• 1738 Citations
  • 23 h-Index
20062020

Research output per year

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Research Outputs

  • 1738 Citations
  • 23 h-Index
  • 44 Article
  • 7 Meeting abstract
  • 4 Review article
  • 2 Chapter
2020

Inflammation and kynurenine pathway dysregulation in post-partum women with severe and suicidal depression

Achtyes, E., Keaton, S. A., Smart, L. A., Burmeister, A. R., Heilman, P. L., Krzyzanowski, S., Nagalla, M., Guillemin, G. J., Escobar Galvis, M. L., Lim, C. K., Muzik, M., Postolache, T. T., Leach, R. & Brundin, L., 1 Jan 2020, In : Brain, Behavior, and Immunity. 83, p. 239-247 9 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Kynurenine pathway modulation reverses the experimental autoimmune encephalomyelitis mouse disease progression

Sundaram, G., Lim, C. K., Brew, B. J. & Guillemin, G. J., 6 Jun 2020, In : Journal of Neuroinflammation. 17, 1, p. 1-14 14 p., 176.

Research output: Contribution to journalArticle

Open Access
File
2019

A brief diet intervention can reduce symptoms of depression in young adults – A randomised controlled trial

Francis, H. M., Stevenson, R. J., Chambers, J. R., Gupta, D., Newey, B. & Lim, C. K., 9 Oct 2019, In : PLoS ONE. 14, 10, p. 1-17 17 p., e0222768.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
241 Downloads (Pure)
14 Citations (Scopus)

Dysregulation of kynurenine metabolism is related to proinflammatory cytokines, attention, and prefrontal cortex volume in schizophrenia

Kindler, J., Lim, C. K., Weickert, C. S., Boerrigter, D., Galletly, C., Liu, D., Jacobs, K. R., Balzan, R., Bruggemann, J., O’Donnell, M., Lenroot, R., Guillemin, G. J. & Weickert, T. W., 3 Apr 2019, In : Molecular Psychiatry.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Epithelial indoleamine 2,3-dioxygenase 1 modulates aryl hydrocarbon receptor and notch signaling to increase differentiation of secretory cells and alter mucus-associated microbiota

Alvarado, D. M., Chen, B., Iticovici, M., Thaker, A. I., Dai, N., VanDussen, K. L., Shaikh, N., Lim, C. K., Guillemin, G. J., Tarr, P. I. & Ciorba, M. A., 1 Oct 2019, In : Gastroenterology. 157, 4, p. 1093-1108 27 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
8 Citations (Scopus)

Plasma neurofilament light chain and amyloid-β are associated with the kynurenine pathway metabolites in preclinical Alzheimer's disease

Chatterjee, P., Zetterberg, H., Goozee, K., Lim, C. K., Jacobs, K. R., Ashton, N. J., Hye, A., Pedrini, S., Sohrabi, H. R., Shah, T., Asih, P. R., Dave, P., Shen, K., Taddei, K., Lovejoy, D. B., Guillemin, G. J., Blennow, K. & Martins, R. N., 10 Oct 2019, In : Journal of Neuroinflammation. 16, 1, p. 1-12 12 p., 186.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
2 Downloads (Pure)
2018

Alterations in serum kynurenine pathway metabolites in individuals with high neocortical amyloid-β load: a pilot study

Chatterjee, P., Goozee, K., Lim, C. K., James, I., Shen, K., Jacobs, K. R., Sohrabi, H. R., Shah, T., Asih, P. R., Dave, P., ManYan, C., Taddei, K., Lovejoy, D. B., Chung, R., Guillemin, G. J. & Martins, R. N., 1 Dec 2018, In : Scientific Reports. 8, 1, p. 1-10 10 p., 8008.

