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Research Outputs

  • 337 Citations
  • 7 h-Index
  • 13 Article
  • 2 Meeting abstract
  • 1 Abstract
2020

Amyotrophic lateral sclerosis-linked UBQLN2 mutants inhibit endoplasmic reticulum to Golgi transport, leading to Golgi fragmentation and ER stress

Halloran, M., Ragagnin, A. M. G., Vidal, M., Parakh, S., Yang, S., Heng, B., Grima, N., Shahheydari, H., Soo, K-Y., Blair, I., Guillemin, G. J., Sundaramoorthy, V. & Atkin, J. D., Oct 2020, In : Cellular and Molecular Life Sciences. 77, 19, p. 3859-3873 15 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

CYLD is a causative gene for frontotemporal dementia - amyotrophic lateral sclerosis

Dobson-Stone, C., Hallupp, M., Shahheydari, H., Ragagnin, A. M. G., Chatterton, Z., Carew-Jones, F., Shepherd, C. E., Stefen, H., Paric, E., Fath, T., Thompson, E. M., Blumbergs, P., Short, C. L., Field, C. D., Panegyres, P. K., Hecker, J., Nicholson, G., Shaw, A. D., Fullerton, J. M., Luty, A. A. & 19 others, Schofield, P. R., Brooks, W. S., Rajan, N., Bennett, M. F., Bahlo, M., Shankaracharya, Landers, J. E., Piguet, O., Hodges, J. R., Halliday, G. M., Topp, S. D., Smith, B. N., Shaw, C. E., McCann, E., Fifita, J. A., Williams, K. L., Atkin, J. D., Blair, I. P. & Kwok, J. B., 1 Mar 2020, In : Brain : a journal of neurology. 143, 3, p. 783-799 17 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Impaired NHEJ repair in amyotrophic lateral sclerosis is associated with TDP-43 mutations

Konopka, A., Whelan, D. R., Jamali, M. S., Perri, E., Shahheydari, H., Toth, R. P., Parakh, S., Robinson, T., Cheong, A., Mehta, P., Vidal, M., Ragagnin, A. M. G., Khizhnyak, I., Jagaraj, C. J., Galper, J., Grima, N., Deva, A., Shadfar, S., Nicholson, G. A., Yang, S. & 6 others, Cutts, S. M., Horejsi, Z., Bell, T. D. M., Walker, A. K., Blair, I. P. & Atkin, J. D., 9 Sep 2020, In : Molecular Neurodegeneration. 15, 1, p. 1-28 28 p., 51.

Research output: Contribution to journalArticle

Open Access
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3 Downloads (Pure)

The redox activity of protein disulfide isomerase inhibits ALS phenotypes in cellular and zebrafish models

Parakh, S., Shadfar, S., Perri, E. R., Ragagnin, A. M. G., Piattoni, C. V., Fogolín, M. B., Yuan, K. C., Shahheydari, H., Don, E. K., Thomas, C. J., Hong, Y., Comini, M. A., Laird, A. S., Spencer, D. M. & Atkin, J. D., 22 May 2020, In : iScience. 23, 5, p. 1-27 44 p., 101097.

Research output: Contribution to journalArticle

Open Access
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1 Citation (Scopus)
4 Downloads (Pure)

Motor neuron abnormalities correlate with impaired movement in zebrafish that express mutant superoxide dismutase 1

Robinson, K. J., Yuan, K. C., Don, E. K., Hogan, A. L., Winnick, C. G., Tym, M. C., Lucas, C. W., Shahheydari, H., Watchon, M., Blair, I. P., Atkin, J. D., Nicholson, G. A., Cole, N. J. & Laird, A. S., 1 Feb 2019, In : Zebrafish. 16, 1, p. 8-14 7 p.

Research output: Contribution to journalArticle

Open Access
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2 Citations (Scopus)
9 Downloads (Pure)

Pathogenic mutation in the ALS/FTD gene, CCNF, causes elevated Lys48-linked ubiquitylation and defective autophagy.

Lee, A., Rayner, S. L., Gwee, S. S. L., De Luca, A., Shahheydari, H., Sundaramoorthy, V., Morsch, M., Hogan, A., Don, E., Williams, K., Yerbury, J. J., Blair, I., Atkin, J. D., Molloy, M. P. & Chung, R. S., 8 Feb 2019. 1 p.

