Gene Hart-Smith

Dr

  • 882 Citations
  • 21 h-Index
20072020
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Personal profile

Biography

Dr Gene Hart-Smith is a recent ARC Discovery Early Career Researcher Award holder working within the Department of Molecular Sciences. In 2010 he completed a PhD at the UNSW School of Chemistry, in which he utilised mass spectrometry as a primary tool to study synthetic polymers. He has since been applying this expertise in mass spectrometry to the study of biological systems.

Gene has a particular interest in the nascent principles of molecular systems biology and network theory. These principles provide a foundation from which to make sense of the large-scale molecular ‘parts lists’ (e.g. lists of genes and proteins) that are being generated for many species in contemporary biological research. They suggest that if the connections between these parts are studied and contextualised within biomolecular interaction networks, unique and important insights can be gained into the operation and organisation of living things.

Much of Gene's research involves studying biomolecular interaction networks involving proteins. He has a particular interest in how small modifications to proteins, post-translational modifications, regulate how these networks change over different conditions or time points. He has developed and applied mass spectrometric methods towards organism-wide studies of these phenomena in the model organism Saccharomyces cerevisiae (baker’s yeast). He is now using these methods to gain a better understanding of the root architecture of rice (Oryza sativa), the biggest user of water in agriculture worldwide, with the goal of improving the efficiency of rice water use.

Education/Academic qualification

Chemistry, PhD, The University of New South Wales

20062010

Industrial Chemistry, Bachelor of Engineering (Honours Class 1), The University of New South Wales

20012005

External positions

UNSW Research Fellow, The University of New South Wales

20182019

ARC DECRA Fellow, The University of New South Wales

20152018

UNSW Research Fellow, The University of New South Wales

20142015

ARC Australian Postdoctoral Fellow, The University of New South Wales

20112014

Postdoctoral Researcher, Bioanalytical Mass Spectrometry Facility

20102011

Fingerprint Dive into the research topics where Gene Hart-Smith is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

Methylation Chemical Compounds
Mass spectrometry Chemical Compounds
Electrospray ionization Chemical Compounds
Polymers Chemical Compounds
Yeast Chemical Compounds
Proteins Chemical Compounds
Saccharomyces cerevisiae Medicine & Life Sciences
Methyltransferases Medicine & Life Sciences

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Research Outputs 2007 2020

  • 882 Citations
  • 21 h-Index
  • 46 Article
  • 2 Review article
  • 1 Chapter

Crosstalk of phosphorylation and arginine methylation in disordered SRGG repeats of Saccharomyces cerevisiae fibrillarin and its association with nucleolar localization

Smith, D-L., Erce, M. A., Lai, Y-W., Tomasetig, F., Hart-Smith, G., Hamey, J. J. & Wilkins, M. R., 17 Jan 2020, In : Journal of molecular biology. 432, 2, p. 448-466 19 p.

Research output: Contribution to journalArticleResearchpeer-review

Methylation
Saccharomyces cerevisiae
Arginine
Phosphorylation
Proteins

Phenotypic screen for oxygen consumption rate identifies an anti-cancer naphthoquinone that induces mitochondrial oxidative stress

Byrne, F. L., Olzomer, E. M., Marriott, G. R., Quek, L-E., Katen, A., Su, J., Nelson, M. E., Hart-Smith, G., Larance, M., Sebesfi, V. F., Cuff, J., Martyn, G. E., Childress, E., Alexopoulos, S. J., Poon, I. K., Faux, M. C., Burgess, A. W., Reid, G., McCarroll, J. A., Santos, W. L. & 5 othersQuinlan, K. GR., Turner, N., Fazakerley, D. J., Kumar, N. & Hoehn, K. L., Jan 2020, In : Redox Biology. 28, p. 1-10 10 p., 101374.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Naphthoquinones
Oxidative stress
Oxygen Consumption
Peroxiredoxin III
Oxidative Stress

Control of cognate sense mRNA translation by cis-natural antisense RNAs

Deforges, J., Reis, R. S., Jacquet, P., Sheppard, S., Gadekar, V. P., Hart-Smith, G., Tanzer, A., Hofacker, I. L., Iseli, C., Xenarios, I. & Poirier, Y., May 2019, In : Plant Physiology. 180, 1, p. 305-322 18 p.

Research output: Contribution to journalArticleResearchpeer-review

antisense RNA
Antisense RNA
Protein Biosynthesis
translation (genetics)
Arabidopsis

MS2-Deisotoper: a tool for deisotoping high-resolution MS/MS spectra in normal and heavy isotope-labelled samples

Tay, A. P., Liang, A., Hamey, J. J., Hart-Smith, G. & Wilkins, M. R., Sep 2019, In : Proteomics. 19, 17, p. 1-13 13 p., 1800444.

Research output: Contribution to journalArticleResearchpeer-review

Isotopes
Peptides
Peptide Fragments
Proteins
User interfaces

Non-canonical ubiquitination of the cholesterol-regulated degron of squalene monooxygenase

Chua, N. K., Hart-Smith, G. & Brown, A. J., 17 May 2019, In : Journal of Biological Chemistry. 294, 20, p. 8134-8147 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Squalene Monooxygenase
Ubiquitination
Cholesterol
Degradation
Serine