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Dr Shklovskaya studied medicine in Russia, graduating with distinction before completing her PhD in the area of haematopoietic stem cell research in Russia and Switzerland. She undertook postdoctoral training in experimental haematology at the Research Department (ZLF) of Basel University Hospital in Switzerland, where she studied mechanisms of bone marrow failure and haematopoietic recovery after stem cell transplantation for malignancy. Her work into regulation of cytokine release underlying haematopoietic recovery received an ongoing support from the Swiss Cancer League and resulted in nine publications in international journals, including four in Blood. In 2002, Dr Shklovskaya moved to Australia and joined Professor Barbara Fazekas de St Groth at Centenary Institute in Sydney. She studied immune regulation in autoimmunity and cancer, combining complex transgenic animal models and multiparameter flow cytometry to discover a new paradigm in immunology - a population of antigen-presenting cells exclusively committed to maintaining immune tolerance on body surfaces. She also developed animal models to study adaptive immune responses in cancer, before moving into translational cancer immunology research and joining Professor Helen Rizos at MQ University in 2017. She is combining flow cytometry and in vitro models to gain insights into immune regulation in metastatic melanoma, particularly in patients who acquired resistance to immunotherapy.
Experimental Haematology, PhD, Russian Academy of Medical Sciences - Siberian Branch
Award Date: 15 Sep 1995
Medicine, MBBS (Distinction), State Medical University Novosibirsk
Award Date: 30 Jul 1988
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MQRIS Large 2023: Nano-flow Cytometry Facility
Wang, Y., Rodger, A., Garcia-Bennett, A., Sunna, A., Cain, A., Ponton, F., Palmisano, G., Thaysen-Andersen, M., Packer, N., Jaschke, P., Inglis, D., Li, M., Nasiri, N., Wu, S., Lu, Y., Volz, T., Shklovskaya, E., Zou, A., Rizos, H., Shi, B., Yang, S., Guller, A. & Tavakkoliyaraki, M.
16/11/22 → 15/11/23
Understanding the immune contexture and signalling crosstalk between tumour and immune cells in glioblastoma
Vaqueirinho de Pinho, A., Shklovskaya, E., Rizos, H. & De Souza, P.
1/01/19 → 31/12/20
IFN-γ signaling sensitizes melanoma cells to BH3 mimeticsMing, Z., Lim, S. Y., Stewart, A., Pedersen, B., Shklovskaya, E., Menzies, A. M., Carlino, M. S., Kefford, R. F., Lee, J. H., Scolyer, R. A., Long, G. V. & Rizos, H., 1 Feb 2023, (Accepted/In press) In: Journal of Investigative Dermatology.
Research output: Contribution to journal › Article › peer-review
The molecular and functional landscape of resistance to immune checkpoint blockade in melanomaLim, S. Y., Shklovskaya, E., Lee, J. H., Pedersen, B., Stewart, A., Ming, Z., Irvine, M., Shivalingam, B., Saw, R. P. M., Menzies, A. M., Carlino, M. S., Scolyer, R. A., Long, G. V. & Rizos, H., 18 Mar 2023, In: Nature Communications. 14, 1, p. 1-18 18 p., 1516.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile2 Downloads (Pure)
Durable responses to anti-PD1 and anti-CTLA4 in a preclinical model of melanoma displaying key immunotherapy response biomarkersShklovskaya, E., Pedersen, B., Stewart, A., Simpson, J. O. G., Ming, Z., Irvine, M., Scolyer, R. A., Long, G. V. & Rizos, H., 3 Oct 2022, In: Cancers. 14, 19, p. 1-18 18 p., 4830.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile20 Downloads (Pure)
SERS characterization of colorectal cancer cell surface markers upon anti-EGFR treatmentLyu, N., Pedersen, B., Shklovskaya, E., Rizos, H., Molloy, M. P. & Wang, Y., Jun 2022, In: Exploration. 2, 3, p. 1-10 10 p., 20210176.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile12 Downloads (Pure)
Melanoma cell state-specific responses to TNFαLim, S. Y., Alavi, S., Ming, Z., Shklovskaya, E., Fung, C., Stewart, A. & Rizos, H., Jun 2021, In: Biomedicines. 9, 6, p. 1-11 11 p., 605.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile
ICB Best Publication of the Year award, 2016
Shklovskaya, Elena (Recipient), Dec 2017
Prize: Other distinction