If you made any changes in Pure these will be visible here soon.

Research Outputs 2009 2019

  • 482 Citations
  • 12 h-Index
  • 22 Article
  • 2 Meeting abstract
  • 2 Letter
  • 1 Review article
2019

Neuroprotective effect of myxobacterial extracts on quinolinic acid-induced toxicity in primary human neurons

Dehhaghi, M., Tan, V., Heng, B., Braidy, N., Mohammadipanah, F. & Guillemin, G. J., Feb 2019, In : Neurotoxicity Research. 35, 2, p. 281-290 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Quinolinic Acid
Neuroprotective Agents
Neurons
Toxicity
Stigmatella

Novel dual-action prodrug triggers apoptosis in glioblastoma cells by releasing a glutathione quencher and lysine-specific histone demethylase 1A inhibitor

Engel, M., Gee, Y. S., Cross, D., Maccarone, A., Heng, B., Hulme, A., Smith, G., Guillemin, G. J., Stringer, B. W., Hyland, C. J. T. & Ooi, L., 1 May 2019, In : Journal of Neurochemistry. 149, 4, p. 535-550 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Histone Demethylases
Prodrugs
Glioblastoma
Lysine
Glutathione

Protective effects of myxobacterial extracts on hydrogen peroxide-induced toxicity on human primary astrocytes

Dehhaghi, M., Tan, V., Heng, B., Mohammadipanah, F. & Guillemin, G. J., 10 Feb 2019, In : Neuroscience. 399, p. 1-11 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Astrocytes
Hydrogen Peroxide
Oxidative Stress
Cell Death
Myxococcales
2017

Human regulatory macrophages are potent in suppression of the xenoimmune response via indoleamine-2,3-dioxygenase-involved mechanism(s)

Guo, F., Hu, M., Huang, D., Zhao, Y., Heng, B., Guillemin, G., Lim, C. K., Hawthorne, W. J. & Yi, S., Oct 2017, In : Xenotransplantation. 24, 5, p. 1-11 11 p., e12326.

Research output: Contribution to journalArticleResearchpeer-review

Indoleamine-Pyrrole 2,3,-Dioxygenase
Macrophages
Mixed Lymphocyte Culture Test
Heterologous Transplantation
Blood Cells
2016

Genetic basis of hindlimb loss in a naturally occurring vertebrate model

Don, E. K., De Jong-Curtain, T. A., Doggett, K., Hall, T. E., Heng, B., Badrock, A. P., Winnick, C., Nicholson, G. A., Guillemin, G. J., Currie, P. D., Hesselson, D., Heath, J. K. & Cole, N. J., 15 Mar 2016, In : Biology Open. 5, 3, p. 359-366 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Hindlimb
fins
Vertebrates
vertebrates
Cloning

Keratin 14 expression in epithelial progenitor cells of the developing human cornea

Eghtedari, Y., Richardson, A., Mai, K., Heng, B., Guillemin, G. J., Wakefield, D. & Di Girolamo, N., 1 May 2016, In : Stem Cells and Development. 25, 9, p. 699-711 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Keratin-14
Cornea
Stem Cells
Epithelial Cells
Integrins

Soluble LILRA3 promotes neurite outgrowth and synapses formation through a high-affinity interaction with Nogo 66

An, H., Brettle, M., Lee, T., Heng, B., Lim, C. K., Guillemin, G. J., Lord, M. S., Klotzsch, E., Geczy, C. L., Bryant, K., Fath, T. & Tedla, N., 2016, In : Journal of Cell Science. 129, 6, p. 1198-1209 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Synapses
Immunoglobulins
Leukocytes
Central Nervous System
Neurons

Synergistic induction of CXCL10 by interferon-gamma and lymphotoxin-alpha in astrocytes: Possible role in cerebral malaria

Bakmiwewa, S. M., Weiser, S., Grey, M., Heng, B., Guillemin, G. J., Ball, H. J. & Hunt, N. H., 1 Feb 2016, In : Cytokine. 78, p. 79-86 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Cerebral Malaria
Lymphotoxin-alpha
Astrocytes
Interferon-gamma
Cytokines

Understanding the role of the kynurenine pathway in human breast cancer immunobiology

