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Research Outputs 1990 2018

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Article
2018

A common periodic representation of interaural time differences in mammalian cortex

Salminen, N. H., Jones, S. J., Christianson, G. B., Marquardt, T. & McAlpine, D., 15 Feb 2018, In : NeuroImage. 167, p. 95-103 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Hearing
Mammals
Auditory Cortex
Aptitude
Cues

Hidden hearing loss selectively impairs neural adaptation to loud sound environments

Bakay, W. M. H., Anderson, L. A., Garcia-Lazaro, J. A., McAlpine, D. & Schaette, R., 16 Oct 2018, In : Nature Communications. 9, 1, p. 1-11 11 p., 4298.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
auditory defects
Audition
Hearing Loss
Acoustic waves
Noise

Increased spontaneous firing rates in auditory midbrain following noise exposure are specifically abolished by a Kv3 channel modulator

Anderson, L. A., Hesse, L. L., Pilati, N., Bakay, W. M. H., Alvaro, G., Large, C. H., McAlpine, D., Schaette, R. & Linden, J. F., Aug 2018, In : Hearing Research. 365, p. 77-89 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Mesencephalon
Noise
Inferior Colliculi
Hyperacusis
Pathology
2017

Differences in the temporal course of interaural time difference sensitivity between acoustic and electric hearing in amplitude modulated stimuli

Hu, H., Ewert, S. D., McAlpine, D. & Dietz, M., 2017, In : Journal of the Acoustical Society of America. 141, 3, p. 1862-1873 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Acoustics
Hearing
Cochlear Implants
Cues
Electrodes

Influence of envelope waveform on ITD sensitivity of neurons in the auditory midbrain

Greenberg, D., Monaghan, J. J. M., Dietz, M., Marquardt, T. & McAlpine, D., 17 Oct 2017, In : Journal of Neurophysiology. 118, 4, p. 2358-2370 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Mesencephalon
Neurons
Cues
Electrophysiology
Urethane
2016

Meta-adaptation in the auditory midbrain under cortical influence

Robinson, B. L., Harper, N. S. & McAlpine, D., 24 Nov 2016, In : Nature Communications. 7, p. 1-8 8 p., 13442.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Mesencephalon
Neurons
Acoustic intensity
neurons
Auditory Cortex
Open Access
File
Ear
Phase Transition
Noise
Electroencephalography
Brain

Non-monotonic relation between noise exposure severity and neuronal hyperactivity in the auditory midbrain

Hesse, L. L., Bakay, W., Ong, H. C., Anderson, L., Ashmore, J., McAlpine, D., Linden, J. & Schaette, R., 8 Aug 2016, In : Frontiers in Neurology. 7, p. 1-13 13 p., 133.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Mesencephalon
Hearing Loss
Noise
Tinnitus
Cochlear Nerve

Objective measures of neural processing of interaural time differences

McAlpine, D., Haywood, N., Undurraga, J. & Marquardt, T., 2016, In : Advances in Experimental Medicine and Biology. 894, p. 197-205 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Phase modulation
Ear
Processing
Acoustic waves
Neurons

Sensitivity to Interaural Time Differences Conveyed in the Stimulus Envelope: Estimating Inputs of Binaural Neurons Through the Temporal Analysis of Spike Trains

Dietz, M., Wang, L., Greenberg, D. & McAlpine, D., 1 Aug 2016, In : JARO - Journal of the Association for Research in Otolaryngology. 17, 4, p. 313-330 18 p.

Research output: Contribution to journalArticleResearchpeer-review

Neurons
Ear
Sound Localization
Inferior Colliculi
Cochlear Implants
2015
Open Access
File

Phosphoinositide modulation of heteromeric Kv1 channels adjusts output of spiral ganglion neurons from hearing mice

Smith, K. E., Browne, L., Selwood, D. L., McAlpine, D. & Jagger, D. J., 12 Aug 2015, In : Journal of Neuroscience. 35, 32, p. 11221-11232 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Spiral Ganglion
Phosphatidylinositols
Hearing
Kv1.2 Potassium Channel
Neurons

