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Research Outputs 1993 2020

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Article
2019

Genetic and immunopathological analysis of CHCHD10 in Australian amyotrophic lateral sclerosis and frontotemporal dementia and transgenic TDP-43 mice

McCann, E. P., Fifita, J. A., Grima, N., Galper, J., Mehta, P., Freckleton, S. E., Zhang, K. Y., Henden, L., Hogan, A. L., Chan Moi Fat, S., Wu, S. S. L., Jagaraj, C. J., Berning, B. A., Williams, K. L., Twine, N. A., Bauer, D., Piguet, O., Hodges, J., Kwok, J. B. J., Halliday, G. M. & 7 othersKiernan, M. C., Atkin, J., Rowe, D. B., Nicholson, G. A., Walker, A. K., Blair, I. P. & Yang, S., 5 Nov 2019, In : Journal of Neurology, Neurosurgery and Psychiatry.

Research output: Contribution to journalArticleResearchpeer-review

Sclerosis
DNA-Binding Proteins
Transgenic Mice
Spinal Cord
Proteins

Is cytoplasmic FUS a feature of all ALS?

Vidal, M. & Atkin, J. D., 1 Sep 2019, In : Brain : a journal of neurology. 142, 9, p. 2546-2549 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Amyotrophic Lateral Sclerosis
Brain

Motor neuron abnormalities correlate with impaired movement in zebrafish that express mutant superoxide dismutase 1

Robinson, K. J., Yuan, K. C., Don, E. K., Hogan, A. L., Winnick, C. G., Tym, M. C., Lucas, C. W., Shahheydari, H., Watchon, M., Blair, I. P., Atkin, J. D., Nicholson, G. A., Cole, N. J. & Laird, A. S., 1 Feb 2019, In : Zebrafish. 16, 1, p. 8-14 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Motor Neurons
Zebrafish
motor neurons
Danio rerio
superoxide dismutase

Protein disulphide isomerase is associated with mutant SOD1 in canine degenerative myelopathy

Chang, R. C., Parakh, S., Coates, J. R., Long, S. & Atkin, J. D., 2 Jan 2019, In : NeuroReport. 30, 1, p. 8-13 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Protein Disulfide-Isomerases
Spinal Cord Diseases
Canidae
Amyotrophic Lateral Sclerosis
Endoplasmic Reticulum Stress

The microglial NLRP3 inflammasome is activated by amyotrophic lateral sclerosis proteins

Deora, V., Lee, J. D., Albornoz, E. A., McAlary, L., Jagaraj, C. J., Robertson, A. A. B., Atkin, J. D., Cooper, M. A., Schroder, K., Yerbury, J. J., Gordon, R. & Woodruff, T. M., 9 Oct 2019, In : GLIA. 68, 2, p. 407-421 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Inflammasomes
Amyotrophic Lateral Sclerosis
Microglia
Caspase 1
Proteins
2018

ERp57 is protective against mutant SOD1-induced cellular pathology in amyotrophic lateral sclerosis

Parakh, S., Jagaraj, C. J., Vidal, M., Ragagnin, A. M. G., Perri, E. R., Konopka, A., Toth, R. P., Galper, J., Blair, I. P., Thomas, C. J., Walker, A. K., Yang, S., Spencer, D. M. & Atkin, J. D., 15 Apr 2018, In : Human molecular genetics. 27, 8, p. 1311-1331 21 p.

Research output: Contribution to journalArticleResearchpeer-review

Amyotrophic Lateral Sclerosis
Endoplasmic Reticulum Stress
Pathology
Apoptosis
DNA-Binding Proteins

Pathogenic mutation in the ALS/FTD gene, CCNF, causes elevated Lys48-linked ubiquitylation and defective autophagy

Lee, A., Rayner, S. L., Gwee, S. S. L., De Luca, A., Shahheydari, H., Sundaramoorthy, V., Ragagnin, A., Morsch, M., Radford, R., Galper, J., Freckleton, S., Shi, B., Walker, A. K., Don, E. K., Cole, N. J., Yang, S., Williams, K. L., Yerbury, J. J., Blair, I. P., Atkin, J. D. & 2 othersMolloy, M. P. & Chung, R. S., Jan 2018, In : Cellular and Molecular Life Sciences. 75, 2, p. 335–354 20 p.

