Janet Van Eersel

Dr

  • 1624 Citations
  • 13 h-Index
20082019
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Personal profile

Biography

Dr Janet van Eersel is a group leader in the Dementia Research Centre in the Department of Biomedical Sciences of the Faculty of Medicine and Health Sciences at Macquarie University. Janet recieved her PhD from the Department of Pathology at the University of Sydney in 2010. She then began working as a postdoctoral fellow at the Brain and Mind Research Centre where she continued her work on dementia. In 2011, she was awarded a Discovery Early Career Researcher Award from the Australian Research Council to support her fellowship. In 2013, Janet moved to the University of NSW where she worked as a junior group leader and research-only Lecturer in the Dementia Research Unit headed by Prof Lars Ittner in the Faculty of Medicine. In 2018, Janet then joined Macquarie University as a group leader in the Dementia Research Centre.

Research interests

The research of Dr van Eersel focuses on the pathology and mechanisms underlying common forms of dementia, such as Alzheimer's disease and Frontotemporal Lobar Degeneration. To study these disorders, Dr van Eersel utilises multiple techniques and methods including animal models, cell culture, molecular biology, histology and biochemistry. Most recently, Dr van Eersel has started to focus in on the protein Tau and how it can potentially be secreted from neurons within the brain and the role that endoplasmic reticulum stress may play in this process.

Education/Academic qualification

PhD (Pathology Department), University of Sydney

Ba. Science, University of Sydney

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Neurofibrillary Tangles Medicine & Life Sciences
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Projects 2018 2019

Targeting Post-synaptic Tau to Treat Alzheimer's Disease

Ittner, L., Housley, G., Kassiou, M., Karl, T. & Van Eersel, J.

1/11/1831/12/19

Project: Other

Research Outputs 2008 2019

  • 1624 Citations
  • 13 h-Index
  • 14 Article
  • 3 Review article
  • 1 Chapter

Sphingosine kinase 2 potentiates amyloid deposition but protects against hippocampal volume loss and demyelination in a mouse model of Alzheimer's disease

Lei, M., Teo, J. D., Song, H., McEwen, H. P., Yup Lee, J., Couttas, T. A., Duncan, T., Chesworth, R., Bertz, J., Przybyla, M., Van Eersel, J., Heng, B., Guillemin, G. J., Ittner, L. M., Fath, T., Garner, B., Ittner, A., Karl, T. & Don, A. S., 27 Nov 2019, In : The Journal of Neuroscience. 39, 48, p. 9645-9659 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Demyelinating Diseases
Amyloid
Alzheimer Disease
Oligodendroglia
Amyloid beta-Protein Precursor

Mouse models of frontotemporal dementia: a comparison of phenotypes with clinical symptomatology

Ahmed, R. M., Irish, M., van Eersel, J., Ittner, A., Ke, Y. D., Volkerling, A., van der Hoven, J., Tanaka, K., Karl, T., Kassiou, M., Kril, J. J., Piguet, O., Götz, J., Kiernan, M. C., Halliday, G. M., Hodges, J. R. & Ittner, L. M., Mar 2017, In : Neuroscience and Biobehavioral Reviews. 74, p. 126-138 13 p.

Research output: Contribution to journalReview articleResearchpeer-review

Frontotemporal Dementia
Phenotype
Dementia
Mutation
Proteins

Tau exacerbates excitotoxic brain damage in an animal model of stroke

Bi, M., Gladbach, A., van Eersel, J., Ittner, A., Przybyla, M., van Hummel, A., Chua, S. W., van der Hoven, J., Lee, W. S., Müller, J., Parmar, J., von Jonquieres, G., Stefen, H., Guccione, E., Fath, T., Housley, G. D., Klugmann, M., Ke, Y. D. & Ittner, L. M., 1 Dec 2017, In : Nature Communications. 8, 1, p. 1-15 15 p., 473.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
brain damage
animal models
strokes
Brain
Animals

The polyphenol altenusin inhibits in vitro fibrillization of tau and reduces induced tau pathology in primary neurons

Chua, S. W., Cornejo, A., van Eersel, J., Stevens, C. H., Vaca, I., Cueto, M., Kassiou, M., Gladbach, A., Macmillan, A., Lewis, L., Whan, R. & Ittner, L. M., 19 Apr 2017, In : ACS Chemical Neuroscience. 8, 4, p. 743-751 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Polyphenols
Pathology
Neurons
Neurofibrillary Tangles
Agglomeration

Disinhibition-like behavior in a P301S mutant tau transgenic mouse model of frontotemporal dementia

Przybyla, M., Stevens, C. H., van der Hoven, J., Harasta, A., Bi, M., Ittner, A., van Hummel, A., Hodges, J. R., Piguet, O., Karl, T., Kassiou, M., Housley, G. D., Ke, Y. D., Ittner, L. M. & Eersel, J. V., 19 Sep 2016, In : Neuroscience Letters. 631, p. 24-29 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Frontotemporal Dementia
Transgenic Mice
Amygdala
Mutation
Genes