• 1738 Citations
  • 23 h-Index

Research output per year

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Personal profile


Dr Edwin Lim is a neuroscientist and biostatistician, graduated with a PhD in Physiology and Pharmacology (focus: neuroscience) at the University of New South Wales, and a Master of Biostatistics at University of Sydney in 2011 and 2018, respectively. He is an emerging leader in the field of targeted metabolomics (tryptophan) in neuroscience research: he held two Early Career Fellowships from Multiple Sclerosis Research Australia and Society for Mental Health Research; he leads the Translational Metabolomics Research Platform and the Analytical Lab in the Faculty of Medicine and Health Sciences, Macquarie University; is an Executive Committee member of the International Society for Tryptophan Research (ISTRY), and Deputy Editor-in-Chief of the International Journal of Tryptophan Research.

Dr Lim has attracted ~$3.8M in research funding with over $1.5M as a chief investigator. He has over 59 peer-reviewed publications in prestigious journals such as New England Journal of Medicine, Progress in Neurobiology and Molecular Psychiatry.

Research interests

Dr Lim’s research focuses on using biofluids (such as blood, urine, saliva, tears) as surrogate biomarker for neurological diseases. The aim of Dr Lim’s research is to unravel the complexity of environment-host interactions during disease progression and devise a platform for biomarker-guided precision medicine to help overcome medical conditions of a heterogeneous nature. He uses innovative approaches, combining biochemical analyses with mass spectrometry techniques and data analytics with machine learning to identify early predictors for disease prognosis.

Research student supervision

Dr Lim supervise students in PhD, and Master of Research who are interested in metabolomics, neuroinflammation, complex data analytics and biomarker discoveries. Topics include metabolomics &: modifiable lifestyle risk factors, cognitive function, microbiomes, and genomic (tryptophan-related) interactions. 


Current research topics

Metabolomics of microbiota-host interaction in the gut-brain axis of neurological diseases;

Metabolomics of complex symptoms in the progression of neuroinflammatory conditions (neurodegenerative & psychiatric disorders);

Targeted Metabolome-Phenome interaction of Traditional Chinese medicine.

Education/Academic qualification

Biostatistics, MBiostat (Biostatistics Collaboration of Australia), University of Sydney


Physiology and Pharmacology, Ph.D, The University of New South Wales


Research Management and Commercialisation, Grad Cert, The University of New South Wales


Biochemistry and Pharmacology, BSc (Hon 1), The University of New South Wales


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Research Outputs

  • 1738 Citations
  • 23 h-Index
  • 44 Article
  • 7 Meeting abstract
  • 4 Review article
  • 2 Chapter

Inflammation and kynurenine pathway dysregulation in post-partum women with severe and suicidal depression

Achtyes, E., Keaton, S. A., Smart, L. A., Burmeister, A. R., Heilman, P. L., Krzyzanowski, S., Nagalla, M., Guillemin, G. J., Escobar Galvis, M. L., Lim, C. K., Muzik, M., Postolache, T. T., Leach, R. & Brundin, L., 1 Jan 2020, In : Brain, Behavior, and Immunity. 83, p. 239-247 9 p.

Research output: Contribution to journalArticle

  • 2 Citations (Scopus)

    Kynurenine pathway modulation reverses the experimental autoimmune encephalomyelitis mouse disease progression

    Sundaram, G., Lim, C. K., Brew, B. J. & Guillemin, G. J., 6 Jun 2020, In : Journal of Neuroinflammation. 17, 1, p. 1-14 14 p., 176.

    Research output: Contribution to journalArticle

    Open Access
  • A brief diet intervention can reduce symptoms of depression in young adults – A randomised controlled trial

    Francis, H. M., Stevenson, R. J., Chambers, J. R., Gupta, D., Newey, B. & Lim, C. K., 9 Oct 2019, In : PLoS ONE. 14, 10, p. 1-17 17 p., e0222768.

    Research output: Contribution to journalArticle

    Open Access
  • 1 Citation (Scopus)
    240 Downloads (Pure)
  • 14 Citations (Scopus)

    Dysregulation of kynurenine metabolism is related to proinflammatory cytokines, attention, and prefrontal cortex volume in schizophrenia

    Kindler, J., Lim, C. K., Weickert, C. S., Boerrigter, D., Galletly, C., Liu, D., Jacobs, K. R., Balzan, R., Bruggemann, J., O’Donnell, M., Lenroot, R., Guillemin, G. J. & Weickert, T. W., 3 Apr 2019, In : Molecular Psychiatry.

    Research output: Contribution to journalArticle

  • 12 Citations (Scopus)


  • Activities

    • 1 Editorial work
    • 1 Membership of committee

    International Society for Tryptophan Research (Executive Committee) (External organisation)

    Gilles Guillemin (Chair), Florian Zepf (Chair), Trevor Stone (Member), Kuniaki Saito (Member), Sophie Erhardt (Member), Edwin Lim (Member)
    2018 → …

    Activity: MembershipMembership of committee

    International Journal of Tryptophan Research (Journal)

    Gilles Guillemin (Editor in chief), Edwin Lim (Editor in chief)
    2015 → …

    Activity: Publication peer-review and editorial workEditorial work