Research output: Contribution to conferenceAbstract

2018

Pathogenic mutation in the ALS/FTD gene, CCNF, causes elevated Lys48-linked ubiquitylation and defective autophagy

Lee, A., Rayner, S. L., Gwee, S. S. L., De Luca, A., Shahheydari, H., Sundaramoorthy, V., Ragagnin, A., Morsch, M., Radford, R., Galper, J., Freckleton, S., Shi, B., Walker, A. K., Don, E. K., Cole, N. J., Yang, S., Williams, K. L., Yerbury, J. J., Blair, I. P., Atkin, J. D. & 2 others, Molloy, M. P. & Chung, R. S., Jan 2018, In : Cellular and Molecular Life Sciences. 75, 2, p. 335–354 20 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
2017

Casein kinase II phosphorylation of cyclin F at serine 621 regulates the Lys48-ubiquitylation E3 ligase activity of the SCF(cyclin F) complex

Lee, A., Rayner, S. L., De Luca, A., Gwee, S. S. L., Morsch, M., Sundaramoorthy, V., Shahheydari, H., Ragagnin, A., Shi, B., Yang, S., Williams, K. L., Don, E. K., Walker, A. K., Zhang, K. Y., Yerbury, J. J., Cole, N. J., Atkin, J. D., Blair, I. P., Molloy, M. P. & Chung, R. S., 2017, In : Open Biology. 7, 10, p. 1-11 11 p., 170058.

Research output: Contribution to journalArticle

Open Access
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7 Citations (Scopus)
13 Downloads (Pure)

Protein quality control and the amyotrophic lateral sclerosis/frontotemporal dementia continuum

Shahheydari, H., Ragagnin, A., Walker, A. K., Toth, R. P., Vidal, M., Jagaraj, C. J., Perri, E. R., Konopka, A., Sultana, J. M. & Atkin, J. D., 10 May 2017, In : Frontiers in Molecular Neuroscience. 10, p. 1-25 25 p., 119.

Research output: Contribution to journalArticle

Open Access
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19 Citations (Scopus)
11 Downloads (Pure)
2015

Preexisting MEK1(P124) Mutations Diminish Response to BRAF Inhibitors in Metastatic Melanoma Patients

Carlino, M. S., Fung, C., Shahheydari, H., Todd, J. R., Boyd, S. C., Irvine, M., Nagrial, A. M., Scolyer, R. A., Kefford, R. F., Long, G. V. & Rizos, H., 1 Jan 2015, In : Clinical Cancer Research. 21, 1, p. 98-105 8 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)
2014

Correlation between pre-existing MEK1(P124) mutations and clinical and in vitro response to BRAF inhibitors in metastatic melanoma

Carlino, M. S., Fung, C., Shahheydari, H., Todd, J. R., Scolyer, R. A., Kefford, R., Long, G. V. & Rizos, H., 20 May 2014, In : Journal of Clinical Oncology. 32, 15 supplement, p. 9004-9004 1 p.

Research output: Contribution to journalMeeting abstract

Identification of PLP2 and RAB5C as novel TPD52 binding partners through yeast two-hybrid screening

Shahheydari, H., Frost, S., Smith, B. J., Groblewski, G. E., Chen, Y. & Byrne, J. A., Jul 2014, In : Molecular Biology Reports. 41, 7, p. 4565-4572 8 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Increased MAPK reactivation in early resistance to dabrafenib/trametinib combination therapy of BRAF-mutant metastatic melanoma

Long, G. V., Fung, C., Menzies, A. M., Pupo, G. M., Carlino, M. S., Hyman, J., Shahheydari, H., Tembe, V., Thompson, J. F., Saw, R. P., Howle, J., Hayward, N. K., Johansson, P., Scolyer, R. A., Kefford, R. F. & Rizos, H., Dec 2014, In : Nature Communications. 5, p. 1-9 9 p., 5694.

Research output: Contribution to journalArticle

168 Citations (Scopus)
2010

Regulation of GSK-3β and β-Catenin by Gαq in HEK293T cells

Salmanian, S., Najafi, S. M. A., Rafipour, M., Arjomand, M. R., Shahheydari, H., Ansari, S., Kashkooli, L., Rasouli, S. J., Jazi, M. S. & Minaei, T., 14 May 2010, In : Biochemical and Biophysical Research Communications. 395, 4, p. 577-582 6 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

The formin INF2 regulates basolateral-to-apical transcytosis and lumen formation in association with Cdc42 and MAL2

Madrid, R., Aranda, J. F., Rodríguez-Fraticelli, A. E., Ventimiglia, L., Andrés-Delgado, L., Shehata, M., Fanayan, S., Shahheydari, H., Gómez, S., Jiménez, A., Martín-Belmonte, F., Byrne, J. A. & Alonso, M. A., May 2010, In : Developmental Cell. 18, 5, p. 814-827 14 p.

Research output: Contribution to journalArticle

62 Citations (Scopus)