Annika van Hummel

Dr

  • 239 Citations
  • 6 h-Index
20082018
If you made any changes in Pure these will be visible here soon.

Personal profile

Biography

Annika van Hummel completed her PhD in S100 proteins in osteoarthritis in 2014 under the supervision of Prof Hala Zreiqat and Prof Christopher Little at The University of Sydney. She then joined the Dementia Research Unit at The University of New South Wales working as a postdoctoral researcher with Prof Lars Ittner and moved to Macquarie University as part of the new Dementia Research Centre in December 2018.

Research interests

Since joining the Ittner group in 2014, Annika van Hummel has developed an interest in the use of genetically modified mice as models of neurodegenerative diseases (e.g. Motor Neuron Disease, Frontotemporal Dementia, Alzheimer's Disease), both to better understand the underlying cellular mechanisms and to test new treatment options.

Education/Academic qualification

PhD, University of Sydney

Fingerprint Dive into the research topics where Annika van Hummel is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 3 Similar Profiles
Transgenic Mice Medicine & Life Sciences
Frontotemporal Dementia Medicine & Life Sciences
Dental Schools Medicine & Life Sciences
DNA-Binding Proteins Medicine & Life Sciences
Alzheimer Disease Medicine & Life Sciences
Amyotrophic Lateral Sclerosis Medicine & Life Sciences
Medicine Medicine & Life Sciences
Frontotemporal Lobar Degeneration Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Outputs 2008 2018

  • 239 Citations
  • 6 h-Index
  • 7 Article

Selective spatiotemporal vulnerability of central nervous system neurons to pathologic TAR DNA-binding protein 43 in aged transgenic mice

van Hummel, A., Chan, G., van der Hoven, J., Morsch, M., Ippati, S., Suh, L., Bi, M., Asih, P. R., Lee, W. S., Butler, T. A., Przybyla, M., Halliday, G. M., Piguet, O., Kiernan, M. C., Chung, R. S., Ittner, L. M. & Ke, Y. D., 1 Jun 2018, In : American Journal of Pathology. 188, 6, p. 1447-1456 10 p.

Research output: Contribution to journalArticleResearchpeer-review

DNA-Binding Proteins
Transgenic Mice
Motor Neurons
Central Nervous System
Neurons

Tau exacerbates excitotoxic brain damage in an animal model of stroke

Bi, M., Gladbach, A., van Eersel, J., Ittner, A., Przybyla, M., van Hummel, A., Chua, S. W., van der Hoven, J., Lee, W. S., Müller, J., Parmar, J., von Jonquieres, G., Stefen, H., Guccione, E., Fath, T., Housley, G. D., Klugmann, M., Ke, Y. D. & Ittner, L. M., 1 Dec 2017, In : Nature Communications. 8, 1, p. 1-15 15 p., 473.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
brain damage
animal models
strokes
Brain
Animals

Disinhibition-like behavior in a P301S mutant tau transgenic mouse model of frontotemporal dementia

Przybyla, M., Stevens, C. H., van der Hoven, J., Harasta, A., Bi, M., Ittner, A., van Hummel, A., Hodges, J. R., Piguet, O., Karl, T., Kassiou, M., Housley, G. D., Ke, Y. D., Ittner, L. M. & Eersel, J. V., 19 Sep 2016, In : Neuroscience Letters. 631, p. 24-29 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Frontotemporal Dementia
Transgenic Mice
Amygdala
Mutation
Genes

No overt deficits in aged tau-deficient C57Bl/6.Mapttm1(EGFP)kit GFP knockin mice

Van Hummel, A., Bi, M., Ippati, S., van der Hoven, J., Volkerling, A., Lee, W. S., Tan, D. C. S., Bongers, A., Ittner, A., Ke, Y. D. & Ittner, L. M., 1 Oct 2016, In : PLoS ONE. 11, 10, p. 1-14 14 p., e0163236.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Gene encoding
mice
Nutrition
Genes
gene targeting

Site-specific phosphorylation of tau inhibits amyloid-β toxicity in Alzheimer's mice

Ittner, A., Chua, S. W., Bertz, J., Volkerling, A., van der Hoven, J., Gladbach, A., Przybyla, M., Bi, M., van Hummel, A., Stevens, C. H., Ippati, S., Suh, L. S., Macmillan, A., Sutherland, G., Kril, J. J., Silva, A. P. G., Mackay, J., Poljak, A., Delerue, F., Ke, Y. D. & 1 othersIttner, L. M., 18 Nov 2016, In : Science. 354, 6314, p. 904-908 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Amyloid
Phosphorylation
Alzheimer Disease
tau Proteins
p38 Mitogen-Activated Protein Kinases