Projects per year
Personal profile
Biography
Dr. Bhumika Shah is a structural biologist with research interests focused on understanding how molecular adaptations translate into ecological success in helpful and harmful microorganisms, by utilising global approaches such as genomics, in combination with molecular biology and biochemistry techniques.
Research interests
Dr Shah's current research investigates marine cyanobacteria, abundant primary producers that underpin the entire oceanic food web. Extensive genomic resources exist for these model organisms, providing a framework to understand how adaptation contributes to their physiology and ecology. Dr Shah's work specifically focusses on the physiological and biochemical interpretation of high-affinity transport proteins that facilitate nutrient assimilation, a protein family that plays key roles in the interaction of the cell with its environment.
Research Projects available:
- Discovering nutrient uptake mechanisms of photosynthetic bacteria via recombinant protein characterisation pipeline
- Gene editing in cyanobacteria using CRISPR methods
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Projects
- 1 Active
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Biomolecular Discovery and Design Research Centre
Packer, N., Paulsen, I., Nevalainen, H., Haynes, P., Molloy, M., Atwell, B., Barron, A., Beggs, P., Bergquist, P. L., Brown, L., Cornish, J., Chung, R., De Deene, Y., Garcia-Bennett, A., Gillings, M., Goodchild, A., Guillemin, G., Hallinan, J., Hose, G., Jaschke, P., Mabbutt, B., Raftos, D., Ranganathan, S., Sofronov, G., Sunna, A., Tetu, S., Andersen, M., Willows, R., Ahn, C., Breen, E., Campbell, M., Care, A., Cordina, N., Curach, N., Everest Dass, A., Elbourne, L., Goold, H., Hassan, K., Kautto, L., Krisp, C., Kroukamp, H., Lee, A., Lin, C., Mackie, A., McKay, M., McQuade, L., Mirzaei, M., Mohamedali, A., Ostrowski, M., Parker, L., Pascovici, D., Penesyan, A., Shah, B., Sun, A., Thompson, E. & Williams, T.
1/01/17 → …
Project: Research
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Identification of a novel ciprofloxacin tolerance gene, aciT, which contributes to filamentation in Acinetobacter baumannii
Naidu, V., Shah, B., Kamath, K. S., Chien, A., Nagy, S., Pokhrel, A., Molloy, M., Hassan, K. A. & Paulsen, I. T., Jun 2021, In: Antimicrobial Agents and Chemotherapy. 65, 6, p. 1-9 9 p., e01400.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Downloads (Pure) -
Comparative membrane proteomics reveal contrasting adaptation strategies for coastal and oceanic marine Synechococcus cyanobacteria
Teoh, F., Shah, B., Ostrowski, M. & Paulsen, I., May 2020, In: Environmental microbiology. 22, 5, p. 1816-1828 13 p.Research output: Contribution to journal › Article › peer-review
1 Citation (Scopus) -
Crystal structure of a UDP-GlcNAc epimerase for surface polysaccharide biosynthesis in Acinetobacter baumannii
Shah, B. S., Ashwood, H. E., Harrop, S. J., Farrugia, D. N., Paulsen, I. T. & Mabbutt, B. C., 19 Jan 2018, In: PLoS ONE. 13, 1, p. 1-19 19 p., e0191610.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)18 Downloads (Pure) -
Investigating Acinetobacter baumannii pathogenesis: crystal structure of WbjB epimerase from a polysaccharide biosynthesis cluster
Shah, B. S., Hassan, K. A. H. A., Clift, H. E., Harrop, S. J., Paulsen, I. T. & Mabbutt, B. C., Oct 2015, In: Protein science : a publication of the Protein Society. 24, S1, p. 63-63 1 p.Research output: Contribution to journal › Meeting abstract
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Structure of a short-chain dehydrogenase/reductase (SDR) within a genomic island from a clinical strain of Acinetobacter baumannii
Shah, B. S., Tetu, S. G., Harrop, S. J., Paulsen, I. T. & Mabbutt, B. C., 1 Oct 2014, In: Acta Crystallographica. Section F: Structural Biology Communications. 70, p. 1318-1323 6 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)26 Downloads (Pure)