Research output: Contribution to journalArticleResearchpeer-review

Cyclins
Ubiquitination
Autophagy
Mutation
Genes

SOD1 mutations causing familial amyotrophic lateral sclerosis induce toxicity in astrocytes: evidence for bystander effects in a continuum of astrogliosis

Wallis, N., Lau, C. L., Farg, M. A., Atkin, J. D., Beart, P. M. & O’Shea, R. D., 1 Jan 2018, In : Neurochemical Research. 43, 1, p. 166-179 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Bystander Effect
Astrocytes
Toxicity
Mutation
Amyotrophic Lateral Sclerosis
2017

A novel amyotrophic lateral sclerosis mutation in OPTN induces ER stress and Golgi fragmentation in vitro

Fifita, J. A., Williams, K. L., Sundaramoorthy, V., Mccann, E. P., Nicholson, G. A., Atkin, J. D. & Blair, I. P., 2 Jan 2017, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 18, 1-2, p. 126-133 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Amyotrophic Lateral Sclerosis
Mutation
Genes
In Vitro Techniques

Casein kinase II phosphorylation of cyclin F at serine 621 regulates the Lys48-ubiquitylation E3 ligase activity of the SCF(cyclin F) complex

Lee, A., Rayner, S. L., De Luca, A., Gwee, S. S. L., Morsch, M., Sundaramoorthy, V., Shahheydari, H., Ragagnin, A., Shi, B., Yang, S., Williams, K. L., Don, E. K., Walker, A. K., Zhang, K. Y., Yerbury, J. J., Cole, N. J., Atkin, J. D., Blair, I. P., Molloy, M. P. & Chung, R. S., 2017, In : Open Biology. 7, 10, p. 1-11 11 p., 170058.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Casein Kinase II
Phosphorylation
Cyclins
Ubiquitin-Protein Ligases
Ubiquitination

Protein quality control and the amyotrophic lateral sclerosis/frontotemporal dementia continuum

Shahheydari, H., Ragagnin, A., Walker, A. K., Toth, R. P., Vidal, M., Jagaraj, C. J., Perri, E. R., Konopka, A., Sultana, J. M. & Atkin, J. D., 10 May 2017, In : Frontiers in Molecular Neuroscience. 10, p. 1-25 25 p., 119.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Quality Control
Proteins
Neurodegenerative Diseases
Endoplasmic Reticulum-Associated Degradation
Molecular Chaperones

The DNA damage response (DDR) is induced by the C9orf72 repeat expansion in amyotrophic lateral sclerosis

Farg, M. A., Konopka, A., Soo, K. Y., Ito, D. & Atkin, J. D., 1 Aug 2017, In : Human molecular genetics. 26, 15, p. 2882-2896 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Amyotrophic Lateral Sclerosis
DNA Damage
Ataxia Telangiectasia
Dipeptides
Motor Neurons
2016

CCNF mutations in amyotrophic lateral sclerosis and frontotemporal dementia

Williams, K. L., Topp, S., Yang, S., Smith, B., Fifita, J. A., Warraich, S. T., Zhang, K. Y., Farrawell, N., Vance, C., Hu, X., Chesi, A., Leblond, C. S., Lee, A., Rayner, S. L., Sundaramoorthy, V., Dobson-Stone, C., Molloy, M. P., Van Blitterswijk, M., Dickson, D. W., Petersen, R. C. & 48 othersGraff-Radford, N. R., Boeve, B. F., Murray, M. E., Pottier, C., Don, E., Winnick, C., McCann, E. P., Hogan, A., Daoud, H., Levert, A., Dion, P. A., Mitsui, J., Ishiura, H., Takahashi, Y., Goto, J., Kost, J., Gellera, C., Gkazi, A. S., Miller, J., Stockton, J., Brooks, W. S., Boundy, K., Polak, M., Muñoz-Blanco, J. L., Esteban-Pérez, J., Rábano, A., Hardiman, O., Morrison, K. E., Ticozzi, N., Silani, V., De Belleroche, J., Glass, J. D., Kwok, J. B. J., Guillemin, G. J., Chung, R. S., Tsuji, S., Brown, R. H., García-Redondo, A., Rademakers, R., Landers, J. E., Gitler, A. D., Rouleau, G. A., Cole, N. J., Yerbury, J. J., Atkin, J. D., Shaw, C. E., Nicholson, G. A. & Blair, I. P., 15 Apr 2016, In : Nature Communications. 7, p. 1-8 8 p., 11253.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Ubiquitinated Proteins
mutations
Ubiquitin-Protein Ligase Complexes
proteins
Mutation

