• 1452 Citations
  • 8 h-Index
20092021
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Personal profile

Biography

Doctor Fabien Delerue is the Head of the Genome Editing at Macquarie (GEM), a transgenic core developed in joint venture by the Dementia Research Centre (DRC) and the Macquarie Animal Research Services (MARS). Fabien graduated from the University of Bordeaux in France and received his PhD from the University of Sydney in 2013. Fabien gained his first research experience in the preclinical CNS Centre of Hoffmann-La Roche Ltd (Basel, Switzerland) where he became an expert in in vivo activities (i.e. animal models of diseases). In 2013, Fabien moved to the University of New South Wales, where he became Lecturer and managed the Transgenic Animal Unit. His research focused on developing new gene transfer techniques particularly applicable to dementia and rare genetic diseases. In 2018 he became Senior Lecturer and joined Macquarie University to head the GEM transgenic facility and develop in parallel a research program on rare genetic disorders.

Research interests

Fabien’s contribution to the field of transgenesis and genome editing is internationally recognized. Fabien’s career spans over 20 years practice in assisted reproduction and generation of animal models of diseases. Current projects include:

-      Optimization of gene transfer methods for the generation of transgenic animal models

-      Development of new assisted reproductive techniques

-      Discovery and engineering of new endonucleases 

-      Investigating the pathomechanisms of FoxG1 syndrome

Education/Academic qualification

MSc., University of Bordeaux

PhD, University of Sydney

Fingerprint Dive into the research topics where Fabien Delerue is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

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Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2018 2021

NBR: Defining the spatial and temporal regulation of neurite branching

Fath, T., Gunning, P., Brandt, R., Klotzsch, E., Karl, T. & Delerue, F.

18/12/1817/12/21

Project: Other

Research Outputs 2009 2019

  • 1452 Citations
  • 8 h-Index
  • 14 Article
  • 1 Chapter

Developmental expression of mutant PFN1 in motor neurons impacts neuronal growth and motor performance of young and adult mice

Brettle, M., Stefen, H., Djordjevic, A., Fok, S. Y. Y., Chan, J. W., van Hummel, A., van der Hoven, J., Przybyla, M., Volkerling, A., Ke, Y. D., Delerue, F., Ittner, L. M. & Fath, T., 27 Sep 2019, In : Frontiers in Molecular Neuroscience. 12, p. 1-12 12 p., 231.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Profilins
Motor Neurons
Young Adult
Amyotrophic Lateral Sclerosis
Transgenic Mice

Generation of a new tau knockout (tau Δex1) line using CRISPR/Cas9 genome editing in mice

Tan, D. C. S., Yao, S., Ittner, A., Bertz, J., Ke, Y. D., Ittner, L. M. & Delerue, F., 1 Jan 2018, In : Journal of Alzheimer's Disease. 62, 2, p. 571-578 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Clustered Regularly Interspaced Short Palindromic Repeats
Introns
Dementia
Exons
Alzheimer Disease

Uncoupling N-acetylaspartate from brain pathology: implications for Canavan disease gene therapy

von Jonquieres, G., Spencer, Z. H. T., Rowlands, B. D., Klugmann, C. B., Bongers, A., Harasta, A. E., Parley, K. E., Cederholm, J., Teahan, O., Pickford, R., Delerue, F., Ittner, L. M., Fröhlich, D., McLean, C. A., Don, A. S., Schneider, M., Housley, G. D., Rae, C. D. & Klugmann, M., 1 Jan 2018, In : Acta Neuropathologica. 135, 1, p. 95-113 19 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Canavan Disease
Genetic Therapy
Pathology
Brain
Oligodendroglia

Accelerated aging exacerbates a pre-existing pathology in a tau transgenic mouse model

Bodea, L-G., Evans, H. T., Van der Jeugd, A., Ittner, L. M., Delerue, F., Kril, J., Halliday, G., Hodges, J., Kiernan, M. C. & Götz, J., 1 Apr 2017, In : Aging Cell. 16, 2, p. 377-386 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Transgenic Mice
Pathology
Tauopathies
Phosphorylation
Amygdala

Generation of genetically modified mice through the microinjection of oocytes

Delerue, F. & Ittner, L. M., 15 Jun 2017, In : Journal of Visualized Experiments. 2017, 124, p. 1-12 12 p., e55765.

Research output: Contribution to journalArticleResearchpeer-review

Clustered Regularly Interspaced Short Palindromic Repeats
Microinjections
Oocytes
DNA
Gene Targeting