Cara Hildreth

Dr

  • 289 Citations
  • 12 h-Index
20082019
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Research Outputs 2008 2019

2019

Increased excitatory regulation of the hypothalamic paraventricular nucleus and circulating vasopressin results in the hypertension observed in polycystic kidney disease

Underwood, C. F., Boyd, R., Phillips, J. K. & Hildreth, C. M., 1 Jan 2019, In : Journal of Hypertension. 37, 1, p. 109-115 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Polycystic Kidney Diseases
Paraventricular Hypothalamic Nucleus
Vasopressins
Hypertension
Baroreflex
Deglutition
Central Pattern Generators
Neurons
Personnel Selection
Swallows

Respiratory sympathetic modulation is augmented in chronic kidney disease

Saha, M., Menuet, C., Sun, Q. J., Burke, P. G. R., Hildreth, C. M., Allen, A. M. & Phillips, J. K., 1 Apr 2019, In : Respiratory Physiology and Neurobiology. 262, p. 57-66 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Polycystic Kidney Diseases
Chronic Renal Insufficiency
Hypercapnia
Area Under Curve
Splanchnic Nerves

The subfornical organ drives hypertension in polycystic kidney disease via the hypothalamic paraventricular nucleus

Underwood, C., McMullan, S., Phillips, J. K. & Hildreth, C., 15 Nov 2019, p. 18. 1 p.

Research output: Contribution to conferenceAbstractResearchpeer-review

Subfornical Organ
Polycystic Kidney Diseases
Paraventricular Hypothalamic Nucleus
Hypertension
Prosencephalon
2018

Effect of anaesthetic and choice of neuromuscular blocker on vagal control of heart rate under laboratory animal experimental conditions

Kandukuri, D. S., Phillips, J. K., Tahmindjis, M. & Hildreth, C. M., Jun 2018, In : Laboratory Animals. 52, 3, p. 280-291 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Neuromuscular Blocking Agents
Laboratory Animals
anesthetics
laboratory animals
Anesthetics

Osmoregulation in polycystic kidney disease: relationship with cystogenesis and hypertension

Underwood, C. F., Phillips, J. K. & Hildreth, C. M., 1 Jun 2018, In : Annals of Nutrition and Metabolism. 72, suppl 2, p. 33-38 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Osmoregulation
Polycystic Kidney Diseases
Vasopressins
Hypertension
Dehydration
2017
Polycystic Kidney Diseases
Carotid Sinus
Denervation
Chronic Renal Insufficiency
Animal Models

Chronic kidney disease impairs renal nerve and haemodynamic reflex responses to vagal afferent input through a central mechanism

Salman, I. M., Hildreth, C. M. & Phillips, J. K., May 2017, In : Autonomic Neuroscience: Basic and Clinical. 204, p. 65-73 9 p.

Research output: Contribution to journalReview articleResearchpeer-review

Polycystic Kidney Diseases
Chronic Renal Insufficiency
Reflex
Hemodynamics
Kidney

Increased arterial stiffness does not respond to renal denervation in an animal model of secondary hypertension

Yao, Y., Hildreth, C. M., Li, S., Boyd, R., Kouchaki, Z., Butlin, M., Avolio, A. P., Pilowsky, P. M. & Phillips, J. K., 13 Sep 2017, 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) 2017 : proceedings: Smarter Technology for a Healthier World. Institute of Electrical and Electronics Engineers (IEEE), p. 258-261 4 p. 8036811

Research output: Chapter in Book/Report/Conference proceedingConference proceeding contributionResearchpeer-review

Vascular Stiffness
Denervation
Animals
Animal Models
Blood pressure

The predictive utility of heart rate variability in chronic kidney disease: a marker of patient outcomes

Hildreth, C. M., Goodchild, A. K., Kandukuri, D. S. & Phillips, J. K., 1 Jan 2017, ECG time series variability analysis: engineering and medicine. Jelinek, H. F., Cornforth, D. J. & Khandoker, A. H. (eds.). CRC Press, Taylor & Francis Group, p. 417-437 21 p.

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review

Heart Rate Variability
Kidney
Chronic Renal Insufficiency
Heart Rate
Likely

Uraemia: an unrecognized driver of central neurohumoral dysfunction in chronic kidney disease?

