Projects per year
Personal profile
Biography
Annika van Hummel completed her PhD in S100 proteins in osteoarthritis in 2014 under the supervision of Prof Hala Zreiqat and Prof Christopher Little at The University of Sydney. She then joined the Dementia Research Unit at The University of New South Wales working as a postdoctoral researcher with Prof Lars Ittner and moved to Macquarie University as part of the new Dementia Research Centre in December 2018.
Research interests
Since joining the Ittner group in 2014, Annika van Hummel has developed an interest in the use of genetically modified mice as models of neurodegenerative diseases (e.g. Motor Neuron Disease, Frontotemporal Dementia, Alzheimer's Disease), both to better understand the underlying cellular mechanisms and to test new treatment options.
Education/Academic qualification
PhD, S100 Proteins in Cartilage, University of Sydney
Award Date: 21 Jul 2014
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Collaborations and top research areas from the last five years
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Projects
- 2 Finished
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Targeting pathogenic TAR DNA-binding protein 43 to treat frontotemporal dementia and motor neuron disease
Ke, Y., van Hummel, A., Ariawan, D., Ittner, L. & Martin, A.
1/01/21 → 31/12/23
Project: Research
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Clearance of TDP-43 by PROteolysis TArgeting Chimera (PROTAC) dual targeting to treat amyotrophic lateral sclerosis (ALS)
Lee, A., Rayner, S., Martin, A., van Hummel, A., Morsch, M., Shi, B., Ke, Y., Ittner, L. & Chung, R.
4/05/20 → 3/05/21
Project: Research
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Targeting 14-3-3θ-mediated TDP-43 pathology in amyotrophic lateral sclerosis and frontotemporal dementia mice
Ke, Y. D., van Hummel, A., Au, C., Chan, G., Lee, W. S., van der Hoven, J., Przybyla, M., Deng, Y., Sabale, M., Morey, N., Bertz, J., Feiten, A., Ippati, S., Stevens, C. H., Yang, S., Gladbach, A., Haass, N. K., Kril, J. J., Blair, I. P., Delerue, F., & 1 others, 17 Apr 2024, In: Neuron. 112, 8, p. 1249-1264.e8 25 p.Research output: Contribution to journal › Article › peer-review
2 Citations (Scopus) -
Methyl donor supplementation reduces phospho-Tau, Fyn and demethylated protein phosphatase 2A levels and mitigates learning and motor deficits in a mouse model of tauopathy
van Hummel, A., Taleski, G., Sontag, J-M., Feiten, A. F., Ke, Y. D., Ittner, L. M. & Sontag, E., 11 Aug 2023, In: Neuropathology and Applied Neurobiology. 49, 4, p. 1-13 13 p., e12931.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)46 Downloads (Pure) -
TDP-43 pathology and functional deficits in wild-type and ALS/FTD mutant cyclin F mouse models
van Hummel, A., Sabale, M., Przybyla, M., van der Hoven, J., Chan, G., Feiten, A. F., Chung, R. S., Ittner, L. M. & Ke, Y. D., Apr 2023, In: Neuropathology and Applied Neurobiology. 49, 2, p. 1-12 12 p., e12902.Research output: Contribution to journal › Article › peer-review
Open AccessFile75 Downloads (Pure) -
Loss of LAMP5 interneurons drives neuronal network dysfunction in Alzheimer's disease
Deng, Y., Bi, M., Delerue, F., Forrest, S. L., Chan, G., van der Hoven, J., van Hummel, A., Feiten, A. F., Lee, S., Martinez-Valbuena, I., Karl, T., Kovacs, G. G., Morahan, G., Ke, Y. D. & Ittner, L. M., Oct 2022, In: Acta Neuropathologica. 144, 4, p. 637-650 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile17 Citations (Scopus)68 Downloads (Pure) -
Rapid initiation of cell cycle reentry processes protects neurons from amyloid-β toxicity
Ippati, S., Deng, Y., Hoven, J. V. D., Heu, C., Hummel, A. V., Chua, S. W., Paric, E., Chan, G., Feiten, A., Fath, T., Ke, Y. D., Haass, N. K. & Ittner, L. M., 23 Mar 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 12, p. 1-9 9 p., e2011876118.Research output: Contribution to journal › Article › peer-review
19 Citations (Scopus)
Prizes
Activities
- 1 Membership of committee
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Faculty of Medicine, Health and Human Sciences (Organisational unit)
Mitchell Sarkies (Member), Fiona Bright (Member), Katie De Luca (Member), Emre Ilhan (Member), Amy Nguyen (Member), Elizabeth Austin (Member), Ann Carrigan (Member), Karla Seaman (Member), Chris Bladen (Member), Annika van Hummel (Member), Jannah Baker (Member), Robert Ross (Member), Sian Genoud (Member), Emily Don (Chair), Nitin Chitranshi (Member), Rae-Anne Hardie (Chair), Rimante Ronto (Member), Gemma Sicouri (Member), Kelly Williams (Member), Syeda Somyyah Owais (Member), Anna Guller (Member), Robert Newport (Member), Marina Junqueira Santiago (Member), Philippe Gilchrist (Member), Jessamine Chen (Member), Ella Oar (Member), Alison Hogan (Member), Jodie Wills (Member), Kathleen Yin (Member), Gillian Hulst (Member), Benjamin Brown (Member), Loes Koring (Member), Stephney Whillier (Member), Milena Gandy (Member), Carly Johnco (Member), Lauren McLellan (Member) & Michael Swain (Member)
2020 → …Activity: Membership › Membership of committee