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Research Outputs

1993

Purification and characterization of chimeric human IgA1 and IgA2 expressed in COS and Chinese hamster ovary cells

Morton, H. C., Atkin, J. D., Owens, R. J. & Woof, J. M., 1993, In : Journal of Immunology. 151, 9, p. 4743-4752 10 p.

Research output: Contribution to journalArticle

66 Citations (Scopus)

Recombinant human antibodies: linkage of an Fab fragment from a combinatorial library to an Fc fragment for expression in mammalian cell culture

Bender, E., Woof, J. M., Atkin, J. D., Barker, M. D., Bebbington, C. R. & Burton, D. R., 1993, In : Human Antibodies. 4, 2, p. 74-79 6 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)
1996

Mutagenesis of the human IgA1 heavy chain tailpiece that prevents dimer assembly

Atkin, J. D., Pleass, R. J., Owens, R. J. & Woof, J. M., 1 Jul 1996, In : Journal of Immunology. 157, 1, p. 156-159 4 p.

Research output: Contribution to journalArticle

60 Citations (Scopus)

Recognition of an octapeptide sequence by multiple Galα(1,3)Gal-binding proteins

Vaughan, H. A., Oldenburg, K. R., Gallop, M. A., Atkin, J. D., McKenzie, I. F. C. & Sandrin, M. S., Feb 1996, In : Xenotransplantation. 3, 1 PART 1, p. 18-23 6 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

Strategies to overcome the anti-Galα(1-3)Gal reaction in xenotransplantation

McKenzie, I. F. C., Osman, N., Cohney, S., Vaughan, H. A., Patton, K., Mouhtouris, E., Atkin, J. D., Elliott, E., Fodor, W. L., Squinto, S. P., Burton, D., Gallop, M. A., Oldenburg, K. R. & Sandrin, M. S., 1996, In : Transplantation Proceedings. 28, 2, p. 537 1 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)
1997

Mutagenesis of J chain residues critical for IgA dimer assembly

Krugmann, S., Pleass, R. J., Atkin, J. D. & Woof, J. M., 1997, In : Biochemical Society Transactions. 25, 2, p. 323S 1 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Structural Requirements for Assembly of Dimeric IgA Probed by Site-Directed Mutagenesis of J Chain and a Cysteine Residue of the α-Chain CH2 Domain

Krugmann, S., Pleass, R. J., Atkin, J. D. & Woof, J. M., 1997, In : Journal of Immunology. 159, 1, p. 244-249 6 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)
2004

Brain β-amyloid accumulation in transgenic mice expressing mutant superoxide dismutase 1

Turner, B. J., Li, Q. X., Laughton, K. M., Masters, C. L., Lopes, E. C., Atkin, J. D. & Cheema, S. S., Dec 2004, In : Neurochemical Research. 29, 12, p. 2281-2286 6 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
2005

Impaired extracellular secretion of mutant superoxide dismutase 1 associates with neurotoxicity in familial amyotrophic lateral sclerosis

Turner, B. J., Atkin, J. D., Farg, M. A., Da, W. Z., Rembach, A., Lopes, E. C., Patch, J. D., Hill, A. F. & Cheema, S. S., 5 Jan 2005, In : Journal of Neuroscience. 25, 1, p. 108-117 10 p.

Research output: Contribution to journalArticle

145 Citations (Scopus)

Properties of slow- and fast-twitch muscle fibres in a mouse model of amyotrophic lateral sclerosis

Atkin, J. D., Scott, R. L., West, J. M., Lopes, E., Quah, A. K. J. & Cheema, S. S., May 2005, In : Neuromuscular Disorders. 15, 5, p. 377-388 12 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)

Structural requirements for the interaction of human IgA with the human polymeric Ig receptor

Lewis, M. J., Pleass, R. J., Batten, M. R., Atkin, J. D. & Woof, J. M., 15 Nov 2005, In : Journal of Immunology. 175, 10, p. 6694-6701 8 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)
2006

ER stress and UPR in familial amyotrophic lateral sclerosis

Turner, B. J. & Atkin, J. D., Feb 2006, In : Current Molecular Medicine. 6, 1, p. 79-86 8 p.

