Projects per year
Personal profile
Biography
Dr. Devaraj Basavarajappa is a Senior Research Fellow at the Macquarie Medical School, Faculty of Medicine, Health and Human Sciences. His research focuses on uncovering the mechanisms of neurodegeneration and neuroinflammation in optic neuropathies and trans-synaptic neurodegeneration within the brain, using a range of degenerative animal models. His primary aim is to redefine our understanding of neurodegenerative diseases affecting the retina and the visual pathway, with a focus on cellular signaling, cell death pathways, microRNAs, and neuroinflammatory processes.
He received his PhD from the Council of Scientific and Industrial Research (CSIR) laboratory in India. He brings extensive research experience in vision neuroscience, inflammation, and inflammatory resolution, gained from his work at the Dean McGee Eye Institute in the USA and the Nobel Prize-winning laboratory at the Karolinska Institute in Sweden.
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Collaborations and top research areas from the last five years
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Novel Protective Effects of Neuropeptide Y for Glaucoma Retina
Basavarajappa, D. (Primary Chief Investigator), Chitranshi, N. (Chief Investigator), Raniga, A. (Chief Investigator), Viswanathan, D. (Chief Investigator), Gupta, V. (Co-Investigator) & Graham, S. L. (Co-Investigator)
1/01/25 → 30/06/26
Project: Research
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The next generation of medicine-Gene therapy for glaucoma
Basavarajappa, D., Chitranshi, N. & Vishwanath, D.
1/01/22 → 31/12/22
Project: Research
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Retinal Changes as diagnostic marker to identify Early Alzheimer’s Disease
Gupta, V., You, Y., Schulz, A., Basavarajappa, D., Graham, S. L. & Gupta, V. B.
1/12/19 → 31/12/21
Project: Other
Research Outputs
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Glial and immune dysregulation in glaucoma independent of retinal ganglion cell loss: a human post-mortem histopathology study
Salkar, A., Palanivel, V., Basavarajappa, D., Mirzaei, M., Schulz, A., Yan, P., Gupta, V., Graham, S. & You, Y., 28 Jun 2025, In: Acta Neuropathologica Communications. 13, 1, p. 1-16 16 p., 141.Research output: Contribution to journal › Article › peer-review
Open AccessFile8 Downloads (Pure) -
Retinoid X receptor agonist 9CDHRA mitigates retinal ganglion cell apoptosis and neuroinflammation in a mouse model of glaucoma
Basavarajappa, D., Chitranshi, N., Mirshahvaladi, S. S. O., Gupta, V. B., Palanivel, V., Parrilla, G. E., Salkar, A., Mirzaei, M., Komáromy, A. M., Krezel, W., Graham, S. L. & Gupta, V., 31 Mar 2025, In: FASEB Journal. 39, 6, p. 1-18 18 p., e70465.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)23 Downloads (Pure) -
Retinoid X receptor alpha overexpression protects retinal ganglion cells and modulates inflammatory response in experimental glaucoma
Chitranshi, N., Basavarajappa, D., Palanivel, V., Parrilla, G. E., Gupta, V., Paulo, J. A., Salkar, A., Mirzaei, M., Koronyo-Hamaoui, M., Krezel, W., Graham, S. L. & Gupta, V. K., 27 Aug 2025, (E-pub ahead of print) In: Molecular Therapy.Research output: Contribution to journal › Article › peer-review
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Brain-derived neurotrophic factor Val66Met is associated with variation in cortical structure in healthy aging subjects
Shen, T., Sheriff, S., You, Y., Jiang, J., Schulz, A., Francis, H., Mirzaei, M., Saks, D., Palanivel, V., Basavarajappa, D., Chitranshi, N., Gupta, V., Wen, W., Sachdev, P. S., Jia, H., Sun, X., Graham, S. L. & Gupta, V. K., 1 Oct 2024, In: Aging and Disease. 15, 5, p. 2315-2327 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)35 Downloads (Pure) -
Elevated CD11b-positive microglia and CD3-positive cells in glaucoma: insights from post-mortem retinal analysis
Salkar, A. A., Vander Wall, R., Basavarajappa, D., Chitranshi, N., Gupta, V., You, Y. & Graham, S. L., 17 Jun 2024, In: Investigative Ophthalmology and Visual Science. 65, 7, p. 6768 1 p.Research output: Contribution to journal › Meeting abstract
File19 Downloads (Pure)