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Research Outputs

2012

Membrane trafficking defects as determinants of motor neuron susceptibility and degeneration in ALS

Turner, B. J. & Atkin, J. D., 2012, Motor Neuron Diseases: Causes, Classification and Treatments. Turner, B. J. & Atkin, J. B. (eds.). New York: Nova Science Publishers, p. 39-74 36 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Motor neuron diseases: causes, classification, and treatments

Turner, B. J. (ed.) & Atkin, J. B. (ed.), Feb 2012, New York: Nova Science Publishers. 248 p.

Research output: Book/ReportEdited Book/Anthology

Mutant FUS induces endoplasmic reticulum stress in amyotrophic lateral sclerosis and interacts with protein disulfide-isomerase

Farg, M. A., Soo, K. Y., Walker, A. K., Pham, H., Orian, J., Horne, M. K., Warraich, S. T., Williams, K. L., Blair, I. P. & Atkin, J. D., Dec 2012, In : Neurobiology of Aging. 33, 12, p. 2855-2868 14 p.

Research output: Contribution to journalArticle

61 Citations (Scopus)

Preface

Turner, B. J. & Atkin, J. B., Feb 2012, Motor neuron diseases: causes, classification and treatments. Turner, B. J. & Atkin, J. B. (eds.). Hauppauge, NY: Nova Science Publishers, p. vii-xii 6 p.

Research output: Chapter in Book/Report/Conference proceedingForeword/postscript/introduction

2011

Mechanisms of neuroprotection by protein disulphide isomerase in amyotrophic lateral sclerosis

Walker, A. K. & Atkin, J. D., Feb 2011, In : Neurology Research International. 2011, p. 1-7 7 p., 317340.

Research output: Contribution to journalReview article

Open Access
File
11 Citations (Scopus)
17 Downloads (Pure)

Molecular motor proteins and amyotrophic lateral sclerosis

Soo, K. Y., Farg, M. & Atkin, J. D., Dec 2011, In : International Journal of Molecular Sciences. 12, 12, p. 9057-9082 26 p.

Research output: Contribution to journalReview article

Open Access
File
13 Citations (Scopus)
1 Downloads (Pure)

Stress signaling from the endoplasmic reticulum: A central player in the pathogenesis of amyotrophic lateral sclerosis

Walker, A. K. & Atkin, J. D., Sep 2011, In : IUBMB Life. 63, 9, p. 754-763 10 p.

Research output: Contribution to journalReview article

63 Citations (Scopus)
2010

Multifaceted deaths orchestrated by mitochondria in neurones

Nagley, P., Higgins, G. C., Atkin, J. D. & Beart, P. M., Jan 2010, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1802, 1, p. 167-185 19 p.

Research output: Contribution to journalReview article

89 Citations (Scopus)

Protein disulphide isomerase protects against protein aggregation and is S-nitrosylated in amyotrophic lateral sclerosis

Walker, A. K., Farg, M. A., Bye, C. R., McLean, C. A., Horne, M. K. & Atkin, J. D., Jan 2010, In : Brain. 133, 1, p. 105-116 12 p.

Research output: Contribution to journalArticle

114 Citations (Scopus)

Serum matrix metalloproteinase-9 activity is dysregulated with disease progression in the mutant SOD1 transgenic mice

Soon, C. P. W., Crouch, P. J., Turner, B. J., McLean, C. A., Laughton, K. M., Atkin, J. D., Masters, C. L., White, A. R. & Li, Q. X., Apr 2010, In : Neuromuscular Disorders. 20, 4, p. 260-266 7 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)
2009

Endoplasmic reticulum stress and protein misfolding in amyotrophic lateral sclerosis

Walker, A. K., Turner, B. J. & Atkin, J. D., 2009, Protein Misfolding Disorders: A Trip into the ER. Claudio, H. (ed.). Chile: Bentham Science Publishers Ltd., p. 56-76 21 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Recruitment of mitochondria into apoptotic signaling correlates with the presence of inclusions formed by amyotrophic lateral sclerosis-associated SOD1 mutations

Soo, K. Y., Atkin, J. D., Horne, M. K. & Nagley, P., Feb 2009, In : Journal of Neurochemistry. 108, 3, p. 578-590 13 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)
2008

Coupling ER stress to motor neuron degeneration in ALS

Turner, B. J. & Atkin, J. D., 2008, Motor neuron disease research progress. Mancini, R. L. (ed.). New York: Nova Science Publishers, p. 51-81 31 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Endoplasmic reticulum stress and induction of the unfolded protein response in human sporadic amyotrophic lateral sclerosis

Atkin, J. D., Farg, M. A., Walker, A. K., McLean, C., Tomas, D. & Horne, M. K., Jun 2008, In : Neurobiology of Disease. 30, 3, p. 400-407 8 p.

