Lars Ittner

Director, Dementia Research Centre, Professor

  • 7540 Citations
  • 44 h-Index
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Personal profile


Professor Lars Ittner is the Director of the Dementia Research Centre and Professor in the Department of Biomedical Sciences of the Faculty of Medicine and Health Sciences at Macquarie University. Lars graduated in Medicine from the University of Ulm in Germany and received his M.D. from the University of Zurich in Switzerland in 2002. This was followed by postdoctoral fellowships at the University of Zurich, where he studied neuronal stem cells and signalling pathways, and after moving to Australia in 2005, at the University of Sydney, focusing on basic pathomechanisms underlying neurodegenerative diseases. He became an independent group leader and Associate Professor at the University of Sydney in 2011, followed by an appointment to the University of New South Wales in 2013, where he became a Professor and headed the Dementia Research Unit and Transgenic Animal Unit in the Faculty of Medicine. In 2018 he joined Macquarie University to build the Dementia Research Centre. Lars was a German Research Foundation Fellow, a NHMRC Senior Research Fellow and is a current NHMRC Principal Research Fellow.

Research interests

Lars has made major contributions to the understanding of fundamental pathomechanisms in Alzheimer’s disease and frontotemporal dementia and identified several novel targets for drug development in these diseases. After 15 years of discovery research dedicated to identifying novel mechanisms underlying neuronal dysfunction and loss in dementia, his research program has evolved to translate these findings into novel therapeutic approaches. This new work is based on a portfolio of novel compounds, proprietary tools, drug target and preclinical disease models. Current projects include;

  • Develop small molecular inhibitors of disease-relevant kinases
  • Development of peptidomimetic modulators of excitotoxicity
  • Develop new antibodies for the treatment of dementia
  • Develop new gene therapies for neurodegenerative diseases

Education/Academic qualification

Medicine, M.D., University of Zurich

PG Course in Experimental Medicine and Biology, University of Zurich

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Alzheimer Disease Medicine & Life Sciences
Transgenic Mice Medicine & Life Sciences
Amyloid Medicine & Life Sciences
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Pathology Medicine & Life Sciences
Frontotemporal Lobar Degeneration Medicine & Life Sciences
Neurofibrillary Tangles Medicine & Life Sciences
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Projects 2017 2023

Research Outputs 2002 2019

Dendritic tau in Alzheimer's disease

Ittner, A. & Ittner, L. M., 11 Jul 2018, In : Neuron. 99, 1, p. 13-27 15 p.

Research output: Contribution to journalReview articleResearchpeer-review

Alzheimer Disease
Microtubule-Associated Proteins

Site-specific phosphorylation of tau inhibits amyloid-β toxicity in Alzheimer's mice

Ittner, A., Chua, S. W., Bertz, J., Volkerling, A., van der Hoven, J., Gladbach, A., Przybyla, M., Bi, M., van Hummel, A., Stevens, C. H., Ippati, S., Suh, L. S., Macmillan, A., Sutherland, G., Kril, J. J., Silva, A. P. G., Mackay, J., Poljak, A., Delerue, F., Ke, Y. D. & 1 othersIttner, L. M., 18 Nov 2016, In : Science. 354, 6314, p. 904-908 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Alzheimer Disease
tau Proteins
p38 Mitogen-Activated Protein Kinases

Tau exacerbates excitotoxic brain damage in an animal model of stroke

Bi, M., Gladbach, A., van Eersel, J., Ittner, A., Przybyla, M., van Hummel, A., Chua, S. W., van der Hoven, J., Lee, W. S., Müller, J., Parmar, J., von Jonquieres, G., Stefen, H., Guccione, E., Fath, T., Housley, G. D., Klugmann, M., Ke, Y. D. & Ittner, L. M., 1 Dec 2017, In : Nature Communications. 8, 1, p. 1-15 15 p., 473.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
brain damage
animal models

Amyloid-β and tau: a toxic pas de deux in Alzheimer's disease

Ittner, L. M. & Götz, J., 1 Feb 2011, In : Nature Reviews Neuroscience. 12, 2, p. 67-72 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Alzheimer Disease
Microtubule-Associated Proteins

Dendritic function of tau mediates amyloid-β toxicity in alzheimer's disease mouse models

Ittner, L. M., Ke, Y. D., Delerue, F., Bi, M., Gladbach, A., van Eersel, J., Wölfing, H., Chieng, B. C., Christie, M. J., Napier, I. A., Eckert, A., Staufenbiel, M., Hardeman, E. & Götz, J., 1 Aug 2010, In : Cell. 142, 3, p. 387-397 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Alzheimer Disease
N-Methyl-D-Aspartate Receptors
src-Family Kinases

Activities 2016 2016

  • 1 Editorial work

Journal of Biological Chemistry (Journal)

Lars Ittner (Member of editorial board)

Activity: Publication peer-review and editorial workEditorial work