Projects per year
Personal profile
Biography
Katherine's research is focused on understanding the basic mechanisms driving the neurodegenerative disease, Machado Joseph Disease (MJD). Katherine is particularly interested how calpain proteases may contribute to the formation of pathological protein aggregates and aims to identify novel drug treatments that may slow or halt the neurodegenerative process.
Research interests
- Understanding the role of cerebellar circuit dysfunction in the pathogenesis of Machado Joseph Disease/Spinocerebellar Ataxia-3.
- The role of glutamate-induced excitotoxicity and proteolytic cleavage in neurodegeneration.
- Overlapping pathogenic mechanisms or pathologies across neurodegenerative diseases with differing underlying genetic causes.
- Identifying novel candidates for the treatment of neurodegenerative diseases.
Fingerprint
Dive into the research topics where Katherine Jane Robinson is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 1 Similar Profiles
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Projects
- 1 Active
-
Understanding the role of cellular energetics and the gut-brain axis in MJD
Laird, A. (Primary Chief Investigator), Lee, A. (Chief Investigator), Hewawasam Gamage, H. (Chief Investigator), Robinson, K. J. (Chief Investigator) & Simo, I. (Chief Investigator)
1/03/25 → 28/02/26
Project: Research
-
Gut transit and gut microbiome changes occur prior to the onset of motor impairment in a mouse model of Machado-Joseph disease
Zvyagina, V., Kuriakose, A., Simó, I., Kam, J. Y., Chakraborty, P., Robinson, K. J., Potapenko, A., Watchon, M., Paulsen, I. T., Gamage, H. K. A. H. & Laird, A. S., Nov 2025, In: Neurobiology of Disease. 216, p. 1-15 15 p., 107121.Research output: Contribution to journal › Article › peer-review
Open AccessFile12 Downloads (Pure) -
Spermidine treatment: induction of autophagy but also apoptosis?
Watchon, M., Wright, A. L., Ahel, H. I., Robinson, K. J., Plenderleith, S. K., Kuriakose, A., Yuan, K. C. & Laird, A. S., 5 Mar 2024, In: Molecular Brain. 17, 1, p. 1-15 15 p., 15.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)59 Downloads (Pure) -
Treatment with sodium butyrate induces autophagy resulting in therapeutic benefits for spinocerebellar ataxia type 3
Watchon, M., Robinson, K. J., Luu, L., An, Y., Yuan, K. C., Plenderleith, S. K., Cheng, F., Don, E. K., Nicholson, G. A., Lee, A. & Laird, A. S., 31 Jan 2024, In: FASEB Journal. 38, 2, p. 1-19 19 p., e23429.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus)55 Downloads (Pure) -
Machado Joseph disease severity is linked with gut microbiota alterations in transgenic mice
Gamage, H. K. A. H., Robinson, K. J., Luu, L., Paulsen, I. T. & Laird, A. S., Apr 2023, In: Neurobiology of Disease. 179, p. 1-13 13 p., 106051.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)86 Downloads (Pure) -
Treatment with sodium butyrate induces autophagy resulting in therapeutic benefits for spinocerebellar ataxia type 3
Watchon, M., Robinson, K. J., Luu, L., An, Y., Yuan, K. C., Plenderleith, S. K., Cheng, F., Don, E. K., Nicholson, G. A., Lee, A. & Laird, A. S., 12 Dec 2023, (Submitted) (bioRxiv).Research output: Working paper › Preprint