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Research Outputs 1996 2019

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2019

A conserved GXXXG motif in the transmembrane domain of CLIC proteins is essential for their cholesterol-dependant membrane interaction

Hossain, K. R., Turkewitz, D. R., Holt, S. A., Herson, L., Brown, L. J., Cornell, B. A., Curmi, P. M. G. & Valenzuela, S. M., Aug 2019, In : Biochimica et Biophysica Acta - General Subjects. 1863, 8, p. 1243-1253 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Cholesterol
Membranes
Proteins
Ion Channels
Membrane Proteins
Troponin C
Hypertrophic Cardiomyopathy
Magnetic Resonance Spectroscopy
Nuclear magnetic resonance
Mutation

Influence of surface chemistry on the formation of a protein corona on nanodiamonds

Garcia-Bennett, A. E., Everest-Dass, A., Moroni, I., Rastogi, I. D., Parker, L. M., Packer, N. H. & Brown, L. J., 7 Jun 2019, In : Journal of Materials Chemistry B. 7, 21, p. 3383-3389 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Nanodiamonds
Surface chemistry
Proteins
Surface charge
Diamond
2018

Influence of surface composition on the colloidal stability of ultra-small detonation nanodiamonds in biological media

Bradac, C., Rastogi, I. D., Cordina, N. M., Garcia-Bennett, A. & Brown, L. J., 1 Mar 2018, In : Diamond and Related Materials. 83, p. 38-45 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Nanodiamonds
Detonation
detonation
Surface structure
resilience

Reduced background autofluorescence for cell imaging using nanodiamonds and lanthanide chelates

Cordina, N. M., Sayyadi, N., Parker, L. M., Everest-Dass, A., Brown, L. J. & Packer, N. H., 14 Mar 2018, In : Scientific Reports. 8, 1, p. 1-14 14 p., 4521.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Nanodiamonds
Lanthanoid Series Elements
Optical Imaging
Europium
E-Selectin
2017

The concerted movement of the switch region of Troponin I in cardiac muscle thin filaments as tracked by conventional and pulsed (DEER) EPR

Potluri, P. R., Chamoun, J., Cooke, J. A., Badr, M., Guse, J. A., Rayes, R., Cordina, N. M., McCamey, D., Fajer, P. G. & Brown, L. J., Dec 2017, In : Journal of Structural Biology. 200, 3, p. 376-387 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Troponin I
Myocardium
Electrons
Troponin C
Protein Isoforms
2016

Brightness and Photostability of Emerging Red and Near-IR Fluorescent Nanomaterials for Bioimaging

Reineck, P., Francis, A., Orth, A., Lau, D. W. M., Nixon-Luke, R. D. V., Rastogi, I. D., Razali, W. A. W., Cordina, N. M., Parker, L. M., Sreenivasan, V. K. A., Brown, L. J. & Gibson, B. C., 1 Oct 2016, In : Advanced Optical Materials. 4, 10, p. 1549-1557 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Nanostructured materials
Luminance
emerging
brightness
biology

CLIC1 regulates dendritic cell antigen processing and presentation by modulating phagosome acidification and proteolysis

Salao, K., Jiang, L., Li, H., Tsai, V. W. W., Husaini, Y., Curmi, P. M. G., Brown, L. J., Brown, D. A. & Breit, S. N., 15 May 2016, In : Biology Open. 5, 5, p. 620-630 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Proteolysis
chloride channels
phagosomes
Phagosomes
Chloride Channels

Interaction of Human Chloride Intracellular Channel Protein 1 (CLIC1) with Lipid Bilayers: A Fluorescence Study

Hare, J. E., Goodchild, S. C., Breit, S. N., Curmi, P. M. G. & Brown, L. J., 12 Jul 2016, In : Biochemistry. 55, 27, p. 3825-3833 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Lipid bilayers
Lipid Bilayers
Chlorides
Fluorescence
Proteins

