Projects per year
Personal profile
Biography
My Education and work experience reflect two of my main passions in life, Science and the Environment. I have written over 30 Publications on these topics and have presented my work both nationally and internationally as both posters and oral presentations. I obtained my PhD in Neuroscience in December 2014 from the University of Calgary's faculty of Medicine.
The focus of my thesis was pain, epilepsy and ion channel physiology, with a view to understanding the interactions between drugs and ion channels so that cures and better therapies can be developed for the numerous diseases associated with ion channels (Channelopathies).
My skills include; extensive experience in Electrophysiology, Molecular biology and Biochemistry, obtained during the many years I have spent in both Academia and Industry.
My new position at Macquarie University will build on this expertise by studying Drug/Ion Channel physiology, with an emphasis on developing novel Cannabinoid-based therapies that will regulate abnormal ion channel activity associated with epilepsy, pain and other diseases. 250,000 Australians currently live with epilepsy, and chronic pain costs Australian healthcare more than cancer, heart disease and HIV combined. Drugs that target ion channels is a multibillion-dollar industry due to their effectiveness in treating diseases. This project aims to identify selective and potent cannabinoids and define their mode of action on ion channels by electrophysiology and molecular biology approaches.
My other passion is for Ecology and Environmental and Health Management. I recently graduated from the U of Calgary environmental management certification program which complimented my undergraduate background from Wales in Ecology. I used both my scientific and environmental background to help tackle some of the major environmental problems associated with Northern Alberta’s Oilsands mining industry, in particular, cleaning-up the vast tailings ponds created by this industry.
Education/Academic qualification
Environmental management, Certified, Enironmental Management Consultant, University of Calgary
3 Jan 2015 → 1 Jun 2017
Award Date: 6 Apr 2017
Neuroscience, PhD, “Developing T-type calcium channel blockers as potential therapies for pain”., University of Calgary
1 May 2010 → 8 Dec 2014
Award Date: 8 Dec 2014
Freshwater ecology, B.Sc., University of Wales
7 Sept 1987 → 26 Jun 1990
Award Date: 26 Jun 1992
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Collaborations and top research areas from the last five years
Projects
- 1 Finished
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Developing next-generation pain therapies based on Cannabinoid derivatives
15/05/18 → 15/05/19
Project: Research
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Functional profile of synthetic cannabinoid receptor agonists: exploring cannabinoid and noncannabinoid targets
Sachdev, S., Santiago, M. & Bladen, C., 1 Jan 2023, Cannabis use, neurobiology, psychology, and treatment. Martin, C. R., Patel, V. B. & Preedy, V. R. (eds.). United Kingdom: Elsevier, p. 383-393 11 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
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MEPIRAPIM-derived synthetic cannabinoids inhibit T-type calcium channels with divergent effects on seizures in rodent models of epilepsy
Harman, T., Udoh, M., McElroy, D. L., Anderson, L. L., Kevin, R. C., Banister, S. D., Ametovski, A., Markham, J., Bladen, C., Doohan, P. T., Greba, Q., Laprairie, R. B., Snutch, T. P., McGregor, I. S., Howland, J. G. & Arnold, J. C., 4 Apr 2023, In: Frontiers in Physiology. 14, p. 1-15 15 p., 1086243.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)56 Downloads (Pure) -
A synthetically accessible small-molecule inhibitor of USP5-Cav3.2 calcium channel interactions with analgesic properties
Garcia-Caballero, A., Gadotti, V. M., Ali, M. Y., Bladen, C., Gambeta, E., Van Humbeck, J. F., Maccallum, J. L. & Zamponi, G. W., 3 Feb 2022, In: ACS Chemical Neuroscience. 13, 4, p. 524-536 13 p.Research output: Contribution to journal › Article › peer-review
16 Citations (Scopus) -
Inhibition of human recombinant T-type calcium channels by phytocannabinoids in vitro
Mirlohi, S., Bladen, C., Santiago, M. J., McGregor, I. S., Arnold, J. C. & Connor, M., Aug 2022, In: British Journal of Pharmacology. 179, 15, p. 4031-4043 13 p., 15842.Research output: Contribution to journal › Article › peer-review
Open AccessFile15 Citations (Scopus)142 Downloads (Pure) -
Modulation of recombinant human T-type calcium channels by Δ9-tetrahydrocannabinolic acid in vitro
Mirlohi, S., Bladen, C., Santiago, M. & Connor, M., Feb 2022, In: Cannabis and Cannabinoid Research. 7, 1, p. 34-45 12 p.Research output: Contribution to journal › Article › peer-review
Open Access8 Citations (Scopus)
Activities
- 1 Membership of committee
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Faculty of Medicine, Health and Human Sciences (Organisational unit)
Mitchell Sarkies (Member), Fiona Bright (Member), Katie De Luca (Member), Emre Ilhan (Member), Amy Nguyen (Member), Elizabeth Austin (Member), Ann Carrigan (Member), Karla Seaman (Member), Chris Bladen (Member), Annika van Hummel (Member), Jannah Baker (Member), Robert Ross (Member), Sian Genoud (Member), Emily Don (Chair), Nitin Chitranshi (Member), Rae-Anne Hardie (Chair), Rimante Ronto (Member), Gemma Sicouri (Member), Kelly Williams (Member), Syeda Somyyah Owais (Member), Anna Guller (Member), Robert Newport (Member), Marina Junqueira Santiago (Member), Philippe Gilchrist (Member), Jessamine Chen (Member), Ella Oar (Member), Alison Hogan (Member), Jodie Wills (Member), Kathleen Yin (Member), Gillian Hulst (Member), Benjamin Brown (Member), Loes Koring (Member), Stephney Whillier (Member), Milena Gandy (Member), Carly Johnco (Member), Lauren McLellan (Member) & Michael Swain (Member)
2020 → …Activity: Membership › Membership of committee