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20172024

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Personal profile

Biography

Katherine's research is focused on understanding the basic mechanisms driving the neurodegenerative disease, Machado Joseph Disease (MJD). Katherine is particularly interested how calpain proteases may contribute to the formation of pathological protein aggregates and aims to identify novel drug treatments that may slow or halt the neurodegenerative process.

Research interests

  • Understanding the role of cerebellar circuit dysfunction in the pathogenesis of Machado Joseph Disease/Spinocerebellar Ataxia-3. 
  • The role of glutamate-induced excitotoxicity and proteolytic cleavage in neurodegeneration. 
  • Overlapping pathogenic mechanisms or pathologies across neurodegenerative diseases with differing underlying genetic causes.
  • Identifying novel candidates for the treatment of neurodegenerative diseases. 

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