Projects per year
Personal profile
Biography
Dr Luan Luu is an early career post-doctoral research fellow in the Department of Biomedical Science, Macquarie University. He completed his PhD at The University of Melbourne where he studied the Amyloid Precursor Protein in Alzheimer’s Disease. Upon obtaining his PhD he moved to Macquarie University and joined Angela Lairds lab where he investigates potential therapeutics for Spinocerebellar Ataxia type 3.
Research interests
Dr Luan Luu focuses on therapeutics that enhances processes (macroautophagy) that degrade pathogenic misfolded proteins and organelles to restore cellular homeostasis. He has developed cellular models of Spinocerebellar Ataxia type 3 for screening potential therapeutics which can be trailed in animals of the disease. The compounds tested not only have a potential for the treatment of Spinocerebellar Ataxia type 3 but for other diseases that involve misfolded proteins, such as Huntington’s or other PolyQ disease.
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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FightMND 24: Developing an extracellular vesicle-based nanoplatform for precision targeting of intraneuronal TDP-43
Yang, S. (Primary Chief Investigator), Wang, Y. (Co-Investigator), Luu, L. (Co-Investigator) & Chung, R. (Associate Investigator)
30/04/25 → 29/04/27
Project: Research
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UQ Led: New viral-mediated TDP-43 mouse models of MND
Walker, A. (Chief Investigator), Morsch, M. (Primary Chief Investigator), Brown-Wright, H. (Chief Investigator), Lisowski, L. (Chief Investigator), Russell, A. P. (Chief Investigator), Della Gatta, P. (Chief Investigator) & Luu, L. (Chief Investigator)
3/10/23 → 2/10/26
Project: Research
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MNDRA24: Targeting the nucleus: Is TDP-43 supplementation in the nucleus enough to delay disease progression?
Morsch, M. (Primary Chief Investigator), Luu, L. (Chief Investigator) & Hogan, A. (Chief Investigator)
3/06/24 → 2/06/25
Project: Research
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Critical impact of lysine 136 in TDP-43 phase separation, compartmentalization, and aggregation in living vertebrates
Maurel, C., Scherer, N. M., Luu, L., Radford, R. A., Hogan, A., Merjane, J., Vidal-Itriago, A., Don, E. K., Chapman, T., Cull, S., Vourc’h, P., Lisowski, L., Lee, A., Chung, R. & Morsch, M., 18 Jul 2025, In: iScience. 28, 7, p. 1-19, e1-e5 25 p., 112761.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Link opens in a new tab Citations (Scopus)33 Downloads (Pure) -
Cyclin F, Neurodegeneration, and the Pathogenesis of ALS/FTD
Rayner, S. L., Hogan, A., Davidson, J. M., Cheng, F., Luu, L., Morsch, M., Blair, I., Chung, R. & Lee, A., Apr 2024, In: Neuroscientist. 30, 2, p. 214-228 15 p.Research output: Contribution to journal › Review article › peer-review
10 Link opens in a new tab Citations (Scopus) -
Cyclin F can alter the turnover of TDP-43
Rayner, S. L., Hogan, A., Davidson, J. M., Chapman, T., Cheng, F., Luu, L., Wu, S., Zhang, S., Yang, S., Blair, I., Morsch, M., Chung, R. & Lee, A., Mar 2024, In: Neurobiology of Disease. 192, p. 1-10 10 p., 106421.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Link opens in a new tab Citations (Scopus)136 Downloads (Pure) -
Modified polypeptides and uses thereof
Chung, R. (Inventor), Lee, A. (Inventor), Rayner, S. (Inventor), Morsch, M. (Inventor) & Luu, L. (Inventor), 20 Jun 2024, IPC No. C07K 14/ 47 A I, Patent No. US2024199713, Priority date 22 Apr 2021, Priority No. AU2021901193Research output: Patent
Open Access -
Modified polypeptides and uses thereof
Chung, R. (Inventor), Lee, A. (Inventor), Rayner, S. (Inventor), Morsch, M. (Inventor) & Luu, L. (Inventor), 28 Feb 2024, IPC No. A61P 25/ 28 A I, A61K 48/00, Patent No. EP4326340, Priority date 22 Apr 2021, Priority No. AU2021901193Research output: Patent
Open Access
Activities
- 1 Participating in a conference, workshop or event series
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Faculty of Medicine and Health Sciences 2nd Annual EnCouRage Research Symposium
Turner, D. (Organiser), Laird, A. (Organiser), Don, E. (Organiser), Lam, M. (Organiser), Walker, A. K. (Organiser), Morsch, M. (Organiser), Heng, B. (Organiser), Tan, V. (Organiser), Lim, E. (Organiser), Junqueira Santiago, M. (Organiser), Shahheydari, H. (Organiser), Luu, L. (Organiser) & Butlin, M. (Poster judge)
27 Oct 2017Activity: Participating in or organising an event › Participating in a conference, workshop or event series