Efficacy of peptide nucleic acid and selected conjugates against specific cellular pathologies of amyotrophic lateral sclerosis

Browne, E. C., Parakh, S., Duncan, L. F., Langford, S. J., Atkin, J. D. & Abbott, B. M., 1 Apr 2016, In : Bioorganic and Medicinal Chemistry. 24, 7, p. 1520-1527 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Peptide Nucleic Acids
Amyotrophic Lateral Sclerosis
Pathology
Superoxide Dismutase
Nucleic acid sequences

NFκB is a central regulator of protein quality control in response to protein aggregation stresses via autophagy modulation

Nivon, M., Fort, L., Muller, P., Richet, E., Simon, S., Guey, B., Fournier, M., Arrigo, A. P., Hetz, C., Atkin, J. D. & Kretz-Remy, C., 1 Jun 2016, In : Molecular Biology of the Cell. 27, 11, p. 1712-1727 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Autophagy
Heat-Shock Proteins
Quality Control
Proteins
Poisons
2015

C9ORF72 expression and cellular localization over mouse development

Atkinson, R. A. K., Fernandez-Martos, C. M., Atkin, J. D., Vickers, J. C. & King, A. E., 25 Sep 2015, In : Acta neuropathologica communications. 3, p. 1-11 11 p., 59.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Protein Isoforms
Fluorescent Antibody Technique
Neurons
Growth Cones
Proteins

Defects in optineurin- and myosin VI-mediated cellular trafficking in amyotrophic lateral sclerosis

Sundaramoorthy, V., Walker, A. K., Tan, V., Fifita, J. A., McCann, E. P., Williams, K. L., Blair, I. P., Guillemin, G. J., Farg, M. A. & Atkin, J. D., 1 Jul 2015, In : Human molecular genetics. 24, 13, p. 3830-3846 17 p., ddv126.

Research output: Contribution to journalArticleResearchpeer-review

Amyotrophic Lateral Sclerosis
Motor Neurons
Lysosomes
Autophagy
Mutation

Novel roles for protein disulphide isomerase in disease states: a double edged sword?

Parakh, S. & Atkin, J. D., 2015, In : Frontiers in cell and developmental biology. 3, p. 1-11 11 p., 30.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Protein Disulfide-Isomerases
Post Translational Protein Processing
Endoplasmic Reticulum
Oxidation-Reduction

Phosphorylation of hnRNP K by cyclin-dependent kinase 2 controls cytosolic accumulation of TDP-43

Moujalled, D., James, J. L., Yang, S., Zhang, K., Duncan, C., Moujalled, D. M., Parker, S. J., Caragounis, A., Lidgerwood, G., Turner, B. J., Atkin, J. D., Grubman, A., Liddell, J. R., Proepper, C., Boeckers, T. M., Kanninen, K. M., Blair, I., Crouch, P. J. & White, A. R., 2015, In : Human molecular genetics. 24, 6, p. 1655-1669 15 p., ddu578.

Research output: Contribution to journalArticleResearchpeer-review

Cyclin-Dependent Kinase 2
Ribonucleoproteins
DNA-Binding Proteins
Phosphorylation
Amyotrophic Lateral Sclerosis

Rab1-dependent ER-Golgi transport dysfunction is a common pathogenic mechanism in SOD1, TDP-43 and FUS-associated ALS

Soo, K. Y., Halloran, M., Sundaramoorthy, V., Parakh, S., Toth, R. P., Southam, K. A., McLean, C. A., Lock, P., King, A., Farg, M. A. & Atkin, J. D., 1 Nov 2015, In : Acta Neuropathologica. 130, 5, p. 679-697 19 p.

Research output: Contribution to journalArticleResearchpeer-review

Amyotrophic Lateral Sclerosis
Endoplasmic Reticulum
Protein Transport
Motor Neurons
Endoplasmic Reticulum Stress

The unfolded protein response and the role of Protein Disulfide Isomerase in neurodegeneration

Perri, E. R., Thomas, C. J., Parakh, S., Spencer, D. M. & Atkin, J. D., 2015, In : Frontiers in cell and developmental biology. 3, p. 1-17 17 p., 80.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Protein Disulfide-Isomerases
Unfolded Protein Response
Endoplasmic Reticulum Stress
Endoplasmic Reticulum
Neurodegenerative Diseases
2014

C9ORF72, implicated in amytrophic lateral sclerosis and frontotemporal dementia, regulates endosomal trafficking

Farg, M. A., Sundaramoorthy, V., Sultana, J. M., Yang, S., Atkinson, R. A. K., Levina, V., Halloran, M. A., Gleeson, P. A., Blair, I. P., Soo, K. Y., King, A. E. & Atkin, J. D., 2014, In : Human molecular genetics. 23, 13, p. 3579-3595 17 p., ddu068.

