• 908 Citations
  • 14 h-Index
20102020

Research output per year

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Personal profile

Biography

Arne graduated in Molecular Biology and Biochemistry from Swiss Federal Institute of Technology Zurich (ETH Zurich), Switzerland, in 2006 and received his PhD from ETH Zurich in 2010 for work on signal transduction by protein kinases. Arne moved then to University of Sydney, Australia, to work as post-doctoral fellow at the Brain and Mind Research Institute from 2011 to 2013. In 2013, he continued his post-doctoral work at University of New South Wales (UNSW Sydney), where he eventually started his own research team on signal transduction and phosphorylation events in neurons. Arne was a post-doctoral fellow with the Alzheimer’s Australia Dementia Research Foundation in 2016. Arne’s work is currently supported by ARC and NHMRC.

Research interests

Protein kinases are critical components that interpret signals in all living cells, including brain cells (=neurons). Arne’s research program focusses on the neurobiology of protein kinases and one of their key targets in neurons: the tau protein, a key player in Alzheimer’s disease. Protein kinases modify target proteins (a process called protein phosphorylation). Phosphorylation of the tau protein has long been thought to aggravate Alzheimer’s. Arne’s team could show that phosphorylation of tau has unexpected beneficial functions in Alzheimer’s. Future projects expand on healthy and disease-related aspects of tau phosphorylation.

Key protein kinases in this context are mitogen-activated protein kinases of the p38 family. Arne revealed non-redundant functions of p38 kinases in the context of neurobiology. Future work expands on regulation, targets and function of p38 kinases in brain cells.

Current projects include:

  • Gain insight into the function of tau phosphorylation in health and disease
  • Elucidate functions of protein kinases in neurons and cognition
  • Develop tools for signal transduction and post-translational modification in neurons
  • Investigate signal transduction by genome editing

Research student supervision

Current students:

1 PhD student

1 MRes student

Community engagement

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Projects

Cannabidiol (CBD): A novel therapeutic for Alzheimer's disease.

Karl, T., Garner, B., Ittner, A. & Ittner, L.

2/01/1931/12/21

Project: Research

The Role of LIM Domain Kinase 1 in the Pathogenesis of Alzheimer’s Disease

Ke, Y., Ittner, A., Tan, R. H., Halliday, G., Krill, J., Ittner, L., Klugmann, M., Kassiou, M. & Gunning, P.

1/11/1831/12/20

Project: Other

Research Outputs

  • 908 Citations
  • 14 h-Index
  • 20 Article
  • 7 Review article
  • 3 Patent

Novel behavioural characteristics of male human P301S mutant tau transgenic mice: a model for tauopathy

Watt, G., Przybyla, M., Zak, V., van Eersel, J., Ittner, A., Ittner, L. & Karl, T., 1 Apr 2020, In : Neuroscience. 431, p. 166-175 10 p.

Research output: Contribution to journalArticle

  • 1 Citation (Scopus)

    Onset of hippocampal network aberration and memory deficits in P301S tau mice are associated with an early gene signature

    Przybyla, M., Van Eersel, J., van Hummel, A., van der Hoven, J., Sabale, M., Harasta, A., Müller, J., Gajwani, M., Prikas, E., Mueller, T., Stevens, C. H., Power, J., Housley, G. D., Karl, T., Kassiou, M., Ke, Y. D., Ittner, A. & Ittner, L. M., Jun 2020, In : Brain. 143, 6, p. 1889-1904 16 p.

    Research output: Contribution to journalArticle

  • CNS cell type-specific gene profiling of P301S tau transgenic mice identifies genes dysregulated by progressive tau accumulation

    Ke, Y. D., Chan, G., Stefanoska, K., Au, C., Bi, M., Müller, J., Przybyla, M., Feiten, A., Prikas, E., Halliday, G. M., Piguet, O., Kiernan, M. C., Kassiou, M., Hodges, J. R., Loy, C. T., Mattick, J. S., Ittner, A., Kril, J. J., Sutherland, G. T. & Ittner, L. M., 20 Sep 2019, In : Journal of Biological Chemistry. 294, 38, p. 14149-14162 14 p.

    Research output: Contribution to journalArticle

  • 1 Citation (Scopus)

    Sphingosine kinase 2 potentiates amyloid deposition but protects against hippocampal volume loss and demyelination in a mouse model of Alzheimer's disease

    Lei, M., Teo, J. D., Song, H., McEwen, H. P., Yup Lee, J., Couttas, T. A., Duncan, T., Chesworth, R., Bertz, J., Przybyla, M., Van Eersel, J., Heng, B., Guillemin, G. J., Ittner, L. M., Fath, T., Garner, B., Ittner, A., Karl, T. & Don, A. S., 27 Nov 2019, In : The Journal of Neuroscience. 39, 48, p. 9645-9659 15 p.

    Research output: Contribution to journalArticle

    Open Access
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    Prizes

  • Paxinos-Watson award

    Arne Ittner (Recipient) & Lars Ittner (Recipient), 2017

    Prize

    PhD

    Arne Ittner (Recipient), 15 Nov 2010

    Prize: Other distinction

    File