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Biography
Hannah is a Post Doctoral Research Fellow at The Dementia Research Centre, Macquarie University. With a academic background, Hannah holds a Bachelor’s in Medical Science (specialising in Pathology), a Master of Biotechnology and a Master of Research in Science and Engineering, specialising in Thermal Proteomic Investigations into Protein Drug Targets, in collaboration with the Australian Proteome Analysis Facility. Additionally, Hannah earned a PhD in Biomedical Sciences from The Centre of Motor Neuron Disease Research, focusing on Proteomic Investigations into MND Plasma Biomarkers.
Hannah has developed expertise in utilizing both in vivo (mice models) and in vitro (primary cells) research models, alongside molecular tools, to investigate biological processes in normal and altered states. Central to Hannah's research is mass spectrometry-based proteomics, which is instrumental in gaining insights into neurodegenerative diseases. Additionally, they focus on employing sound disease modelling to understand disease progression, cellular affects, protein interactions, aggregation and spread along with contributing to the understanding of Dementia. This all combined is hoped to improve patient outcomes, quality of life and care along with helping carers and families.
Hannah's research interests lie in the field of proteomics, encompassing both targeted and global studies. Their work aims to elucidate protein interactions, quantitation, mechanistic actions, and the roles proteins play in molecular cell biology. Furthermore, Hannah is dedicated to advancing the understanding of disease models of neurodegeneration, contributing valuable insights into the molecular mechanisms underlying these conditions.
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Collaborations and top research areas from the last five years
Projects
- 3 Finished
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Predicting Motor Neuron Disease (MND) Patient Status by Machine Learning
Lee, A., Liu, S. & Suddull, H.
24/01/21 → 31/12/22
Project: Research
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How can proteomics help solve the lack of biomarkers to aid in the early diagnosis of motor neuron disease (MND)?
Suddull, H. J., Rosa-Fernandes, L. & Lee, A., 2 Sept 2023, In: Expert Review of Proteomics. 20, 7-9, p. 121-123 3 p.Research output: Contribution to journal › Editorial › peer-review
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Proteomics analysis of the TDP-43 interactome in cellular models of ALS pathogenesis
Cheng, F., Chapman, T., Venturato, J., Davidson, J. M., Polido, S. A., Rosa-Fernandes, L., San Gil, R., Suddull, H. J., Zhang, S., Macaslam, C. Y., Szwaja, P., Chung, R., Walker, A. K., Rayner, S. L., Morsch, M. & Lee, A., May 2025, In: Journal of Neurochemistry. 169, 5, p. 1-21 21 p., e70079.Research output: Contribution to journal › Article › peer-review
Open AccessFile12 Downloads (Pure) -
Sodium valproate increases activity of the sirtuin pathway resulting in beneficial effects for spinocerebellar ataxia-3 in vivo
Watchon, M., Luu, L., Robinson, K. J., Yuan, K. C., De Luca, A., Suddull, H. J., Tym, M. C., Guillemin, G. J., Cole, N. J., Nicholson, G. A., Chung, R. S., Lee, A. & Laird, A. S., 20 Aug 2021, In: Molecular Brain. 14, 1, p. 1-16 16 p., 128.Research output: Contribution to journal › Article › peer-review
Open AccessFile15 Citations (Scopus)82 Downloads (Pure) -
Unbiased label-free quantitative proteomics of cells expressing amyotrophic lateral sclerosis (ALS) mutations in CCNF reveals activation of the apoptosis pathway: a workflow to screen pathogenic gene mutations
Cheng, F., Luca, A. D., Hogan, A. L., Rayner, S. L., Davidson, J. M., Watchon, M., Stevens, C. H., Muñoz, S. S., Ooi, L., Yerbury, J. J., Don, E. K., Fifita, J. A., Villalva, M. D., Suddull, H., Chapman, T. R., Hedl, T. J., Walker, A. K., Yang, S., Morsch, M., Shi, B., & 4 others , 27 Apr 2021, In: Frontiers in Molecular Neuroscience. 14, p. 1-18 18 p., 627740.Research output: Contribution to journal › Article › peer-review
Open AccessFile14 Citations (Scopus)115 Downloads (Pure)