• 793 Citations
  • 14 h-Index
20102024
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Personal profile

Biography

Arne graduated in Molecular Biology and Biochemistry from Swiss Federal Institute of Technology Zurich (ETH Zurich), Switzerland, in 2006 and received his PhD from ETH Zurich in 2010 for work on signal transduction by protein kinases. Arne moved then to University of Sydney, Australia, to work as post-doctoral fellow at the Brain and Mind Research Institute from 2011 to 2013. In 2013, he continued his post-doctoral work at University of New South Wales (UNSW Sydney), where he eventually started his own research team on signal transduction and phosphorylation events in neurons. Arne was a post-doctoral fellow with the Alzheimer’s Australia Dementia Research Foundation in 2016. Arne’s work is currently supported by ARC and NHMRC.

Research interests

Protein kinases are critical components that interpret signals in all living cells, including brain cells (=neurons). Arne’s research program focusses on the neurobiology of protein kinases and one of their key targets in neurons: the tau protein, a key player in Alzheimer’s disease. Protein kinases modify target proteins (a process called protein phosphorylation). Phosphorylation of the tau protein has long been thought to aggravate Alzheimer’s. Arne’s team could show that phosphorylation of tau has unexpected beneficial functions in Alzheimer’s. Future projects expand on healthy and disease-related aspects of tau phosphorylation.

Key protein kinases in this context are mitogen-activated protein kinases of the p38 family. Arne revealed non-redundant functions of p38 kinases in the context of neurobiology. Future work expands on regulation, targets and function of p38 kinases in brain cells.

Current projects include:

  • Gain insight into the function of tau phosphorylation in health and disease
  • Elucidate functions of protein kinases in neurons and cognition
  • Develop tools for signal transduction and post-translational modification in neurons
  • Investigate signal transduction by genome editing

Research student supervision

Current students:

1 PhD student

1 MRes student

Community engagement

Fingerprint Dive into the research topics where Arne Ittner is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 12 Similar Profiles
Alzheimer Disease Medicine & Life Sciences
Transgenic Mice Medicine & Life Sciences
Frontotemporal Dementia Medicine & Life Sciences
Amyloid Medicine & Life Sciences
tau Proteins Medicine & Life Sciences
Neurons Medicine & Life Sciences
Immunization Chemical Compounds
Pathology Chemical Compounds

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2017 2024

Cannabidiol (CBD): A novel therapeutic for Alzheimer's disease.

Karl, T., Garner, B., Ittner, A. & Ittner, L.

2/01/1931/12/21

Project: Research

The Role of LIM Domain Kinase 1 in the Pathogenesis of Alzheimer’s Disease

Ke, Y., Ittner, A., Tan, R. H., Halliday, G. M., Krill, J., Ittner, L., Klugmann, M., Kassiou, M. & Gunning, P.

1/11/1831/12/20

Project: Other

Research Outputs 2010 2019

  • 793 Citations
  • 14 h-Index
  • 16 Article
  • 7 Review article

CNS cell type-specific gene profiling of P301S tau transgenic mice identifies genes dysregulated by progressive tau accumulation

Ke, Y. D., Chan, G., Stefanoska, K., Au, C., Bi, M., Müller, J., Przybyla, M., Feiten, A., Prikas, E., Halliday, G. M., Piguet, O., Kiernan, M. C., Kassiou, M., Hodges, J. R., Loy, C. T., Mattick, J. S., Ittner, A., Kril, J. J., Sutherland, G. T. & Ittner, L. M., 20 Sep 2019, In : Journal of Biological Chemistry. 294, 38, p. 14149-14162 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Neurology
Transgenic Mice
Central Nervous System
Genes
Brain

An N-terminal motif unique to primate tau enables differential protein–protein interactions

Stefanoska, K., Volkerling, A., Bertz, J., Poljak, A., Ke, Y. D., Ittner, L. M. & Ittner, A., 9 Mar 2018, In : Journal of Biological Chemistry. 293, 10, p. 3710-3719 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Primates
tau Proteins
Proteins
Synaptotagmin I
Synapsins

Dendritic tau in Alzheimer's disease

Ittner, A. & Ittner, L. M., 11 Jul 2018, In : Neuron. 99, 1, p. 13-27 15 p.

Research output: Contribution to journalReview articleResearchpeer-review

Amyloid
Alzheimer Disease
Synapses
Microtubule-Associated Proteins
Workplace

Generation of a new tau knockout (tau Δex1) line using CRISPR/Cas9 genome editing in mice

Tan, D. C. S., Yao, S., Ittner, A., Bertz, J., Ke, Y. D., Ittner, L. M. & Delerue, F., 1 Jan 2018, In : Journal of Alzheimer's Disease. 62, 2, p. 571-578 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Clustered Regularly Interspaced Short Palindromic Repeats
Introns
Dementia
Exons
Alzheimer Disease

Neuronal MAP kinase p38α inhibits c-Jun N-terminal kinase to modulate anxiety-related behaviour

Stefanoska, K., Bertz, J., Volkerling, A. M., van der Hoven, J., Ittner, L. M. & Ittner, A., 1 Dec 2018, In : Scientific Reports. 8, 1, p. 1-12 12 p., 14296.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Mitogen-Activated Protein Kinase 14
JNK Mitogen-Activated Protein Kinases
Phosphotransferases
Anxiety
Knockout Mice

Prizes

Research Personnel
Medicine

Paxinos-Watson award

Arne Ittner (Recipient) & Lars Ittner (Recipient), 2017

Prize

PhD

Arne Ittner (Recipient), 15 Nov 2010

Prize: Other distinction

File