Projects per year
Personal profile
Biography
Dr. Lim is an early career postdoctoral fellow in the Precision Cancer Therapy (PCT) group at Macquarie University, and she is currently investigating the transcriptomic and proteomic profiles of melanoma patients treated with selective kinase inhibitors and immunotherapy. Her overarching research goal is to delineate mechanisms of immune responses and translate these findings to clinical applications, particularly in improving immunotherapy efficacy.
Dr. Lim has had over 7 years cancer research experience with a focus on cancer cell biology and tumour immunology. She was previously appointed as a postdoctoral researcher at the University of Oxford (from 2011-2015), and her past studies defined pro-metastatic activity of immune cells in sustaining liver metastasis of colorectal cancer. These findings provided valuable insights into the role of the host immune system in cancer progression and were published in Hepatology (2011 and 2013) and Oncogene (2016).
Dr. Lim graduated from the University of New South Wales with a PhD degree in Pathology, and her postgraduate research elucidated how oxidative modifications of inflammatory proteins regulate immune responses, and were published in the Journal of Immunology (2008) and Journal of Biological Chemistry (2010). Prior to her PhD, Dr. Lim undertook an Honours project in her final undergraduate year, on the production and characterization of monoclonal antibodies against the chloride intracellular channel 1 (CLIC1) protein, and was awarded first class honours. In the interim of commencing her PhD degree, she worked as a research assistant in close collaboration with industrial research partners and was involved in the production of specific monoclonal antibodies under cGMP conditions for use in Phase I clinical trials.
Education/Academic qualification
Pathology, PhD, The University of New South Wales
2006 → 2010
Award Date: 28 Aug 2010
Biotechnology, Bachelor of Science, The University of New South Wales
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Collaborations and top research areas from the last five years
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Differential effects of MAPK inhibition on immune activity determine melanoma response
Lim, E., Rizos, H. & Kefford, R.
17/04/17 → …
Project: Research
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Establishing an advanced platform for single cell fluorescent imaging and analysis
Morsch, M., Yang, S., Lee, A., Lim, E., Chung, R., Blair, I., Rizos, H. & Atkin, J.
1/01/18 → 31/12/18
Project: Other
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PKC-independent PI3K signalling diminishes PKC inhibitor sensitivity in uveal melanoma
Park, J. J., Hamad, S. A., Stewart, A., Carlino, M. S., Lim, S. Y. & Rizos, H., 28 Feb 2024, In: Oncogenesis. 13, 1, p. 1-9 9 p., 9.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)54 Downloads (Pure) -
Single-cell RNA sequencing in melanoma: what have we learned so far?
Lim, S. Y. & Rizos, H., Feb 2024, In: EBioMedicine. 100, p. 1-10 10 p., 104969.Research output: Contribution to journal › Review article › peer-review
Open AccessFile3 Citations (Scopus)59 Downloads (Pure) -
Single-cell RNA sequencing reveals melanoma cell state-dependent heterogeneity of response to MAPK inhibitors
Lim, S. Y., Lin, Y., Lee, J. H., Pedersen, B., Stewart, A., Scolyer, R. A., Long, G. V., Yang, J. Y. H. & Rizos, H., Sept 2024, In: EBioMedicine. 107, p. 1-14 14 p., 105308.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Downloads (Pure) -
Size matters: integrating tumour volume and immune activation signatures predicts immunotherapy response
Lim, S. Y., Pires da Silva, I., Adegoke, N. A., Lo, S. N., Menzies, A. M., Carlino, M. S., Scolyer, R. A., Long, G. V., Lee, J. H. & Rizos, H., 11 Oct 2024, In: Molecular Cancer. 23, p. 1-6 6 p., 228.Research output: Contribution to journal › Letter › peer-review
Open AccessFile -
IFN-γ signaling sensitizes melanoma cells to BH3 mimetics
Ming, Z., Lim, S. Y., Stewart, A., Pedersen, B., Shklovskaya, E., Menzies, A. M., Carlino, M. S., Kefford, R. F., Lee, J. H., Scolyer, R. A., Long, G. V. & Rizos, H., Jul 2023, In: Journal of Investigative Dermatology. 143, 7, p. 1246-1256.e8 19 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus)
Activities
- 2 Participating in a conference, workshop or event series
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Macquarie University Open Day
Cara Hildreth (Participant), Mark Butlin (Participant), Esther Lim (Participant), Marina Junqueira Santiago (Participant), Albert Lee (Participant) & David Lovejoy (Participant)
14 Aug 2021Activity: Participating in or organising an event › Participating in a conference, workshop or event series
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Faculty of Medicine and Health Sciences 2nd Annual EnCouRage Research Symposium
Dane Turner (Organiser), Angela Laird (Organiser), Emily Don (Organiser), Magdalena Lam (Organiser), Adam Keith Walker (Organiser), Marco Morsch (Organiser), Benjamin Heng (Organiser), Vanessa Tan (Organiser), Esther Lim (Organiser), Marina Junqueira Santiago (Organiser), Hami Shahheydari (Organiser), Luan Luu (Organiser) & Mark Butlin (Poster judge)
27 Oct 2017Activity: Participating in or organising an event › Participating in a conference, workshop or event series