Briardo is the Chief Scientist of the Australian Genome Foundry (AGF), an Associate Investigator at the Australian Research Council Centre of Excellence in Synthetic Biology (CoESB), and Group Leader and Associate Professor at Macquarie University in Sydney, Australia. Before joining the AGF and CoESB, Briardo was a CSIRO Synthetic Biology Future Science Fellow. He also served as a Marie Curie Fellow and a Juan de la Cierva Fellow at Barcelona's CRAG and worked as a visiting researcher at the University of Aarhus in Denmark and the Salk Institute in California. Briardo completed his PhD at the INGEBI and the University of Buenos Aires, Argentina.

Briardo is interested in tackling major challenges through synthetic biology while pushing the boundaries of genomic, metabolic, and intercellular engineering. His team engages in diverse research areas, ranging from re-engineering symbiosis and genomes to enhancing biomanufacturing and developing improved crops and medicines.