Heng, B., Lim, C. K., Lovejoy, D. B., Bessede, A., Gluch, L. & Guillemin, G. J., 9 Feb 2016, In : Oncotarget. 7, 6, p. 6506-6520 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Kynurenine
Breast Neoplasms
Dioxygenases
Early Medical Intervention
3-Hydroxyanthranilic Acid
2015

Activation of the kynurenine pathway and increased production of the excitotoxin quinolinic acid following traumatic brain injury in humans

Yan, E. B., Frugier, T., Lim, C. K., Heng, B., Sundaram, G., Tan, M., Rosenfeld, J. V., Walker, D. W., Guillemin, G. J. & Morganti-Kossmann, M. C., 30 May 2015, In : Journal of Neuroinflammation. 12, p. 1-17 17 p., 110.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Quinolinic Acid
Kynurenine
Neurotoxins
Indoleamine-Pyrrole 2,3,-Dioxygenase
Kynurenic Acid

An effective, low-cost method for achieving and maintaining hypoxia during cell culture studies

Bakmiwewa, S. M., Heng, B., Guillemin, G. J., Ball, H. J. & Hunt, N. H., 1 Oct 2015, In : BioTechniques. 59, 4, p. 223-229 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Cell culture
Cell Culture Techniques
Oxygen
Costs and Cost Analysis
Vacuum

Cytotoxic activity of the MK2 inhibitor CMPD1 in glioblastoma cells is independent of MK2

Gurgis, F. M. S., Åkerfeldt, M. C., Heng, B., Wong, C., Adams, S., Guillemin, G. J., Johns, T. G., Chircop, M. & Munoz, L., 2015, In : Cell death discovery. 1, p. 1-11 11 p., 15028.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Glioblastoma
Protein Kinase Inhibitors
Protein Kinases
Tubulin
Phosphotransferases

Human Papilloma viruses and breast cancer

Lawson, J. S., Glenn, W. K., Salyakina, D., Delprado, W., Clay, R., Antonsson, A., Heng, B., Miyauchi, S., Tran, D. D., Ngan, C. C., Lutze-Mann, L. & Whitaker, N. J., 2015, In : Frontiers in Oncology. 5, p. 1-12 12 p., 277.

Research output: Contribution to journalArticleResearchpeer-review

Papillomaviridae
Breast Neoplasms
Papillomavirus E7 Proteins
Breast
Human papillomavirus 18

Lycopene pretreatment ameliorates acute ethanol induced NAD(+) depletion in human astroglial cells

Guest, J., Guillemin, G. J., Heng, B. & Grant, R., 2015, In : Oxidative Medicine and Cellular Longevity. 2015, p. 1-8 8 p., 741612.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
NAD
Ethanol
Brain
Astrocytes
Sirtuin 1

Optimisation of LRRK2 inhibitors and assessment of functional efficacy in cell-based models of neuroinflammation

Munoz, L., Kavanagh, M. E., Phoa, A. F., Heng, B., Dzamko, N., Chen, E. J., Doddareddy, M. R., Guillemin, G. J. & Kassiou, M., 5 May 2015, In : European Journal of Medicinal Chemistry. 95, p. 29-34 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Inhibitory Concentration 50
Microglia
Leucine
Glioma
Astrocytes

The MAPK-activated protein kinase 2 (MK2) inhibitor CMPD1 is a novel microtubule targeting agent for glioblastoma therapy

Gurgis, F., Åkerfeldt, M., Wong, C., Heng, B., Guillemin, G. J., Chircop, M. & Munoz, L., Aug 2015, In : Clinical Therapeutics. 37, 8 Supplement, p. e114 1 p.

Research output: Contribution to journalMeeting abstractResearchpeer-review

The p38-MK2-HuR pathway potentiates EGFRvIII-IL-1β-driven IL-6 secretion in glioblastoma cells

Gurgis, F. M. S., Yeung, Y. T., Tang, M. X. M., Heng, B., Buckland, M., Ammit, A. J., Haapasalo, J., Haapasalo, H., Guillemin, G. J., Grewal, T. & Munoz, L., 28 May 2015, In : Oncogene. 34, 22, p. 2934-2942 9 p.

