• 1079 Citations
  • 14 h-Index
20092021
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Personal profile

Biography

After joining Department of Biomedical Sciences in 2015, I started to build an independent Brain Drug Delivery Research Group with the supervision of senior mentors. My research ambition is to address one of the major challenges for brain disease therapy – which is the successful delivery of therapeutic agents across the Blood Brain Barrier (BBB) – the BBB acts as a cellular barrier that prevents toxins, foreign materials and other dangerous molecules from entering the brain, however as a consequence this poses major challenges for getting therapeutic molecules into the brain.

To overcome this, my research program is developing advanced brain drug delivery system to efficiently transport the therapeitic drug across BBB into Brain for prelinical brain disease therapy evaluation. Supported by two Macquarie University Research Fellowship (Dr Shi and Dr Zou), one NHMRC-ARC Dementia Research Development fellowship (Dr Shi), one Mason Foundation project grant (Dr Shi), one NHMRC project grant (Dr Shi is CIA), one Australian Endeavour Research Fellowship (Dr. Shi) and other internal/industry fundings, I have developed three main research streams:1) nanoparticle-based blood–brain barrier (BBB) penetration mechanisms (led by Dr Libing Fu); 2) the development of alternate brain delivery systems (led by Dr Anne Zou); 3) pre-clinical evaluation of therapies for brain diseases (led by Dr Amanda Wright). This is supported through a research group structure that I lead, which includes one mid-career researcher, three early career researchers, three PhD students. In my accelerated-trajectory career, I have delivered more than 50 high-qulified journal publications on this topic, developed several core patented technologies for brain delivery systems (eg:Bio-NPs and Glu-NPs), set up multiple collaboration networks (across Australia, US and China), made close connections with industry and hospital partners, and had access to avenues for professional development and contribution. 

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Projects 2015 2021

Research Outputs 2009 2019

  • 1079 Citations
  • 14 h-Index
  • 43 Article
  • 4 Review article
  • 2 Conference proceeding contribution
  • 2 Meeting abstract

Glutathione-responsive prodrug nanoparticles for effective drug delivery and cancer therapy

Ling, X., Tu, J., Wang, J., Shajii, A., Kong, N., Feng, C., Zhang, Y., Yu, M., Xie, T., Bharwani, Z., Aljaeid, B. M., Shi, B., Tao, W. & Farokhzad, O. C., 22 Jan 2019, In : ACS Nano. 13, 1, p. 357-370 14 p.

Research output: Contribution to journalArticleResearchpeer-review

glutathione
Prodrugs
Platinum
Drug delivery
Glutathione

Label-free fluorescent poly(amidoamine) dendrimer for traceable and controlled drug delivery

Wang, G., Fu, L., Walker, A., Chen, X., Lovejoy, D. B., Hao, M., Lee, A., Chung, R., Rizos, H., Irvine, M., Zheng, M., Liu, X., Lu, Y. & Shi, B., 13 May 2019, In : Biomacromolecules. 20, 5, p. 2148-2158 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Controlled drug delivery
Dendrimers
Cytotoxicity
Doxorubicin
Labels

Synthesis of photo-excited Chlorin e6 conjugated silica nanoparticles for enhanced anti-bacterial efficiency to overcome methicillin-resistant Staphylococcus aureus

Lin, J., Li, J., Gopal, A., Munshi, T., Chu, Y-W., Wang, J-X., Liu, T., Shi, B., Chen, X. & Li, Y., 4 Mar 2019, In : Chemical communications (Cambridge, England). 55, 18, p. 2656-2659 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Methicillin
Silicon Dioxide
Silica
Nanoparticles
Photosensitizing Agents

The siRNAsome: a cation free and versatile nanostructure for siRNA and drug codelivery

Zheng, M., Jiang, T., Yang, W., Zou, Y., Wu, H., Liu, X., McDonald, K., Ling, D., Shi, J., Zhu, F., Qian, R. & Shi, B., 1 Apr 2019, In : Angewandte Chemie - International Edition. 58, 15, p. 4938-4942 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
RNA
Small Interfering RNA
Cations
Nanostructures
Positive ions
Ligases
Ubiquitin
Neurodegenerative Diseases
Proteomics
Ubiquitin-Protein Ligases