsbury, C., Rinkwitz, S., Becker, T. S., Nicholson, G. A. & Laird, A. S., 2017, In : Journal of Neuroscience. 37, 32, p. 7782-7794 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Machado-Joseph Disease
Calpain
Autophagy
Zebrafish
Ataxin-3

Expression of ALS/FTD-linked mutant CCNF in zebrafish leads to increased cell death in the spinal cord and an aberrant motor phenotype

Hogan, A. L., Don, E. K., Rayner, S. L., Lee, A., Laird, A. S., Watchon, M., Winnick, C., Tarr, I. S., Morsch, M., Fifita, J. A., Gwee, S. S. L., Formella, I., Hortle, E., Yuan, K. C., Molloy, M. P., Williams, K. L., Nicholson, G. A., Chung, R. S., Blair, I. P. & Cole, N. J., 15 Jul 2017, In : Human molecular genetics. 26, 14, p. 2616-2626 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Amyotrophic Lateral Sclerosis
Zebrafish
Spinal Cord
Cell Death
Phenotype

Prizes

Best Early Career Researcher article

Angela Laird (Recipient), 2017

Prize: Honorary award

Best poster presentation

Angela Laird (Recipient), 2007

Prize: Honorary award

Best Poster Presentation

Angela Laird (Recipient), 2007

Prize: Honorary award

Senior Researcher Travel Award

Angela Laird (Recipient), 2016

Prize: Honorary award

Sir Grafton Elliot-Smith Award

Angela Laird (Recipient), 2007

Prize: Honorary award

Activities 2008 2016

  • 5 Other
  • 1 Participating in a conference, workshop, ...

Woman’s Camp for MJD Patients

Angela Laird (Participant)
2012

Activity: Participating in or organising an eventParticipating in a conference, workshop, ...

Provides bi-annual laboratory tours for MJD Foundation members and patients

Angela Laird (Participant)
2011 → …

Activity: Other

Press / Media

Zebrafish study offers hope to MJD sufferers, The Australian

Angela Laird

8/08/17

1 item of media coverage

Press/Media: Other

Australia Wide, ABC TV

Angela Laird

1/10/16

1 item of media coverage

Press/Media: Public Engagement Activities

Researchers eye zebrafish in bid to cure fatal Machado Joseph Disease

Angela Laird

23/04/16

1 item of media coverage

Press/Media: Public Engagement Activities