Projects per year
Personal profile
Biography
Dr. Bhumika Shah is a structural biologist with research interests focused on understanding how molecular adaptations translate into ecological success in helpful and harmful microorganisms, by utilising global approaches such as genomics, in combination with molecular biology and biochemistry techniques.
Research interests
Dr Shah's current research investigates marine cyanobacteria, abundant primary producers that underpin the entire oceanic food web. Extensive genomic resources exist for these model organisms, providing a framework to understand how adaptation contributes to their physiology and ecology. Dr Shah's work specifically focusses on the physiological and biochemical interpretation of high-affinity transport proteins that facilitate nutrient assimilation, a protein family that plays key roles in the interaction of the cell with its environment.
Research Projects available:
- Discovering nutrient uptake mechanisms of photosynthetic bacteria via recombinant protein characterisation pipeline
- Gene editing in cyanobacteria using CRISPR methods
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Projects
- 1 Active
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Biomolecular Discovery and Design Research Centre
Packer, N., Paulsen, I., Nevalainen, H., Haynes, P., Molloy, M., Atwell, B., Barron, A., Beggs, P., Bergquist, P. L., Brown, L., Cornish, J., Chung, R., De Deene, Y., Garcia-Bennett, A., Gillings, M., Goodchild, A., Guillemin, G., Hallinan, J., Hose, G., Jaschke, P., Mabbutt, B., Raftos, D., Ranganathan, S., Sofronov, G., Sunna, A., Tetu, S., Andersen, M., Willows, R., Ahn, C., Breen, E., Campbell, M., Care, A., Cordina, N., Curach, N., Everest Dass, A., Elbourne, L., Goold, H., Hassan, K., Kautto, L., Krisp, C., Kroukamp, H., Lee, A., Lin, C., Mackie, A., McKay, M., McQuade, L., Mirzaei, M., Mohamedali, A., Ostrowski, M., Parker, L., Pascovici, D., Penesyan, A., Shah, B., Sun, A., Thompson, E. & Williams, T.
1/01/17 → …
Project: Research
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Novel functional insights into a modified sugar-binding protein from Synechococcus MITS9220
Ford, B. A., Michie, K. A., Paulsen, I., Mabbutt, B. C. & Shah, B. S., 21 Mar 2022, In: Scientific Reports. 12, p. 16 1 p., 4805.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Downloads (Pure) -
Functional characterisation of substrate-binding proteins to address nutrient uptake in marine picocyanobacteria
Ford, B. A., Sullivan, G. J., Moore, L., Varkey, D., Zhu, H., Ostrowski, M., Mabbutt, B. C., Paulsen, I. T. & Shah, B. S., Dec 2021, In: Biochemical Society Transactions. 49, 6, p. 2465-2481 17 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile2 Downloads (Pure) -
Identification of a novel ciprofloxacin tolerance gene, aciT, which contributes to filamentation in Acinetobacter baumannii
Naidu, V., Shah, B., Kamath, K. S., Chien, A., Nagy, S., Pokhrel, A., Molloy, M., Hassan, K. A. & Paulsen, I. T., May 2021, In: Antimicrobial Agents and Chemotherapy. 65, 6, p. 1-9 9 p., e01400.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)28 Downloads (Pure) -
The Acinetobacter baumannii disinfectant resistance protein, AmvA, is a spermidine and spermine efflux pump
Short, F. L., Liu, Q., Shah, B., Clift, H. E., Naidu, V., Li, L., Prity, F. T., Mabbutt, B. C., Hassan, K. A. & Paulsen, I. T., 22 Sep 2021, In: Communications Biology. 4, 1, p. 1-12 12 p., 1114.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)11 Downloads (Pure) -
Comparative membrane proteomics reveal contrasting adaptation strategies for coastal and oceanic marine Synechococcus cyanobacteria
Teoh, F., Shah, B., Ostrowski, M. & Paulsen, I., May 2020, In: Environmental Microbiology. 22, 5, p. 1816-1828 13 p.Research output: Contribution to journal › Article › peer-review
2 Citations (Scopus)