Nano-assembly of nanodiamonds by conjugation to actin filaments

Bradac, C., Say, J. M., Rastogi, I. D., Cordina, N. M., Volz, T. & Brown, L. J., 1 Mar 2016, In : Journal of Biophotonics. 9, 3, p. 296-304 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Nanodiamonds
conjugation
Actin Cytoskeleton
Actins
filaments
2015

Members of the chloride intracellular ion channel protein family demonstrate glutaredoxin-like enzymatic activity

Al Khamici, H., Brown, L. J., Hossain, K. R., Hudson, A. L., Sinclair-Burton, A. A., Ng, J. P. H. M., Daniel, E. L., Hare, J. E., Cornell, B. A., Curmi, P. M. G., Davey, M. W. & Valenzuela, S. M., 2015, In : PLoS ONE. 10, 1, p. 1-19 19 p., e115699.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Glutaredoxins
Chloride Channels
ion channels
Ion Channels
Chlorides
2014

Ca2+-induced PRE-NMR changes in the troponin complex reveal the possessive nature of the cardiac isoform for its regulatory switch

Cordina, N. M., Liew, C. K., Potluri, P. R., Curmi, P. M., Fajer, P. G., Logan, T. M., Mackay, J. P. & Brown, L. J., 13 Nov 2014, In : PLoS ONE. 9, 11, p. 1-11 11 p., 0112976.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Troponin C
troponins
Troponin
Protein Isoforms
Switches

CLIC proteins, ezrin, radixin, moesin and the coupling of membranes to the actin cytoskeleton: A smoking gun?

Jiang, L., Phang, J. M., Yu, J., Harrop, S. J., Sokolova, A. V., Duff, A. P., Wilk, K. E., Alkhamici, H., Breit, S. N., Valenzuela, S. M., Brown, L. J. & Curmi, P. M. G., Feb 2014, In : Biochimica et Biophysica Acta - Biomembranes. 1838, 2, p. 643-657 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Actin Cytoskeleton
Actins
Membranes
Proteins
rho GTP-Binding Proteins

Therapeutic inflammatory monocyte modulation using immune-modifying microparticles

Getts, D. R., Terry, R. L., Getts, M. T., Deffrasnes, C., Müller, M., Vreden, C., Ashhurst, T. M., Chami, B., McCarthy, D., Wu, H., Jin, M., Martin, A., Shae, L. D., Witting, P., Kansas, G. S., Kühn, J., Hafezi, W., Campbell, I. L., Reilly, D., Say, J. & 8 othersBrown, L., White, M. Y., Cordwell, S. J., Chadban, S. J., Thorp, E. B., Bao, S., Miller, S. D. & King, N. J. C., 15 Jan 2014, In : Science Translational Medicine. 6, 219, p. 1-16 16 p., 219ra7.

Research output: Contribution to journalArticleResearchpeer-review

Monocytes
Therapeutics
Spleen
Opsonin Proteins
Thioglycolates
2013

Effect of labeling with iron oxide particles or nanodiamonds on the functionality of adipose-derived mesenchymal stem cells

Blaber, S. P., Hill, C. J., Webster, R. A., Say, J. M., Brown, L. J., Wang, S. C., Vesey, G. & Herbert, B. R., 3 Jan 2013, In : PLoS ONE. 8, 1, p. 1-10 10 p., e52997.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
nanodiamonds
Nanodiamonds
iron oxides
Stem cells
Mesenchymal Stromal Cells

Effects of calcium binding and the hypertrophic cardiomyopathy A8V mutation on the dynamic equilibrium between closed and open conformations of the regulatory N-domain of isolated cardiac troponin C

Cordina, N. M., Liew, C. K., Gell, D. A., Fajer, P. G., MacKay, J. P. & Brown, L. J., 19 Mar 2013, In : Biochemistry. 52, 11, p. 1950-1962 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Troponin C
Hypertrophic Cardiomyopathy
Conformations
Calcium
Mutation

Point mutations in the transmembrane region of the CLIC1 ion channel selectively modify its biophysical properties