Reducing current spread by use of a novel pulse shape for electrical stimulation of the auditory nerve

Ballestero, J., Recugnat, M., Laudanski, J., Smith, K. E., Jagger, D. J., Gnansia, D. & McAlpine, D., 30 Dec 2015, In : Trends in hearing. 19, p. 1-12 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Sensitivity to envelope interaural time differences at high modulation rates

Monaghan, J. J. M., Bleeck, S. & McAlpine, D., 2015, In : Trends in hearing. 19, p. 1-14 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2014

A model that predicts the binaural advantage to speech intelligibility from the mixed target and interferer signals

Cosentino, S., Marquardt, T., McAlpine, D., Culling, J. F. & Falk, T. H., 2014, In : Journal of the Acoustical Society of America. 135, 2, p. 796-807 12 p.

Research output: Contribution to journalArticleResearchpeer-review

intelligibility
ear
cancellation
frequency modulation
recording

"Change deafness" arising from inter-feature masking within a single auditory object

Barascud, N., Griffiths, T. D., McAlpine, D. & Chait, M., 2014, In : Journal of cognitive neuroscience. 26, 3, p. 514-528 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Magnetoencephalography
deafness
Deafness
Psychophysics
Aptitude

Cochlear implant filterbank design and optimization: A simulation study

Cosentino, S., Falk, T. H., McAlpine, D. & Marquardt, T., 2014, In : IEEE Transactions on Audio, Speech and Language Processing. 22, 2, p. 347-353 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Cochlear implants
Cochlear Implants
filters
frequency analysis
simulation

Emphasis of spatial cues in the temporal fine structure during the rising segments of amplitude-modulated sounds II: Single-neuron recordings

Dietz, M., Marquardt, T., Stange, A., Pecka, M., Grothe, B. & McAlpine, D., 2014, In : Journal of Neurophysiology. 111, 10, p. 1973-1985 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Cues
Inferior Colliculi
Neurons
Gerbillinae
Guinea Pigs

Selective adaptation to "Oddball" sounds by the human auditory system

Simpson, A. J. R., Harper, N. S., Reiss, J. D. & McAlpine, D., 2014, In : Journal of Neuroscience. 34, 5, p. 1963-1969 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Auditory Perception
Mammals
Discrimination (Psychology)

Subthreshold resonance properties contribute to the efficient coding of auditory spatial cues

Remme, M. W. H., Donato, R., Mikiel-Hunter, J., Ballestero, J. A., Foster, S., Rinzel, J. & McAlpine, D., 3 Jun 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 22, p. E2339-E2348 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Cues
Neurons
Extremities
Electric Impedance
Brain Stem

The neural code for auditory space depends on sound frequency and head size in an optimal manner

Harper, N. S., Scott, B. H., Semple, M. N. & McAlpine, D., 5 Nov 2014, In : PLoS ONE. 9, 11, p. 1-10 10 p., e108154.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Head
Acoustic waves
Cues
Dipodomys
Neurophysiology
2013

Emphasis of spatial cues in the temporal fine structure during the rising segments of amplitude-modulated sounds

Dietz, M., Marquardt, T., Salminen, N. H. & McAlpine, D., 10 Sep 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 37, p. 15151-15156 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Cues
Aptitude
Brain
Psychoacoustics
Magnetoencephalography

Evaluation of the acoustic coordinated reset (CR ®) neuromodulation therapy for tinnitus: study protocol for a double-blind randomized placebo-controlled trial

Hoare, D. J., Pierzycki, R. H., Thomas, H., McAlpine, D. & Hall, D. A., 10 Jul 2013, In : Trials. 14, p. 1-8 8 p., 207.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Tinnitus
Acoustics
Randomized Controlled Trials
Placebos
Therapeutics

Tuning of human modulation filters is carrier-frequency dependent

Simpson, A. J. R., Reiss, J. D. & McAlpine, D., 29 Aug 2013, In : PLoS ONE. 8, 8, p. 1-9 9 p., e73590.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Tuning
Modulation
Noise
Acoustic waves
methodology
2012

