• 1896 Citations
  • 27 h-Index
1993 …2021
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  • 29 Similar Profiles
Amyotrophic Lateral Sclerosis Medicine & Life Sciences
Endoplasmic Reticulum Stress Medicine & Life Sciences
Protein Disulfide-Isomerases Medicine & Life Sciences
Motor Neurons Medicine & Life Sciences
Unfolded Protein Response Medicine & Life Sciences
Endoplasmic Reticulum Medicine & Life Sciences
Mutation Medicine & Life Sciences
Neurodegenerative Diseases Medicine & Life Sciences

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Projects 2014 2021

Validating the NLRP3 Inflammasome as a Therapeutic Target in Motor Neuron Disease

Atkin, J., Woodruff, T. M., McCombe, P. A., Walker, A., Robertson, A. & Gordon, R.

1/01/1831/12/21

Project: Research

The role of mutant CYLD in frontotemporal dementia and motor neuron disease

Blair, I., Dobson-Stone, C., Kwok, J. B., Atkin, J., Ooi, L., Ittner, A., Lee, A., Mather, K. A., Thompson, E. & Burgio, G.

1/01/1831/12/21

Project: Research

Research Output 1993 2018

Dysfunction of optineurin in amyotrophic lateral sclerosis and glaucoma

Toth, R. P. & Atkin, J. D. 23 May 2018 In : Frontiers in Immunology. 9, p. 1-19 19 p., 1017

Research output: Contribution to journalReview article

Open Access
File
Amyotrophic Lateral Sclerosis
Glaucoma
Autophagy
Neurodegenerative Diseases
Mutation

ERp57 is protective against mutant SOD1-induced cellular pathology in amyotrophic lateral sclerosis

Parakh, S., Jagaraj, C. J., Vidal, M., Ragagnin, A. M. G., Perri, E. R., Konopka, A., Toth, R. P., Galper, J., Blair, I. P., Thomas, C. J., Walker, A. K., Yang, S., Spencer, D. M. & Atkin, J. D. 15 Apr 2018 In : Human Molecular Genetics. 27, 8, p. 1311-1331 21 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Endoplasmic Reticulum Stress
Pathology
Apoptosis
DNA-Binding Proteins

Pathogenic mutation in the ALS/FTD gene, CCNF, causes elevated Lys48-linked ubiquitylation and defective autophagy

Lee, A. , Rayner, S. L. , Gwee, S. S. L. , De Luca, A. , Shahheydari, H. , Sundaramoorthy, V. , Ragagnin, A. , Morsch, M. , Radford, R. , Galper, J. , Freckleton, S. , Shi, B. , Walker, A. K. , Don, E. K. , Cole, N. J. , Yang, S. , Williams, K. L. , Yerbury, J. J. , Blair, I. P. , Atkin, J. D. & 2 others Molloy, M. P. & Chung, R. S. Jan 2018 In : Cellular and Molecular Life Sciences. 75, 2, p. 335–354 20 p.

Research output: Contribution to journalArticle

Cyclins
Ubiquitination
Autophagy
Mutation
Genes

SOD1 mutations causing familial amyotrophic lateral sclerosis induce toxicity in astrocytes: evidence for bystander effects in a continuum of astrogliosis

Wallis, N., Lau, C. L., Farg, M. A., Atkin, J. D., Beart, P. M. & O’Shea, R. D. 1 Jan 2018 In : Neurochemical Research. 43, 1, p. 157-170 14 p.

Research output: Contribution to journalArticle

Bystander Effect
Astrocytes
Toxicity
Mutation
Amyotrophic Lateral Sclerosis
Open Access
File
pathogenesis
Chromosomes, Human, Pair 9
chromosomes
Amyotrophic Lateral Sclerosis
Chromosomes