Janet Van Eersel

Research Fellow, Department of Biomedical Sciences
Dementia Research Centre

https://orcid.org/0000-0002-1354-6171

Phone+61 2 9850 2670
Emailjanet.vaneersel@mq.edu.au

1756 Citations
14 h-Index

Research output per year

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Personal profile

Biography

Dr Janet van Eersel is a group leader in the Dementia Research Centre in the Department of Biomedical Sciences of the Faculty of Medicine and Health Sciences at Macquarie University. Janet recieved her PhD from the Department of Pathology at the University of Sydney in 2010. She then began working as a postdoctoral fellow at the Brain and Mind Research Centre where she continued her work on dementia. In 2011, she was awarded a Discovery Early Career Researcher Award from the Australian Research Council to support her fellowship. In 2013, Janet moved to the University of NSW where she worked as a junior group leader and research-only Lecturer in the Dementia Research Unit headed by Prof Lars Ittner in the Faculty of Medicine. In 2018, Janet then joined Macquarie University as a group leader in the Dementia Research Centre.

Research interests

The research of Dr van Eersel focuses on the pathology and mechanisms underlying common forms of dementia, such as Alzheimer's disease and Frontotemporal Lobar Degeneration. To study these disorders, Dr van Eersel utilises multiple techniques and methods including animal models, cell culture, molecular biology, histology and biochemistry. Most recently, Dr van Eersel has started to focus in on the protein Tau and how it can potentially be secreted from neurons within the brain and the role that endoplasmic reticulum stress may play in this process.

Education/Academic qualification

PhD (Pathology Department), University of Sydney

Ba. Science, University of Sydney

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Projects

1 Finished

Targeting Post-synaptic Tau to Treat Alzheimer's Disease

Ittner, L., Housley, G., Kassiou, M., Karl, T. & Van Eersel, J.

1/11/18 → 31/12/19

Project: Other

Research Outputs

1756 Citations
14 h-Index
17 Article
3 Review article
1 Chapter
1 Patent

Contribution of endogenous antibodies to learning deficits and astrocytosis in human P301S mutant tau transgenic mice

van der Hoven, J., van Hummel, A., Przybyla, M., Asih, P., Gajwani, M., Feiten, A., Ke, Y., Ittner, A., Van Eersel, J. & Ittner, L., May 2020, (Accepted/In press) In : Scientific Reports.

Research output: Contribution to journal › Article

Novel behavioural characteristics of male human P301S mutant tau transgenic mice: a model for tauopathy

Watt, G., Przybyla, M., Zak, V., van Eersel, J., Ittner, A., Ittner, L. & Karl, T., 1 Apr 2020, In : Neuroscience. 431, p. 166-175 10 p.

Research output: Contribution to journal › Article

1 Citation (Scopus)

Onset of hippocampal network aberration and memory deficits in P301S tau mice are associated with an early gene signature

Przybyla, M., Van Eersel, J., van Hummel, A., van der Hoven, J., Sabale, M., Harasta, A., Müller, J., Gajwani, M., Prikas, E., Mueller, T., Stevens, C. H., Power, J., Housley, G. D., Karl, T., Kassiou, M., Ke, Y. D., Ittner, A. & Ittner, L. M., Jun 2020, In : Brain. 143, 6, p. 1889-1904 16 p.

Research output: Contribution to journal › Article

Sphingosine kinase 2 potentiates amyloid deposition but protects against hippocampal volume loss and demyelination in a mouse model of Alzheimer's disease

Lei, M., Teo, J. D., Song, H., McEwen, H. P., Yup Lee, J., Couttas, T. A., Duncan, T., Chesworth, R., Bertz, J., Przybyla, M., Van Eersel, J., Heng, B., Guillemin, G. J., Ittner, L. M., Fath, T., Garner, B., Ittner, A., Karl, T. & Don, A. S., 27 Nov 2019, In : The Journal of Neuroscience. 39, 48, p. 9645-9659 15 p.

Research output: Contribution to journal › Article

Open Access

File

1 Downloads (Pure)

Mouse models of frontotemporal dementia: a comparison of phenotypes with clinical symptomatology

Ahmed, R. M., Irish, M., van Eersel, J., Ittner, A., Ke, Y. D., Volkerling, A., van der Hoven, J., Tanaka, K., Karl, T., Kassiou, M., Kril, J. J., Piguet, O., Götz, J., Kiernan, M. C., Halliday, G. M., Hodges, J. R. & Ittner, L. M., Mar 2017, In : Neuroscience and Biobehavioral Reviews. 74, p. 126-138 13 p.

Research output: Contribution to journal › Review article