• 1642 Citations
  • 22 h-Index
1993 …2019
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Personal profile

Research interests

Arteriovenous Malformations

Radiobiology

Atherosclerosis

Vascular Restenosis

Abdominal Aortic Aneurysms

Neurovascular dementia

 

Teaching

Certificate: Foundations in Learning and Teaching, Macquarie University (2017)

Guest Lecturer in:

Blood Supply to the Brain (B Clin Sci)

Cell Cycle and Disease (B Clin Sci)

DNA damage and repair (B Clin Sci)

Cellular and Hormone Signalling (MD Program)

Blood supply to the CNS and the CSF system (MD program)

Cell cycle (MD program & Clinical Science year 1)

Respiratory infections (MD program)

CNS blood supply and aberrations (MD program)

Unit Convenor: Renal, Reproductive and Endocrine Systems, Sem II, 2020

 

 

Biography

Professional overview

Dr McRobb is a scientist with over 25 years of research experience in microbiology, biochemistry, cell biology and cell signalling, with a primary focus in the area of vascular disease. Prior to her PhD, Dr McRobb was a senior scientist in the School of Molecular Biosciences (University of Sydney) studying the molecular mechanisms of bacterial evolution and adaptation to nutrient stress. She received her PhD in the area of vascular biology from the University of Sydney in 2008 and held postdoctoral positions at The Heart Research Institute (Sydney) and the Centre for Vascular Research (University of NSW). In 2014, Dr McRobb joined the Neurosurgery group at Macquarie (Department of Clinical Medicine) led by Professor Marcus Stoodley, to study brain vascular malformations. She has been a guest lecturer in the Bachelor of Clinical Science since 2016 and in the MD program since 2018.

Areas of research interest

Dr McRobb is interested in understanding the pathogenesis of vascular disease and vascular abnormalities and using this information to develop novel treatment approaches. Her previous studies have investigated the role of androgens (male hormones) in driving atherosclerosis and vascular calcification, and the development of small molecule inhibitors for the treatment of vascular disorders such as abdominal aortic aneurysms and vascular restenosis after coronary interventions. Dr McRobb’s current research studies in the Neurosurgery group aim to develop vascular targeting agents (VTAs) for the treatment of brain arteriovenous malformations (AVMs). These are abnormal vascular structures prone to rupture, which are the leading cause of haemorrhagic stroke in children and young adults. VTA development first involves identifying novel and specific molecular targets in gamma-radiated AVMs. Pre-clinical models and proteomic analysis have been used to identify up-regulated proteins expressed on the surface of irradiated cells lining the vascular wall. Current studies aim to complete the validation of several novel molecules induced by radiation and to develop targeted drugs designed to occlude the abnormal AVM vessels and eliminate the risk of rupture and stroke. 

Education/Academic qualification

Vascular Disease, PhD, University of Sydney

1 Jul 200415 Jan 2008

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Research Outputs 1993 2019

  • 1642 Citations
  • 22 h-Index
  • 36 Article
  • 5 Meeting abstract
  • 2 Abstract
  • 1 Review article

Consent in spinal surgery: a survey of practice

Li Ching Ng, A., White, S. J., McRobb, L., Cyna, A. M., Seex, K. & Cartmill, J., 25 Oct 2019. 1 p.

Research output: Contribution to conferenceAbstractResearchpeer-review

Consent in spinal surgery: a survey of practice

Li Ching Ng, A., McRobb, L., White, S. J., Cyna, A., Seex, K. & Cartmill, J., 8 Nov 2019. 2 p.

Research output: Contribution to conferenceAbstractResearchpeer-review

Occlusion of animal model arteriovenous malformations using vascular targeting

Gauden, A. J., McRobb, L. S., Lee, V. S., Subramanian, S., Moutrie, V., Zhao, Z. & Stoodley, M. A., 5 Dec 2019, In : Translational Stroke Research. 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Arteriovenous Malformations
Blood Vessels
Animal Models
Thrombin
Phosphatidylserines

Radiation-stimulated translocation of CD166 and CRYAB to the endothelial surface provides potential vascular targets on irradiated brain arteriovenous malformations

McRobb, L. S., McKay, M. J., Gauden, A. J., Lee, V. S., Subramanian, S., Thomas, S. G., Wiedmann, M. K. H., Moutrie, V., Grace, M., Zhao, Z., Molloy, M. P. & Stoodley, M. A., Dec 2019, In : International Journal of Molecular Sciences. 20, 23, p. 1-13 13 p., 5830.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Arteriovenous Malformations
Surface potential
brain
Blood Vessels
Brain

Effects of FOXM1 inhibition and ionizing radiation on melanoma cells

Lee, V. S., McRobb, L. S., Moutrie, V., Santos, E. D. & Siu, T. L., 1 Nov 2018, In : Oncology Letters. 16, 5, p. 6822-6830 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Ionizing Radiation
Melanoma
Cell Death
Radiation
Cell Line