Projects per year
Personal profile
Biography
Dr Edwin Lim is a neuroscientist and biostatistician, graduated with a PhD in Physiology and Pharmacology (focus: neuroscience) at the University of New South Wales, and a Master of Biostatistics at University of Sydney in 2011 and 2018, respectively. He is an emerging leader in the field of targeted metabolomics (tryptophan) in neuroscience research: he held two Early Career Fellowships from Multiple Sclerosis Research Australia and Society for Mental Health Research; he leads the Translational Metabolomics Research Platform and the Analytical Lab in the Faculty of Medicine and Health Sciences, Macquarie University; is the Secretary of the Executive Committee of the International Society for Tryptophan Research (ISTRY), and Deputy Editor-in-Chief of the International Journal of Tryptophan Research.
Dr Lim has attracted ~$4.3M in research funding with over $2.2M as a chief investigator. He has over 60 peer-reviewed publications in prestigious journals such as New England Journal of Medicine, Progress in Neurobiology and Molecular Psychiatry.
Research interests
Dr Lim’s research focuses on using biofluids (such as blood, urine, saliva, tears) as surrogate biomarker for neurological diseases. The aim of Dr Lim’s research is to unravel the complexity of environment-host interactions during disease progression and devise a platform for biomarker-guided precision medicine to help overcome medical conditions of a heterogeneous nature. He uses innovative approaches, combining biochemical analyses with mass spectrometry techniques and data analytics with machine learning to identify early predictors for disease prognosis.
Research student supervision
Dr Lim supervise students in PhD, and Master of Research who are interested in metabolomics, neuroinflammation, complex data analytics and biomarker discoveries. Topics include metabolomics &: modifiable lifestyle risk factors, cognitive function, microbiomes, and genomic (tryptophan-related) interactions.
Current research topics
Metabolomics of microbiota-host interaction in the gut-brain axis of neurological diseases;
Metabolomics of complex symptoms in the progression of neuroinflammatory conditions (neurodegenerative & psychiatric disorders);
Targeted Metabolome-Phenome interaction of Traditional Chinese medicine.
Education/Academic qualification
Biostatistics, MBiostat (Biostatistics Collaboration of Australia), University of Sydney
2015 → 2019
Award Date: 20 Dec 2019
Physiology and Pharmacology, Ph.D, The University of New South Wales
2007 → 2010
Award Date: 18 Mar 2011
Research Management and Commercialisation, Grad Cert, The University of New South Wales
2009
Biochemistry and Pharmacology, BSc (Hon 1), The University of New South Wales
2003 → 2005
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Network
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Disease susceptibility, precision medicine and ALS
Atkin, J., Blair, I., Rowe, D. & Lim, E.
30/09/19 → 11/04/23
Project: Other
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Advanced protein quantification capability
Walker, A. K., Lee, A., Connor, M., Atkin, J., Lim, E., Baker, M. S., Rizos, H., Phillips, J. K., Yang, S. & Blair, I.
1/01/17 → …
Project: Research
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YSEP-NSI: Australia China Young Scientist Exchange Program - Next Step Initiative - Lim
19/03/18 → 1/08/18
Project: Other
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Investigating cyanobacteria toxin as a causative environmental factor in pathogenesis of ALS
Lim, E., Tan, V., Guillemin, G., Peyrin, J. M. & SH Tan, P.
1/02/18 → 31/01/19
Project: Other
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New directions for early diagnosis of MND: a large-scale longitudinal analysis of multiple biomarkers to find diagnostic and prognostic "fingerprints"
Guillemin, G., Rowe, D., Blair, I., Atkin, J., Zetterberg, H., Rogers, M., Lovejoy, D., Lim, E. & Tan, V.
1/01/18 → 31/12/18
Project: Research
Research Outputs
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Kynurenic acid as a biochemical factor underlying the association between Western-style diet and depression: a cross-sectional study
Francis, H. M., Stevenson, R. J., Tan, L. S. Y., Ehrenfeld, L., Byeon, S., Attuquayefio, T., Gupta, D. & Lim, C. K., 2022, In: Frontiers in Nutrition. 9, p. 1-13 13 p., 945538.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Downloads (Pure) -
Kynurenine-3-monooxygenase expression is activated in the pancreatic endocrine cells by diabetes and its blockade improves glucose-stimulated insulin secretion
Liu, J., Balibe, D., Raynal, S., Carbonne, C., Zhen, D., Dairou, J., Gausseres, B., Armanet, M., Domet, T., Pitasi, C. L., Movassat, J., Lim, C. K., Guillemin, G. J., Autier, V., Kergoat, M. & Portha, B., 1 Nov 2022, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1868, 11, p. 1-10 10 p., 166509.Research output: Contribution to journal › Article › peer-review
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Systemic perturbations of the kynurenine pathway precede progression to dementia independently of amyloid-β
Cespedes, M., Jacobs, K. R., Maruff, P., Rembach, A., Fowler, C. J., Trounson, B., Pertile, K. K., Rumble, R. L., Rainey-Smith, S. R., Rowe, C. C., Villemagne, V. L., Bourgeat, P., Lim, C. K., Chatterjee, P., Martins, R. N., Ittner, A., Masters, C. L., Doecke, J. D., Guillemin, G. J. & Lovejoy, D. B., Sep 2022, In: Neurobiology of Disease. 171, p. 1-9 9 p., 105783.Research output: Contribution to journal › Article › peer-review
Open AccessFile11 Downloads (Pure) -
The cytokines CXCL10 and CCL2 and the kynurenine metabolite anthranilic acid accurately predict patients at risk of developing dengue with warning signs
Jusof, F. F., Lim, C. K., Aziz, F. N., Soe, H. J., Raju, C. S., Sekaran, S. D. & Guillemin, G. J., 29 Jun 2022, (Accepted/In press) In: Journal of Infectious Diseases. 10 p.Research output: Contribution to journal › Article › peer-review
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Aggressive breast cancer subtype eats tryptophan!
Heng, B., Bilgin, A., Tan, V., Milioli, H., Lovejoy, D., Bustamante, S., Gluch, L., Moscato, P., Lim, C. & Guillemin, G., Sep 2021, In: Asia-Pacific Journal of Clinical Oncology. 17, S5, p. 15-16 2 p.Research output: Contribution to journal › Meeting abstract
Prizes
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Eureka Prize J&J Innovation in Medical Research (Finalist)
Lim, Edwin (Recipient), 2017
Prize: Other distinction
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Macquarie University ECR of the Year Awards (Highly Commended Finalist)
Lim, Edwin (Recipient), 2015
Prize: Other distinction
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Multiple Sclerosis Research Australia Postdoctoral Research Fellowship
Lim, Edwin (Recipient), 2011
Prize
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International Society for Tryptophan Research (Executive Committee) (External organisation)
Gilles Guillemin (Chair), Florian Zepf (Chair), Trevor Stone (Member), Kuniaki Saito (Member), Sophie Erhardt (Member) & Edwin Lim (Member)
2018 → …Activity: Membership › Membership of committee
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International Journal of Tryptophan Research (Journal)
Gilles Guillemin (Editor in chief) & Edwin Lim (Editor in chief)
2015 → …Activity: Peer-review and editorial of research outputs › Editorial work