Projects per year
Personal profile
Biography
Dr. Lim is a mid career postdoctoral fellow in the Precision Cancer Therapy (PCT) group at Macquarie University, and she is currently investigating the transcriptomic and proteomic profiles of melanoma patients treated with selective kinase inhibitors and immunotherapy. Her overarching research goal is to delineate mechanisms of immune responses and translate these findings to clinical applications, particularly in improving immunotherapy efficacy.
Dr. Lim has had over 10 years cancer research experience with a focus on cancer cell biology and tumour immunology. She was previously appointed as a postdoctoral researcher at the University of Oxford (from 2011-2015), and her past studies defined pro-metastatic activity of immune cells in sustaining liver metastasis of colorectal cancer. These findings provided valuable insights into the role of the host immune system in cancer progression.
Dr. Lim graduated from the University of New South Wales with a PhD degree in Pathology, and her postgraduate research elucidated how oxidative modifications of inflammatory proteins regulate immune responses. Prior to her PhD, Dr. Lim undertook an Honours project in her final undergraduate year, on the production and characterization of monoclonal antibodies against the chloride intracellular channel 1 (CLIC1) protein, and was awarded first class honours. In the interim of commencing her PhD degree, she worked as a research assistant in close collaboration with industrial research partners and was involved in the production of specific monoclonal antibodies under cGMP conditions for use in Phase I clinical trials.
Education/Academic qualification
Pathology, PhD, The University of New South Wales
2006 → 2010
Award Date: 28 Aug 2010
Biotechnology, Bachelor of Science, The University of New South Wales
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Collaborations and top research areas from the last five years
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Single-cell transcriptome sequencing coupled with a cell-free DNA methylation panel to examine immunotherapy response in metastatic soft tissue sarcoma
Lim, E. (Primary Chief Investigator), Park, J. (Chief Investigator) & Diefenbach, R. (Chief Investigator)
15/09/25 → 14/09/26
Project: Research
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ID24: Ribbon Cable Connectivity of the Carotid Body: Insights for Selective Targeting in Disease
McMullan, S. (Primary Chief Investigator), Paton, J. (Chief Investigator), Dempsey, B. (Chief Investigator), de Melo, M. R. (Chief Investigator), Bokiniec, P. (Chief Investigator), Allen, A. (Associate Investigator) & Lim, E. (Associate Investigator)
1/01/25 → 31/12/28
Project: Research
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Differential effects of MAPK inhibition on immune activity determine melanoma response
Lim, E. (Primary Chief Investigator), Rizos, H. (Associate Investigator) & Kefford, R. (Associate Investigator)
17/04/17 → …
Project: Research
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Establishing an advanced platform for single cell fluorescent imaging and analysis
Morsch, M. (Primary Chief Investigator), Yang, S. (Chief Investigator), Lee, A. (Chief Investigator), Lim, E. (Chief Investigator), Chung, R. (Chief Investigator), Blair, I. (Chief Investigator), Rizos, H. (Chief Investigator) & Atkin, J. (Chief Investigator)
1/01/18 → 31/12/18
Project: Other
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Distinct immunologic patterns of response and resistance to anti-PD-1/PD-L1-based immunotherapy in patients with soft tissue sarcoma
Mannah, B. A., Yang, F., Yu, L., Gurney, H., Yang, J. Y. H., Park, J. J. & Lim, S. Y., 5 Mar 2026, In: Frontiers in Immunology. 17, p. 1-14 14 p., 1783216.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Downloads (Pure) -
Prednisolone modulates CD8⁺ and regulatory T-cell activity to dampen response to immune checkpoint inhibitor therapy in melanoma
Brown, J. R., Pedersen, B., Long, G. V., Maher, N. G., Lim, S. Y., Rizos, H. & Shklovskaya, E., 2026, In: OncoImmunology. 15, 1, p. 1-16 16 p., 2643494.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Link opens in a new tab Citation (Scopus)6 Downloads (Pure) -
Blood-based biomarkers in soft tissue sarcoma: implications for immune checkpoint inhibitor therapy
Mannah, B.-A., Park, J. J. & Lim, S. Y., 15 Sept 2025, In: International Journal of Cancer. 157, 6, p. 1031-1042 12 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile3 Link opens in a new tab Citations (Scopus)1 Downloads (Pure) -
Circulating IFNγ-associated protein signatures predict response to neoadjuvant immunotherapy in patients with stage III melanoma
Yang, F., Lim, S. Y., da Silva, I. P., Yu, L., Conway, J. W., Menzies, A. M., Long, G. V., Yang, J. Y. H. & Rizos, H., Dec 2025, In: Cancer Cell International. 25, 1, p. 1-11 11 p., 424.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Link opens in a new tab Citations (Scopus)2 Downloads (Pure) -
Circulating MicroRNAs: functional biomarkers for melanoma prognosis and treatment
Lim, S. Y., Boyd, S. C., Diefenbach, R. J. & Rizos, H., 28 Mar 2025, In: Molecular Cancer. 24, 1, p. 1-17 17 p., 99.Research output: Contribution to journal › Review article › peer-review
Open AccessFile24 Link opens in a new tab Citations (Scopus)14 Downloads (Pure)
Activities
- 2 Participating in a conference, workshop or event series
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Macquarie University Open Day
Hildreth, C. (Participant), Butlin, M. (Participant), Lim, E. (Participant), Junqueira Santiago, M. (Participant), Lee, A. (Participant) & Lovejoy, D. (Participant)
14 Aug 2021Activity: Participating in or organising an event › Participating in a conference, workshop or event series
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Faculty of Medicine and Health Sciences 2nd Annual EnCouRage Research Symposium
Turner, D. (Organiser), Laird, A. (Organiser), Don, E. (Organiser), Lam, M. (Organiser), Walker, A. K. (Organiser), Morsch, M. (Organiser), Heng, B. (Organiser), Tan, V. (Organiser), Lim, E. (Organiser), Junqueira Santiago, M. (Organiser), Shahheydari, H. (Organiser), Luu, L. (Organiser) & Butlin, M. (Poster judge)
27 Oct 2017Activity: Participating in or organising an event › Participating in a conference, workshop or event series