Research output: Contribution to journalReview article

54 Citations (Scopus)
2007
16 Citations (Scopus)
2008

Coupling ER stress to motor neuron degeneration in ALS

Turner, B. J. & Atkin, J. D., 2008, Motor neuron disease research progress. Mancini, R. L. (ed.). New York: Nova Science Publishers, p. 51-81 31 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Endoplasmic reticulum stress and induction of the unfolded protein response in human sporadic amyotrophic lateral sclerosis

Atkin, J. D., Farg, M. A., Walker, A. K., McLean, C., Tomas, D. & Horne, M. K., Jun 2008, In : Neurobiology of Disease. 30, 3, p. 400-407 8 p.

Research output: Contribution to journalArticle

258 Citations (Scopus)

Sex-specific behavioural effects of environmental enrichment in a transgenic mouse model of amyotrophic lateral sclerosis

Stam, N. C., Nithianantharajah, J., Howard, M. L., Atkin, J. D., Cheema, S. S. & Hannan, A. J., Aug 2008, In : European Journal of Neuroscience. 28, 4, p. 717-723 7 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)

The complement factor C5a contributes to pathology in a rat model of amyotrophic lateral sclerosis

Woodruff, T. M., Costantini, K. J., Crane, J. W., Atkin, J. D., Monk, P. N., Taylor, S. M. & Noakes, P. G., 15 Dec 2008, In : Journal of Immunology. 181, 12, p. 8727-8734 8 p.

Research output: Contribution to journalArticle

92 Citations (Scopus)
2009

Endoplasmic reticulum stress and protein misfolding in amyotrophic lateral sclerosis

Walker, A. K., Turner, B. J. & Atkin, J. D., 2009, Protein Misfolding Disorders: A Trip into the ER. Claudio, H. (ed.). Chile: Bentham Science Publishers Ltd., p. 56-76 21 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Recruitment of mitochondria into apoptotic signaling correlates with the presence of inclusions formed by amyotrophic lateral sclerosis-associated SOD1 mutations

Soo, K. Y., Atkin, J. D., Horne, M. K. & Nagley, P., Feb 2009, In : Journal of Neurochemistry. 108, 3, p. 578-590 13 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)
2010

Multifaceted deaths orchestrated by mitochondria in neurones

Nagley, P., Higgins, G. C., Atkin, J. D. & Beart, P. M., Jan 2010, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1802, 1, p. 167-185 19 p.

Research output: Contribution to journalReview article

89 Citations (Scopus)

Protein disulphide isomerase protects against protein aggregation and is S-nitrosylated in amyotrophic lateral sclerosis

Walker, A. K., Farg, M. A., Bye, C. R., McLean, C. A., Horne, M. K. & Atkin, J. D., Jan 2010, In : Brain. 133, 1, p. 105-116 12 p.

Research output: Contribution to journalArticle

115 Citations (Scopus)

Serum matrix metalloproteinase-9 activity is dysregulated with disease progression in the mutant SOD1 transgenic mice

Soon, C. P. W., Crouch, P. J., Turner, B. J., McLean, C. A., Laughton, K. M., Atkin, J. D., Masters, C. L., White, A. R. & Li, Q. X., Apr 2010, In : Neuromuscular Disorders. 20, 4, p. 260-266 7 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)
2011

Mechanisms of neuroprotection by protein disulphide isomerase in amyotrophic lateral sclerosis

Walker, A. K. & Atkin, J. D., Feb 2011, In : Neurology Research International. 2011, p. 1-7 7 p., 317340.

Research output: Contribution to journalReview article

Open Access
File
11 Citations (Scopus)
17 Downloads (Pure)

Molecular motor proteins and amyotrophic lateral sclerosis

Soo, K. Y., Farg, M. & Atkin, J. D., Dec 2011, In : International Journal of Molecular Sciences. 12, 12, p. 9057-9082 26 p.