Adaptive coding is constrained to midline locations in a spatial listening task

Maier, J. K., Hehrmann, P., Harper, N. S., Klump, G. M., Pressnitzer, D. & McAlpine, D., 1 Oct 2012, In : Journal of Neurophysiology. 108, 7, p. 1856-1868 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Mesencephalon
Sound Localization
Acoustics
Cues
Guinea Pigs

Cortical responses to changes in acoustic regularity are differentially modulated by attentional load

Chait, M., Ruff, C. C., Griffiths, T. D. & McAlpine, D., 16 Jan 2012, In : NeuroImage. 59, 2, p. 1932-1941 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Acoustics
Auditory Cortex
Brain
2011

Tinnitus with a normal audiogram: Physiological evidence for hidden hearing loss and computational model

Schaette, R. & McAlpine, D., 21 Sep 2011, In : Journal of Neuroscience. 31, 38, p. 13452-13457 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Tinnitus
Hearing Loss
Cochlea
Cochlear Nerve
Brain Stem Auditory Evoked Potentials
2010

Context effects in the discriminability of spatial cues

Maier, J. K., McAlpine, D., Klump, G. M. & Pressnitzer, D., Jun 2010, In : JARO - Journal of the Association for Research in Otolaryngology. 11, 2, p. 319-328 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Cues
Aptitude
Noise
2009

Masking with interaurally "double-delayed" stimuli: The range of internal delays in the human brain

Marquardt, T. & McAlpine, D., 2009, In : Journal of the Acoustical Society of America. 126, 6, p. EL177-EL182 6 p.

Research output: Contribution to journalArticleResearchpeer-review

masking
stimuli
mammals
brain
bandwidth

The synaptic representation of sound source location in auditory cortex

Chadderton, P., Agapiou, J. P., McAlpine, D. & Margrie, T. W., 11 Nov 2009, In : Journal of Neuroscience. 29, 45, p. 14127-14135 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Auditory Cortex
Excitatory Postsynaptic Potentials
Pyramidal Cells
Acoustic Stimulation
Patch-Clamp Techniques
2008

Low-frequency envelope sensitivity produces asymmetric binaural tuning curves

Agapiou, J. P. & McAlpine, D., Oct 2008, In : Journal of Neurophysiology. 100, 4, p. 2381-2396 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Inferior Colliculi
Mesencephalon
Neurons
Cues
Space Perception

Rapid neural adaptation to sound level statistics

Dean, I., Robinson, B. L., Harper, N. S. & McAlpine, D., 18 Jun 2008, In : Journal of Neuroscience. 28, 25, p. 6430-6438 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Neurons
Mesencephalon
Population

Responses to interaural time delay in human cortex

Von Kriegstein, K., Griffiths, T. D., Thompson, S. K. & McAlpine, D., Nov 2008, In : Journal of Neurophysiology. 100, 5, p. 2712-2718 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Brain
Ear
Inferior Colliculi
Human Activities
Neuroimaging
2006

Representation of interaural time delay in the human auditory midbrain

Thompson, S. K., Von Kriegstein, K., Deane-Pratt, A., Marquardt, T., Deichmann, R., Griffiths, T. D. & McAlpine, D., Sep 2006, In : Nature Neuroscience. 9, 9, p. 1096-1098 3 p.

Research output: Contribution to journalArticleResearchpeer-review

Mesencephalon
Sound Localization
Cues
Ear
Magnetic Resonance Imaging
2005

Creating a sense of auditory space

McAlpine, D., 1 Jul 2005, In : Journal of Physiology. 566, 1, p. 21-28 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Ear
Strigiformes
Mammals
Neurons
Hearing

GABAergic inhibition controls neural gain in inferior colliculus neurons sensitive to interaural time differences

Ingham, N. J. & McAlpine, D., 29 Jun 2005, In : Journal of Neuroscience. 25, 26, p. 6187-6198 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Neural Inhibition
Inferior Colliculi
Neurons
gamma-Aminobutyric Acid
GABA Antagonists

Neural population coding of sound level adapts to stimulus statistics

Dean, I., Harper, N. S. & McAlpine, D., Dec 2005, In : Nature Neuroscience. 8, 12, p. 1684-1689 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Population
Neurons
Hearing
Social Adjustment
Mesencephalon