Underwood, C. F., Hildreth, C. M., Wyse, B. F., Boyd, R., Goodchild, A. K. & Phillips, J. K., Jan 2017, In : Acta Physiologica. 219, 1, p. 305-323 19 p.

Research output: Contribution to journalReview articleResearchpeer-review

Uremia
Chronic Renal Insufficiency
Superoxides
Baroreflex
Vasopressins
2016

Inhibition of central respiratory drive attenuates baroreflex dysfunction in Lewis polycystic kidney rats - a genetic model of CKD

Saha, M., Sun, Q., Hildreth, C. & Phillips, J., Sep 2016, In : Nephrology. 21, Supplement S2, p. 101-102 2 p.

Research output: Contribution to journalMeeting abstractResearchpeer-review

Tonically active cAMP-dependent signaling in the ventrolateral medulla regulates sympathetic and cardiac vagal outflows

Tallapragada, V. J., Hildreth, C. M., Burke, P. G. R., Raley, D. A., Hassan, S. F., McMullan, S. & Goodchild, A. K., 1 Feb 2016, In : Journal of Pharmacology and Experimental Therapeutics. 356, 2, p. 424-433 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Cyclic AMP
Splanchnic Nerves
Cyclic AMP-Dependent Protein Kinases
Heart Rate
Baroreflex
2015

Abnormal central control underlies impaired baroreflex control of heart rate and sympathetic nerve activity in female Lewis polycystic kidney rats

Salman, I. M., Phillips, J. K., Ameer, O. Z. & Hildreth, C. M., Jul 2015, In : Journal of Hypertension. 33, 7, p. 1418-1428 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Polycystic Kidney Diseases
Baroreflex
Heart Rate
Reflex
Vagus Nerve Stimulation

Direct conscious telemetry recordings demonstrate increased renal sympathetic nerve activity in rats with chronic kidney disease

Salman, I. M., Kandukuri, D. S., Harrison, J. L., Hildreth, C. M. & Phillips, J. K., 2015, In : Frontiers in Physiology. 6, p. 1-10 10 p., 218.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Telemetry
Chronic Renal Insufficiency
Kidney
Arterial Pressure
Polycystic Kidney Diseases

The effect of losartan on differential reflex control of sympathetic nerve activity in chronic kidney disease

Yao, Y., Hildreth, C. M., Farnham, M. M., Saha, M., Sun, Q. J., Pilowsky, P. M. & Phillips, J. K., 6 Jun 2015, In : Journal of Hypertension. 33, 6, p. 1249-1260 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Polycystic Kidney Diseases
Losartan
Chronic Renal Insufficiency
Reflex
Viscera
2014

Differential contribution of afferent and central pathways to the development of baroreflex dysfunction in chronic kidney disease

Salman, I. M., Hildreth, C. M., Ameer, O. Z. & Phillips, J. K., 2014, In : Hypertension. 63, 4, p. 804-810 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Afferent Pathways
Baroreflex
Polycystic Kidney Diseases
Chronic Renal Insufficiency
Kidney

Losartan normalizes peripheral chemoreflex control of sympathetic nerve activity in chronic kidney disease

Yao, Y., Hildreth, C. M., Farnham, M. M. & Phillips, J., Jun 2014, In : Hypertension. 63, 6, p. E157-E157 1 p., H-073.

Research output: Contribution to journalMeeting abstractResearch

Sympathetic overactivity prevails over the vascular amplifier phenomena in a chronic kidney disease rat model of hypertension

Ameer, O. Z., Hildreth, C. M. & Phillips, J. K., 2014, In : Physiological Reports. 2, 11, p. 1-11 11 p., e12205.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Polycystic Kidney Diseases
Hexamethonium
Chronic Renal Insufficiency
Blood Vessels
Inbred SHR Rats
2013

Insight into autonomic nervous system control of heart rate in the rat using analysis of heart rate variability and baroreflex sensitivity

Hildreth, C. M., Goodchild, A. K. & Phillips, J. K., 2013, Stimulation and Inhibition of Neurons. Pilowsky, P. M., Farnham, M. M. J. & Fong, A. Y. (eds.). New York: Humana Press, p. 203-223 21 p. (Neuromethods; vol. 78).

