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Personal profile

Biography

Dr Edwin Lim is a neuroscientist and biostatistician, graduated with a PhD in Physiology and Pharmacology (focus: neuroscience) at the University of New South Wales, and a Master of Biostatistics at University of Sydney in 2011 and 2018, respectively. He is an emerging leader in the field of targeted metabolomics (tryptophan) in neuroscience research: he held two Early Career Fellowships from Multiple Sclerosis Research Australia and Society for Mental Health Research; he leads the Translational Metabolomics Research Platform and the Analytical Lab in the Faculty of Medicine and Health Sciences, Macquarie University; is an Executive Committee member of the International Society for Tryptophan Research (ISTRY), and Deputy Editor-in-Chief of the International Journal of Tryptophan Research.

Dr Lim has attracted ~$3.8M in research funding with over $1.5M as a chief investigator. He has over 59 peer-reviewed publications in prestigious journals such as New England Journal of Medicine, Progress in Neurobiology and Molecular Psychiatry.

Research interests

Dr Lim’s research focuses on using biofluids (such as blood, urine, saliva, tears) as surrogate biomarker for neurological diseases. The aim of Dr Lim’s research is to unravel the complexity of environment-host interactions during disease progression and devise a platform for biomarker-guided precision medicine to help overcome medical conditions of a heterogeneous nature. He uses innovative approaches, combining biochemical analyses with mass spectrometry techniques and data analytics with machine learning to identify early predictors for disease prognosis.

Research student supervision

Dr Lim supervise students in PhD, and Master of Research who are interested in metabolomics, neuroinflammation, complex data analytics and biomarker discoveries. Topics include metabolomics &: modifiable lifestyle risk factors, cognitive function, microbiomes, and genomic (tryptophan-related) interactions. 

 

Current research topics

Metabolomics of microbiota-host interaction in the gut-brain axis of neurological diseases;

Metabolomics of complex symptoms in the progression of neuroinflammatory conditions (neurodegenerative & psychiatric disorders);

Targeted Metabolome-Phenome interaction of Traditional Chinese medicine.

Education/Academic qualification

Biostatistics, MBiostat (Biostatistics Collaboration of Australia), University of Sydney

20152018

Physiology and Pharmacology, Ph.D, The University of New South Wales

20072010

Research Management and Commercialisation, Grad Cert, The University of New South Wales

2009

Biochemistry and Pharmacology, BSc (Hon 1), The University of New South Wales

20032005

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Projects 2012 2019

Macquarie University Centre for Motor Neuron Disease Research

Blair, I., Rowe, D., Guillemin, G., Chung, R., Atkin, J., Cole, N., Laird, A., Lim, C., Williams, K., Yang, S., Morsch, M., Lee, A., Shi, B., Walker, A., Lovejoy, D., Furlong, S., Adams, L., Syal, D., Bazzi, R., Svahn, A., Parakh, S., Shahheydari, H., Konopka, A., Ragagnin, A., Mehta, P., Wright, A., Bourbon, L., Sabaretnam, M., Don, E., Hortle, E., De Luca, A., Zhang, K., Tarr, I., Galper, J., Varney, B., Chow, S. & Formella, I.

1/01/1731/12/19

Project: Research

Research Outputs 2006 2019

  • 1353 Citations
  • 22 h-Index
  • 39 Article
  • 7 Meeting abstract
  • 4 Review article
  • 2 Chapter

Correlation between plasma and CSF concentrations of kynurenine pathway metabolites in Alzheimer’s disease and relationship to amyloid-β and tau

Jacobs, K., Lim, C. K., Blennow, K., Zetterberg, H., Chatterjee, P., Martins, R. N., Brew, B., Guillemin, G. & Lovejoy, D., 1 Aug 2019, In : Neurobiology of Aging. 80, p. 11-20 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Kynurenine
Amyloid
Cerebrospinal Fluid
Alzheimer Disease
Quinolinic Acid

Dysregulation of kynurenine metabolism is related to proinflammatory cytokines, attention, and prefrontal cortex volume in schizophrenia

Kindler, J., Lim, C. K., Weickert, C. S., Boerrigter, D., Galletly, C., Liu, D., Jacobs, K. R., Balzan, R., Bruggemann, J., O’Donnell, M., Lenroot, R., Guillemin, G. J. & Weickert, T. W., 3 Apr 2019, In : Molecular Psychiatry.

Research output: Contribution to journalArticleResearchpeer-review

Kynurenine
Prefrontal Cortex
Schizophrenia
Cytokines
Messenger RNA

Kynurenine 3-monooxygenase activity in human primary neurons and effect on cellular bioenergetics identifies new neurotoxic mechanisms

Castellano-Gonzalez, G., Jacobs, K. R., Don, E., Cole, N. J., Adams, S., Lim, C. K., Lovejoy, D. B. & Guillemin, G. J., Apr 2019, In : Neurotoxicity Research. 35, 3, p. 530-541 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Kynurenine 3-Monooxygenase
Kynurenine
Human Activities
Energy Metabolism
Quinolinic Acid

Alterations in serum kynurenine pathway metabolites in individuals with high neocortical amyloid-β load: a pilot study

Chatterjee, P., Goozee, K., Lim, C. K., James, I., Shen, K., Jacobs, K. R., Sohrabi, H. R., Shah, T., Asih, P. R., Dave, P., ManYan, C., Taddei, K., Lovejoy, D. B., Chung, R., Guillemin, G. J. & Martins, R. N., 1 Dec 2018, In : Scientific Reports. 8, 1, p. 1-10 10 p., 8008.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Kynurenine
Amyloid
Serum
Alzheimer Disease
Social Adjustment

Loss of the Chr16p11.2 ASD candidate gene QPRT leads to aberrant neuronal differentiation in the SH-SY5Y neuronal cell model

Haslinger, D., Waltes, R., Yousaf, A., Lindlar, S., Schneider, I., Lim, C. K., Tsai, M. M., Garvalov, B. K., Acker-Palmer, A., Krezdorn, N., Rotter, B., Acker, T., Guillemin, G. J., Fulda, S., Freitag, C. M. & Chiocchetti, A. G., 6 Nov 2018, In : Molecular autism. 9, 1, p. 1-17 17 p., 56.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Genes
Gene Regulatory Networks
Tryptophan
Autism Spectrum Disorder
nicotinate-nucleotide diphosphorylase (carboxylating)

Prizes

science
young
programme
Biomarkers
Innovation
grant
travel
leader
Singapore
recipient
sclerosis
honors and awards
biochemical pathways

Activities 2015 2018

  • 1 Editorial work
  • 1 Membership of committee

International Society for Tryptophan Research (Executive Committee) (External organisation)

Gilles Guillemin (Chair), Florian Zepf (Chair), Trevor Stone (Member), Kuniaki Saito (Member), Sophie Erhardt (Member), Edwin Lim (Member)
2018 → …

Activity: MembershipMembership of committee

International Journal of Tryptophan Research (Journal)

Gilles Guillemin (Editor in chief), Edwin Lim (Editor in chief)
2015 → …

Activity: Publication peer-review and editorial workEditorial work