Lars Ittner

Director, Dementia Research Centre, Professor

  • 8015 Citations
  • 45 h-Index

Research output per year

If you made any changes in Pure these will be visible here soon.

Personal profile


Professor Lars Ittner is the Director of the Dementia Research Centre and Professor in the Department of Biomedical Sciences of the Faculty of Medicine, Health and Human Sciences at Macquarie University. Lars graduated from the University of Ulm in Germany and completed his thesis at the University of Zurich in Switzerland in 2002. This was followed by postdoctoral fellowships at the University of Zurich, where he studied neuronal stem cells and signalling pathways, and after moving to Australia in 2005, at the University of Sydney, focusing on basic pathomechanisms underlying neurodegenerative diseases. He became an independent group leader and Associate Professor at the University of Sydney in 2011, followed by an appointment to the University of New South Wales in 2013, where he became a Professor and headed the Dementia Research Unit and Transgenic Animal Unit in the Faculty of Medicine. In 2018 he joined Macquarie University to build the Dementia Research Centre. Lars was a German Research Foundation Fellow, a NHMRC Senior Research Fellow and is a current NHMRC Principal Research Fellow.

Research interests

Lars has made major contributions to the understanding of fundamental pathomechanisms in Alzheimer’s disease and frontotemporal dementia and identified several novel targets for drug development in these diseases. After 15 years of discovery research dedicated to identifying novel mechanisms underlying neuronal dysfunction and loss in dementia, his research program has evolved to translate these findings into novel therapeutic approaches. This new work is based on a portfolio of novel compounds, proprietary tools, drug target and preclinical disease models. Current projects include;

  • Develop small molecular inhibitors of disease-relevant kinases
  • Development of peptidomimetic modulators of excitotoxicity
  • Develop new antibodies for the treatment of dementia
  • Develop new gene therapies for neurodegenerative diseases

Fingerprint Dive into the research topics where Lars Ittner is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 11 Similar Profiles

Network Recent external collaboration on country level. Dive into details by clicking on the dots.


Research Outputs

Dendritic tau in Alzheimer's disease

Ittner, A. & Ittner, L. M., 11 Jul 2018, In : Neuron. 99, 1, p. 13-27 15 p.

Research output: Contribution to journalReview article

  • 35 Citations (Scopus)

    Site-specific phosphorylation of tau inhibits amyloid-β toxicity in Alzheimer's mice

    Ittner, A., Chua, S. W., Bertz, J., Volkerling, A., van der Hoven, J., Gladbach, A., Przybyla, M., Bi, M., van Hummel, A., Stevens, C. H., Ippati, S., Suh, L. S., Macmillan, A., Sutherland, G., Kril, J. J., Silva, A. P. G., Mackay, J., Poljak, A., Delerue, F., Ke, Y. D. & 1 others, Ittner, L. M., 18 Nov 2016, In : Science. 354, 6314, p. 904-908 5 p.

    Research output: Contribution to journalArticle

  • 95 Citations (Scopus)

    Tau exacerbates excitotoxic brain damage in an animal model of stroke

    Bi, M., Gladbach, A., van Eersel, J., Ittner, A., Przybyla, M., van Hummel, A., Chua, S. W., van der Hoven, J., Lee, W. S., Müller, J., Parmar, J., von Jonquieres, G., Stefen, H., Guccione, E., Fath, T., Housley, G. D., Klugmann, M., Ke, Y. D. & Ittner, L. M., 1 Dec 2017, In : Nature Communications. 8, 1, p. 1-15 15 p., 473.

    Research output: Contribution to journalArticle

    Open Access
  • 41 Citations (Scopus)
    18 Downloads (Pure)

    Amyloid-β and tau: a toxic pas de deux in Alzheimer's disease

    Ittner, L. M. & Götz, J., 1 Feb 2011, In : Nature Reviews Neuroscience. 12, 2, p. 67-72 6 p.

    Research output: Contribution to journalArticle

  • 739 Citations (Scopus)

    Dendritic function of tau mediates amyloid-β toxicity in alzheimer's disease mouse models

    Ittner, L. M., Ke, Y. D., Delerue, F., Bi, M., Gladbach, A., van Eersel, J., Wölfing, H., Chieng, B. C., Christie, M. J., Napier, I. A., Eckert, A., Staufenbiel, M., Hardeman, E. & Götz, J., 1 Aug 2010, In : Cell. 142, 3, p. 387-397 11 p.

    Research output: Contribution to journalArticle

  • 1019 Citations (Scopus)


    • 1 Editorial work

    Journal of Biological Chemistry (Journal)

    Lars Ittner (Member of editorial board)

    Activity: Publication peer-review and editorial workEditorial work