Projects per year
Personal profile
Biography
Dr. Hui Xin Ong holds a Bachelor of Pharmacy (Hons) and a PhD in Pharmaceutical Science from the University of Sydney. Her research is focused on developing pharmaceutical and medical device technologies that can be used for the treatment of respiratory and infectious diseases, and methodological platforms that can help promote the translation of new discoveries to clinical practice. Specifically, her expertise lies in the study of the dynamic interactions between the different biological barriers in the respiratory tract and aerosol particles in a representative manner which captures the true nature of aerosol interactions in the lung. Her research is currently a blend of basic, applied and clinical disciplines. Dr. Ong has worked with diverse renown experts from academia and industry partners leading to development of various state-of-the-art pharmaceutical formulations and an outstanding publication record in leading journals in the field.
Education/Academic qualification
Pharmaceuticals, PhD , University of Sydney
Award Date: 16 Oct 2013
Pharmacy, B. Pharm. (Hons), University of Sydney
Award Date: 15 Dec 2009
External positions
Research Leader , Woolcock Institute of Medical Research Limited
2020 → …
Director, Ab Initio Pharma
2019 → …
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Collaborations and top research areas from the last five years
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LP23 (Monash led): Engineering optimal particle maturation in multicomponent sprays
Duke, D. (Chief Investigator), Ong, H. X. (Primary Chief Investigator), Young, P. (Chief Investigator), Traini, D. (Chief Investigator), Myatt, B. (Partner Investigator) & Stein, S. W. (Partner Investigator)
24/03/25 → 23/03/28
Project: Research
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Development of a nasal integrated model for targeted drug delivery testing
Ong, H. X. (Primary Chief Investigator) & Traini, D. (Supervisor)
1/10/23 → 30/09/27
Project: Research
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Development of a smart intranasal brain delivery nanogel for treatment of Alzheimer’s Disease
Traini, D. (Primary Chief Investigator), Ong, H. X. (Chief Investigator), Fathi, A. (Partner Investigator), Chung, R. (Chief Investigator) & Wong, J. (Partner Investigator)
1/09/22 → 31/01/27
Project: Research
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Developing a nasal in vitro biological olfactory region for targeted drug delivery testing
Ong, H. X. (Primary Chief Investigator), Traini, D. (Supervisor), Pannadewi, T. (Student CI) & Suman, J. (Supervisor)
1/07/24 → 30/06/25
Project: Research
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Cause and effect: new mechanisms of particles formation in thunderstorms
Traini, D. (Primary Chief Investigator), Spicer, P. (Chief Investigator), Davies, J. M. (Chief Investigator), Prescott, S. (Chief Investigator) & Ong, H. X. (Chief Investigator)
4/11/22 → 30/06/23
Project: Research
Research Outputs
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Biofabrication of 3D bioprinted and organ-on-chip blood-brain barrier models using hCMEC/D3 for intranasal delivery of central nervous system therapeutics
Wong, C. Y. J., Pannadewi, T., Khan, T. T. S., Ong, H. X. & Traini, D., 7 Jan 2026, (Accepted/In press) In: Biofabrication.Research output: Contribution to journal › Article › peer-review
Open Access -
Rayleigh-based soft mist inhalers preserve mRNA-LNP integrity for pulmonary delivery
He, P., Sibum, I., Nijdam, W., Buchmann, N. A., Soria, J., Ong, H. X. & Traini, D., Jan 2026, In: Journal of Drug Delivery Science and Technology. 115, p. 1-8 8 p., 107651.Research output: Contribution to journal › Article › peer-review
Open AccessFile45 Downloads (Pure) -
Combining innovation and sustainable development in the 3D printing manufacturing of drug delivery and testing devices
Fratini, C., Zhang, Y., Moroni, S., Tiboni, M., Ong, H. X., Young, P. M., Casettari, L. & Traini, D., 30 Jun 2025, In: International Journal of Pharmaceutics. 679, p. 1-14 14 p., 125751.Research output: Contribution to journal › Review article › peer-review
Open AccessFile7 Downloads (Pure) -
Evaluation of Rayleigh Jet Atomizer for intranasal delivery of lipid nanoparticle-siRNA formulations: stability, deposition, and device performance
Wang, H., Zhang, Y., Zhang, Y., Kelleher, A., Ahlenstiel, C., Zhang, M. X., van Rijn, C. J. M., Ong, H. X. & Traini, D., 15 Oct 2025, In: International Journal of Pharmaceutics. 683, p. 1-9 9 p., 126084.Research output: Contribution to journal › Article › peer-review
Open AccessFile12 Downloads (Pure) -
Evaluation of the Resyca® PFSI™ soft mist inhaler for efficient delivery of mRNA-lipid nanoparticles to the Lungs
He, P., Chaugule, V., Sibum, I., Nijdam, W., Buchman, N., Soria, J., Ong, H. X. & Traini, D., May 2025, RDD Europe 2025: Bringing the respiratory world together. Dalby, R. N., Peart, J., Traini, D., Young, P. M. & Suman, J. D. (eds.). Portugal: RDD Online, p. 308-312 5 p.Research output: Chapter in Book/Report/Conference proceeding › Conference proceeding contribution › peer-review
Prizes
Press/Media
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Fast-tracking new aerosol treatments into clinical practice
29/10/21
1 Media contribution
Press/Media: Expert Comment