Averaimo, S., Abeti, R., Savalli, N., Brown, L. J., Curmi, P. M. G., Breit, S. N. & Mazzanti, M., 18 Sep 2013, In : PLoS ONE. 8, 9, p. 1-14 14 p., e74523.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
ion channels
point mutation
Ion Channels
Point Mutation
chlorides

Regulation of the membrane insertion and conductance activity of the metamorphic chloride intracellular channel protein CLIC1 by cholesterol

Valenzuela, S. M., Alkhamici, H., Brown, L. J., Almond, O. C., Goodchild, S. C., Carne, S., Curmi, P. M. G., Holt, S. A. & Cornell, B. A., 14 Feb 2013, In : PLoS ONE. 8, 2, p. 1-8 8 p., e56948.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Chloride Channels
Chlorides
chlorides
Cholesterol
cholesterol

Three-dimensional optical manipulation of a single electron spin

Geiselmann, M., Juan, M. L., Renger, J., Say, J. M., Brown, L. J., Javier García De Abajo, F., Koppens, F. & Quidant, R., Mar 2013, In : Nature Nanotechnology. 8, 3, p. 175-179 5 p.

Research output: Contribution to journalArticleResearchpeer-review

electron spin
Vacancies
manipulators
Nitrogen
nitrogen
2012

Interdomain orientation of cardiac troponin C characterized by paramagnetic relaxation enhancement NMR reveals a compact state

Cordina, N. M., Liew, C. K., Gell, D. A., Fajer, P. G., Mackay, J. P. & Brown, L. J., Sep 2012, In : Protein science : a publication of the Protein Society. 21, 9, p. 1376-1387 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Troponin C
Nuclear magnetic resonance
Troponin
Conformations
Calcium

Intracellular chloride channel protein CLIC1 regulates macrophage function through modulation of phagosomal acidification

Jiang, L., Salao, K., Li, H., Rybicka, J. M., Yates, R. M., Luo, X. W., Shi, X. X., Kuffner, T., Tsai, V. W. W., Husaini, Y., Wu, L., Brown, D. A., Grewal, T., Brown, L. J., Curmi, P. M. G. & Breit, S. N., 15 Nov 2012, In : Journal of Cell Science. 125, 22, p. 5479-5488 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Chloride Channels
Macrophages
Proteins
Zymosan
Cytoplasmic Structures

Processing 15-nm nanodiamonds containing nitrogen-vacancy centres for single-molecule FRET

Say, J. M., Bradac, C., Gaebel, T., Rabeau, J. R. & Brown, L. J., 2012, In : Australian Journal of Chemistry. 65, 5, p. 496-503 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Nanodiamonds
Vacancies
Nitrogen
Molecules
Processing

Size-reduction of nanodiamonds via air oxidation

Gaebel, T., Bradac, C., Chen, J., Say, J. M., Brown, L., Hemmer, P. & Rabeau, J. R., Jan 2012, In : Diamond and Related Materials. 21, p. 28-32 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Nanodiamonds
Vacancies
Nitrogen
nitrogen
Oxidation
2011

Crystal structure of importin-α bound to a peptide bearing the nuclear localisation signal from chloride intracellular channel protein 4

Mynott, A. V., Harrop, S. J., Brown, L. J., Breit, S. N., Kobe, B. & Curmi, P. M. G., May 2011, In : FEBS Journal. 278, 10, p. 1662-1675 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Bearings (structural)
alpha Karyopherins
Nuclear Localization Signals
Chloride Channels
Chlorides

Transmembrane extension and oligomerization of the CLIC1 chloride intracellular channel protein upon membrane interaction

Goodchild, S. C., Angstmann, C. N., Breit, S. N., Curmi, P. M. G. & Brown, L. J., 20 Dec 2011, In : Biochemistry. 50, 50, p. 10887-10897 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Oligomerization
Chloride Channels
Fluorescence Resonance Energy Transfer
Chlorides
Membrane Proteins
2010