Research output: Contribution to journalReview article

Open Access
File
13 Citations (Scopus)
1 Downloads (Pure)

Stress signaling from the endoplasmic reticulum: A central player in the pathogenesis of amyotrophic lateral sclerosis

Walker, A. K. & Atkin, J. D., Sep 2011, In : IUBMB Life. 63, 9, p. 754-763 10 p.

Research output: Contribution to journalReview article

64 Citations (Scopus)
2012

Bim links ER stress and apoptosis in cells expressing mutant SOD1 associated with amyotrophic lateral sclerosis

Soo, K. Y., Atkin, J. D., Farg, M., Walker, A. K., Horne, M. K. & Nagley, P., 16 Apr 2012, In : PLoS ONE. 7, 4, p. 1-11 11 p., e35413.

Research output: Contribution to journalArticle

Open Access
File
27 Citations (Scopus)
2 Downloads (Pure)

Membrane trafficking defects as determinants of motor neuron susceptibility and degeneration in ALS

Turner, B. J. & Atkin, J. D., 2012, Motor Neuron Diseases: Causes, Classification and Treatments. Turner, B. J. & Atkin, J. B. (eds.). New York: Nova Science Publishers, p. 39-74 36 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Motor neuron diseases: causes, classification, and treatments

Turner, B. J. (ed.) & Atkin, J. B. (ed.), Feb 2012, New York: Nova Science Publishers. 248 p.

Research output: Book/ReportEdited Book/Anthology

Mutant FUS induces endoplasmic reticulum stress in amyotrophic lateral sclerosis and interacts with protein disulfide-isomerase

Farg, M. A., Soo, K. Y., Walker, A. K., Pham, H., Orian, J., Horne, M. K., Warraich, S. T., Williams, K. L., Blair, I. P. & Atkin, J. D., Dec 2012, In : Neurobiology of Aging. 33, 12, p. 2855-2868 14 p.

Research output: Contribution to journalArticle

61 Citations (Scopus)

Preface

Turner, B. J. & Atkin, J. B., Feb 2012, Motor neuron diseases: causes, classification and treatments. Turner, B. J. & Atkin, J. B. (eds.). Hauppauge, NY: Nova Science Publishers, p. vii-xii 6 p.

Research output: Chapter in Book/Report/Conference proceedingForeword/postscript/introduction

2013

ALS-associated TDP-43 induces endoplasmic reticulum stress, which drives cytoplasmic TDP-43 accumulation and stress granule formation

Walker, A. K., Soo, K. Y., Sundaramoorthy, V., Parakh, S., Ma, Y., Farg, M. A., Wallace, R. H., Crouch, P. J., Turner, B. J., Horne, M. K. & Atkin, J. D., 29 Nov 2013, In : PLoS ONE. 8, 11, p. 1-12 12 p., e81170.

Research output: Contribution to journalArticle

Open Access
File
78 Citations (Scopus)
2 Downloads (Pure)

Ataxin-2 interacts with FUS and intermediate-length polyglutamine expansions enhance FUS-related pathology in amyotrophic lateral sclerosis

Farg, M. A., Soo, K. Y., Warraich, S. T., Sundaramoorthy, V., Blair, I. P. & Atkin, J. D., Feb 2013, In : Human Molecular Genetics. 22, 4, p. 717-728 12 p., dds479.

Research output: Contribution to journalArticle

Dysregulation of the complement cascade in the hSOD1G93A transgenic mouse model of amyotrophic lateral sclerosis

Lee, J. D., Kamaruzaman, N. A., Fung, J. N. T., Taylor, S. M., Turner, B. J., Atkin, J. D., Woodruff, T. M. & Noakes, P. G., 26 Sep 2013, In : Journal of Neuroinflammation. 10, p. 1-14 14 p., 119.

