Projects per year
Personal profile
Biography
Julie is interested in the basic cellular and molecular singalling mechanisms involved in neurons as well as other cells. She is particularly interested in processes that trigger neurodegeneration in amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND), and related condition frontotemporal dementia (FTD). This includes the role of cellular trafficking and the DNA damage response, as well as the protein disulphide isomerase family of chaperones.
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Collaborations and top research areas from the last five years
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MND 24: Novel approaches to examining the environmental risks associated with ALS
Saravanabavan, S. (Primary Chief Investigator) & Atkin, J. (Associate Investigator)
30/06/25 → 29/06/26
Project: Research
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MND 24: Investigating the role of GABAA agonists as novel therapeutic against TDP-43 pathology.
Parakh, S., Blizzard, C. A. & Atkin, J.
1/06/25 → 31/05/26
Project: Research
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FightMND 24: Novel Gene Therapy Approaches for Targeting Aging in MND
Shadfar, S. (Primary Chief Investigator), Atkin, J. (Chief Investigator), Dhungel, B. (Chief Investigator) & Thordarson, P. (Partner Investigator)
3/03/25 → 2/03/27
Project: Research
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DARF 2024: Determining the role of a novel RNA species in the pathogenesis of frontotemporal dementia (FTD)
Saravanabavan, S. (Primary Chief Investigator) & Atkin, J. (Associate Investigator)
1/03/25 → 1/03/27
Project: Research
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A slower-progressing TDP-43 rNLS8 mouse model for ALS: implications for preclinical and mechanistic studies
Jagaraj, C. J., Mehta, P., Hunter, J. & Atkin, J. D., Dec 2025, In: NeuroMolecular Medicine. 27, 1, p. 1-17 17 p., 59.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Downloads (Pure) -
Pathological forms of TDP-43 in amyotrophic lateral sclerosis (ALS) promote aberrant telomere elongation
Konopka, A., Jamali, M. S., Fowler, M., Mehta, P., Parakh, S., Takalloo, Z., Farzana, F., Mumtaz, N., Hunter, J., Shadfar, S., Rogers, M.-L. & Atkin, J. D., Oct 2025, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1871, 7, p. 1-13 13 p., 167906.Research output: Contribution to journal › Article › peer-review
Open AccessFile48 Downloads (Pure) -
The redox activity of protein disulphide isomerase functions in non-homologous end-joining repair to prevent DNA damage
Shadfar, S., Farzana, F., Saravanabavan, S., Rozario, A. M., Vidal, M., Jagaraj, C. J., Parakh, S., Paric, E., Yuan, K. C., Brocardo, M., Whelan, D. R., Laird, A. S. & Atkin, J. D., Jul 2025, In: Aging Cell. 24, 7, p. 1-23 23 p., e70079.Research output: Contribution to journal › Article › peer-review
Open AccessFile18 Downloads (Pure) -
C9orf72-associated dipeptide repeat expansions perturb ER-golgi vesicular trafficking, inducing golgi fragmentation and ER stress, in ALS/FTD
Sultana, J., Ragagnin, A. M. G., Parakh, S., Saravanabavan, S., Soo, K. Y., Vidal, M., Jagaraj, C. J., Ding, K., Wu, S., Shadfar, S., Don, E. K., Deva, A., Nicholson, G., Rowe, D. B., Blair, I., Yang, S. & Atkin, J. D., Dec 2024, In: Molecular Neurobiology. 61, 12, p. 10318-10338 21 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)27 Downloads (Pure) -
Molecular hallmarks of ageing in amyotrophic lateral sclerosis
Jagaraj, C. J., Shadfar, S., Kashani, S. A., Saravanabavan, S., Farzana, F. & Atkin, J. D., 2 Mar 2024, In: Cellular and Molecular Life Sciences. 81, 1, p. 1-30 30 p., 111.Research output: Contribution to journal › Review article › peer-review
Open AccessFile18 Citations (Scopus)68 Downloads (Pure)