Research output: Contribution to journalArticleResearchpeer-review

Frontotemporal Dementia
Motor Neuron Disease
Reading
Autophagy
Motor Neurons

Mutant SOD1 inhibits ER-Golgi transport in amyotrophic lateral sclerosis

Atkin, J. D., Farg, M. A., Soo, K. Y., Walker, A. K., Halloran, M., Turner, B. J., Nagley, P. & Horne, M. K., 2014, In : Journal of Neurochemistry. 129, 1, p. 190-204 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Amyotrophic Lateral Sclerosis
Endoplasmic Reticulum
Endoplasmic Reticulum Stress
Apoptosis
Capsid Proteins
2013

ALS-associated TDP-43 induces endoplasmic reticulum stress, which drives cytoplasmic TDP-43 accumulation and stress granule formation

Walker, A. K., Soo, K. Y., Sundaramoorthy, V., Parakh, S., Ma, Y., Farg, M. A., Wallace, R. H., Crouch, P. J., Turner, B. J., Horne, M. K. & Atkin, J. D., 29 Nov 2013, In : PLoS ONE. 8, 11, p. 1-12 12 p., e81170.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Endoplasmic Reticulum Stress
DNA-binding proteins
Amyotrophic Lateral Sclerosis
DNA-Binding Proteins
endoplasmic reticulum

Ataxin-2 interacts with FUS and intermediate-length polyglutamine expansions enhance FUS-related pathology in amyotrophic lateral sclerosis

Farg, M. A., Soo, K. Y., Warraich, S. T., Sundaramoorthy, V., Blair, I. P. & Atkin, J. D., Feb 2013, In : Human molecular genetics. 22, 4, p. 717-728 12 p., dds479.

Research output: Contribution to journalArticleResearchpeer-review

Amyotrophic Lateral Sclerosis
Sarcoma
Pathology
Endoplasmic Reticulum Stress
Motor Neurons

Dysregulation of the complement cascade in the hSOD1G93A transgenic mouse model of amyotrophic lateral sclerosis

Lee, J. D., Kamaruzaman, N. A., Fung, J. N. T., Taylor, S. M., Turner, B. J., Atkin, J. D., Woodruff, T. M. & Noakes, P. G., 26 Sep 2013, In : Journal of Neuroinflammation. 10, p. 1-14 14 p., 119.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Amyotrophic Lateral Sclerosis
Transgenic Mice
Spinal Cord
Motor Neurons
Disease Progression

Extracellular wildtype and mutant SOD1 induces ER-Golgi pathology characteristic of amyotrophic lateral sclerosis in neuronal cells

Sundaramoorthy, V., Walker, A. K., Yerbury, J., Soo, K. Y., Farg, M. A., Hoang, V., Zeineddine, R., Spencer, D. & Atkin, J. D., Nov 2013, In : Cellular and Molecular Life Sciences. 70, 21, p. 4181-4195 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Amyotrophic Lateral Sclerosis
Pathology
Motor Neurons
Cell Death
Golgi Apparatus

N-linked glycosylation modulates dimerization of protein disulfide isomerase family A member 2 (PDIA2)

Walker, A. K., Soo, K. Y., Levina, V., Talbo, G. H. & Atkin, J. D., Jan 2013, In : FEBS Journal. 280, 1, p. 233-243 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Protein Disulfide-Isomerases
Glycosylation
Dimerization
Endoplasmic Reticulum
Post Translational Protein Processing
2012

Bim links ER stress and apoptosis in cells expressing mutant SOD1 associated with amyotrophic lateral sclerosis

Soo, K. Y., Atkin, J. D., Farg, M., Walker, A. K., Horne, M. K. & Nagley, P., 16 Apr 2012, In : PLoS ONE. 7, 4, p. 1-11 11 p., e35413.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Endoplasmic Reticulum Stress
Amyotrophic Lateral Sclerosis
Bearings (structural)
endoplasmic reticulum
Superoxide Dismutase

