Projects per year
Dr Edwin Lim is a neuroscientist and biostatistician, graduated with a PhD in Physiology and Pharmacology (focus: neuroscience) at the University of New South Wales, and a Master of Biostatistics at University of Sydney in 2011 and 2018, respectively. He is an emerging leader in the field of targeted metabolomics (tryptophan) in neuroscience research: he held two Early Career Fellowships from Multiple Sclerosis Research Australia and Society for Mental Health Research; he leads the Translational Metabolomics Research Platform and the Analytical Lab in the Faculty of Medicine and Health Sciences, Macquarie University; is the Secretary of the Executive Committee of the International Society for Tryptophan Research (ISTRY), and Deputy Editor-in-Chief of the International Journal of Tryptophan Research.
Dr Lim has attracted ~$4.3M in research funding with over $2.2M as a chief investigator. He has over 60 peer-reviewed publications in prestigious journals such as New England Journal of Medicine, Progress in Neurobiology and Molecular Psychiatry.
Dr Lim’s research focuses on using biofluids (such as blood, urine, saliva, tears) as surrogate biomarker for neurological diseases. The aim of Dr Lim’s research is to unravel the complexity of environment-host interactions during disease progression and devise a platform for biomarker-guided precision medicine to help overcome medical conditions of a heterogeneous nature. He uses innovative approaches, combining biochemical analyses with mass spectrometry techniques and data analytics with machine learning to identify early predictors for disease prognosis.
Research student supervision
Dr Lim supervise students in PhD, and Master of Research who are interested in metabolomics, neuroinflammation, complex data analytics and biomarker discoveries. Topics include metabolomics &: modifiable lifestyle risk factors, cognitive function, microbiomes, and genomic (tryptophan-related) interactions.
Current research topics
Metabolomics of microbiota-host interaction in the gut-brain axis of neurological diseases;
Metabolomics of complex symptoms in the progression of neuroinflammatory conditions (neurodegenerative & psychiatric disorders);
Targeted Metabolome-Phenome interaction of Traditional Chinese medicine.
Biostatistics, MBiostat (Biostatistics Collaboration of Australia), University of Sydney
2015 → 2018
Physiology and Pharmacology, Ph.D, The University of New South Wales
2007 → 2010
Research Management and Commercialisation, Grad Cert, The University of New South Wales
Biochemistry and Pharmacology, BSc (Hon 1), The University of New South Wales
2003 → 2005
30/09/19 → 30/09/21
19/03/18 → 1/08/18
1/02/18 → 31/01/19
Exploring the roles of tryptophan metabolism in MS beyond neuroinflammation and neurodegeneration: a paradigm shift to neuropsychiatric symptomsTan, L., Francis, H. & Lim, C. K., 4 Jan 2021, (Accepted/In press) In : Brain, Behavior, & Immunity - Health.
Research output: Contribution to journal › ArticleOpen Access
Differential kynurenine pathway metabolism in highly metastatic aggressive breast cancer subtypes: beyond IDO1-induced immunosuppressionHeng, B., Bilgin, A. A., Lovejoy, D. B., Tan, V. X., Milioli, H. H., Gluch, L., Bustamante, S., Sabaretnam, T., Moscato, P., Lim, C. K. & Guillemin, G. J., 27 Oct 2020, In : Breast Cancer Research. 22, 1, p. 1-14 14 p., 113.
Research output: Contribution to journal › ArticleOpen AccessFile4 Downloads (Pure)
Dysregulation of kynurenine metabolism is related to proinflammatory cytokines, attention, and prefrontal cortex volume in schizophreniaKindler, J., Lim, C. K., Weickert, C. S., Boerrigter, D., Galletly, C., Liu, D., Jacobs, K. R., Balzan, R., Bruggemann, J., O’Donnell, M., Lenroot, R., Guillemin, G. J. & Weickert, T. W., Nov 2020, In : Molecular Psychiatry. 25, 11, p. 2860-2872 13 p.
Research output: Contribution to journal › ArticleOpen AccessFile28 Citations (Scopus)1 Downloads (Pure)
Electrophysiological correlates of the brain-derived neurotrophic factor (BDNF) Val66Met polymorphismRoy, N., Barry, R. J., Fernandez, F. E., Lim, C. K., Al-Dabbas, M. A., Karamacoska, D., Broyd, S. J., Solowij, N., Chiu, C. L. & Steiner, G. Z., 21 Oct 2020, In : Scientific Reports. 10, 1, p. 1-11 11 p., 17915.
Research output: Contribution to journal › ArticleOpen AccessFile2 Downloads (Pure)
Inflammation and kynurenine pathway dysregulation in post-partum women with severe and suicidal depressionAchtyes, E., Keaton, S. A., Smart, L. A., Burmeister, A. R., Heilman, P. L., Krzyzanowski, S., Nagalla, M., Guillemin, G. J., Escobar Galvis, M. L., Lim, C. K., Muzik, M., Postolache, T. T., Leach, R. & Brundin, L., 1 Jan 2020, In : Brain, Behavior, and Immunity. 83, p. 239-247 9 p.
Research output: Contribution to journal › Article
Edwin Lim (Recipient), 2017
Prize: Other distinction
Edwin Lim (Recipient), 2015
Prize: Other distinction
Edwin Lim (Recipient), 2011
Gilles Guillemin (Chair), Florian Zepf (Chair), Trevor Stone (Member), Kuniaki Saito (Member), Sophie Erhardt (Member), Edwin Lim (Member)2018 → …
Activity: Membership › Membership of committee
Gilles Guillemin (Editor in chief), Edwin Lim (Editor in chief)2015 → …
Activity: Peer-review and editorial of research outputs › Editorial work