Research output: Contribution to journalArticle

Open Access
File
12 Citations (Scopus)
13 Downloads (Pure)

Loss of the Chr16p11.2 ASD candidate gene QPRT leads to aberrant neuronal differentiation in the SH-SY5Y neuronal cell model

Haslinger, D., Waltes, R., Yousaf, A., Lindlar, S., Schneider, I., Lim, C. K., Tsai, M. M., Garvalov, B. K., Acker-Palmer, A., Krezdorn, N., Rotter, B., Acker, T., Guillemin, G. J., Fulda, S., Freitag, C. M. & Chiocchetti, A. G., 6 Nov 2018, In : Molecular autism. 9, 1, p. 1-17 17 p., 56.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
4 Downloads (Pure)

Neopterin preconditioning prevents inflammasome activation in mammalian astrocytes

de Paula Martins, R., Ghisoni, K., Lim, C. K., Aguiar, A. S., Guillemin, G. J. & Latini, A., 1 Feb 2018, In : Free Radical Biology and Medicine. 115, p. 371-382 12 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Neurotoxicity of the cyanotoxin BMAA through axonal degeneration and intercellular spreading

Tan, V. X., Lassus, B., Lim, C. K., Tixador, P., Courte, J., Bessede, A., Guillemin, G. J. & Peyrin, J. M., Jan 2018, In : Neurotoxicity Research. 33, 1, p. 62-75 14 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Tryptophan metabolism through the kynurenine pathway is associated with endoscopic inflammation in ulcerative colitis

Sofia, M. A., Ciorba, M. A., Meckel, K., Lim, C. K., Guillemin, G. J., Weber, C. R., Bissonnette, M. & Pekow, J. R., Jul 2018, In : Inflammatory Bowel Diseases. 24, 7, p. 1471-1480 10 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
2017

Human regulatory macrophages are potent in suppression of the xenoimmune response via indoleamine-2,3-dioxygenase-involved mechanism(s)

Guo, F., Hu, M., Huang, D., Zhao, Y., Heng, B., Guillemin, G., Lim, C. K., Hawthorne, W. J. & Yi, S., Oct 2017, In : Xenotransplantation. 24, 5, p. 1-11 11 p., e12326.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Involvement of the kynurenine pathway in the pathogenesis of Parkinson's disease

Lim, C. K., Fernández-Gomez, F. J., Braidy, N., Estrada, C., Costa, C., Costa, S., Bessede, A., Fernandez-Villalba, E., Zinger, A., Herrero, M. T. & Guillemin, G. J., Aug 2017, In : Progress in Neurobiology. 155, p. 76-95 20 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)

Kynurenine pathway metabolomics predicts and provides mechanistic insight into multiple sclerosis progression

Lim, C. K., Bilgin, A., Lovejoy, D. B., Tan, V., Bustamante, S., Taylor, B. V., Bessede, A., Brew, B. J. & Guillemin, G. J., 3 Feb 2017, In : Scientific Reports. 7, p. 1-9 9 p., 41473.

Research output: Contribution to journalArticle

Open Access
File
60 Citations (Scopus)
15 Downloads (Pure)

Metabolome analysis reveals the association between the kynurenine pathway and human herpesvirus 6 encephalopathy in immunocompetent children

Torii, Y., Kawano, Y., Sato, H., Fujimori, T., Sasaki, K., Kawada, J., Takikawa, O., Lim, C. K., Guillemin, G. J., Ohashi, Y. & Ito, Y., Nov 2017, In : Metabolomics. 13, 11, p. 1-10 10 p., 126.

Research output: Contribution to journalArticle

3 Citations (Scopus)

NAD deficiency, congenital malformations, and niacin supplementation

Shi, H., Enriquez, A., Rapadas, M., Martin, E. M. M. A., Wang, R., Moreau, J., Lim, C. K., Szot, J. O., Ip, E., Hughes, J. N., Sugimoto, K., Humphreys, D. T., McInerney-Leo, A. M., Leo, P. J., Maghzal, G. J., Halliday, J., Smith, J., Colley, A., Mark, P. R., Collins, F. & 13 others, Sillence, D. O., Winlaw, D. S., Ho, J. W. K., Guillemin, G. J., Brown, M. A., Kikuchi, K., Thomas, P. Q., Stocker, R., Giannoulatou, E., Chapman, G., Duncan, E. L., Sparrow, D. B. & Dunwoodie, S. L., 10 Aug 2017, In : New England Journal of Medicine. 377, 6, p. 544-552 9 p.

Research output: Contribution to journalArticle

54 Citations (Scopus)

Recent evidence for an expanded role of the kynurenine pathway of tryptophan metabolism in neurological diseases

Lovelace, M. D., Varney, B., Sundaram, G., Lennon, M. J., Lim, C. K., Jacobs, K., Guillemin, G. J. & Brew, B. J., 1 Jan 2017, In : Neuropharmacology. 112, PartB, p. 373-388 16 p.

