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Personal profile

Biography

Prof Gilles Guillemin has been working in the fields of Neuroimmunology and tryptophan metabolism for more than 20 years.

He is the Co-funder of the MND and Neurodegenerative Diseases Research Centre, The Co-funder of the Macquarie University MND Biobank and the Head of the Neuroinflammation group at Macquarie University.

Prof Guillemin’s team is one of the world’s leading research groups working on the involvement of the tryptophan catabolism (via the kynurenine pathway) in human neurodegenerative diseases.

He demonstrated the roles of this pathway in multiple sclerosis, Alzheimer's disease, amyotrophic lateral sclerosis, suicide…

He is the President of the International Society for Tryptophan Research and Editor-in-Chief of the International Journal for Tryptophan Research.

He has published more than 200 peer reviewed scientific articles. His current h-index is currently 51 and has more than 10.000 citations.

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

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Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2012 2024

Acoustic liquid handling robotics for bioactive compound discovery

Karuso, P., Poulsen, S., Avery, V., Quinn, R., Jonathan, B., Scanlon, M., Cooper, M., Booker, G., Professor, S., Guillemin, G., Smith, J., Ryan, J. & Peat, T.

10/03/17 → …

Project: Research

Slowing progression of Alzheimer's disease by modulating the kynurenine pathway

Guillemin, G., Lovejoy, D., Ittner, A., Braidy, N., Doecke, J., Lim, C., Nicolazzo, J. & Ittner, L.

1/01/17 → …

Project: Research

Macquarie University Centre for Motor Neuron Disease Research

Blair, I., Rowe, D., Guillemin, G., Chung, R., Atkin, J., Cole, N., Laird, A., Lim, C., Williams, K., Yang, S., Morsch, M., Lee, A., Shi, B., Walker, A., Lovejoy, D., Furlong, S., Adams, L., Syal, D., Bazzi, R., Svahn, A., Parakh, S., Shahheydari, H., Konopka, A., Ragagnin, A., Mehta, P., Wright, A., Bourbon, L., Sabaretnam, T., Don, E., Hortle, E., De Luca, A., Zhang, K., Tarr, I., Galper, J., Varney, B., Chow, S. & Formella, I.

1/01/1731/12/19

Project: Research

Research Outputs 1993 2019

Amelioration of aluminum maltolate-induced inflammation and endoplasmic reticulum stress-mediated apoptosis by tannoid principles of Emblica officinalis in neuronal cellular model

Dhivya Bharathi, M., Justin-Thenmozhi, A., Manivasagam, T., Ahmad Rather, M., Saravana Babu, C., Mohamed Essa, M. & Guillemin, G. J., 1 Feb 2019, In : Neurotoxicity Research. 35, 2, p. 318-330 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Phyllanthus emblica
Endoplasmic Reticulum Stress
Eukaryotic Initiation Factor-2
Apoptosis
Inflammation

Antioxidant therapies in attention deficit hyperactivity disorder

Moghadas, M., Essa, M. M., Ba-Omar, T., Al-Shehi, A., Qoronfleh, M. W., Eltayeb, E. A., Guillemin, G. J., Manivasagam, T., Justin-Thenmozhi, A., Al-Bulushi, B. S., Al-Adawi, S. & Edalatmanesh, M. A., 1 Jan 2019, In : Frontiers in bioscience (Landmark edition). 24, 2, p. 313-333 21 p.

Research output: Contribution to journalArticleResearchpeer-review

Attention Deficit Disorder with Hyperactivity
Antioxidants
Pediatrics
Oxidative stress
Cell membranes

Asiatic acid attenuated aluminum chloride-induced tau pathology, oxidative stress and apoptosis via AKT/GSK-3β signaling pathway in Wistar rats

Ahmad Rather, M., Justin-Thenmozhi, A., Manivasagam, T., Saravanababu, C., Guillemin, G. J. & Essa, M. M., 15 May 2019, In : Neurotoxicity Research. 35, 4, p. 955-968 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Oxidative stress
Pathology
Wistar Rats
Rats
Oxidative Stress

Chemical reprogramming enhances homology-directed genome editing in zebrafish embryos

Aksoy, Y. A., Nguyen, D. T., Chow, S., Chung, R. S., Guillemin, G. J., Cole, N. J. & Hesselson, D., 23 May 2019, In : Communications Biology. 2, p. 1-9 9 p., 198.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Zebrafish
Embryonic Structures
Clustered Regularly Interspaced Short Palindromic Repeats
DNA Repair
DNA

Correlation between plasma and CSF concentrations of kynurenine pathway metabolites in Alzheimer’s disease and relationship to amyloid-β and tau

Jacobs, K., Lim, C. K., Blennow, K., Zetterberg, H., Chatterjee, P., Martins, R. N., Brew, B., Guillemin, G. & Lovejoy, D., 1 Apr 2019, (Accepted/In press) In : Neurobiology of Aging. 80, p. 11-20 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Kynurenine
Amyloid
Cerebrospinal Fluid
Alzheimer Disease
Quinolinic Acid

Activities 2015 2018

  • 1 Editorial work
  • 1 Membership of committee

International Society for Tryptophan Research (Executive Committee) (External organisation)

Gilles Guillemin (Chair), Florian Zepf (Chair), Trevor Stone (Member), Kuniaki Saito (Member), Sophie Erhardt (Member), Edwin Lim (Member)
2018 → …

Activity: MembershipMembership of committee

International Journal of Tryptophan Research (Journal)

Gilles Guillemin (Editor in chief), Edwin Lim (Editor in chief)
2015 → …

Activity: Publication peer-review and editorial workEditorial work