Mutant FUS induces endoplasmic reticulum stress in amyotrophic lateral sclerosis and interacts with protein disulfide-isomerase

Farg, M. A., Soo, K. Y., Walker, A. K., Pham, H., Orian, J., Horne, M. K., Warraich, S. T., Williams, K. L., Blair, I. P. & Atkin, J. D., Dec 2012, In : Neurobiology of Aging. 33, 12, p. 2855-2868 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Protein Disulfide-Isomerases
Endoplasmic Reticulum Stress
Amyotrophic Lateral Sclerosis
Sarcoma
Motor Neurons
2010

Protein disulphide isomerase protects against protein aggregation and is S-nitrosylated in amyotrophic lateral sclerosis

Walker, A. K., Farg, M. A., Bye, C. R., McLean, C. A., Horne, M. K. & Atkin, J. D., Jan 2010, In : Brain. 133, 1, p. 105-116 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Protein Disulfide-Isomerases
Amyotrophic Lateral Sclerosis
Endoplasmic Reticulum Stress
Proteins
Motor Neurons

Serum matrix metalloproteinase-9 activity is dysregulated with disease progression in the mutant SOD1 transgenic mice

Soon, C. P. W., Crouch, P. J., Turner, B. J., McLean, C. A., Laughton, K. M., Atkin, J. D., Masters, C. L., White, A. R. & Li, Q. X., Apr 2010, In : Neuromuscular Disorders. 20, 4, p. 260-266 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Matrix Metalloproteinase 9
Transgenic Mice
Disease Progression
Serum
Amyotrophic Lateral Sclerosis
2009

Recruitment of mitochondria into apoptotic signaling correlates with the presence of inclusions formed by amyotrophic lateral sclerosis-associated SOD1 mutations

Soo, K. Y., Atkin, J. D., Horne, M. K. & Nagley, P., Feb 2009, In : Journal of Neurochemistry. 108, 3, p. 578-590 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Mitochondria
Amyotrophic Lateral Sclerosis
Superoxide Dismutase
Mutation
Apoptosis
2008

Endoplasmic reticulum stress and induction of the unfolded protein response in human sporadic amyotrophic lateral sclerosis

Atkin, J. D., Farg, M. A., Walker, A. K., McLean, C., Tomas, D. & Horne, M. K., Jun 2008, In : Neurobiology of Disease. 30, 3, p. 400-407 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Unfolded Protein Response
Endoplasmic Reticulum Stress
Amyotrophic Lateral Sclerosis
Rodentia
Protein Disulfide-Isomerases

Sex-specific behavioural effects of environmental enrichment in a transgenic mouse model of amyotrophic lateral sclerosis

Stam, N. C., Nithianantharajah, J., Howard, M. L., Atkin, J. D., Cheema, S. S. & Hannan, A. J., Aug 2008, In : European Journal of Neuroscience. 28, 4, p. 717-723 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Amyotrophic Lateral Sclerosis
Transgenic Mice
Disease Progression
Nerve Degeneration
Twin Studies

The complement factor C5a contributes to pathology in a rat model of amyotrophic lateral sclerosis

Woodruff, T. M., Costantini, K. J., Crane, J. W., Atkin, J. D., Monk, P. N., Taylor, S. M. & Noakes, P. G., 15 Dec 2008, In : Journal of Immunology. 181, 12, p. 8727-8734 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Complement C5a
Amyotrophic Lateral Sclerosis
Spinal Cord
Pathology
Complement Activation
2007

Increased number and differentiation of neural precursor cells in the brainstem of superoxide dismutase 1G93A G1H transgenic mouse model of amyotrophic lateral sclerosis

Juan, L., Dawei, Z. & Julie, A. D., Mar 2007, In : Neurological Research. 29, 2, p. 204-209 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Amyotrophic Lateral Sclerosis
Transgenic Mice
Brain Stem
Superoxide Dismutase
Glial Fibrillary Acidic Protein
2005

Impaired extracellular secretion of mutant superoxide dismutase 1 associates with neurotoxicity in familial amyotrophic lateral sclerosis

Turner, B. J., Atkin, J. D., Farg, M. A., Da, W. Z., Rembach, A., Lopes, E. C., Patch, J. D., Hill, A. F. & Cheema, S. S., 5 Jan 2005, In : Journal of Neuroscience. 25, 1, p. 108-117 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Brefeldin A
Inclusion Bodies
Amyotrophic Lateral Sclerosis
Transgenic Rats
Secretory Pathway