Research output: Contribution to journalReview article

97 Citations (Scopus)
2016

Altered kynurenine pathway metabolism in autism: Implication for immune-induced glutamatergic activity

Lim, C. K., Essa, M. M., de Paula Martins, R., Lovejoy, D. B., Bilgin, A. A., Waly, M. I., Al-Farsi, Y. M., Al-Sharbati, M., Al-Shaffae, M. A. & Guillemin, G. J., 1 Jun 2016, In : Autism Research. 9, 6, p. 621-631 11 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

An enzyme in the kynurenine pathway that governs vulnerability to suicidal behavior by regulating excitotoxicity and neuroinflammation

Brundin, L., Sellgren, C. M., Lim, C. K., Grit, J., Pålsson, E., Landén, M., Samuelsson, M., Lundgren, K., Brundin, P., Fuchs, D., Postolache, T. T., Traskman-Bendz, L., Guillemin, G. J. & Erhardt, S., 2 Aug 2016, In : Translational Psychiatry. 6, p. 1-9 9 p., e865.

Research output: Contribution to journalArticle

Open Access
File
56 Citations (Scopus)
12 Downloads (Pure)

Characterization of the Kynurenine Pathway in CD8+ Human Primary Monocyte-Derived Dendritic Cells

Braidy, N., Rossez, H., Lim, C. K., Jugder, B. E., Brew, B. J. & Guillemin, G. J., 1 Nov 2016, In : Neurotoxicity Research. 30, 4, p. 620-632 13 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Current evidence for a role of the kynurenine pathway of tryptophan metabolism in multiple sclerosis

Lovelace, M. D., Varney, B., Sundaram, G., Franco, N. F., Ng, M. L., Pai, S., Lim, C. K., Guillemin, G. J. & Brew, B. J., 4 Aug 2016, In : Frontiers in Immunology. 7, p. 1-22 22 p., 246.

Research output: Contribution to journalReview article

Open Access
File
45 Citations (Scopus)
70 Downloads (Pure)

Kynurenines, gender and neuroinflammation; showcase schizophrenia

de Bie, J., Lim, C. K. & Guillemin, G. J., 1 Oct 2016, In : Neurotoxicity Research. 30, 3, p. 285-294 10 p.

Research output: Contribution to journalReview article

8 Citations (Scopus)
5 Citations (Scopus)

Quantitative metabolome profiling reveals the involvement of the kynurenine pathway in influenza-associated encephalopathy

Torii, Y., Kawano, Y., Sato, H., Sasaki, K., Fujimori, T., Kawada, J. I., Takikawa, O., Lim, C. K., Guillemin, G. J., Ohashi, Y. & Ito, Y., 1 May 2016, In : Metabolomics. 12, 5, p. 1-9 9 p., 84.

Research output: Contribution to journalArticle

9 Citations (Scopus)
Open Access
File
5 Citations (Scopus)
12 Downloads (Pure)

Serum tryptophan metabolites and Ido1 expression as biomarkers of mucosal inflammation in ulcerative colitis

Sofia, A., Ciorba, M. A., Meckel, K., Lim, E., Guillemin, G., Bissonnette, M. & Pekow, J., Apr 2016, In : Gastroenterology. 150, 4 Supplement 1, p. S549 1 p., Su1783.

Research output: Contribution to journalMeeting abstract

Soluble LILRA3 promotes neurite outgrowth and synapses formation through a high-affinity interaction with Nogo 66

An, H., Brettle, M., Lee, T., Heng, B., Lim, C. K., Guillemin, G. J., Lord, M. S., Klotzsch, E., Geczy, C. L., Bryant, K., Fath, T. & Tedla, N., 2016, In : Journal of Cell Science. 129, 6, p. 1198-1209 12 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Understanding the role of the kynurenine pathway in human breast cancer immunobiology

Heng, B., Lim, C. K., Lovejoy, D. B., Bessede, A., Gluch, L. & Guillemin, G. J., 9 Feb 2016, In : Oncotarget. 7, 6, p. 6506-6520 15 p.

