Projects per year
Personal profile
Biography
Dr. Janet van Eersel earned her PhD from the University of Sydney's Department of Pathology in 2010. She then expanded her expertise with postdoctoral research roles at the Brain and Mind Research Centre (University of Sydney) and the Dementia Research Unit (University of NSW).
In 2018, Dr van Eersel took on a leadership role at Macquarie University's Dementia Research Centre. Here, she leads a dedicated team of researchers exploring the biological mechanisms behind neurological conditions such as dementia and epilepsy. As the team uncovers new information about these disorders, Dr van Eersel leverages this knowledge to design and develop innovative new therapies, with the ultimate goal of providing more effective treatments to patients world wide.
Research interests
Dr. van Eersel's research program is dedicated to unravelling the mechanisms behind common forms of dementia, such as Alzheimer's disease and Frontotemporal Dementia. Additionally, her team explores the cellular mechanisms that cause neurons of the brain to become overactive in conditions such as epilepsy.
Alongside investigating disease mechanisms, Dr van Eersel's research also focuses on developing innovative new treatments. Her team employs a variety of therapeutic approaches, including small molecules, gene therapy, peptides and immunotherapies. This comprehensive approach aims to bring new hope to those affected by neurological conditions.
To tackle these complex projects, the team utilises a diverse array of methodologies, including animal models, cell culture, molecular biology, histology, and biochemistry. This comprehensive approach allows them to gain deeper insights into these neurological disorders and work towards developing more effective treatments.
Research Opportunities:
We currently have several opportunities for undergraduate, Masters, and PhD students. If you have a keen interest in neuroscience, dementia, epilepsy, or drug development, we encourage you to get in touch.
Feel free to reach out if you're passionate about making a difference in the field of neurological research!
Education/Academic qualification
PhD (Pathology Department), University of Sydney
Award Date: 18 Nov 2010
Ba. Science, (Honours in Pharmacology), University of Sydney
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Collaborations and top research areas from the last five years
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DARF: Investigating mechanisms of tau uptake and release in glia
Genoud, S., Fath, T., Van Eersel, J. & Ittner, L.
8/04/24 → 8/04/26
Project: Research
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DP24: Transcriptional and translational regulation of the neuronal protein tau
1/01/24 → 31/12/26
Project: Research
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IDEAS 23: Development of next-generation gene therapy vectors for the treatment of epilepsy
Van Eersel, J., Ittner, L. & Ke, Y.
1/01/24 → 31/12/26
Project: Research
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MQRAS 21 R2: A novel and versatile gene therapy for the treatment of both dementia and epilepsy.
25/01/22 → 31/12/22
Project: Research
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Design of peptide therapeutics as protein-protein interaction inhibitors to treat neurodegenerative diseases
Ariawan, D., Pushpitha, K. P. M., El-Omar, A., van der Hoven, J., Genoud, S., Stefen, H., Fath, T., van Eersel, J., Ittner, L. M. & Tietz, O., 30 Oct 2024, In: RSC Advances. 14, 47, p. 34637-34642 6 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)25 Downloads (Pure) -
Engineered cyclotide blocks neuronal excitotoxicity
Ariawan, D., van der Hoven, J., Morey, N., Pushpitha, K., Genoud, S., Stefen, H., Veltman, S., Przybyla, M., Deng, Y., Fath, T., Tietz, O., van Eersel, J. & Ittner, L. M., 4 Dec 2024, (E-pub ahead of print) In: Journal of Medicinal Chemistry. 11 p.Research output: Contribution to journal › Article › peer-review
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Inhibitors and uses therefor
Ittner, L. M., Ariawan, D., Tietz, O. & Van Eersel, J., 8 Feb 2024, IPC No. C07D 471/04 A I, A61K 31/4545 2006.1, A61K 31/517 2006.1, A61P 31/14 2006.1, C07D 401/14 2006.1, C07D 409/14 2006.1, Patent No. WO2024026540, Priority date 5 Aug 2022, Priority No. AU20220902202Research output: Patent
Open Access -
Recent progress in synthetic self-adjuvanting vaccine development
Ariawan, D., van Eersel, J., Martin, A. D., Ke, Y. D. & Ittner, L. M., 26 Jul 2022, In: Biomaterials Science. 10, 15, p. 4037-4057 21 p.Research output: Contribution to journal › Review article › peer-review
7 Citations (Scopus) -
Treatment of epilepsy using a targeted p38γ kinase gene therapy
Morey, N., Przybyla, M., van der Hoven, J., Ke, Y. D., Delerue, F., van Eersel, J. & Ittner, L. M., 2 Dec 2022, In: Science Advances. 8, 48, p. 1-8 8 p., eadd2577.Research output: Contribution to journal › Article › peer-review
Open AccessFile8 Citations (Scopus)83 Downloads (Pure)
Prizes
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International Society for Neurochemistry Travel Award
Van Eersel, Janet (Recipient), Aug 2015
Prize: Other distinction
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Australia Research Council (ARC) (External organisation)
Janet Van Eersel (Member)
2024 → 2027Activity: Membership › Membership of council
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Neuropathology and Applied Neurobiology (Journal)
Janet Van Eersel (Reviewer)
2020Activity: Peer-review and editorial of research outputs › Publication Peer-review
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Neuron (Journal)
Janet Van Eersel (Reviewer)
2020Activity: Peer-review and editorial of research outputs › Publication Peer-review
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Hippocampal Network Aberrations in Tau Transgenic Mice is Linked to Hyperexcitation
Janet Van Eersel (Speaker)
2019Activity: Talk or presentation › Invited talk
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Behavioural Brain Research (Journal)
Janet Van Eersel (Reviewer)
2019Activity: Peer-review and editorial of research outputs › Publication Peer-review