Research output: Contribution to journalArticle

255 Citations (Scopus)

Sex-specific behavioural effects of environmental enrichment in a transgenic mouse model of amyotrophic lateral sclerosis

Stam, N. C., Nithianantharajah, J., Howard, M. L., Atkin, J. D., Cheema, S. S. & Hannan, A. J., Aug 2008, In : European Journal of Neuroscience. 28, 4, p. 717-723 7 p.

Research output: Contribution to journalArticle

41 Citations (Scopus)

The complement factor C5a contributes to pathology in a rat model of amyotrophic lateral sclerosis

Woodruff, T. M., Costantini, K. J., Crane, J. W., Atkin, J. D., Monk, P. N., Taylor, S. M. & Noakes, P. G., 15 Dec 2008, In : Journal of Immunology. 181, 12, p. 8727-8734 8 p.

Research output: Contribution to journalArticle

91 Citations (Scopus)
2007
16 Citations (Scopus)
2006

ER stress and UPR in familial amyotrophic lateral sclerosis

Turner, B. J. & Atkin, J. D., Feb 2006, In : Current Molecular Medicine. 6, 1, p. 79-86 8 p.

Research output: Contribution to journalReview article

54 Citations (Scopus)
2005

Impaired extracellular secretion of mutant superoxide dismutase 1 associates with neurotoxicity in familial amyotrophic lateral sclerosis

Turner, B. J., Atkin, J. D., Farg, M. A., Da, W. Z., Rembach, A., Lopes, E. C., Patch, J. D., Hill, A. F. & Cheema, S. S., 5 Jan 2005, In : Journal of Neuroscience. 25, 1, p. 108-117 10 p.

Research output: Contribution to journalArticle

143 Citations (Scopus)

Properties of slow- and fast-twitch muscle fibres in a mouse model of amyotrophic lateral sclerosis

Atkin, J. D., Scott, R. L., West, J. M., Lopes, E., Quah, A. K. J. & Cheema, S. S., May 2005, In : Neuromuscular Disorders. 15, 5, p. 377-388 12 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)

Structural requirements for the interaction of human IgA with the human polymeric Ig receptor

Lewis, M. J., Pleass, R. J., Batten, M. R., Atkin, J. D. & Woof, J. M., 15 Nov 2005, In : Journal of Immunology. 175, 10, p. 6694-6701 8 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)
2004

Brain β-amyloid accumulation in transgenic mice expressing mutant superoxide dismutase 1

Turner, B. J., Li, Q. X., Laughton, K. M., Masters, C. L., Lopes, E. C., Atkin, J. D. & Cheema, S. S., Dec 2004, In : Neurochemical Research. 29, 12, p. 2281-2286 6 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
1997

Mutagenesis of J chain residues critical for IgA dimer assembly

Krugmann, S., Pleass, R. J., Atkin, J. D. & Woof, J. M., 1997, In : Biochemical Society Transactions. 25, 2, p. 323S 1 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Structural Requirements for Assembly of Dimeric IgA Probed by Site-Directed Mutagenesis of J Chain and a Cysteine Residue of the α-Chain CH2 Domain

Krugmann, S., Pleass, R. J., Atkin, J. D. & Woof, J. M., 1997, In : Journal of Immunology. 159, 1, p. 244-249 6 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)
1996

Mutagenesis of the human IgA1 heavy chain tailpiece that prevents dimer assembly

Atkin, J. D., Pleass, R. J., Owens, R. J. & Woof, J. M., 1 Jul 1996, In : Journal of Immunology. 157, 1, p. 156-159 4 p.

Research output: Contribution to journalArticle

60 Citations (Scopus)

Recognition of an octapeptide sequence by multiple Galα(1,3)Gal-binding proteins

Vaughan, H. A., Oldenburg, K. R., Gallop, M. A., Atkin, J. D., McKenzie, I. F. C. & Sandrin, M. S., Feb 1996, In : Xenotransplantation. 3, 1 PART 1, p. 18-23 6 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

Strategies to overcome the anti-Galα(1-3)Gal reaction in xenotransplantation

McKenzie, I. F. C., Osman, N., Cohney, S., Vaughan, H. A., Patton, K., Mouhtouris, E., Atkin, J. D., Elliott, E., Fodor, W. L., Squinto, S. P., Burton, D., Gallop, M. A., Oldenburg, K. R. & Sandrin, M. S., 1996, In : Transplantation Proceedings. 28, 2, p. 537 1 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)
1993

Purification and characterization of chimeric human IgA1 and IgA2 expressed in COS and Chinese hamster ovary cells

Morton, H. C., Atkin, J. D., Owens, R. J. & Woof, J. M., 1993, In : Journal of Immunology. 151, 9, p. 4743-4752 10 p.

Research output: Contribution to journalArticle

66 Citations (Scopus)

Recombinant human antibodies: linkage of an Fab fragment from a combinatorial library to an Fc fragment for expression in mammalian cell culture

Bender, E., Woof, J. M., Atkin, J. D., Barker, M. D., Bebbington, C. R. & Burton, D. R., 1993, In : Human Antibodies. 4, 2, p. 74-79 6 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)