• 49 Citations
  • 4 h-Index
20152021

Research output per year

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Personal profile

Biography

Dr Lyndal Henden is an Early Career Postdoctoral Researcher in the Genomics and Bioinformatic Team within the Centre for Motor Neuron Disease Research at Macquarie University. She completed her PhD in 2017 at the Walter and Eliza Hall Institute of Medical Research, where she developed statistical methods to identify cryptic relatedness in the human genome and the genomes of microorganisms that cause disease. Her methods have been successfully used to discover and quantify unknown or misspecified familial relatedness, and to identify loci containing disease susceptibility genes in disorders such as Autism, Epilepsy and Intellectual Disability. She has also identified loci under positive selection that are suspected of being associated with antimalarial drug resistance in a global Plasmodium falciparum cohort.

Dr Henden’s current research is focused on understanding the genetic basis of Motor Neuron Disease (MND) and Frontotemporal Dementia (FTD). Her expertise in cryptic relatedness analysis is being applied to large MND/FTD patient cohorts to identify candidate disease loci for gene screening in the hopes of identifying novel gene mutations that are causing disease. Her research findings will have significant genetic counselling implications for MND/FTD patients and their family members.

Teaching

MEDI2201

Education/Academic qualification

PhD, Walter and Eliza Hall Institute of Medical Research

Mathematics and Statistics, BSc (Honours I), Massey University

External positions

Postdoctoral Researcher, Walter and Eliza Hall Institute of Medical Research

Mar 2017Mar 2018

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Projects

Research Outputs

  • 49 Citations
  • 4 h-Index
  • 6 Article

Genetic and immunopathological analysis of CHCHD10 in Australian amyotrophic lateral sclerosis and frontotemporal dementia and transgenic TDP-43 mice

McCann, E. P., Fifita, J. A., Grima, N., Galper, J., Mehta, P., Freckleton, S. E., Zhang, K. Y., Henden, L., Hogan, A. L., Chan Moi Fat, S., Wu, S. S. L., Jagaraj, C. J., Berning, B. A., Williams, K. L., Twine, N. A., Bauer, D., Piguet, O., Hodges, J., Kwok, J. B. J., Halliday, G. M. & 7 others, Kiernan, M. C., Atkin, J., Rowe, D. B., Nicholson, G. A., Walker, A. K., Blair, I. P. & Yang, S., 1 Feb 2020, In : Journal of Neurology, Neurosurgery and Psychiatry. 91, 2, p. 162-171 10 p.

Research output: Contribution to journalArticle

  • Identity-by-descent analyses for measuring population dynamics and selection in recombining pathogens

    Henden, L., Lee, S., Mueller, I., Barry, A. & Bahlo, M., 1 May 2018, In : PLoS Genetics. 14, 5, p. 1-31 31 p., e1007279.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 13 Citations (Scopus)

    EIF2S3 mutations associated with severe X-linked intellectual disability syndrome MEHMO

    Skopkova, M., Hennig, F., Shin, B. S., Turner, C. E., Stanikova, D., Brennerova, K., Stanik, J., Fischer, U., Henden, L., Müller, U., Steinberger, D., Leshinsky-Silver, E., Bottani, A., Kurdiova, T., Ukropec, J., Nyitrayova, O., Kolnikova, M., Klimes, I., Borck, G., Bahlo, M. & 6 others, Haas, S. A., Kim, J. R., Lotspeich-Cole, L. E., Gasperikova, D., Dever, T. E. & Kalscheuer, V. M., 1 Apr 2017, In : Human mutation. 38, 4, p. 409-425 17 p.

    Research output: Contribution to journalArticle

  • 17 Citations (Scopus)

    Identity by descent fine mapping of familial adult myoclonus epilepsy (FAME) to 2p11.2–2q11.2

    Henden, L., Freytag, S., Afawi, Z., Baldassari, S., Berkovic, S. F., Bisulli, F., Canafoglia, L., Casari, G., Crompton, D. E., Depienne, C., Gecz, J., Guerrini, R., Helbig, I., Hirsch, E., Keren, B., Klein, K. M., Labauge, P., LeGuern, E., Licchetta, L., Mei, D. & 9 others, Nava, C., Pippucci, T., Rudolf, G., Scheffer, I. E., Striano, P., Tinuper, P., Zara, F., Corbett, M. & Bahlo, M., 1 Oct 2016, In : Human Genetics. 135, 10, p. 1117-1125 9 p.

    Research output: Contribution to journalArticle

  • 10 Citations (Scopus)

    XIBD: software for inferring pairwise identity by descent on the X chromosome

    Henden, L., Wakeham, D. & Bahlo, M., 1 Aug 2016, In : Bioinformatics. 32, 15, p. 2389-2391 3 p.

    Research output: Contribution to journalArticle

  • 4 Citations (Scopus)