Projects per year
Personal profile
Biography
Dr Janet van Eersel is a group leader in the Dementia Research Centre in the Department of Biomedical Sciences of the Faculty of Medicine and Health Sciences at Macquarie University. Janet recieved her PhD from the Department of Pathology at the University of Sydney in 2010. She then began working as a postdoctoral fellow at the Brain and Mind Research Centre where she continued her work on dementia. In 2011, she was awarded a Discovery Early Career Researcher Award from the Australian Research Council to support her fellowship. In 2013, Janet moved to the University of NSW where she worked as a junior group leader and research-only Lecturer in the Dementia Research Unit headed by Prof Lars Ittner in the Faculty of Medicine. In 2018, Janet then joined Macquarie University as a group leader in the Dementia Research Centre.
Research interests
The research of Dr van Eersel focuses on the pathology and mechanisms underlying common forms of dementia, such as Alzheimer's disease and Frontotemporal Lobar Degeneration. To study these disorders, Dr van Eersel utilises multiple techniques and methods including animal models, cell culture, molecular biology, histology and biochemistry. Most recently, Dr van Eersel has started to focus in on the protein Tau and how it can potentially be secreted from neurons within the brain and the role that endoplasmic reticulum stress may play in this process.
Education/Academic qualification
PhD (Pathology Department), University of Sydney
Award Date: 18 Nov 2010
Ba. Science, University of Sydney
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MQRAS 21 R2: A novel and versatile gene therapy for the treatment of both dementia and epilepsy.
25/01/22 → 31/12/22
Project: Research
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MQRAS 21: Identifying and validating a critical gene to treat Alzheimer’s disease using artificial intelligence
Finney, C., Van Eersel, J., Shvetcov, A. & Ittner, L.
3/09/21 → 2/09/22
Project: Research
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Preclinical development of specific tau-binding compounds to target underlying disease mechanisms for the treatment of dementia
Van Eersel, J., Ittner, L. & Kassiou, M.
21/04/21 → 1/03/23
Project: Research
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Unravelling the molecular mechanism of tau spread in Alzheimer's disease
Fath, T., Van Eersel, J., Przybyla, M. & Ittner, L.
1/01/21 → 31/12/24
Project: Research
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Targeting Post-synaptic Tau to Treat Alzheimer's Disease
Ittner, L., Housley, G., Kassiou, M., Karl, T. & Van Eersel, J.
1/11/18 → 31/12/19
Project: Other
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The nature of diamino linker and halogen bonding define selectivity of pyrrolopyrimidine-based LIMK1 inhibitors
Ariawan, D., Au, C., Paric, E., Fath, T., Ke, Y. D., Kassiou, M., van Eersel, J. & Ittner, L. M., 13 Dec 2021, In: Frontiers in Chemistry. 9, p. 1-11 11 p., 781213.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Downloads (Pure) -
Assay and method for identifying compounds that reduce SIL1 expression or activity
Ittner, L. & Van Eersel, J., 28 Apr 2020, IPC No. G01N 33/68, C12Q 1/6883, Patent No. 10634688, 6 Mar 2014, Priority date 6 Mar 2013, Priority No. AU2013900812Research output: Patent
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Contribution of endogenous antibodies to learning deficits and astrocytosis in human P301S mutant tau transgenic mice
van der Hoven, J., van Hummel, A., Przybyla, M., Asih, P., Gajwani, M., Feiten, A., Ke, Y., Ittner, A., Van Eersel, J. & Ittner, L., 14 Aug 2020, In: Scientific Reports. 10, 1, p. 1-16 16 p., 13845.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)11 Downloads (Pure) -
Novel behavioural characteristics of male human P301S mutant tau transgenic mice: a model for tauopathy
Watt, G., Przybyla, M., Zak, V., van Eersel, J., Ittner, A., Ittner, L. & Karl, T., 1 Apr 2020, In: Neuroscience. 431, p. 166-175 10 p.Research output: Contribution to journal › Article › peer-review
3 Citations (Scopus) -
Onset of hippocampal network aberration and memory deficits in P301S tau mice are associated with an early gene signature
Przybyla, M., Van Eersel, J., van Hummel, A., van der Hoven, J., Sabale, M., Harasta, A., Müller, J., Gajwani, M., Prikas, E., Mueller, T., Stevens, C. H., Power, J., Housley, G. D., Karl, T., Kassiou, M., Ke, Y. D., Ittner, A. & Ittner, L. M., Jun 2020, In: Brain. 143, 6, p. 1889-1904 16 p.Research output: Contribution to journal › Article › peer-review
3 Citations (Scopus)
Prizes
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International Society for Neurochemistry Travel Award
Van Eersel, Janet (Recipient), Aug 2015
Prize: Other distinction
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Neuron (Journal)
Janet Van Eersel (Reviewer)
2020Activity: Peer-review and editorial of research outputs › Publication Peer-review
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Neuropathology and Applied Neurobiology (Journal)
Janet Van Eersel (Reviewer)
2020Activity: Peer-review and editorial of research outputs › Publication Peer-review
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Acta Neuropathologica Communications (Journal)
Janet Van Eersel (Reviewer)
2019Activity: Peer-review and editorial of research outputs › Publication Peer-review
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Hippocampal Network Aberrations in Tau Transgenic Mice is Linked to Hyperexcitation
Janet Van Eersel (Speaker)
2019Activity: Talk or presentation › Invited talk
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Behavioural Brain Research (Journal)
Janet Van Eersel (Reviewer)
2019Activity: Peer-review and editorial of research outputs › Publication Peer-review