Projects per year
Dr Shklovskaya studied medicine in Russia, graduating with distinction before completing her PhD in the area of haematopoietic stem cell research in Russia and Switzerland. She undertook postdoctoral training in experimental haematology at the Research Department (ZLF) of Basel University Hospital in Switzerland, where she studied mechanisms of bone marrow failure and haematopoietic recovery after stem cell transplantation for malignancy. Her work into regulation of cytokine release underlying haematopoietic recovery received an ongoing support from the Swiss Cancer League and resulted in nine publications in international journals, including four in Blood. In 2002, Dr Shklovskaya moved to Australia and joined Professor Barbara Fazekas de St Groth at Centenary Institute in Sydney. She studied immune regulation in autoimmunity and cancer, combining complex transgenic animal models and multiparameter flow cytometry to discover a new paradigm in immunology - a population of antigen-presenting cells exclusively committed to maintaining immune tolerance on body surfaces. She also developed animal models to study adaptive immune responses in cancer, before moving into translational cancer immunology research and joining Professor Helen Rizos at MQ University in 2017. She is combining flow cytometry and in vitro models to gain insights into immune regulation in metastatic melanoma, particularly in patients who acquired resistance to immunotherapy.
Experimental Haematology, PhD, Russian Academy of Medical Sciences - Siberian Branch
Medicine, MBBS (Distinction), State Medical University Novosibirsk
Understanding the immune contexture and signalling crosstalk between tumour and immune cells in glioblastoma
1/01/19 → 31/12/20
Spatial and temporal changes in PD-L1 expression in cancer: the role of genetic drivers, tumor microenvironment and resistance to therapyShklovskaya, E. & Rizos, H., 1 Oct 2020, In : International Journal of Molecular Sciences. 21, 19, p. 1-23 23 p., 7139.
Research output: Contribution to journal › Review articleOpen AccessFile
Transcriptional downregulation of MHC class I and melanoma de- differentiation in resistance to PD-1 inhibitionLee, J. H., Shklovskaya, E., Lim, S. Y., Carlino, M. S., Menzies, A. M., Stewart, A., Pedersen, B., Irvine, M., Alavi, S., Yang, J. Y. H., Strbenac, D., Saw, R. P. M., Thompson, J. F., Wilmott, J. S., Scolyer, R. A., Long, G. V., Kefford, R. F. & Rizos, H., 1 Dec 2020, In : Nature Communications. 11, 1, p. 1-12 12 p., 1897.
Research output: Contribution to journal › ArticleOpen AccessFile10 Citations (Scopus)9 Downloads (Pure)
Anti-PD-1-induced high-grade hepatitis associated with corticosteroid-resistant T cells: a case reportMcGuire, H. M., Shklovskaya, E., Edwards, J., Trevillian, P. R., McCaughan, G. W., Bertolino, P., McKenzie, C., Gourlay, R., Gallagher, S. J., Fazekas de St. Groth, B. & Hersey, P., Apr 2018, In : Cancer Immunology, Immunotherapy. 67, 4, p. 563–573 11 p.
Research output: Contribution to journal › ArticleOpen AccessFile27 Citations (Scopus)13 Downloads (Pure)
Kefford, R. F., Lim, S. Y., Shklovskaya, E. & Rizos, H., 2018, In : Frontiers in Immunology. 9, p. 1-12 12 p., 1414.
Research output: Contribution to journal › ArticleOpen AccessFile8 Citations (Scopus)23 Downloads (Pure)
Shklovskaya, E., Tiffen, J., Eccles, M. R. & Hersey, P., 29 Jun 2018, In : iScience. 4, p. 312-325 42 p.
Research output: Contribution to journal › ArticleOpen AccessFile17 Citations (Scopus)20 Downloads (Pure)