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Personal profile


After joining Department of Biomedical Sciences in 2015, I started to build an independent Brain Drug Delivery Research Group with the supervision of senior mentors. My research ambition is to address one of the major challenges for brain disease therapy – which is the successful delivery of therapeutic agents across the Blood Brain Barrier (BBB) – the BBB acts as a cellular barrier that prevents toxins, foreign materials and other dangerous molecules from entering the brain, however as a consequence this poses major challenges for getting therapeutic molecules into the brain.

To overcome this, my research program is developing advanced brain drug delivery system to efficiently transport the therapeitic drug across BBB into Brain for prelinical brain disease therapy evaluation. Supported by two Macquarie University Research Fellowship (Dr Shi and Dr Zou), one NHMRC-ARC Dementia Research Development fellowship (Dr Shi), one Mason Foundation project grant (Dr Shi), one NHMRC project grant (Dr Shi is CIA), one Australian Endeavour Research Fellowship (Dr. Shi) and other internal/industry fundings, I have developed three main research streams:1) nanoparticle-based blood–brain barrier (BBB) penetration mechanisms (led by Dr Libing Fu); 2) the development of alternate brain delivery systems (led by Dr Anne Zou); 3) pre-clinical evaluation of therapies for brain diseases (led by Dr Amanda Wright). This is supported through a research group structure that I lead, which includes one mid-career researcher, three early career researchers, three PhD students. In my accelerated-trajectory career, I have delivered more than 50 high-qulified journal publications on this topic, developed several core patented technologies for brain delivery systems (eg:Bio-NPs and Glu-NPs), set up multiple collaboration networks (across Australia, US and China), made close connections with industry and hospital partners, and had access to avenues for professional development and contribution. 

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  • 2 Similar Profiles
Nanoparticles Chemical Compounds
Genes Chemical Compounds
Drug delivery Chemical Compounds
Silicon Dioxide Chemical Compounds
Sertoli Cells Medicine & Life Sciences
Dendrimers Chemical Compounds
Silica Engineering & Materials Science
DNA Engineering & Materials Science

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Projects 2015 2022

Research Outputs 2009 2020

Central metal-derived co-assembly of biomimetic GdTPP/ZnTPP porphyrin nanocomposites for enhanced dual-modal imaging-guided photodynamic therapy

Wang, J., Wang, Z., Zhong, Y., Zou, Y., Wang, C., Wu, H., Lee, A., Yang, W., Wang, X., Liu, Y., Zhang, D., Yan, J., Hao, M., Zheng, M., Chung, R., Bai, F. & Shi, B., 24 Oct 2019, (Accepted/In press) In : Biomaterials. 229, p. 1-13 13 p., 119576.

Research output: Contribution to journalArticleResearchpeer-review

Photodynamic therapy

Encapsulation of food ingredients by nanophytosomes

Babazadeh, A., Jafari, S. M. & Shi, B., 16 Aug 2019, Lipid-based nanostructures for food encapsulation purposes. Jafari, S. M. (ed.). Elsevier: Academic Press, Vol. 2. p. 405-443 39 p. (Nanoencapsulation in the Food Industry; vol. 2).

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review

Glutathione-responsive prodrug nanoparticles for effective drug delivery and cancer therapy

Ling, X., Tu, J., Wang, J., Shajii, A., Kong, N., Feng, C., Zhang, Y., Yu, M., Xie, T., Bharwani, Z., Aljaeid, B. M., Shi, B., Tao, W. & Farokhzad, O. C., 22 Jan 2019, In : ACS Nano. 13, 1, p. 357-370 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Drug delivery

High expression of meningioma 1 is correlated with reduced survival rates in colorectal cancer patients

Ho, Y. J., Liu, F-C., Chang, J., Shi, B., Yeh, K. T., Lin, Y. M. & Lu, J. W., 1 Jul 2019, In : Acta Histochemica. 121, 5, p. 628-637 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Colorectal Neoplasms
Survival Rate
Proliferating Cell Nuclear Antigen

Intrinsically Fluorescent PAMAM Dendrimer as Drug carrier and Nanoprobe: Bioimaging and Neuron protection Study

Wang, G., Babazadeh, A. & Shi, B., 2019, p. 70. 1 p.

Research output: Contribution to conferencePosterResearchpeer-review

Drug Carriers