Generation and characterization of mice with null mutation of the chloride intracellular channel 1 gene

Qiu, M. R., Jiang, L., Matthaei, K. I., Schoenwaelder, S. M., Kuffner, T., Mangin, P., Joseph, J. E., Low, J., Connor, D., Valenzuela, S. M., Curmi, P. M. G., Brown, L. J., Mahaut-Smith, M., Jackson, S. P. & Breit, S. N., Feb 2010, In : Genesis. 48, 2, p. 127-136 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Gene Knockout Techniques
Alleles
Knockout Mice
Mutation
Genes

Metamorphic response of the CLIC1 chloride intracellular ion channel protein upon membrane interaction

Goodchild, S. C., Howell, M. W., Littler, D. R., Mandyam, R. A., Sale, K. L., Mazzanti, M., Breit, S. N., Curmi, P. M. G. & Brown, L. J., 29 Jun 2010, In : Biochemistry. 49, 25, p. 5278-5289 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Chloride Channels
Ion Channels
Chlorides
Membrane Proteins
Membranes

Observation and control of blinking nitrogen-vacancy centres in discrete nanodiamonds

Bradac, C., Gaebel, T., Naidoo, N., Sellars, M. J., Twamley, J., Brown, L. J., Barnard, A. S., Plakhotnik, T., Zvyagin, A. V. & Rabeau, J. R., May 2010, In : Nature Nanotechnology. 5, 5, p. 345-349 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Nanodiamonds
blinking
Vacancies
Nitrogen
nitrogen

Structure of human CLIC3 at Åresolution

Littler, D. R., Brown, L. J., Breit, S. N., Perrakis, A. & Curmi, P. M. G., 2010, In : Proteins: Structure, Function and Bioinformatics. 78, 6, p. 1594-1600 7 p.

Research output: Contribution to journalArticleResearchpeer-review

2009

Oxidation promotes insertion of the CLIC1 chloride intracellular channel into the membrane

Goodchild, S. C., Howell, M. W., Cordina, N. M., Littler, D. R., Breit, S. N., Curmi, P. M. G. & Brown, L. J., Jan 2009, In : European Biophysics Journal. 39, 1, p. 129-138 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Chloride Channels
Membranes
Intracellular Membranes
Glutathione Transferase
Ion Channels
2008

Comparison of vertebrate and invertebrate CLIC proteins: the crystal structures of Caenorhabditis elegans EXC-4 and drosophila melanogaster DmCLIC

Littler, D. R., Harrop, S. J., Brown, L. J., Pankhurst, G. J., Mynott, A. V., Luciani, P., Mandyam, R. A., Mazzanti, M., Tanda, S., Berryman, M. A., Breit, S. N. & Curmi, P. M. G., Apr 2008, In : Proteins: Structure, Function and Genetics. 71, 1, p. 364-378 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Caenorhabditis elegans
Invertebrates
Drosophila melanogaster
Vertebrates
Lipid bilayers
2007

Structure of the Janus Protein Human CLIC2

Cromer, B. A., Gorman, M. A., Hansen, G., Adams, J. J., Coggan, M., Littler, D. R., Brown, L. J., Mazzanti, M., Breit, S. N., Curmi, P. M. G., Dulhunty, A. F., Board, P. G. & Parker, M. W., 30 Nov 2007, In : Journal of molecular biology. 374, 3, p. 719-731 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Disulfides
Chloride Channels
Oxidation-Reduction
Foot
Proteins
2005

Crystal structure of the soluble form of the redox-regulated chloride ion channel protein CLIC4

Littler, D. R., Assaad, N. N., Harrop, S. J., Brown, L. J., Pankhurst, G. J., Luciani, P., Aguilar, M. I., Mazzanti, M., Berryman, M. A., Breit, S. N. & Curmi, P. M. G., Oct 2005, In : FEBS Journal. 272, 19, p. 4996-5007 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Chloride Channels
Oxidation-Reduction
Crystal structure
Ion Channels
Glutaredoxins
2004

Myosin binding protein C: structural abnormalities in familial hypertrophic cardiomyopathy.