Research output: Contribution to journalArticle

Open Access
File
51 Citations (Scopus)
4 Downloads (Pure)

Extracellular wildtype and mutant SOD1 induces ER-Golgi pathology characteristic of amyotrophic lateral sclerosis in neuronal cells

Sundaramoorthy, V., Walker, A. K., Yerbury, J., Soo, K. Y., Farg, M. A., Hoang, V., Zeineddine, R., Spencer, D. & Atkin, J. D., Nov 2013, In : Cellular and Molecular Life Sciences. 70, 21, p. 4181-4195 15 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

N-linked glycosylation modulates dimerization of protein disulfide isomerase family A member 2 (PDIA2)

Walker, A. K., Soo, K. Y., Levina, V., Talbo, G. H. & Atkin, J. D., Jan 2013, In : FEBS Journal. 280, 1, p. 233-243 11 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Redox regulation in amyotrophic lateral sclerosis

Parakh, S., Spencer, D. M., Halloran, M. A., Soo, K. Y. & Atkin, J. D., 2013, In : Oxidative Medicine and Cellular Longevity. 2013, p. 1-12 12 p., 408681.

Research output: Contribution to journalReview article

Open Access
File
44 Citations (Scopus)
2 Downloads (Pure)
Open Access
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34 Citations (Scopus)
2 Downloads (Pure)
2014

C9ORF72, implicated in amytrophic lateral sclerosis and frontotemporal dementia, regulates endosomal trafficking

Farg, M. A., Sundaramoorthy, V., Sultana, J. M., Yang, S., Atkinson, R. A. K., Levina, V., Halloran, M. A., Gleeson, P. A., Blair, I. P., Soo, K. Y., King, A. E. & Atkin, J. D., Jul 2014, In : Human Molecular Genetics. 23, 13, p. 3579-3595 17 p., ddu068.

Research output: Contribution to journalArticle

214 Citations (Scopus)

Mutant SOD1 inhibits ER-Golgi transport in amyotrophic lateral sclerosis

Atkin, J. D., Farg, M. A., Soo, K. Y., Walker, A. K., Halloran, M., Turner, B. J., Nagley, P. & Horne, M. K., Apr 2014, In : Journal of Neurochemistry. 129, 1, p. 190-204 15 p.

Research output: Contribution to journalArticle

41 Citations (Scopus)
2015

ALS-associated mutant FUS inhibits macroautophagy which is restored by overexpression of Rab1

Soo, K. Y., Sultana, J., King, A. E., Atkinson, R. A. K., Warraich, S. T., Sundaramoorthy, V., Blair, I., Farg, M. A. & Atkin, J. D., 21 Dec 2015, In : Cell Death Discovery. 1, 1, p. 1-12 12 p., 15030.

Research output: Contribution to journalArticle

Open Access
File
28 Citations (Scopus)
1 Downloads (Pure)

Autophagy dysregulation by mutant fused in sarcoma-implications for amyotrophic lateral sclerosis

Soo, K. Y. & Atkin, J. D., 1 Oct 2015, In : Cell Death and Disease. 6, 10, p. 1-3 3 p., e1945.

Research output: Contribution to journalComment/opinion

Open Access
File
4 Citations (Scopus)
11 Downloads (Pure)

C9ORF72 expression and cellular localization over mouse development

Atkinson, R. A. K., Fernandez-Martos, C. M., Atkin, J. D., Vickers, J. C. & King, A. E., 25 Sep 2015, In : Acta Neuropathologica Communications. 3, p. 1-11 11 p., 59.

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
2 Downloads (Pure)

Defects in optineurin- and myosin VI-mediated cellular trafficking in amyotrophic lateral sclerosis

Sundaramoorthy, V., Walker, A. K., Tan, V., Fifita, J. A., McCann, E. P., Williams, K. L., Blair, I. P., Guillemin, G. J., Farg, M. A. & Atkin, J. D., 1 Jul 2015, In : Human Molecular Genetics. 24, 13, p. 3830-3846 17 p., ddv126.

