Bingyang Shi

Dr, Associate Professor

  • 1397 Citations
  • 18 h-Index
20092022
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Personal profile

Biography

With the award of a competitive Macquarie University Research Fellowship in 2014, I relocated to Macquarie Uni (MQ) to lead a new Brain Drug Delivery Group. There I chase my research dream and ambition to address one of the major challenges for brain disease therapy which is the successful delivery of therapeutic agents across the Blood Brain Barrier (BBB) – the BBB acts as a cellular barrier that prevents toxins, foreign materials and other dangerous molecules from entering the brain, however as a consequence this poses major challenges for getting therapeutic molecules into the brain.

To overcome this, my research program is developing advanced brain drug delivery system to efficiently transport the therapeutic drug across BBB into Brain for preclinical brain disease therapy evaluation with three core research streams: 1) development of novel nanoparticle-based blood–brain barrier (BBB) penetration mechanisms; 2) development of brain delivery systems based on the BBB mechanisms discovered in stream 1; 3) preclinical evaluation of therapies for brain diseases based on the delivery systems developed in stream 2. Each research stream is led by an outstanding ECR team member managing 1-2 PhD students, but I maintain overall stewardship by weekly meetings with my ECR team and students to ensure progress remains on track.

I contributed my expertise & knowledge to develop a new Blood-Brain-Barrier (BBB) penetration mechanism, as well as pioneering new strategies for brain drug delivery that led to an NHMRC Peter Doherty Fellowship (GNT1111822) and NHMRC-ARC Dementia Research Development Fellowship (GNT1111611) (Declined the former and took the Dementia one). In 2016, I discovered a novel glucose-transporter-mediated BBB penetration pathway and drug-controlled-release strategy in neuron, developing an effective brain delivery strategy (Glu-NPs; 2017) and attracting a Mason Foundation grant (GNT MAS2017F034) and NHMRC Project Grant (GNT1166024) for dementia therapy (both CIA; 2018). I lead a multidisciplinary team across MQ (myself, brain delivery; Dr Wright, Alzheimer’s disease (AD) biochemistry) and Western Sydney U (Dr. Chesworth, AD mouse behavior) for these funded projects.

Inspired by the unique capabilities of natural cells, I developed another novel biomimetic brain delivery strategy (Bio-NPs) with outstanding therapeutic effects for brain tumor therapy, which led to Australian Government Endeavour Research Fellowship (Recipient ID:6917_2018) to support visit Harvard University for six months to explore the potential applications in brain metastatic brain cancer therapy. Accordingly, I successfully secured an international grant as CIA ($620K AUD, GNT2018YFA0209800) to support a Phase 1 clinical trial. From 2019, I have been leading a 2nd multidisciplinary team across MQ, Henan province hospital, Huashan Hospital and Harvard Medical School for this project.

In recognizing my significant contributions to my research program, I was awarded four competitive fellowships(Macquarie University Research Fellowship, NHMRC Peter Doherty Fellowship, Australian Government Endeavour Research Fellowship, NHMRC-ARC Dementia Research Development Fellowship), many prestigious awards, eg, American Chem Society Rising star Award and MQ Early Career Researcher of the year in 2019.

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Nanoparticles Chemical Compounds
Genes Chemical Compounds
Drug delivery Chemical Compounds
Silicon Dioxide Chemical Compounds
Tumors Chemical Compounds
Sertoli Cells Medicine & Life Sciences
Small Interfering RNA Chemical Compounds
RNA Engineering & Materials Science

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Projects 2015 2022

Research Outputs 2009 2020

Central metal-derived co-assembly of biomimetic GdTPP/ZnTPP porphyrin nanocomposites for enhanced dual-modal imaging-guided photodynamic therapy

Wang, J., Wang, Z., Zhong, Y., Zou, Y., Wang, C., Wu, H., Lee, A., Yang, W., Wang, X., Liu, Y., Zhang, D., Yan, J., Hao, M., Zheng, M., Chung, R., Bai, F. & Shi, B., Jan 2020, In : Biomaterials. 229, p. 1-13 13 p., 119576.

Research output: Contribution to journalArticleResearchpeer-review

Nanocomposites
Biomimetics
Photodynamic therapy
Porphyrins
Photochemotherapy

Charge conversional biomimetic nanocomplexes as a multifunctional platform for boosting orthotopic glioblastoma RNAi therapy

Liu, Y., Zou, Y., Feng, C., Lee, A., Yin, J., Chung, R., Park, J. B., Rizos, H., Tao, W., Zheng, M., Farokhzad, O. C. & Shi, B., 3 Feb 2020, (Accepted/In press) In : Nano Letters.

Research output: Contribution to journalArticleResearchpeer-review

biomimetics
Biomimetics
RNA
Tumors
therapy

SERS-based nanostrategy for rapid anemia diagnosis

Muhammad, P., Hanif, S., Yan, J., Rehman, F. U., Wang, J., Khan, M., Chung, R., Lee, A., Zheng, M., Wang, Y. & Shi, B., 21 Jan 2020, In : Nanoscale. 12, 3, p. 1948-1957 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Raman scattering
Iron
Blood
Cyanides
Assays

Active DNA unwinding and transport by a membrane-adapted helicase nanopore

Sun, K., Zhao, C., Zeng, X., Chen, Y., Jiang, X., Ding, X., Gou, L., Xie, H., Li, X., Zhang, X., Lin, S., Dou, L., Wei, L., Niu, H., Zhang, M., Tian, R., Sawyer, E., Yuan, Q., Huang, Y., Chen, P. & 9 othersZhao, C., Zhou, C., Ying, B., Shi, B., Wei, X., Jiang, R., Zhang, L., Lu, G. & Geng, JI., 2019, In : Nature Communications. 10, p. 1-11 11 p., 5083.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Nanopores
deoxyribonucleic acid
membranes
Membranes
DNA

Encapsulation of food ingredients by nanophytosomes

Babazadeh, A., Jafari, S. M. & Shi, B., 16 Aug 2019, Lipid-based nanostructures for food encapsulation purposes. Jafari, S. M. (ed.). Elsevier: Academic Press, Vol. 2. p. 405-443 39 p. (Nanoencapsulation in the Food Industry; vol. 2).

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review