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Research Outputs 1993 2019

2010

Multifaceted deaths orchestrated by mitochondria in neurones

Nagley, P., Higgins, G. C., Atkin, J. D. & Beart, P. M., Jan 2010, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1802, 1, p. 167-185 19 p.

Research output: Contribution to journalReview articleResearchpeer-review

Mitochondria
Neurons
Cell Death
Necrosis
Apoptosis

Protein disulphide isomerase protects against protein aggregation and is S-nitrosylated in amyotrophic lateral sclerosis

Walker, A. K., Farg, M. A., Bye, C. R., McLean, C. A., Horne, M. K. & Atkin, J. D., Jan 2010, In : Brain. 133, 1, p. 105-116 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Protein Disulfide-Isomerases
Amyotrophic Lateral Sclerosis
Endoplasmic Reticulum Stress
Proteins
Motor Neurons

Serum matrix metalloproteinase-9 activity is dysregulated with disease progression in the mutant SOD1 transgenic mice

Soon, C. P. W., Crouch, P. J., Turner, B. J., McLean, C. A., Laughton, K. M., Atkin, J. D., Masters, C. L., White, A. R. & Li, Q. X., Apr 2010, In : Neuromuscular Disorders. 20, 4, p. 260-266 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Matrix Metalloproteinase 9
Transgenic Mice
Disease Progression
Serum
Amyotrophic Lateral Sclerosis
2009

Endoplasmic reticulum stress and protein misfolding in amyotrophic lateral sclerosis

Walker, A. K., Turner, B. J. & Atkin, J. D., 2009, Protein Misfolding Disorders: A Trip into the ER. Claudio, H. (ed.). Chile: Bentham Science Publishers Ltd., p. 56-76 21 p.

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review

Endoplasmic Reticulum Stress
Amyotrophic Lateral Sclerosis
Sclerosis
Heat-Shock Proteins
Unfolded Protein Response

Recruitment of mitochondria into apoptotic signaling correlates with the presence of inclusions formed by amyotrophic lateral sclerosis-associated SOD1 mutations

Soo, K. Y., Atkin, J. D., Horne, M. K. & Nagley, P., Feb 2009, In : Journal of Neurochemistry. 108, 3, p. 578-590 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Mitochondria
Amyotrophic Lateral Sclerosis
Superoxide Dismutase
Mutation
Apoptosis
2008

Coupling ER stress to motor neuron degeneration in ALS

Turner, B. J. & Atkin, J. D., 2008, Motor neuron disease research progress. Mancini, R. L. (ed.). New York: Nova Science Publishers, p. 51-81 31 p.

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review

Nerve Degeneration
Endoplasmic Reticulum Stress
Amyotrophic Lateral Sclerosis
Motor Neurons
Unfolded Protein Response

Endoplasmic reticulum stress and induction of the unfolded protein response in human sporadic amyotrophic lateral sclerosis

Atkin, J. D., Farg, M. A., Walker, A. K., McLean, C., Tomas, D. & Horne, M. K., Jun 2008, In : Neurobiology of Disease. 30, 3, p. 400-407 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Unfolded Protein Response
Endoplasmic Reticulum Stress
Amyotrophic Lateral Sclerosis
Rodentia
Protein Disulfide-Isomerases

Sex-specific behavioural effects of environmental enrichment in a transgenic mouse model of amyotrophic lateral sclerosis

Stam, N. C., Nithianantharajah, J., Howard, M. L., Atkin, J. D., Cheema, S. S. & Hannan, A. J., Aug 2008, In : European Journal of Neuroscience. 28, 4, p. 717-723 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Amyotrophic Lateral Sclerosis
Transgenic Mice
Disease Progression
Nerve Degeneration
Twin Studies

The complement factor C5a contributes to pathology in a rat model of amyotrophic lateral sclerosis

Woodruff, T. M., Costantini, K. J., Crane, J. W., Atkin, J. D., Monk, P. N., Taylor, S. M. & Noakes, P. G., 15 Dec 2008, In : Journal of Immunology. 181, 12, p. 8727-8734 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Complement C5a
Amyotrophic Lateral Sclerosis
Spinal Cord
Pathology
Complement Activation
2007

Increased number and differentiation of neural precursor cells in the brainstem of superoxide dismutase 1G93A G1H transgenic mouse model of amyotrophic lateral sclerosis

Juan, L., Dawei, Z. & Julie, A. D., Mar 2007, In : Neurological Research. 29, 2, p. 204-209 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Amyotrophic Lateral Sclerosis
Transgenic Mice
Brain Stem
Superoxide Dismutase
Glial Fibrillary Acidic Protein
2006

ER stress and UPR in familial amyotrophic lateral sclerosis

Turner, B. J. & Atkin, J. D., Feb 2006, In : Current Molecular Medicine. 6, 1, p. 79-86 8 p.

