• 1616 Citations
  • 22 h-Index
19932018
If you made any changes in Pure these will be visible here soon.

Personal profile

Research interests

Arteriovenous Malformations

Radiobiology

Atherosclerosis

Vascular Restenosis

Abdominal Aortic Aneurysms

Neurovascular dementia

 

Teaching

Certificate: Foundations in Learning and Teaching, Macquarie University (2017)

Guest Lecturer in:

Blood Supply to the Brain (B Clin Sci)

Cell Cycle and Disease (B Clin Sci)

DNA damage and repair (B Clin Sci)

Cellular and Hormone Signalling (MD Program)

Blood supply to the CNS and the CSF system (MD program)

Cell cycle (MD program & Clinical Science year 1)

Respiratory infections (MD program)

CNS blood supply and aberrations (MD program)

 

 

Biography

Professional overview

Dr McRobb is a scientist with over 25 years of research experience in microbiology, biochemistry, cell biology and cell signalling, with a primary focus in the area of vascular disease. Prior to her PhD, Dr McRobb was a senior scientist in the School of Molecular Biosciences (University of Sydney) studying the molecular mechanisms of bacterial evolution and adaptation to nutrient stress. She received her PhD in the area of vascular biology from the University of Sydney in 2008 and held postdoctoral positions at The Heart Research Institute (Sydney) and the Centre for Vascular Research (University of NSW). In 2014, Dr McRobb joined the Neurosurgery group at Macquarie (Department of Clinical Medicine) led by Professor Marcus Stoodley, to study brain vascular malformations. She has been a guest lecturer in the Bachelor of Clinical Science since 2016 and in the MD program since 2018.

Areas of research interest

Dr McRobb is interested in understanding the pathogenesis of vascular disease and vascular abnormalities and using this information to develop novel treatment approaches. Her previous studies have investigated the role of androgens (male hormones) in driving atherosclerosis and vascular calcification, and the development of small molecule inhibitors for the treatment of vascular disorders such as abdominal aortic aneurysms and vascular restenosis after coronary interventions. Dr McRobb’s current research studies in the Neurosurgery group aim to develop vascular targeting agents (VTAs) for the treatment of brain arteriovenous malformations (AVMs). These are abnormal vascular structures prone to rupture, which are the leading cause of haemorrhagic stroke in children and young adults. VTA development first involves identifying novel and specific molecular targets in gamma-radiated AVMs. Pre-clinical models and proteomic analysis have been used to identify up-regulated proteins expressed on the surface of irradiated cells lining the vascular wall. Current studies aim to complete the validation of several novel molecules induced by radiation and to develop targeted drugs designed to occlude the abnormal AVM vessels and eliminate the risk of rupture and stroke. 

Education/Academic qualification

Vascular Disease, PhD, University of Sydney

1 Jul 200415 Jan 2008

Fingerprint Dive into the research topics where Lucinda McRobb is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 8 Similar Profiles
Escherichia coli Medicine & Life Sciences
Arteriovenous Malformations Medicine & Life Sciences
Glucose Medicine & Life Sciences
Mutation Medicine & Life Sciences
Endothelial Cells Medicine & Life Sciences
Blood Vessels Medicine & Life Sciences
Radiosurgery Medicine & Life Sciences
Growth Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Outputs 1993 2018

  • 1616 Citations
  • 22 h-Index
  • 34 Article
  • 5 Meeting abstract
  • 1 Review article

Effects of FOXM1 inhibition and ionizing radiation on melanoma cells

Lee, V. S., McRobb, L. S., Moutrie, V., Santos, E. D. & Siu, T. L., 1 Nov 2018, In : Oncology Letters. 16, 5, p. 6822-6830 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Ionizing Radiation
Melanoma
Cell Death
Radiation
Cell Line

Stable thrombus formation on irradiated microvascular endothelial cells under pulsatile flow: pre-testing annexin V-thrombin conjugate for treatment of brain arteriovenous malformations

Subramanian, S., Ugoya, S. O., Zhao, Z., McRobb, L. S., Grau, G. E., Combes, V., Inglis, D. W., Gauden, A. J., Lee, V. S., Moutrie, V., Santos, E. D. & Stoodley, M. A., 1 Jul 2018, In : Thrombosis Research. 167, p. 104-112 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Pulsatile Flow
Arteriovenous Malformations
Annexin A5
Phosphatidylserines
Thrombin

Vascular targeting causing thrombosis in an arteriovenous malformation animal model

Gauden, A., Lee, V., Subramanian, S., Moutrie, V., Zhao, Z., Notley-McRobb, L. & Stoodley, M., 2018, In : Journal of Neurosurgery. 128, 4, p. 32 1 p., 564.

Research output: Contribution to journalMeeting abstractResearchpeer-review

Arteriovenous Malformations
Blood Vessels
Thrombosis
Animal Models

Estrogen receptor control of atherosclerotic calcification and smooth muscle cell osteogenic differentiation

McRobb, L. S., McGrath, K. C. Y., Tsatralis, T., Liong, E. C., Tan, J. T. M., Hughes, G., Handelsman, D. J. & Heather, A. K., 1 Jun 2017, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 37, 6, p. 1127-1137 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Vascular Smooth Muscle
Estrogen Receptors
Smooth Muscle Myocytes
Cell Differentiation
Estrogen Receptor alpha

In vivo imaging of endothelial cell adhesion molecule expression after radiosurgery in an animal model of arteriovenous malformation

Raoufi-Rad, N., McRobb, L. S., Lee, V. S., Bervini, D., Grace, M., Ukath, J., McHattan, J. J., Sreenivasan, V. K. A., Zhao, Z. & Stoodley, M., 26 Sep 2017, In : PLoS ONE. 12, 9, p. 1-16 16 p., e0185393.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Vascular Cell Adhesion Molecule-1
Radiosurgery
Arteriovenous Malformations
Endothelial cells
Cell Adhesion Molecules