Research output: Contribution to journalArticleResearchpeer-review

p38 Mitogen-Activated Protein Kinases
Glioblastoma
Epidermal Growth Factor Receptor
Protein Kinases
Interleukin-6
2014

The p38-mk2-hur pathway potentiates egfrviii-il-1 beta-driven il-6 secretion in glioblastoma cells

Gurgis, F., Yeung, Y. T., Tang, M., Heng, B., Buckland, M., Ammit, A. J., Haapasalo, J., Haapasalo, H., Guillemin, G. J., Grewal, T. & Munoz, L., Nov 2014, In : Asia-Pacific Journal of Clinical Oncology. 10, p. 45-45 1 p.

Research output: Contribution to journalMeeting abstractResearch

2013

Characterization of the Kynurenine pathway and quinolinic acid production in macaque macrophages

Lim, C. K., Yap, M. M. C., Kent, S. J., Gras, G., Samah, B., Batten, J. C., De Rose, R., Heng, B., Brew, B. J. & Guillemin, G. J., 2013, In : International Journal of Tryptophan Research. 6, p. 7-19 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Quinolinic Acid
Kynurenine
Macrophages
Macaca
Metabolism

Detecting human papillomavirus in ocular surface diseases

Woods, M., Chow, S., Heng, B., Glenn, W., Whitaker, N., Waring, D., Iwasenko, J., Rawlinson, W., Coroneo, M. T., Wakefield, D. & Di Girolamo, N., 19 Nov 2013, In : Investigative Ophthalmology and Visual Science. 54, 13, p. 8069-8078 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Eye Diseases
Pterygium
Conjunctiva
Human papillomavirus 16
Viral DNA
2012

Epstein-Barr Virus, Human Papillomavirus and Mouse Mammary Tumour Virus as Multiple Viruses in Breast Cancer

Glenn, W. K., Heng, B., Delprado, W., Iacopetta, B., Whitaker, N. J. & Lawson, J. S., 19 Nov 2012, In : PLoS ONE. 7, 11, p. 1-10 10 p., e48788.

Research output: Contribution to journalArticleResearchpeer-review

Mouse mammary tumor virus
Human herpesvirus 4
Papillomaviridae
Human Herpesvirus 4
Viruses
2010

Mouse mammary tumor virus-like sequences in human breast cancer

Lawson, J. S., Glenn, W. K., Salmons, B., Ye, Y., Heng, B., Moody, P., Johal, H., Rawlinson, W. D., Delprado, W., Lutze-Mann, L. & Whitaker, N. J., 1 May 2010, In : Cancer Research. 70, 9, p. 3576-3585 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Mouse mammary tumor virus
Breast Neoplasms
Ductal Carcinoma
Carcinoma, Intraductal, Noninfiltrating
Viral Genes

Reply: Koilocytes indicate a role for human papilloma virus in breast cancer

Glenn, W. K., Heng, B., Whitaker, N. J. & Lawson, J. S., Feb 2010, In : British Journal of Cancer. 102, 4, p. 788 1 p.

Research output: Contribution to journalLetterResearchpeer-review

Reply to Letter to the Editor: Is HPV-18 present in human breast cancer cell lines

Heng, B., Glenn, W. K., Lee, J. H. K., Tan, X. V., Lawson, J. S. & Whitaker, N. J., May 2010, In : British Journal of Cancer. 102, 10, p. 1551-1552 2 p.

Research output: Contribution to journalLetterResearchpeer-review

Viruses and breast cancer

Lawson, J. S. & Heng, B., Jun 2010, In : Cancers. 2, 2, p. 752-772 21 p.

Research output: Contribution to journalReview articleResearchpeer-review

Papillomaviridae
Uterine Cervical Neoplasms
Bovine Leukemia Virus
Breast Neoplasms
Viruses
2009

Human papilloma virus is associated with breast cancer

Heng, B., Glenn, W. K., Ye, Y., Tran, B., Delprado, W., Lutze-Mann, L., Whitaker, N. J. & Lawson, J. S., 20 Oct 2009, In : British Journal of Cancer. 101, 8, p. 1345-1350 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Papillomaviridae
Breast Neoplasms
Uterine Cervical Neoplasms
Polymerase Chain Reaction
Oncogenic Viruses

Koilocytes indicate a role for human papilloma virus in breast cancer

Lawson, J. S., Glenn, W. K., Heng, B., Ye, Y., Tran, B., Lutze-Mann, L. & Whitaker, N. J., 20 Oct 2009, In : British Journal of Cancer. 101, 8, p. 1351-1356 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Papillomaviridae
Breast Neoplasms
Breast
Virus Diseases
Polymerase Chain Reaction