Projects per year
Personal profile
Biography
Dr Edwin Lim is a neuroscientist and biostatistician, graduated with a PhD in Physiology and Pharmacology (focus: neuroscience) at the University of New South Wales, and a Master of Biostatistics at University of Sydney in 2011 and 2018, respectively. He is an emerging leader in the field of targeted metabolomics (tryptophan) in neuroscience research: he held two Early Career Fellowships from Multiple Sclerosis Research Australia and Society for Mental Health Research; he leads the Translational Metabolomics Research Platform and the Analytical Lab in the Faculty of Medicine and Health Sciences, Macquarie University; is an Executive Committee member of the International Society for Tryptophan Research (ISTRY), and Deputy Editor-in-Chief of the International Journal of Tryptophan Research.
Dr Lim has attracted ~$3.8M in research funding with over $1.5M as a chief investigator. He has over 59 peer-reviewed publications in prestigious journals such as New England Journal of Medicine, Progress in Neurobiology and Molecular Psychiatry.
Research interests
Dr Lim’s research focuses on using biofluids (such as blood, urine, saliva, tears) as surrogate biomarker for neurological diseases. The aim of Dr Lim’s research is to unravel the complexity of environment-host interactions during disease progression and devise a platform for biomarker-guided precision medicine to help overcome medical conditions of a heterogeneous nature. He uses innovative approaches, combining biochemical analyses with mass spectrometry techniques and data analytics with machine learning to identify early predictors for disease prognosis.
Research student supervision
Dr Lim supervise students in PhD, and Master of Research who are interested in metabolomics, neuroinflammation, complex data analytics and biomarker discoveries. Topics include metabolomics &: modifiable lifestyle risk factors, cognitive function, microbiomes, and genomic (tryptophan-related) interactions.
Current research topics
Metabolomics of microbiota-host interaction in the gut-brain axis of neurological diseases;
Metabolomics of complex symptoms in the progression of neuroinflammatory conditions (neurodegenerative & psychiatric disorders);
Targeted Metabolome-Phenome interaction of Traditional Chinese medicine.
Education/Academic qualification
Biostatistics, MBiostat (Biostatistics Collaboration of Australia), University of Sydney
2015 → 2018
Physiology and Pharmacology, Ph.D, The University of New South Wales
2007 → 2010
Research Management and Commercialisation, Grad Cert, The University of New South Wales
2009
Biochemistry and Pharmacology, BSc (Hon 1), The University of New South Wales
2003 → 2005
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Projects
Disease susceptibility, precision medicine and ALS
Atkin, J., Blair, I., Rowe, D. & Lim, E.
30/09/19 → 30/09/21
Project: Other
Advanced protein quantification capability
Walker, A. K., Lee, A., Connor, M., Atkin, J., Lim, E., Baker, M. S., Rizos, H., Phillips, J. K., Yang, S. & Blair, I.
1/01/17 → …
Project: Research
YSEP-NSI: Australia China Young Scientist Exchange Program - Next Step Initiative - Lim
19/03/18 → 1/08/18
Project: Other
Investigating cyanobacteria toxin as a causative environmental factor in pathogenesis of ALS
Lim, E., Tan, V., Guillemin, G., Peyrin, J. M. & SH Tan, P.
1/02/18 → 31/01/19
Project: Other
New directions for early diagnosis of MND: a large-scale longitudinal analysis of multiple biomarkers to find diagnostic and prognostic "fingerprints"
Guillemin, G., Rowe, D., Blair, I., Atkin, J., Zetterberg, H., Rogers, M., Lovejoy, D., Lim, E. & Tan, V.
1/01/18 → 31/12/18
Project: Research
Research Outputs
Inflammation and kynurenine pathway dysregulation in post-partum women with severe and suicidal depression
Achtyes, E., Keaton, S. A., Smart, L. A., Burmeister, A. R., Heilman, P. L., Krzyzanowski, S., Nagalla, M., Guillemin, G. J., Escobar Galvis, M. L., Lim, C. K., Muzik, M., Postolache, T. T., Leach, R. & Brundin, L., 1 Jan 2020, In : Brain, Behavior, and Immunity. 83, p. 239-247 9 p.Research output: Contribution to journal › Article
2
Citations
(Scopus)
Kynurenine pathway modulation reverses the experimental autoimmune encephalomyelitis mouse disease progression
Sundaram, G., Lim, C. K., Brew, B. J. & Guillemin, G. J., 6 Jun 2020, In : Journal of Neuroinflammation. 17, 1, p. 1-14 14 p., 176.Research output: Contribution to journal › Article
Open Access
File
A brief diet intervention can reduce symptoms of depression in young adults – A randomised controlled trial
Francis, H. M., Stevenson, R. J., Chambers, J. R., Gupta, D., Newey, B. & Lim, C. K., 9 Oct 2019, In : PLoS ONE. 14, 10, p. 1-17 17 p., e0222768.Research output: Contribution to journal › Article
Open Access
File
1
Citation
(Scopus)
240
Downloads
(Pure)
Correlation between plasma and CSF concentrations of kynurenine pathway metabolites in Alzheimer’s disease and relationship to amyloid-β and tau
Jacobs, K., Lim, C. K., Blennow, K., Zetterberg, H., Chatterjee, P., Martins, R. N., Brew, B., Guillemin, G. & Lovejoy, D., 1 Aug 2019, In : Neurobiology of Aging. 80, p. 11-20 10 p.Research output: Contribution to journal › Article
14
Citations
(Scopus)
Dysregulation of kynurenine metabolism is related to proinflammatory cytokines, attention, and prefrontal cortex volume in schizophrenia
Kindler, J., Lim, C. K., Weickert, C. S., Boerrigter, D., Galletly, C., Liu, D., Jacobs, K. R., Balzan, R., Bruggemann, J., O’Donnell, M., Lenroot, R., Guillemin, G. J. & Weickert, T. W., 3 Apr 2019, In : Molecular Psychiatry.Research output: Contribution to journal › Article
12
Citations
(Scopus)
Prizes
Eureka Prize J&J Innovation in Medical Research (Finalist)
Edwin Lim (Recipient), 2017
Prize: Other distinction
Macquarie University ECR of the Year Awards (Highly Commended Finalist)
Edwin Lim (Recipient), 2015
Prize: Other distinction
Multiple Sclerosis Research Australia Postdoctoral Research Fellowship
Edwin Lim (Recipient), 2011
Prize
Activities
International Society for Tryptophan Research (Executive Committee) (External organisation)
Gilles Guillemin (Chair), Florian Zepf (Chair), Trevor Stone (Member), Kuniaki Saito (Member), Sophie Erhardt (Member), Edwin Lim (Member)2018 → …
Activity: Membership › Membership of committee
International Journal of Tryptophan Research (Journal)
Gilles Guillemin (Editor in chief), Edwin Lim (Editor in chief)2015 → …
Activity: Publication peer-review and editorial work › Editorial work