Research output: Contribution to journalReview articleResearchpeer-review

Unfolded Protein Response
Endoplasmic Reticulum Stress
Heat-Shock Proteins
Endoplasmic Reticulum
Proteins
2005

Impaired extracellular secretion of mutant superoxide dismutase 1 associates with neurotoxicity in familial amyotrophic lateral sclerosis

Turner, B. J., Atkin, J. D., Farg, M. A., Da, W. Z., Rembach, A., Lopes, E. C., Patch, J. D., Hill, A. F. & Cheema, S. S., 5 Jan 2005, In : Journal of Neuroscience. 25, 1, p. 108-117 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Brefeldin A
Inclusion Bodies
Amyotrophic Lateral Sclerosis
Transgenic Rats
Secretory Pathway

Properties of slow- and fast-twitch muscle fibres in a mouse model of amyotrophic lateral sclerosis

Atkin, J. D., Scott, R. L., West, J. M., Lopes, E., Quah, A. K. J. & Cheema, S. S., May 2005, In : Neuromuscular Disorders. 15, 5, p. 377-388 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Slow-Twitch Muscle Fibers
Fast-Twitch Muscle Fibers
Amyotrophic Lateral Sclerosis
Muscles
Neuromuscular Junction

Structural requirements for the interaction of human IgA with the human polymeric Ig receptor

Lewis, M. J., Pleass, R. J., Batten, M. R., Atkin, J. D. & Woof, J. M., 15 Nov 2005, In : Journal of Immunology. 175, 10, p. 6694-6701 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Polymeric Immunoglobulin Receptors
Immunoglobulin A
Secretory Component
Mutation
Transcytosis
2004

Brain β-amyloid accumulation in transgenic mice expressing mutant superoxide dismutase 1

Turner, B. J., Li, Q. X., Laughton, K. M., Masters, C. L., Lopes, E. C., Atkin, J. D. & Cheema, S. S., Dec 2004, In : Neurochemical Research. 29, 12, p. 2281-2286 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Amyloid
Transgenic Mice
Superoxide Dismutase
Brain
Amyotrophic Lateral Sclerosis
1997

Mutagenesis of J chain residues critical for IgA dimer assembly

Krugmann, S., Pleass, R. J., Atkin, J. D. & Woof, J. M., 1997, In : Biochemical Society Transactions. 25, 2, p. 323S 1 p.

Research output: Contribution to journalArticleResearchpeer-review

Structural Requirements for Assembly of Dimeric IgA Probed by Site-Directed Mutagenesis of J Chain and a Cysteine Residue of the α-Chain CH2 Domain

Krugmann, S., Pleass, R. J., Atkin, J. D. & Woof, J. M., 1997, In : Journal of Immunology. 159, 1, p. 244-249 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Site-Directed Mutagenesis
Immunoglobulin A
Cysteine
CHO Cells
Dimerization
1996

Mutagenesis of the human IgA1 heavy chain tailpiece that prevents dimer assembly

Atkin, J. D., Pleass, R. J., Owens, R. J. & Woof, J. M., 1 Jul 1996, In : Journal of Immunology. 157, 1, p. 156-159 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Mutagenesis
Immunoglobulin A
Protein Engineering
Terminator Codon
Dimerization

Recognition of an octapeptide sequence by multiple Galα(1,3)Gal-binding proteins

Vaughan, H. A., Oldenburg, K. R., Gallop, M. A., Atkin, J. D., McKenzie, I. F. C. & Sandrin, M. S., Feb 1996, In : Xenotransplantation. 3, 1 PART 1, p. 18-23 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Carrier Proteins
Swine
Lectins
Epitopes
Endothelial Cells

Strategies to overcome the anti-Galα(1-3)Gal reaction in xenotransplantation

McKenzie, I. F. C., Osman, N., Cohney, S., Vaughan, H. A., Patton, K., Mouhtouris, E., Atkin, J. D., Elliott, E., Fodor, W. L., Squinto, S. P., Burton, D., Gallop, M. A., Oldenburg, K. R. & Sandrin, M. S., 1996, In : Transplantation Proceedings. 28, 2, p. 537 1 p.

Research output: Contribution to journalArticleResearchpeer-review

1993

Purification and characterization of chimeric human IgA1 and IgA2 expressed in COS and Chinese hamster ovary cells

Morton, H. C., Atkin, J. D., Owens, R. J. & Woof, J. M., 1993, In : Journal of Immunology. 151, 9, p. 4743-4752 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Cricetulus
Immunoglobulin A
Ovary
IgA-specific serine endopeptidase
Antibodies

Recombinant human antibodies: linkage of an Fab fragment from a combinatorial library to an Fc fragment for expression in mammalian cell culture

Bender, E., Woof, J. M., Atkin, J. D., Barker, M. D., Bebbington, C. R. & Burton, D. R., 1993, In : Human Antibodies. 4, 2, p. 74-79 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Immunoglobulin Fc Fragments
Immunoglobulin Fab Fragments
Cell Culture Techniques
Antibodies
Immunoglobulins