Research output: Contribution to journalArticle

Open Access
File
54 Citations (Scopus)
25 Downloads (Pure)

Upregulated pathways and products of tryptophan metabolism is associated with the neoplastic transition in the colon epithelium

Santhanam, S., Lim, E., Shabsovich, M., Alvarado, D. M., Bishnupuri, K. S., Guillemin, G. & Ciorba, M. A., Apr 2016, In : Gastroenterology. 150, 4 Supplement 1, p. S492 1 p.

Research output: Contribution to journalMeeting abstract

2015

Activation of the kynurenine pathway and increased production of the excitotoxin quinolinic acid following traumatic brain injury in humans

Yan, E. B., Frugier, T., Lim, C. K., Heng, B., Sundaram, G., Tan, M., Rosenfeld, J. V., Walker, D. W., Guillemin, G. J. & Morganti-Kossmann, M. C., 30 May 2015, In : Journal of Neuroinflammation. 12, p. 1-17 17 p., 110.

Research output: Contribution to journalArticle

Open Access
File
34 Citations (Scopus)
5 Downloads (Pure)

A role for inflammatory metabolites as modulators of the glutamate N-methyl-d-aspartate receptor in depression and suicidality

Bay-Richter, C., Linderholm, K. R., Lim, C. K., Samuelsson, M., Träskman-Bendz, L., Guillemin, G. J., Erhardt, S. & Brundin, L., 1 Jan 2015, In : Brain, Behavior, and Immunity. 43, p. 110-117 8 p.

Research output: Contribution to journalArticle

148 Citations (Scopus)

Does escitalopram reduce neurotoxicity in major depression?

Halaris, A., Myint, A. M., Savant, V., Meresh, E., Lim, E., Guillemin, G., Hoppensteadt, D., Fareed, J. & Sinacore, J., 1 Jul 2015, In : Journal of Psychiatric Research. 66-67, p. 118-126 9 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

Expression of the kynurenine pathway in human peripheral blood mononuclear cells: implications for inflammatory and neurodegenerative disease

Jones, S. P., Franco, N. F., Varney, B., Sundaram, G., Brown, D. A., De Bie, J., Lim, C. K., Guillemin, G. J. & Brew, B. J., 26 Jun 2015, In : PLoS ONE. 10, 6, p. 1-18 18 p., e0131389.

Research output: Contribution to journalArticle

Open Access
File
51 Citations (Scopus)
22 Downloads (Pure)

The kynurenine pathway of tryptophan degradation is activated during osteoblastogenesis

Vidal, C., Li, W., Santner-Nanan, B., Lim, C. K., Guillemin, G. J., Ball, H. J., Hunt, N. H., Nanan, R. & Duque, G., 1 Jan 2015, In : Stem Cells. 33, 1, p. 111-121 11 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

The neuroprotective potential of MIS416, a myeloid-directed innate immune therapeutic in Phase 2B trial for the treatment of secondary progressive multiple sclerosis

Webster, G., Pearson, V., Lim, E. & Mayo, N., Dec 2015, In : Multiple Sclerosis. 21, 14, p. NP25 1 p., PP1.27.

Research output: Contribution to journalMeeting abstract

The next decade in tryptophan metabolism research

Lim, C. K. & Guillemin, G. J., 1 Jan 2015, Targeting the Broadly Pathogenic Kynurenine Pathway. Mittal, S. (ed.). Cham: Springer, Springer Nature, p. 419-425 7 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2014

Antibodies to MOG have a demyelination phenotype and affect oligodendrocyte cytoskeleton

Dale, R. C., Tantsis, E. M., Merheb, V., Kumaran, R. Y. A., Sinmaz, N., Pathmanandavel, K., Ramanathan, S., Booth, D. R., Wienholt, L. A., Prelog, K., Clark, D. R., Guillemin, G. J., Lim, C. K., Mathey, E. K. & Brilot, F., 24 Apr 2014, In : Neurology: Neuroimmunology and Neuroinflammation. 1, 1, p. 1-12 12 p., e12.

Research output: Contribution to journalArticle

Open Access
File
82 Citations (Scopus)
57 Downloads (Pure)

Antibodies to myelin oligodendrocyte glycoprotein have a demyelination phenotype in children and affect oligodendrocyte cytoskeleton

Dale, R. C., Tantsis, E. M., Merheb, V., Kumaran, R. A., Sinmaz, N., Pathmanandavel, K., Ramanathan, S., Booth, D. R., Wienholt, L. A., Prelog, K., Clark, D. R., Guillemin, G. J., Lim, C. K., Mathey, E. K. & Brilot, F., 15 Oct 2014, In : Journal of Neuroimmunology. 275, 1-2, p. 17-17 1 p.

