Projects per year
Personal profile
Biography
Dr Janet van Eersel is a group leader in the Dementia Research Centre in the Department of Biomedical Sciences of the Faculty of Medicine and Health Sciences at Macquarie University. Janet recieved her PhD from the Department of Pathology at the University of Sydney in 2010. She then began working as a postdoctoral fellow at the Brain and Mind Research Centre where she continued her work on dementia. In 2011, she was awarded a Discovery Early Career Researcher Award from the Australian Research Council to support her fellowship. In 2013, Janet moved to the University of NSW where she worked as a junior group leader and research-only Lecturer in the Dementia Research Unit headed by Prof Lars Ittner in the Faculty of Medicine. In 2018, Janet then joined Macquarie University as a group leader in the Dementia Research Centre.
Research interests
The research of Dr van Eersel focuses on the pathology and mechanisms underlying common forms of dementia, such as Alzheimer's disease and Frontotemporal Lobar Degeneration. To study these disorders, Dr van Eersel utilises multiple techniques and methods including animal models, cell culture, molecular biology, histology and biochemistry. Most recently, Dr van Eersel has started to focus in on the protein Tau and how it can potentially be secreted from neurons within the brain and the role that endoplasmic reticulum stress may play in this process.
Education/Academic qualification
PhD (Pathology Department), University of Sydney
Award Date: 18 Nov 2010
Ba. Science, University of Sydney
Fingerprint
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Network
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Unravelling the molecular mechanism of tau spread in Alzheimer's disease
Fath, T., Van Eersel, J., Przybyla, M. & Ittner, L.
1/01/21 → 31/12/24
Project: Research
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MQRAS 21 R2: A novel and versatile gene therapy for the treatment of both dementia and epilepsy.
25/01/22 → 31/12/22
Project: Research
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MQRAS 21: Identifying and validating a critical gene to treat Alzheimer’s disease using artificial intelligence
Finney, C., Van Eersel, J., Shvetcov, A. & Ittner, L.
3/09/21 → 2/09/22
Project: Research
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Preclinical development of specific tau-binding compounds to target underlying disease mechanisms for the treatment of dementia
Van Eersel, J., Ittner, L. & Kassiou, M.
21/04/21 → 1/03/23
Project: Research
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Targeting Post-synaptic Tau to Treat Alzheimer's Disease
Ittner, L., Housley, G., Kassiou, M., Karl, T. & Van Eersel, J.
1/11/18 → 31/12/19
Project: Other
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Recent progress in synthetic self-adjuvanting vaccine development
Ariawan, D., van Eersel, J., Martin, A. D., Ke, Y. D. & Ittner, L. M., 26 Jul 2022, In: Biomaterials Science. 10, 15, p. 4037-4057 21 p.Research output: Contribution to journal › Review article › peer-review
3 Citations (Scopus) -
Treatment of epilepsy using a targeted p38γ kinase gene therapy
Morey, N., Przybyla, M., van der Hoven, J., Ke, Y. D., Delerue, F., van Eersel, J. & Ittner, L. M., 2 Dec 2022, In: Science Advances. 8, 48, p. 1-8 8 p., eadd2577.Research output: Contribution to journal › Article › peer-review
Open AccessFile22 Downloads (Pure) -
The nature of diamino linker and halogen bonding define selectivity of pyrrolopyrimidine-based LIMK1 inhibitors
Ariawan, D., Au, C., Paric, E., Fath, T., Ke, Y. D., Kassiou, M., van Eersel, J. & Ittner, L. M., 13 Dec 2021, In: Frontiers in Chemistry. 9, p. 1-11 11 p., 781213.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)10 Downloads (Pure) -
Assay and method for identifying compounds that reduce SIL1 expression or activity
Ittner, L. & Van Eersel, J., 28 Apr 2020, IPC No. G01N 33/68, C12Q 1/6883, Patent No. 10634688, 6 Mar 2014, Priority date 6 Mar 2013, Priority No. AU2013900812Research output: Patent
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Contribution of endogenous antibodies to learning deficits and astrocytosis in human P301S mutant tau transgenic mice
van der Hoven, J., van Hummel, A., Przybyla, M., Asih, P., Gajwani, M., Feiten, A., Ke, Y., Ittner, A., Van Eersel, J. & Ittner, L., 14 Aug 2020, In: Scientific Reports. 10, 1, p. 1-16 16 p., 13845.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)15 Downloads (Pure)
Prizes
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International Society for Neurochemistry Travel Award
Van Eersel, Janet (Recipient), Aug 2015
Prize: Other distinction
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Neuropathology and Applied Neurobiology (Journal)
Janet Van Eersel (Reviewer)
2020Activity: Peer-review and editorial of research outputs › Publication Peer-review
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Neuron (Journal)
Janet Van Eersel (Reviewer)
2020Activity: Peer-review and editorial of research outputs › Publication Peer-review
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Scientific Reports (Journal)
Janet Van Eersel (Reviewer)
2019Activity: Peer-review and editorial of research outputs › Publication Peer-review
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Hippocampal Network Aberrations in Tau Transgenic Mice is Linked to Hyperexcitation
Janet Van Eersel (Speaker)
2019Activity: Talk or presentation › Invited talk
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Behavioural Brain Research (Journal)
Janet Van Eersel (Reviewer)
2019Activity: Peer-review and editorial of research outputs › Publication Peer-review