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review

Baroreflex
Autonomic Nervous System
Neurology
Rats
Heart Rate

Temporal development of baroreceptor dysfunction in a rodent model of chronic kidney disease

Hildreth, C. M., Kandukuri, D. S., Goodchild, A. K. & Phillips, J. K., Jul 2013, In : Clinical and Experimental Pharmacology and Physiology. 40, 7, p. 458-465 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Pressoreceptors
Chronic Renal Insufficiency
Baroreflex
Rodentia
Blood Pressure

The influence of long term voluntary exercise on cardiac autonomic function in conscious chronic kidney disease animals

Kandukuri, D. S., Hildreth, C. M., Goodchild, A. K., Nalivaiko, E. & Phillips, J. K., Sep 2013, In : Hypertension. 62, Supplement 1, p. 1-1 1 p., A497.

Research output: Contribution to journalMeeting abstractResearch

2012

Baroreflex control of the renal sympathetic nerve in autosomal recessive cystic kidney disease

Salman, I. M., Hildreth, C. M. & Phillips, J., Aug 2012, In : Hypertension. 60, 2, p. 494-494 1 p., 30.

Research output: Contribution to journalMeeting abstractResearch

Cardiac autonomic dysfunction in chronic kidney disease

Kandukuri, D. S., Hildreth, C. M. & Phillips, J. K., 1 Sep 2012, In : Journal of Hypertension. 30, e-Supplement 1, p. e82 1 p.

Research output: Contribution to journalMeeting abstractResearchpeer-review

Chronic Renal Insufficiency
Polycystic Kidney Diseases
Heart Rate
Atenolol
Arterial Pressure

Cross comparison of heart rate variability and baroreflex sensitivity in rodent models of disease

Hildreth, C. M., Goodchild, A. K. & Phillips, J. K., Aug 2012, In : Hypertension. 60, 2, p. 492-492 1 p., 20.

Research output: Contribution to journalMeeting abstractResearch

Impaired renal sympathoinhibitory responses to vagal afferent stimulation in chronic kidney disease

Salman, I. M., Hildreth, C. & Phillips, J. K., 1 Sep 2012, In : Journal of Hypertension. 30, e-Supplement 1, p. e86-e87 2 p.

Research output: Contribution to journalMeeting abstractResearchpeer-review

Polycystic Kidney Diseases
Chronic Renal Insufficiency
Kidney
Heart Rate
Arterial Pressure

Influences of neuromuscular blockers on vagal control of heart rate

Kandukuri, D. S., Hildreth, C. M., Tahmindjis, M. A. & Phillips, J., Aug 2012, In : Hypertension. 60, 2, p. 493-493 1 p., 26.

Research output: Contribution to journalMeeting abstractResearch

Prognostic indicators of cardiovascular risk in renal disease

Hildreth, C. M., 2012, In : Frontiers in Physiology. 2, p. 1-6 6 p., Article 121.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Chronic Kidney Failure
Kidney
Pressoreceptors
Baroreflex
Heart Rate

Regional biomechanical properties of the aorta in polycystic kidney disease rats

Ameer, O. Z., Hildreth, C. M., Butlin, M., Avolio, A. P. & Phillips, J., Aug 2012, In : Hypertension. 60, 2, p. 501-501 1 p., 64.

Research output: Contribution to journalMeeting abstractResearch

2011
Cystic Kidney Diseases
Polycystic Kidney Diseases
Pulse Wave Analysis
Perindopril
Angiotensin-Converting Enzyme Inhibitors

Aortic stiffness is associated with vascular calcification and remodeling in a chronic kidney disease rat model

Ng, K., Hildreth, C. M., Phillips, J. K. & Avolio, A. P., Jun 2011, In : American Journal of Physiology - Renal Physiology. 300, 6, p. F1431-F1436 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Vascular Calcification
Polycystic Kidney Diseases
Pulse Wave Analysis
Vascular Stiffness
Chronic Renal Insufficiency

Chronic perindopril treatment decreases aortic stiffness and calcification in autosomal recessive polycystic kidney disease rats

Ng, K., Hildreth, C., Phillips, J. & Avolio, A., Jun 2011, In : Journal of Hypertension. 29, e-supplement A, p. e352 1 p., PP.22.201.