Research output: Contribution to journalMeeting abstract

Effect of maternal immune activation on the kynurenine pathway in preadolescent rat offspring and on MK801-induced hyperlocomotion in adulthood: Amelioration by COX-2 inhibition

Zavitsanou, K., Lim, C. K., Purves-Tyson, T., Karl, T., Kassiou, M., Banister, S. D., Guillemin, G. J. & Weickert, C. S., 2014, In : Brain, Behavior, and Immunity. 41, p. 173-181 9 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Involvement of the kynurenine pathway in human glioma pathophysiology

Adams, S., Teo, C., McDonald, K. L., Zinger, A., Bustamante, S., Lim, C. K., Sundaram, G., Braidy, N., Brew, B. J. & Guillemin, G. J., 17 Oct 2014, In : PLoS ONE. 9, 11, p. 1-28 28 p., 0112945.

Research output: Contribution to journalArticle

Open Access
File
52 Citations (Scopus)
17 Downloads (Pure)

MS and excitotoxicity

Lim, C. K., 2014, Handbook of neurotoxicity. Kostrzewa, R. M. (ed.). New York: Springer, Springer Nature, p. 1371-1379 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Quinolinic acid toxicity on oligodendroglial cells: Relevance for multiple sclerosis and therapeutic strategies

Sundaram, G., Brew, B. J., Jones, S. P., Adams, S., Lim, C. K. & Guillemin, G. J., 13 Dec 2014, In : Journal of Neuroinflammation. 11, p. 1-11 11 p., 204.

Research output: Contribution to journalArticle

Open Access
File
32 Citations (Scopus)
17 Downloads (Pure)
2013

Characterization of the Kynurenine pathway and quinolinic acid production in macaque macrophages

Lim, C. K., Yap, M. M. C., Kent, S. J., Gras, G., Samah, B., Batten, J. C., De Rose, R., Heng, B., Brew, B. J. & Guillemin, G. J., 2013, In : International Journal of Tryptophan Research. 6, p. 7-19 13 p.

Research output: Contribution to journalArticle

Open Access
File
15 Citations (Scopus)
20 Downloads (Pure)

Connecting inflammation with glutamate agonism in suicidality

Erhardt, S., Lim, C. K., Linderholm, K. R., Janelidze, S., Lindqvist, D., Samuelsson, M., Lundberg, K., Postolache, T. T., Träskman-Bendz, L., Guillemin, G. J. & Brundin, L., Apr 2013, In : Neuropsychopharmacology. 38, 5, p. 743-752 10 p.

Research output: Contribution to journalArticle

Open Access
File
181 Citations (Scopus)
3 Downloads (Pure)

Expression of Tryptophan 2,3-Dioxygenase and Production of Kynurenine Pathway Metabolites in Triple Transgenic Mice and Human Alzheimer's Disease Brain

Wu, W., Nicolazzo, J. A., Wen, L., Chung, R., Stankovic, R., Bao, S. S., Lim, C. K., Brew, B. J., Cullen, K. M. & Guillemin, G. J., 22 Apr 2013, In : PLoS ONE. 8, 4, p. 1-11 11 p., e59749.

Research output: Contribution to journalArticle

Open Access
File
79 Citations (Scopus)
22 Downloads (Pure)

Involvement of the kynurenine pathway in human primary glioma pathophysiology

Adams, S., Teo, C., McDonald, K., Zinger, A., Bustamante, S., Lim, C. K., Braidy, N., Brew, B. J. & Guillemin, G. J., Nov 2013, In : Neuro-Oncology. 15, p. 85-85 1 p.

Research output: Contribution to journalMeeting abstract

Neuroprotective ability of PACAPs against oxidative stress and excitotoxicity in human primary cortical neurons

Lim, E., Reglodi, D. & Guillemin, G. J., 2013, In : Journal of Molecular Neuroscience. 51, Suppl. p, p. S201 1 p.

Research output: Contribution to journalMeeting abstract