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Personal profile


Prof Gilles Guillemin has been working in the fields of Neuroimmunology and tryptophan metabolism for more than 20 years.

He is the Co-funder of the MND and Neurodegenerative Diseases Research Centre, The Co-funder of the Macquarie University MND Biobank and the Head of the Neuroinflammation group at Macquarie University.

Prof Guillemin’s team is one of the world’s leading research groups working on the involvement of the tryptophan catabolism (via the kynurenine pathway) in human neurodegenerative diseases.

He demonstrated the roles of this pathway in multiple sclerosis, Alzheimer's disease, amyotrophic lateral sclerosis, suicide…

He is the President of the International Society for Tryptophan Research and Editor-in-Chief of the International Journal for Tryptophan Research.

He has published more than 200 peer reviewed scientific articles. His current h-index is currently 51 and has more than 10.000 citations.

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

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Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2012 2024

Acoustic liquid handling robotics for bioactive compound discovery

Karuso, P., Poulsen, S., Avery, V., Quinn, R., Jonathan, B., Scanlon, M., Cooper, M., Booker, G., Professor, S., Guillemin, G., Smith, J., Ryan, J. & Peat, T.

10/03/17 → …

Project: Research

Macquarie University Centre for Motor Neuron Disease Research

Blair, I., Rowe, D., Guillemin, G., Chung, R., Atkin, J., Cole, N., Laird, A., Lim, C., Williams, K., Yang, S., Morsch, M., Lee, A., Shi, B., Walker, A., Lovejoy, D., Furlong, S., Adams, L., Syal, D., Bazzi, R., Svahn, A., Parakh, S., Shahheydari, H., Konopka, A., Ragagnin, A., Mehta, P., Wright, A., Bourbon, L., Sabaretnam, T., Don, E., Hortle, E., De Luca, A., Zhang, K., Tarr, I., Galper, J., Varney, B., Chow, S. & Formella, I.


Project: Research

Research Output 1993 2018

Alterations in serum kynurenine pathway metabolites in individuals with high neocortical amyloid-β load: a pilot study

Chatterjee, P., Goozee, K., Lim, C. K., James, I., Shen, K., Jacobs, K. R., Sohrabi, H. R., Shah, T., Asih, P. R., Dave, P., ManYan, C., Taddei, K., Lovejoy, D. B., Chung, R., Guillemin, G. J. & Martins, R. N. 1 Dec 2018 In : Scientific Reports. 8, 1, p. 1-10 10 p., 8008

Research output: Contribution to journalArticle

Open Access
Alzheimer Disease
Social Adjustment

Amelioration of aluminum maltolate-induced inflammation and endoplasmic reticulum stress-mediated apoptosis by tannoid principles of Emblica officinalis in neuronal cellular model

Dhivya Bharathi, M., Justin-Thenmozhi, A., Manivasagam, T., Ahmad Rather, M., Saravana Babu, C., Mohamed Essa, M. & Guillemin, G. J. 21 Sep 2018 In : Neurotoxicity Research.

Research output: Contribution to journalArticle

Phyllanthus emblica
Endoplasmic Reticulum Stress
Eukaryotic Initiation Factor-2

BMAA and Neurodegenerative Illness

Cox, P. A., Kostrzewa, R. M. & Guillemin, G. J. Jan 2018 In : Neurotoxicity Research. 33, 1, p. 178–183 6 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Parkinsonian Disorders
Motor Neurons

Cocoa beans improve mitochondrial biogenesis via PPARγ/PGC1α dependent signalling pathway in MPP+ intoxicated human neuroblastoma cells (SH-SY5Y)

Chidambaram, S. B., Bhat, A., Ray, B., Sugumar, M., Muthukumar, S. P., Manivasagam, T., Justin Thenmozhi, A., Essa, M. M., Guillemin, G. J. & Sakharkar, M. K. 12 Sep 2018 In : Nutritional Neuroscience.

Research output: Contribution to journalArticle

Organelle Biogenesis
Mitochondrial Membrane Potential
Tyrosine 3-Monooxygenase
Parkinson Disease

Demethoxycurcumin, a natural derivative of curcumin abrogates rotenone-induced dopamine depletion and motor deficits by its antioxidative and anti-inflammatory properties in Parkinsonian rats

Ramkumar, M., Rajasankar, S., Gobi, V. V., Janakiraman, U., Manivasagam, T., Thenmozhi, A. J., Essa, M. M., Chidambaram, R., Chidambaram, S. B. & Guillemin, G. J. 1 Jan 2018 In : Pharmacognosy Magazine. 14, 53, p. 9-16 8 p.

Research output: Contribution to journalArticle

Anti-Inflammatory Agents
Parkinson Disease