Research output: Contribution to journalMeeting abstractResearchpeer-review

Isobaric aortic pulse wave velocity is increased in a novel rodent model of autosomal recessive polycystic kidney disease

Ng, K., Hildreth, C., Phillips, J. K. & Avolio, A., Jul 2011, In : Hypertension. 58, 1, p. 116-116 1 p., 9.

Research output: Contribution to journalMeeting abstractResearchpeer-review

2010

Cardiovascular autonomic dysfunction in a novel rodent model of polycystic kidney disease

Harrison, J. L., Hildreth, C. M., Callahan, S. M., Goodchild, A. K. & Phillips, J. K., 15 Jan 2010, In : Autonomic Neuroscience: Basic and Clinical. 152, 1-2, p. 60-66 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Polycystic Kidney Diseases
Baroreflex
Rodentia
Hypertension
Blood Pressure

Role of ionotropic GABA, glutamate and glycine receptors in the tonic and reflex control of cardiac vagal outflow in the rat

Hildreth, C. M. & Goodchild, A. K., Oct 2010, In : BMC Neuroscience. 11, p. 1-11 11 p., 128.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Glycine Receptors
Ionotropic Glutamate Receptors
GABA Receptors
Bradycardia
Reflex
2009

G alpha i/o proteins in the rostral ventrolateral medulla in hypertension

Hildreth, C. M., Hassan, S. & Goodchild, A. K., Jun 2009, In : Hypertension. 53, 6, p. 1108-1108 1 p., 048.

Research output: Contribution to journalMeeting abstractResearch

Neurochemical organisation of tonic and reflex cardiac vagal outflow in the rat

Hildreth, C. & Goodchild, A., 12 Aug 2009, In : Autonomic Neuroscience: Basic and Clinical. 149, 1, p. 113

Research output: Contribution to journalMeeting abstractResearchpeer-review

Role of G alpha i/s/AC/cAMP signaling in the rostral ventrolateral medulla (RVLM) in normotension and hypertension

Goodchild, A. K., Hildreth, C. M., Tallapragada, V. J. & Hassan, S. F., Apr 2009, In : FASEB Journal. 23, 1 p.

Research output: Contribution to journalMeeting abstractResearchpeer-review

Role of Gαi/s/AC/cAMP signaling in the rostral ventrolateral medulla (RVLM) in normotension and hypertension

Goodchild, A., Hildreth, C., Tallapragada, V. & Hassan, S., 1 Apr 2009, In : FASEB Journal. 23, Suppl. 1, p. 958.7

Research output: Contribution to journalMeeting abstractResearchpeer-review

Arterial Pressure
Hypertension
Oxotremorine
8-Hydroxy-2-(di-n-propylamino)tetralin
Pertussis Toxin
2008

Control of sympathetic, respiratory and somatomotor outflow by an intraspinal pattern generator

Goodchild, A. K., Van Deurzen, B. T. M., Hildreth, C. M. & Pilowsky, P. M., Apr 2008, In : Clinical and Experimental Pharmacology and Physiology. 35, 4, p. 447-453 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Bicuculline
GABA-A Receptors
Phrenic Nerve
Diaphragm
Spinal Cord

Impaired serotonergic regulation of heart rate may underlie reduced baroreflex sensitivity in an animal model of depression

Hildreth, C. M., Padley, J. R., Pilowsky, P. M. & Goodchild, A. K., 1 Jan 2008, In : American Journal of Physiology - Heart and Circulatory Physiology. 294, 1, p. H474-H480 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Baroreflex
Animal Models
Heart Rate
Depression
Reflex

Metabotropic neurotransmission and integration of sympathetic nerve activity by the rostral ventrolateral medulla in the rat

Pilowsky, P. M., Abbott, S. B., Burke, P. G. R., Farnham, M. M. J., Hildreth, C. M., Kumar, N. N., Li, Q., Lonergan, T., McMullan, S., Spirovski, D. & Goodchild, A. K., Apr 2008, In : Clinical and Experimental Pharmacology and Physiology. 35, 4, p. 508-511 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Motor Neurons
Synaptic Transmission
Neurotransmitter Agents
Reflex
Medulla Oblongata