Oakley, C. E., Hambly, B. D., Curmi, P. M. G. & Brown, L., 2004, In : Cell research. 14, 2, p. 95-110 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Familial Hypertrophic Cardiomyopathy
Sarcomeres
Mutation
Connectin
Muscle Proteins

The Intracellular Chloride Ion Channel Protein CLIC1 Undergoes a Redox-controlled Structural Transition

Littler, D. R., Harrop, S. J., Fairlie, W. D., Brown, L. J., Pankhurst, G. J., Pankhurst, S., DeMaere, M. Z., Campbell, T. J., Bauskin, A. R., Tonini, R., Mazzanti, M., Breit, S. N. & Curmi, P. M. G., 5 Mar 2004, In : Journal of Biological Chemistry. 279, 10, p. 9298-9305 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Chloride Channels
Oxidation-Reduction
Dimers
Proteins
Glutaredoxins
2002

Functional and spectroscopic studies of an familial hypertrophic cardiomyopathy mutation in Motif X of cardiac myosin binding protein-C

Brown, L. J., Singh, L., Sale, K. L., Yu, B., Trent, R., Fajer, P. G. & Hambly, B. D., Aug 2002, In : European Biophysics Journal With Biophysics Letters. 31, 5, p. 400-408 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Familial Hypertrophic Cardiomyopathy
Cardiac Myosins
Myosins
Mutation
Connectin

Structure of the inhibitory region of troponin by site directed spin labeling electron paramagnetic resonance

Brown, L. J., Sale, K. L., Hills, R., Rouviere, C., Song, L., Zhang, X. & Fajer, P. G., 1 Oct 2002, In : Proceedings of the National Academy of Sciences of the United States of America. 99, 20, p. 12765-12770 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Troponin
Electron Spin Resonance Spectroscopy
Aleurites
Cysteine
Actins
2001

Independent movement of the regulatory and catalytic domains of myosin heads revealed by phosphorescence anisotropy

Brown, L. J., Klonis, N., Sawyer, W. H., Fajer, P. G. & Hambly, B. D., 17 Jul 2001, In : Biochemistry. 40, 28, p. 8283-8291 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Phosphorescence
Anisotropy
Myosins
Catalytic Domain
Myosin Subfragments
1999

Expression and localisation of stanniocalcin 1 in rat bladder, kidney and ovary

Worthington, R. A., Brown, L., Jellinek, D., Chang, A. C. M., Reddel, R. R., Hambly, B. D. & Barden, J. A., Jul 1999, In : Electrophoresis. 20, 10, p. 2071-2076 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Rats
Ovary
Urinary Bladder
Kidney
Fish

Intradomain distances in the regulatory domain of the myosin head in prepower and postpower stroke states: Fluorescence energy transfer

Palm, T., Sale, K., Brown, L., Li, H., Hambly, B. & Fajer, P. G., 5 Oct 1999, In : Biochemistry. 38, 40, p. 13026-13034 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Energy Transfer
Myosins
Energy transfer
Fluorescence
Stroke
1998

Direct cloning of polymerase chain reaction products into the pinpoint Xa1-T vector protein expression system

Brown, L., Yin, J. L. & Hambly, B., May 1998, In : Electrophoresis. 19, 5, p. 860-866 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Cloning
Polymerase chain reaction
Reaction products
Organism Cloning
Polymerase Chain Reaction

EPR and CD spectroscopy of fast myosin light chain conformation during binding of trifluoperazine

Huang, W., Wilson, G. J., Brown, L. J., Lam, H. & Hambly, B. D., 15 Oct 1998, In : European Journal of Biochemistry. 257, 2, p. 457-465 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Trifluoperazine
Myosin Light Chains
Paramagnetic resonance
Conformations
Spectrum Analysis