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Doctor Fabien Delerue is the Head of the Genome Editing at Macquarie (GEM), a transgenic core which is part of the Dementia Research Centre (DRC), a leading discovery-based research centre established in 2018 at Macquarie University. Fabien graduated from the University of Bordeaux in France and received his PhD from the University of Sydney. Fabien gained his first research experience in the preclinical CNS Centre of Hoffmann-La Roche Ltd (Basel, Switzerland) where he became an expert in in vivo activities (i.e. animal models of diseases). In 2013, Fabien moved to the University of New South Wales, where he became Lecturer and managed the Transgenic Animal Unit. In 2018, he became Senior Lecturer and joined Macquarie University to head the GEM transgenic facility. His research focuses on developing new genome editing and gene transfer techniques particularly applicable to dementia. In parallel, Fabien developed a research program on rare genetic disorders.
Fabien’s contribution to the field of transgenesis and genome editing is internationally recognized. Fabien’s career spans over 20 years practice in assisted reproduction and generation of animal models of diseases. Current projects include:
- Optimization of gene transfer methods for the generation of genetically modified animals.
- Development of new assisted reproductive techniques.
- Discovery and engineering of new endonucleases.
- Investigating the pathomechanisms of FoxG1 syndrome.
MSc., University of Bordeaux
PhD, University of Sydney
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1/02/19 → 1/02/21
18/12/18 → 17/12/21
Klugmann, M., Kalotay, E., Delerue, F., Ittner, L. M., Bongers, A., Yu, J., Morris, M. J., Housley, G. D. & Fröhlich, D., Jul 2022, In: Neurochemical Research. 47, 7, p. 1972-1984 13 p.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile3 Downloads (Pure)
Deng, Y., Bi, M., Delerue, F., Forrest, S. L., Chan, G., van der Hoven, J., van Hummel, A., Feiten, A. F., Lee, S., Martinez-Valbuena, I., Karl, T., Kovacs, G. G., Morahan, G., Ke, Y. D. & Ittner, L. M., Oct 2022, In: Acta Neuropathologica. 144, 4, p. 637-650 14 p.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile2 Downloads (Pure)
Microinjection of zygotes for CRISPR/Cas9-mediated insertion of transgenes into the murine Rosa26 safe harborDelerue, F. & Ittner, L. M., 2022, Applications of genome modulation and editing. Verma, P. J., Sumer, H. & Liu, J. (eds.). New York, NY: Humana Press Inc., p. 115-128 14 p. (Methods in Molecular Biology; vol. 2495).
Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
Yang, L., Chen, Z., Stout, E. S., Delerue, F., Ittner, L. M., Wilkins, M. R., Quinlan, K. G. R. & Crossley, M., 22 May 2020, In: Nature Communications. 11, 1, p. 1-10 10 p., 2560.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile
Ittner, A., Asih, P. R., Tan, A. R. P., Prikas, E., Bertz, J., Stefanoska, K., Lin, Y., Volkerling, A. M., Ke, Y. D., Delerue, F. & Ittner, L. M., 1 Sep 2020, In: Acta Neuropathologica. 140, 3, p. 279-294 16 p.
Research output: Contribution to journal › Article › peer-review