• 835 Citations
  • 16 h-Index

Research output per year

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Personal profile


Fei did her undergraduate studies in Chemistry at John Carroll University (University Heights, Ohio), and then moved to New Haven, Connecticut for her PhD studies in Organic Chemistry at Yale. After her PhD, she moved to Boston, Massachusetts as an NIH postdoctoral fellow to work on new biosynthetic approaches in molecular medicine at the Harvard Medical School. In 2004, Fei moved from Boston to Sydney and is currently a Senior Lecturer in the Department of Chemistry and Biomolecular Sciences (CBMS) at Macquarie. The current phase of her research focuses on developing efficient synthetic methods for accessing small molecules with useful properties in chemistry and biology. Her long-term interest in chemical proteomics along with its applications in basic biological discovery and medicine is being pursued in close collaboration with the Australian Proteomics Analysis Facility (APAF). Please visit the Liu Research Group Homepage for further information.


BSc in Chemistry, John Carroll University
PhD in Organic Chemistry, Yale University

Research Interests

  • Asymmetric and catalytic reactions for proficient bond formation and stereocontrolled generation of synthons or biological probes
  • Isozyme specific antagonist discovery by conformational selection
  • Chemistry and biology of post-translational modifications of enzymes or proteomes in cell signalling

Selected Publications

  1. Patel, A.; Ari, Hardianto.; Ranganathan, S; Liu, F.*Org. & Biomol. Chem., 2017, 1570-1574. Divergent response of homologous ATP sites to stereospecific ligand fluorination for selectivity enhancement.
  2. Kenny, R.; Liu, F.* Chemical Record 2017, 535-553. Cooperative Trifunctional Organocatalysts for Proficient Proton Transfer Reactions.
  3. Liu, F.;* Koval, M.; Ranganathan, S.; Fanayan, S.; Hancock, W.; Lundberg, E.;, Beavis, R.; Lane, L.; Duek, P.; McQuade, L.; Kelleher, N.; Baker, M. J. of Prot. Res2016, 339-59. Systems Proteomics View of the Endogenous Human Claudin Protein Family.
  4. Kenny, R.; Liu, F.* Eur. J. Org. Chem., 2015, 5304-5319. Trifunctional Organocatalysts: Catalytic Proficiency by Cooperative Activation.
  5. Patel, A.; Hunter, L.; Bhadbhade, M. M.; Liu, F.* Eur. J. Org. Chem., 2014, 2584-2593. Conformational Regulation of Substituted Azepanes through Mono-, Di-, and Trifluorination.
  6. Patel, A.; Ball, G.; Hunter, L.; Liu, F.* Org. & Biomol. Chem., 2013, 3675-3683. Conformational regulation of substituted azepanes through selective monofluorination.
  7. Dolai, S.; Xu, M.; Liu, F.; Molloy, M.* Proteomics, 2011, 2683-2693. Quantitative chemical proteomics in small scale culture of phorbol ester stimulated basal breast cancer cells.
  8. Garnier, J. M.; Liu, F.* Org. & Biomol. Chem., 2009, 1272-1275. Trifunctional Organocatalyst Promoted Counterion Catalysis for Fast and Enantioselective aza-Morita-Baylis-Hillman Reactions at Ambient Temperature.
  9. Garnier, J-M.; Anstiss, C.; Liu, F.* Adv. Synth. & Catal., 2009, 351, 331-8. Enantioselective Trifunctional Organocatalysts for Rate-Enhanced Aza-Morita-Baylis-Hillman Reactions at Room Temperature. (Highlighted in Synfacts, 2009, 447)
  10. Stephens, B. E.; Liu, F.* J. Org. Chem. 2009, 254-263. A Regio- and Diastereoselective Intramolecular Nitrone Cycloaddition for Practical 3- and 2,3-Substituted Piperidine Synthesis from gamma-Butyrolactone.
  11. Yang, M.; Liu, F.* J. Org. Chem. 2007, 8969-8971. An Ullmann Coupling of Aryl Iodides and Amines Using an Air-Stable Diazaphospholane Ligand.
  12. Patil, S.N; Liu, F.* Org. Lett. 2007, 193-6. Base-assisted Regio- and Diastereoselective Conversion of Functionalized Furans to Butenolides using Singlet Oxygen.
  13. Yin, J., Liu, F.; Schinke, M., Daly, C, Walsh, C.T.* J. Am. Chem. Soc. 2004,13570-1. Phagemid encoded small molecules for high throughput screening of chemical libraries.
  14. Yin, J., Liu, F.; Li, X., Walsh, C.T.* J. Am. Chem. Soc. 2004, 7754-5. Labeling proteins with small molecules by site-specific posttranslational modification.
  15. Liu, F. Gauneau, S.; Walsh, C. T.* Chem & Biol. 2004, 1533-42. Hybrid nonribosomal peptide-polyketide interfaces in epothilone biosynthesis: minimal requirements at N and C termini of EpoB for elongation.
  16. O'Connor, S. E.#; Walsh, C.T.*; Liu, F.# Angew. Chem. Int. Ed. 2003, 3917-21. Cross-System Enzyme Module Recognition for Combinatorial Biosynthesis: Linker-Dependent Interface between the Biosynthetic Pathways of Yersiniabactin and the Epothilones.

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A multi-omics platform for molecular evolution and developmental biology

Ranganathan, S., Ragan, M., Coin, L., Lambert, D., Zhou, Y., Quinn, R., Beagley, K., Liu, F., Lewis, R., Little, M., Mackay-Sim, A. & Gorse, A. D.


Project: Research

Agilent 6130B/1260 LCMS System

Zakoshanski, I., Piggott, A., Karuso, P., Liu, F., Jamie, J., McRae, C., Try, A., Willows, R. & Jin, D.


Project: Research

Research Outputs

  • Diverse dynamics features of novel protein kinase C (PKC) isozymes determine the selectivity of a fluorinated balanol analogue for PKCϵ

    Hardianto, A., Khanna, V., Liu, F. & Ranganathan, S., 4 Feb 2019, In : BMC Bioinformatics. 19, Suppl. 13, p. 1-11 11 p., 342.

    Research output: Contribution to journalArticle

    Open Access
  • 1 Citation (Scopus)
    12 Downloads (Pure)

    Is it time for artificial intelligence to predict the function of natural products based on 2D-structure

    Liu, M., Karuso, P., Feng, Y., Kellenberger, E., Liu, F., Wang, C. & Quinn, R. J., 1 Oct 2019, In : MedChemComm. 10, 10, p. 1667-1677 11 p.

    Research output: Contribution to journalReview article

    Open Access
  • 1 Citation (Scopus)

    Reverse chemical proteomics identifies an unanticipated human target of the antimalarial artesunate

    Gotsbacher, M. P., Cho, S. M., Kim, N. H., Liu, F., Kwon, H. J. & Karuso, P., 19 Apr 2019, In : ACS Chemical Biology. 14, 4, p. 636-643 8 p.

    Research output: Contribution to journalArticle

  • 6 Citations (Scopus)

    Switchable pyrrole-based hydrogen bonding motif in enantioselective trifunctional organocatalysis

    Eliseenko, S. S. & Liu, F., 25 Jan 2019, In : Tetrahedron. 75, 4, p. 518-526 9 p.

    Research output: Contribution to journalArticle

  • 1 Citation (Scopus)


    Hyperdrive Science Pty Ltd

    Peter Karuso (Participant), Fei Liu (Participant)

    Impact: Economy impacts, Other impacts