Properties of slow- and fast-twitch muscle fibres in a mouse model of amyotrophic lateral sclerosis

Atkin, J. D., Scott, R. L., West, J. M., Lopes, E., Quah, A. K. J. & Cheema, S. S., May 2005, In : Neuromuscular Disorders. 15, 5, p. 377-388 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Slow-Twitch Muscle Fibers
Fast-Twitch Muscle Fibers
Amyotrophic Lateral Sclerosis
Muscles
Neuromuscular Junction

Structural requirements for the interaction of human IgA with the human polymeric Ig receptor

Lewis, M. J., Pleass, R. J., Batten, M. R., Atkin, J. D. & Woof, J. M., 15 Nov 2005, In : Journal of Immunology. 175, 10, p. 6694-6701 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Polymeric Immunoglobulin Receptors
Immunoglobulin A
Secretory Component
Mutation
Transcytosis
2004

Brain β-amyloid accumulation in transgenic mice expressing mutant superoxide dismutase 1

Turner, B. J., Li, Q. X., Laughton, K. M., Masters, C. L., Lopes, E. C., Atkin, J. D. & Cheema, S. S., Dec 2004, In : Neurochemical Research. 29, 12, p. 2281-2286 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Amyloid
Transgenic Mice
Superoxide Dismutase
Brain
Amyotrophic Lateral Sclerosis
1997

Mutagenesis of J chain residues critical for IgA dimer assembly

Krugmann, S., Pleass, R. J., Atkin, J. D. & Woof, J. M., 1997, In : Biochemical Society Transactions. 25, 2, p. 323S 1 p.

Research output: Contribution to journalArticleResearchpeer-review

Structural Requirements for Assembly of Dimeric IgA Probed by Site-Directed Mutagenesis of J Chain and a Cysteine Residue of the α-Chain CH2 Domain

Krugmann, S., Pleass, R. J., Atkin, J. D. & Woof, J. M., 1997, In : Journal of Immunology. 159, 1, p. 244-249 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Site-Directed Mutagenesis
Immunoglobulin A
Cysteine
CHO Cells
Dimerization
1996

Mutagenesis of the human IgA1 heavy chain tailpiece that prevents dimer assembly

Atkin, J. D., Pleass, R. J., Owens, R. J. & Woof, J. M., 1 Jul 1996, In : Journal of Immunology. 157, 1, p. 156-159 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Mutagenesis
Immunoglobulin A
Protein Engineering
Terminator Codon
Dimerization

Recognition of an octapeptide sequence by multiple Galα(1,3)Gal-binding proteins

Vaughan, H. A., Oldenburg, K. R., Gallop, M. A., Atkin, J. D., McKenzie, I. F. C. & Sandrin, M. S., Feb 1996, In : Xenotransplantation. 3, 1 PART 1, p. 18-23 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Carrier Proteins
Swine
Lectins
Epitopes
Endothelial Cells

Strategies to overcome the anti-Galα(1-3)Gal reaction in xenotransplantation

McKenzie, I. F. C., Osman, N., Cohney, S., Vaughan, H. A., Patton, K., Mouhtouris, E., Atkin, J. D., Elliott, E., Fodor, W. L., Squinto, S. P., Burton, D., Gallop, M. A., Oldenburg, K. R. & Sandrin, M. S., 1996, In : Transplantation Proceedings. 28, 2, p. 537 1 p.

Research output: Contribution to journalArticleResearchpeer-review

1993

Purification and characterization of chimeric human IgA1 and IgA2 expressed in COS and Chinese hamster ovary cells

Morton, H. C., Atkin, J. D., Owens, R. J. & Woof, J. M., 1993, In : Journal of Immunology. 151, 9, p. 4743-4752 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Cricetulus
Immunoglobulin A
Ovary
IgA-specific serine endopeptidase
Antibodies

Recombinant human antibodies: linkage of an Fab fragment from a combinatorial library to an Fc fragment for expression in mammalian cell culture

Bender, E., Woof, J. M., Atkin, J. D., Barker, M. D., Bebbington, C. R. & Burton, D. R., 1993, In : Human Antibodies. 4, 2, p. 74-79 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Immunoglobulin Fc Fragments
Immunoglobulin Fab Fragments
Cell Culture Techniques
Antibodies
Immunoglobulins