Projects per year
Personal profile
Biography
Dr Shklovskaya studied medicine in Russia, graduating with distinction before completing her PhD in the area of haematopoietic stem cell research in Russia and Switzerland. She undertook postdoctoral training in experimental haematology at the Research Department (ZLF) of Basel University Hospital in Switzerland, where she studied mechanisms of bone marrow failure and haematopoietic recovery after stem cell transplantation for malignancy. Her work into regulation of cytokine release underlying haematopoietic recovery received an ongoing support from the Swiss Cancer League and resulted in nine publications in international journals, including four in Blood. In 2002, Dr Shklovskaya moved to Australia and joined Professor Barbara Fazekas de St Groth at Centenary Institute in Sydney. She studied immune regulation in autoimmunity and cancer, combining complex transgenic animal models and multiparameter flow cytometry to discover a new paradigm in immunology - a population of antigen-presenting cells exclusively committed to maintaining immune tolerance on body surfaces. She also developed animal models to study adaptive immune responses in cancer, before moving into translational cancer immunology research and joining Professor Helen Rizos at MQ University in 2017. She is combining flow cytometry and in vitro models to gain insights into immune regulation in metastatic melanoma, particularly in patients who acquired resistance to immunotherapy.
Education/Academic qualification
Experimental Haematology, PhD, Regulation of haematopoietic stem cell proliferation in health and disease, Russian Academy of Medical Sciences - Siberian Branch
Award Date: 15 Sept 1995
Medicine, MBBS (Distinction), State Medical University Novosibirsk
Award Date: 30 Jul 1988
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Collaborations and top research areas from the last five years
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The ACRF Centre for Advanced Cancer Modelling and Experimental Oncology (COMET)
Rizos, H., Gurney, H., Shklovskaya, E., Long, G. V., Lee, J., Wang, Y., Di Ieva, A., Guller, A., Clarke AM, J. & Gupta, R.
1/01/24 → 31/12/30
Project: Research
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Neoadjuvant Combination Checkpoint Inhibition in Glioblastoma
Rizos, H., Long, G. V., James, W., Shklovskaya, E., Palendira, M. & Vergara, I.
1/03/24 → 28/02/25
Project: Research
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MQRIS Large 2023: Nano-flow Cytometry Facility
Wang, Y., Rodger, A., Garcia-Bennett, A., Sunna, A., Cain, A., Ponton, F., Palmisano, G., Thaysen-Andersen, M., Packer, N., Jaschke, P., Inglis, D., Li, M., Nasiri, N., Wu, S., Lu, Y., Volz, T., Shklovskaya, E., Zou, A., Rizos, H., Shi, B., Yang, S., Guller, A. & Tavakkoliyaraki, M.
16/11/22 → 15/11/23
Project: Research
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Understanding the immune contexture and signalling crosstalk between tumour and immune cells in glioblastoma
Vaqueirinho de Pinho, A., Shklovskaya, E., Rizos, H. & De Souza, P.
1/01/19 → 31/12/20
Project: Research
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Neoadjuvant triplet immune checkpoint blockade in newly diagnosed glioblastoma
Long, G. V., Shklovskaya, E., Satgunaseelan, L., Mao, Y., da Silva, I. P., Perry, K. A., Diefenbach, R. J., Gide, T. N., Shivalingam, B., Buckland, M. E., Gonzalez, M., Caixeiro, N., Vergara, I. A., Bai, X., Rawson, R. V., Hsiao, E., Palendira, U., Phan, T. G., Menzies, A. M., Carlino, M. S., & 15 others , 27 Feb 2025, In: Nature Medicine. 31, 2, 25 p., vdad124.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Downloads (Pure) -
MHCII restriction demonstrates B cells have very limited capacity to activate tumour-specific CD4+ T cells in vivo
Guy, T. V., Terry, A. M., McGuire, H. M., Shklovskaya, E. & Fazekas de St Groth, B., Jan 2024, In: OncoImmunology. 13, 1, p. 1-8 8 p., 2290799.Research output: Contribution to journal › Article › peer-review
Open AccessFile44 Downloads (Pure) -
Diagnosis of breast implant associated anaplastic large cell lymphoma by analysis of cytokines in peri-implant seromas
Hu, H., Shklovskaya, E., Deva, A., Xu, H., Fan, K., Brosamer, K., Willson, R., Khan, I., Sinha, M. & Kadin, M. E., Nov 2023, In: American Journal of Hematology. 98, 11, p. E312-E314 3 p.Research output: Contribution to journal › Letter › peer-review
Open Access2 Citations (Scopus) -
IFN-γ signaling sensitizes melanoma cells to BH3 mimetics
Ming, Z., Lim, S. Y., Stewart, A., Pedersen, B., Shklovskaya, E., Menzies, A. M., Carlino, M. S., Kefford, R. F., Lee, J. H., Scolyer, R. A., Long, G. V. & Rizos, H., Jul 2023, In: Journal of Investigative Dermatology. 143, 7, p. 1246-1256.e8 19 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus) -
Intratumoral CD16+ macrophages are associated with clinical outcomes of patients with metastatic melanoma treated with combination anti-PD-1 and anti-CTLA-4 therapy
Lee, H., Ferguson, A. L., Quek, C., Vergara, I. A., Pires daSilva, I., Allen, R., Gide, T. N., Conway, J. W., Koufariotis, L. T., Hayward, N. K., Waddell, N., Carlino, M. S., Menzies, A. M., Saw, R. P. M., Shklovskaya, E., Rizos, H., Lo, S., Scolyer, R. A., Long, G. V., Palendira, U., & 1 others , 5 Jul 2023, In: Clinical Cancer Research. 29, 13, p. 2513-2524 12 p.Research output: Contribution to journal › Article › peer-review
14 Citations (Scopus)
Prizes
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ICB Best Publication of the Year award, 2016
Shklovskaya, Elena (Recipient), Dec 2017
Prize: Other distinction