Annika van Hummel


  • 275 Citations
  • 6 h-Index
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Personal profile


Annika van Hummel completed her PhD in S100 proteins in osteoarthritis in 2014 under the supervision of Prof Hala Zreiqat and Prof Christopher Little at The University of Sydney. She then joined the Dementia Research Unit at The University of New South Wales working as a postdoctoral researcher with Prof Lars Ittner and moved to Macquarie University as part of the new Dementia Research Centre in December 2018.

Research interests

Since joining the Ittner group in 2014, Annika van Hummel has developed an interest in the use of genetically modified mice as models of neurodegenerative diseases (e.g. Motor Neuron Disease, Frontotemporal Dementia, Alzheimer's Disease), both to better understand the underlying cellular mechanisms and to test new treatment options.

Education/Academic qualification

PhD, University of Sydney

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  • 9 Similar Profiles
Transgenic Mice Medicine & Life Sciences
Frontotemporal Dementia Medicine & Life Sciences
Dental Schools Medicine & Life Sciences
Amyotrophic Lateral Sclerosis Medicine & Life Sciences
DNA-Binding Proteins Medicine & Life Sciences
Motor Neurons Medicine & Life Sciences
Alzheimer Disease Medicine & Life Sciences
Medicine Medicine & Life Sciences

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Research Outputs 2008 2019

  • 275 Citations
  • 6 h-Index
  • 8 Article

Developmental expression of mutant PFN1 in motor neurons impacts neuronal growth and motor performance of young and adult mice

Brettle, M., Stefen, H., Djordjevic, A., Fok, S. Y. Y., Chan, J. W., van Hummel, A., van der Hoven, J., Przybyla, M., Volkerling, A., Ke, Y. D., Delerue, F., Ittner, L. M. & Fath, T., 27 Sep 2019, In : Frontiers in Molecular Neuroscience. 12, p. 1-12 12 p., 231.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Motor Neurons
Young Adult
Amyotrophic Lateral Sclerosis
Transgenic Mice

Selective spatiotemporal vulnerability of central nervous system neurons to pathologic TAR DNA-binding protein 43 in aged transgenic mice

van Hummel, A., Chan, G., van der Hoven, J., Morsch, M., Ippati, S., Suh, L., Bi, M., Asih, P. R., Lee, W. S., Butler, T. A., Przybyla, M., Halliday, G. M., Piguet, O., Kiernan, M. C., Chung, R. S., Ittner, L. M. & Ke, Y. D., 1 Jun 2018, In : American Journal of Pathology. 188, 6, p. 1447-1456 10 p.

Research output: Contribution to journalArticleResearchpeer-review

DNA-Binding Proteins
Transgenic Mice
Motor Neurons
Central Nervous System

Tau exacerbates excitotoxic brain damage in an animal model of stroke

Bi, M., Gladbach, A., van Eersel, J., Ittner, A., Przybyla, M., van Hummel, A., Chua, S. W., van der Hoven, J., Lee, W. S., Müller, J., Parmar, J., von Jonquieres, G., Stefen, H., Guccione, E., Fath, T., Housley, G. D., Klugmann, M., Ke, Y. D. & Ittner, L. M., 1 Dec 2017, In : Nature Communications. 8, 1, p. 1-15 15 p., 473.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
brain damage
animal models

Disinhibition-like behavior in a P301S mutant tau transgenic mouse model of frontotemporal dementia

Przybyla, M., Stevens, C. H., van der Hoven, J., Harasta, A., Bi, M., Ittner, A., van Hummel, A., Hodges, J. R., Piguet, O., Karl, T., Kassiou, M., Housley, G. D., Ke, Y. D., Ittner, L. M. & Eersel, J. V., 19 Sep 2016, In : Neuroscience Letters. 631, p. 24-29 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Frontotemporal Dementia
Transgenic Mice

No overt deficits in aged tau-deficient C57Bl/6.Mapttm1(EGFP)kit GFP knockin mice

Van Hummel, A., Bi, M., Ippati, S., van der Hoven, J., Volkerling, A., Lee, W. S., Tan, D. C. S., Bongers, A., Ittner, A., Ke, Y. D. & Ittner, L. M., 13 Oct 2016, In : PLoS ONE. 11, 10, p. 1-14 14 p., e0163236.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Gene encoding
gene targeting