Research output: Contribution to journalArticle

35 Citations (Scopus)

Golgi fragmentation in amyotrophic lateral sclerosis, an overview of possible triggers and consequences

Sundaramoorthy, V., Sultana, J. M. & Atkin, J. D., 2015, In : Frontiers in Neuroscience. 9, p. 1-11 11 p., 400.

Research output: Contribution to journalReview article

Open Access
File
27 Citations (Scopus)
50 Downloads (Pure)
Open Access
File
42 Citations (Scopus)
7 Downloads (Pure)

Phosphorylation of hnRNP K by cyclin-dependent kinase 2 controls cytosolic accumulation of TDP-43

Moujalled, D., James, J. L., Yang, S., Zhang, K., Duncan, C., Moujalled, D. M., Parker, S. J., Caragounis, A., Lidgerwood, G., Turner, B. J., Atkin, J. D., Grubman, A., Liddell, J. R., Proepper, C., Boeckers, T. M., Kanninen, K. M., Blair, I., Crouch, P. J. & White, A. R., 15 Mar 2015, In : Human Molecular Genetics. 24, 6, p. 1655-1669 15 p., ddu578.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Rab1-dependent ER-Golgi transport dysfunction is a common pathogenic mechanism in SOD1, TDP-43 and FUS-associated ALS

Soo, K. Y., Halloran, M., Sundaramoorthy, V., Parakh, S., Toth, R. P., Southam, K. A., McLean, C. A., Lock, P., King, A., Farg, M. A. & Atkin, J. D., 1 Nov 2015, In : Acta Neuropathologica. 130, 5, p. 679-697 19 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)

The unfolded protein response and the role of Protein Disulfide Isomerase in neurodegeneration

Perri, E. R., Thomas, C. J., Parakh, S., Spencer, D. M. & Atkin, J. D., 2015, In : Frontiers in cell and developmental biology. 3, p. 1-17 17 p., 80.

Research output: Contribution to journalArticle

Open Access
File
71 Citations (Scopus)
15 Downloads (Pure)
2016

CCNF mutations in amyotrophic lateral sclerosis and frontotemporal dementia

Williams, K. L., Topp, S., Yang, S., Smith, B., Fifita, J. A., Warraich, S. T., Zhang, K. Y., Farrawell, N., Vance, C., Hu, X., Chesi, A., Leblond, C. S., Lee, A., Rayner, S. L., Sundaramoorthy, V., Dobson-Stone, C., Molloy, M. P., Van Blitterswijk, M., Dickson, D. W., Petersen, R. C. & 48 others, Graff-Radford, N. R., Boeve, B. F., Murray, M. E., Pottier, C., Don, E., Winnick, C., McCann, E. P., Hogan, A., Daoud, H., Levert, A., Dion, P. A., Mitsui, J., Ishiura, H., Takahashi, Y., Goto, J., Kost, J., Gellera, C., Gkazi, A. S., Miller, J., Stockton, J., Brooks, W. S., Boundy, K., Polak, M., Muñoz-Blanco, J. L., Esteban-Pérez, J., Rábano, A., Hardiman, O., Morrison, K. E., Ticozzi, N., Silani, V., De Belleroche, J., Glass, J. D., Kwok, J. B. J., Guillemin, G. J., Chung, R. S., Tsuji, S., Brown, R. H., García-Redondo, A., Rademakers, R., Landers, J. E., Gitler, A. D., Rouleau, G. A., Cole, N. J., Yerbury, J. J., Atkin, J. D., Shaw, C. E., Nicholson, G. A. & Blair, I. P., 15 Apr 2016, In : Nature Communications. 7, p. 1-8 8 p., 11253.

Research output: Contribution to journalArticle

Open Access
File
83 Citations (Scopus)
15 Downloads (Pure)

Efficacy of peptide nucleic acid and selected conjugates against specific cellular pathologies of amyotrophic lateral sclerosis

Browne, E. C., Parakh, S., Duncan, L. F., Langford, S. J., Atkin, J. D. & Abbott, B. M., 1 Apr 2016, In : Bioorganic and Medicinal Chemistry. 24, 7, p. 1520-1527 8 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)