Personal profile
Biography
Dr Dean Southwood is a Postdoctoral Research Fellow in the Genomics and Bioinformatics Team within the Centre for Motor Neuron Disease Research at Macquarie University. He completed his PhD in 2020 at Macquarie University, with a focus on developing and applying high performance computing pipelines to genomic analysis, in particular reconstructing genomes of other animals. Following his PhD, he applied his work in DNA sequencing analysis to studying neurodegenerative diseases, in particular Frontotemporal Dementia (FTD) and Parkinson's Disease (PD). Using novel biomarkers such as cell-free DNA, and cutting-edge methods such as spatial transcriptomics, his research has been driven by trying to better understand the causes of these diseases, why patient outcomes differ even given the same diagnosis, and how to better detect these diseases earlier and with less invasive methods.
Research interests
Since joining the Centre in 2023, Dr Southwood's current research has focussed on understanding the genetic basis of Motor Neuron Disease (MND), including using high-throughput data analysis and high performance computing methods to better utilise large genomic datasets in the search for novel gene mutations and candidate genes for screening.
Teaching
- BMOL2201 - Biochemistry and Cell Biology
- CHEM1001/02 - Foundations of Chemical and Biomolecular Sciences 1 & 2
- MATH1010/20 - Calculus and Linear Algebra I & II
- MATH2010 - Calculus and Linear Algebra III
- MATH2020 - Vector Calculus and Complex Analysis
- PHYS1010 - Modern Mechanics
- PHYS1020 - Electric and Magnetic Interactions
- PHYS2010 - Classical and Quantum Oscillations and Waves
Education/Academic qualification
PhD, Advanced bioinformatics approaches for hybrid de novo whole-genome assembly, Macquarie University
Award Date: 2 Jun 2021
Juris Doctor, The University of New South Wales
Award Date: 1 Sept 2020
Master of Research, Resolution-Dependent Simulation of Quantum Field Theory Using Wavelets, Macquarie University
Award Date: 28 Jun 2017
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Collaborations and top research areas from the last five years
Research Outputs
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Short tandem repeat expansions in LRP12 are absent in cohorts of familial and sporadic amyotrophic lateral sclerosis patients of European ancestry
Henden, L., Fearnley, L. G., Southwood, D., Smith, A., Rowe, D. B., Kiernan, M. C., Pamphlett, R., Bahlo, M., Blair, I. P. & Williams, K. L., Aug 2024, In: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 25, 5-6, p. 644-647 4 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Link opens in a new tab Citations (Scopus)31 Downloads (Pure) -
RNA sequencing of peripheral blood in amyotrophic lateral sclerosis reveals distinct molecular subtypes: considerations for biomarker discovery
Grima, N., Liu, S., Southwood, D., Henden, L., Smith, A., Lee, A., Rowe, D. B., D'Silva, S., Blair, I. P. & Williams, K. L., Dec 2023, In: Neuropathology and Applied Neurobiology. 49, 6, p. 1-16 16 p., e12943.Research output: Contribution to journal › Article › peer-review
Open AccessFile12 Link opens in a new tab Citations (Scopus)160 Downloads (Pure) -
Brain-derived cell-free DNA
Southwood, D., Singh, S. & Chatterton, Z., Oct 2022, In: Neural Regeneration Research. 17, 10, p. 2213-2214 2 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Link opens in a new tab Citations (Scopus)55 Downloads (Pure) -
In genes we trust: genetic privacy in the age of precision medicine
Southwood, D., 2020, Personhood in the Age of Biolegality: brave new law. de Leeuw, M. & van Wichelen, S. (eds.). Switzerland: Palgrave Macmillan, p. 167-183 17 p. (Biolegalities).Research output: Chapter in Book/Report/Conference proceeding › Conference proceeding contribution › peer-review
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Genome databases and browsers
Southwood, D. & Ranganathan, S., 2019, Encyclopedia of bioinformatics and computational biology: ABC of Bioinformatics. Ranganathan, S., Gribskov, M., Nakai, K. & Schönbach, C. (eds.). Amsterdam: Elsevier, Vol. 2. p. 251-256 6 p.Research output: Chapter in Book/Report/Conference proceeding › Entry for encyclopedia/dictionary/reference book
5 Link opens in a new tab Citations (Scopus)