Neural sensitivity to interaural envelope delays in the inferior colliculus of the guinea pig

Griffin, S. J., Bernstein, L. R., Ingham, N. J. & McAlpine, D., Jun 2005, In : Journal of Neurophysiology. 93, 6, p. 3463-3478 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Inferior Colliculi
Guinea Pigs
Cochlear Nerve
Nerve Fibers
Sound Localization
2004

Neural sensitivity to periodicity in the inferior colliculus: Evidence for the role of cochlear distortions

McAlpine, D., Sep 2004, In : Journal of Neurophysiology. 92, 3, p. 1295-1311 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Inferior Colliculi
Cochlea
Periodicity
Ear
Basilar Membrane

Optimal neural population coding of an auditory spatial cue

Harper, N. S. & McAlpine, D., 5 Aug 2004, In : Nature. 430, 7000, p. 682-686 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Cues
Head
Population
Ear
Strigiformes

Spike-Frequency Adaptation in the Inferior Colliculus

Ingham, N. J. & McAlpine, D., Feb 2004, In : Journal of Neurophysiology. 91, 2, p. 632-645 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Inferior Colliculi
Neurons
Urethane
Guinea Pigs
2002

Blocking GABAergic inhibition increases sensitivity to sound motion cues in the inferior colliculus

McAlpine, D. & Palmer, A. R., 15 Feb 2002, In : Journal of Neuroscience. 22, 4, p. 1443-1453 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Inferior Colliculi
Cues
Bicuculline
Neurons
gamma-Aminobutyric Acid

Neural mechanisms of binaural hearing

Palmer, A. R., Shackleton, T. M. & McAlpine, D., Mar 2002, In : Acoustical Science and Technology. 23, 2, p. 61-68 8 p.

Research output: Contribution to journalArticleResearchpeer-review

binaural hearing
ear
cues
neurons
acoustics

Precise inhibition is essential for microsecond interaural time difference coding

Brand, A., Behrend, O., Marquardt, T., McAlpine, D. & Grothe, B., 2002, In : Nature. 417, 6888, p. 543-547 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Glycine
Neurons
Ear
Iontophoresis
Strychnine
2001

A neural code for low-frequency sound localization in mammals

McAlpine, D., Jiang, D. & Palmer, A. R., 2001, In : Nature Neuroscience. 4, 4, p. 396-401 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Sound Localization
Mammals
Neurons
Inferior Colliculi
Mesencephalon

Spatial receptive fields of inferior colliculus neurons to auditory apparent motion in free field

Ingham, N. J., Hart, H. C. & McAlpine, D., 2001, In : Journal of Neurophysiology. 85, 1, p. 23-33 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Inferior Colliculi
Neurons
Direction compound
Cues
2000

Modelling convergent input onto interaural-delay-sensitive inferior colliculus neurones

Shackleton, T. M., McAlpine, D. & Palmer, A. R., 2000, In : Hearing Research. 149, 1-2, p. 199-215 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Inferior Colliculi
Neurons
Cochlear Nerve
Synaptic Potentials
Basilar Membrane

Neural responses in the inferior colliculus to binaural masking level differences created by inverting the noise in one ear

Palmer, A. R., Jiang, D. & McAlpine, D., 2000, In : Journal of Neurophysiology. 84, 2, p. 844-852 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Inferior Colliculi
Ear
Noise
Neurons
Guinea Pigs

Responses of neurons in the inferior colliculus to dynamic interaural phase cues: Evidence for a mechanism of binaural adaptation

McAlpine, D., Jiang, D., Shackleton, T. M. & Palmer, A. R., 2000, In : Journal of Neurophysiology. 83, 3, p. 1356-1365 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Inferior Colliculi
Cues
Neurons
History
Urethane
1999

Desynchronizing responses to correlated noise: A mechanism for binaural masking level differences at the inferior colliculus

Palmer, A. R., Jiang, D. & Mcalpine, D., 1999, In : Journal of Neurophysiology. 81, 2, p. 722-734 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Inferior Colliculi
Noise
Neurons