Research output per year
Research output per year
Personal profile
Biography
Katherine's research is focused on understanding the basic mechanisms driving the neurodegenerative disease, Machado Joseph Disease (MJD). Katherine is particularly interested how calpain proteases may contribute to the formation of pathological protein aggregates and aims to identify novel drug treatments that may slow or halt the neurodegenerative process.
Research interests
- Understanding the role of cerebellar circuit dysfunction in the pathogenesis of Machado Joseph Disease/Spinocerebellar Ataxia-3.
- The role of glutamate-induced excitotoxicity and proteolytic cleavage in neurodegeneration.
- Overlapping pathogenic mechanisms or pathologies across neurodegenerative diseases with differing underlying genetic causes.
- Identifying novel candidates for the treatment of neurodegenerative diseases.
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Machado Joseph disease severity is linked with gut microbiota alterations in transgenic mice
Gamage, H. K. A. H., Robinson, K. J., Luu, L., Paulsen, I. T. & Laird, A. S., Apr 2023, In: Neurobiology of Disease. 179, p. 1-13 13 p., 106051.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Downloads (Pure) -
Oxytocin as an adolescent treatment for methamphetamine addiction after early life stress in male and female rats
Baracz, S. J., Robinson, K. J., Wright, A. L., Turner, A. J., McGregor, I. S., Cornish, J. L. & Everett, N., Jul 2022, In: Neuropsychopharmacology. 47, 8, p. 1561–1573 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)6 Downloads (Pure) -
The effect of self-administered methamphetamine on GABAergic interneuron populations and functional connectivity of the nucleus accumbens and prefrontal cortex
Robinson, K. J., Everett, N. A., Baracz, S. J. & Cornish, J. L., Sep 2022, In: Psychopharmacology. 239, 9, p. 2903–2919 17 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile16 Downloads (Pure) -
A novel calpain inhibitor compound has protective effects on a zebrafish model of spinocerebellar ataxia type 3
Robinson, K. J., Yuan, K., Plenderleith, S. K., Watchon, M. & Laird, A., 29 Sep 2021, In: Cells. 10, 10, p. 1-15 15 p., 2592.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)26 Downloads (Pure) -
Flow cytometry allows rapid detection of protein aggregates in cell culture and zebrafish models of spinocerebellar ataxia-3
Robinson, K. J., Tym, M. C., Hogan, A., Watchon, M., Yuan, K. C., Plenderleith, S. K., Don, E. K. & Laird, A. S., 10 Mar 2021, (Submitted) In: bioRxiv.Research output: Contribution to journal › Article
File23 Downloads (Pure)