• 831 Citations
  • 16 h-Index
20082019
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Personal profile

Biography

Dr. Lim is an early career postdoctoral fellow in the Precision Cancer Therapy (PCT) group at Macquarie University, and she is currently investigating the transcriptomic and proteomic profiles of melanoma patients treated with selective kinase inhibitors and immunotherapy. Her overarching research goal is to delineate mechanisms of immune responses and translate these findings to clinical applications, particularly in improving immunotherapy efficacy.

 

Dr. Lim has had over 7 years cancer research experience with a focus on cancer cell biology and tumour immunology. She was previously appointed as a postdoctoral researcher at the University of Oxford (from 2011-2015), and her past studies defined pro-metastatic activity of immune cells in sustaining liver metastasis of colorectal cancer. These findings provided valuable insights into the role of the host immune system in cancer progression and were published in Hepatology (2011 and 2013) and Oncogene (2016).

 

Dr. Lim graduated from the University of New South Wales with a PhD degree in Pathology, and her postgraduate research elucidated how oxidative modifications of inflammatory proteins regulate immune responses, and were published in the Journal of Immunology (2008) and Journal of Biological Chemistry (2010). Prior to her PhD, Dr. Lim undertook an Honours project in her final undergraduate year, on the production and characterization of monoclonal antibodies against the chloride intracellular channel 1 (CLIC1) protein, and was awarded first class honours. In the interim of commencing her PhD degree, she worked as a research assistant in close collaboration with industrial research partners and was involved in the production of specific monoclonal antibodies under cGMP conditions for use in Phase I clinical trials.

Education/Academic qualification

Pathology, PhD, The University of New South Wales

20062010

Biotechnology, Bachelor of Science, The University of New South Wales

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  • 12 Similar Profiles
Neoplasm Metastasis Medicine & Life Sciences
Myeloid Cells Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Melanoma Medicine & Life Sciences
Liver Medicine & Life Sciences
Pancreatic Stellate Cells Medicine & Life Sciences
Pancreatic Neoplasms Medicine & Life Sciences
Adenocarcinoma Medicine & Life Sciences

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Projects 2017 2018

Research Outputs 2008 2019

  • 831 Citations
  • 16 h-Index
  • 22 Article
  • 7 Meeting abstract
  • 7 Review article

Circulating cytokines predict immune-related toxicity in melanoma patients receiving anti-PD-1 based immunotherapy

Lim, S. Y., Lee, J. H., Nur Gide, T., Menzies, A. M., Guminski, A., Carlino, M. S., Breen, E., Yang, J. Y. H., Ghazanfar, S., Kefford, R. F., Scolyer, R. A., Long, G. V. & Rizos, H., Mar 2019, In : Clinical Cancer Research. 25, 5, p. 1557-1563 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Immunotherapy
Melanoma
Cytokines
Confidence Intervals
Therapeutics

Distinct immune cell populations define response to anti-PD-1 monotherapy and anti-PD-1/anti-CTLA-4 combined therapy

Gide, T. N., Quek, C., Menzies, A. M., Tasker, A. T., Shang, P., Holst, J., Madore, J., Lim, S. Y., Velickovic, R., Wongchenko, M., Yan, Y., Lo, S., Carlino, M. S., Guminski, A., Saw, R. P. M., Pang, A., McGuire, H. M., Palendira, U., Thompson, J. F., Rizos, H. & 5 othersSilva, I. P. D., Batten, M., Scolyer, R. A., Long, G. V. & Wilmott, J. S., 11 Feb 2019, In : Cancer Cell. 35, 2, p. 238-255.e6 24 p.

Research output: Contribution to journalArticleResearchpeer-review

T-Lymphocytes
Immunotherapy
Population
Neoplasms
Therapeutics

Integrated molecular and immunophenotypic analysis of NK cells in anti-PD-1 treated metastatic melanoma patients

Lee, H., Quek, C., Silva, I., Tasker, A., Batten, M., Rizos, H., Lim, S. Y., Nur Gide, T., Shang, P., Attrill, G. H., Madore, J., Edwards, J., Carlino, M. S., Guminski, A., Saw, R. P. M., Thompson, J. F., Ferguson, P. M., Palendira, U., Menzies, A. M., Long, G. V. & 2 othersScolyer, R. A. & Wilmott, J. S., Feb 2019, In : OncoImmunology. 8, 2, p. 1-10 10 p., e1537581.

Research output: Contribution to journalArticleResearchpeer-review

Natural Killer Cells
Melanoma
Major Histocompatibility Complex
Therapeutics
Neoplasms

Pharmacokinetic and cytokine profiles of melanoma patients with dabrafenib and trametinib-induced pyrexia

Kim, H. Y., Duong, J. K., Gonzalez, M., Long, G. V., Menzies, A. M., Rizos, H., Lim, S. Y., Lee, J. & Boddy, A. V., 8 Apr 2019, In : Cancer Chemotherapy and Pharmacology. 83, 4, p. 693-704 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Pharmacokinetics
Metabolites
Melanoma
Fever
Cytokines

Colorectal cancer liver metastatic growth depends on PAD4-driven citrullination of the extracellular matrix

Yuzhalin, A. E., Gordon-Weeks, A. N., Tognoli, M. L., Jones, K., Markelc, B., Konietzny, R., Fischer, R., Muth, A., O’Neill, E., Thompson, P. R., Venables, P. J., Kessler, B. M., Lim, S. Y. & Muschel, R. J., 1 Dec 2018, In : Nature Communications. 9, 1, p. 1-15 15 p., 4783.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Liver Neoplasms
liver
Liver
Extracellular Matrix
Colorectal Neoplasms