• 1177 Citations
  • 16 h-Index
19962020

Research output per year

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Personal profile

Biography

Dr Shklovskaya studied medicine in Russia, graduating with distinction before completing her PhD in the area of haematopoietic stem cell research in Russia and Switzerland. She undertook postdoctoral training in experimental haematology at the Research Department (ZLF) of Basel University Hospital in Switzerland, where she studied mechanisms of bone marrow failure and haematopoietic recovery after stem cell transplantation for malignancy. Her work into regulation of cytokine release underlying haematopoietic recovery received an ongoing support from the Swiss Cancer League and resulted in nine publications in international journals, including four in Blood. In 2002, Dr Shklovskaya moved to Australia and joined Professor Barbara Fazekas de St Groth at Centenary Institute in Sydney. She studied immune regulation in autoimmunity and cancer, combining complex transgenic animal models and multiparameter flow cytometry to discover a new paradigm in immunology - a population of antigen-presenting cells exclusively committed to maintaining immune tolerance on body surfaces. She also developed animal models to study adaptive immune responses in cancer, before moving into translational cancer immunology research and joining Professor Helen Rizos at MQ University in 2017. She is combining flow cytometry and in vitro models to gain insights into immune regulation in metastatic melanoma, particularly in patients who acquired resistance to immunotherapy.

Education/Academic qualification

Experimental Haematology, PhD, Russian Academy of Medical Sciences - Siberian Branch

Medicine, MBBS (Distinction), State Medical University Novosibirsk

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Projects

Research Outputs

  • 1177 Citations
  • 16 h-Index
  • 32 Article
  • 2 Review article
  • 1 Chapter

Transcriptional downregulation of MHC class I and melanoma de- differentiation in resistance to PD-1 inhibition

Lee, J. H., Shklovskaya, E., Lim, S. Y., Carlino, M. S., Menzies, A. M., Stewart, A., Pedersen, B., Irvine, M., Alavi, S., Yang, J. Y. H., Strbenac, D., Saw, R. P. M., Thompson, J. F., Wilmott, J. S., Scolyer, R. A., Long, G. V., Kefford, R. F. & Rizos, H., 1 Dec 2020, In : Nature Communications. 11, 1, p. 1-12 12 p., 1897.

Research output: Contribution to journalArticle

Open Access
File
  • 4 Downloads (Pure)

    Anti-PD-1-induced high-grade hepatitis associated with corticosteroid-resistant T cells: a case report

    McGuire, H. M., Shklovskaya, E., Edwards, J., Trevillian, P. R., McCaughan, G. W., Bertolino, P., McKenzie, C., Gourlay, R., Gallagher, S. J., Fazekas de St. Groth, B. & Hersey, P., Apr 2018, In : Cancer Immunology, Immunotherapy. 67, 4, p. 563–573 11 p.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 17 Citations (Scopus)
    12 Downloads (Pure)

    Interferon signaling is frequently downregulated in melanoma

    Alavi, S., Stewart, A. J., Kefford, R. F., Lim, S. Y., Shklovskaya, E. & Rizos, H., 2018, In : Frontiers in Immunology. 9, p. 1-12 12 p., 1414.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 4 Citations (Scopus)
    19 Downloads (Pure)

    Marked global DNA hypomethylation is associated with constitutive PD-L1 expression in melanoma

    Chatterjee, A., Rodger, E. J., Ahn, A., Stockwell, P. A., Parry, M., Motwani, J., Gallagher, S. J., Shklovskaya, E., Tiffen, J., Eccles, M. R. & Hersey, P., 29 Jun 2018, In : iScience. 4, p. 312-325 42 p.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 13 Citations (Scopus)
    7 Downloads (Pure)

    Epigenetic modulation in cancer immunotherapy

    Gallagher, S. J., Shklovskaya, E. & Hersey, P., 1 Aug 2017, In : Current Opinion in Pharmacology. 35, p. 48-56 9 p.

    Research output: Contribution to journalReview article

  • 16 Citations (Scopus)

    Prizes

    ICB Best Publication of the Year award, 2016

    Elena Shklovskaya (Recipient), Dec 2017

    Prize: Other distinction