Personal profile

Biography

Professor Maija Kohonen-Corish is a Research Leader at the MQ-affiliated Woolcock Institute of Medical Research and the head of Woolcock Centre for Lung Cancer. She joined Macquarie University in April 2023.

Maija is a Human Genetics Society of Australasia-certified molecular geneticist (MHGSA) with a track record of discovery in basic and translational research in lung and colorectal cancer. 

Maija completed a BSc and MSc at the University of Helsinki in Finland. This was followed by a PhD at John Curtin School of Medical Research in Canberra. There she established one of the first laboratories in Australia to identify inherited gene defects in Lynch Syndrome. Maija is a member of the Variant Interpretation Committee of International Society for Gastrointestinal Hereditary Tumours (InSiGHT), which produces international guidelines on how to interpret the pathogenicity of Lynch Syndrome gene variants.

Maija was a Cancer Institute NSW Fellow and the head of lung and colon cancer research at Garvan Institute of Medical Research 2002-2017. She was appointed to lead the Woolcock Centre for Lung Cancer in 2019. 

Research engagement

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Professor Kohonen-Corish has identified several tumour biomarkers of prognosis and therapeutic responsiveness which have improved the clinical management of cancer patients. Maija has also discovered novel biomarkers which have provided important mechanistic insight and potential drug targets for cancer treatment. For example, she discovered the significance of MCC as a tumour suppressor gene which is epigenetically silenced in colon tumours and causes a novel DNA repair defect. Maija has extensively utilised mouse models of cancer in her research and developed a new model for an aggressive type of proximal colon cancer that has been adopted by other researchers.

At the Woolcock Maija leads the Lung Cancer Network and a research program on harnessing the microbiome to improve cancer therapies, in collaboration with Microbiome Research Centre UNSW, Macquarie Hospital, Chris O’Brien Lifehouse, Royal Prince Alfred and other hospitals. 

Her team is developing new interventions that allow more effective use of standard cancer therapies. These include creating diagnostic microbiome-based tools to determine which patients will benefit from additional treatment interventions. The team recently demonstrated that taking a certain kind of antibiotic during chemotherapy is associated with greatly increased survival time of people with late-stage lung cancer.

Education/Academic qualification

Molecular Genetics, MHGSA Certification, Human Genetics Society of Australasia

Award Date: 1 May 2005

Human Genetics, PhD, Australian National University, John Curtin School of Medical Research

Genetics, MSc, University of Helsinki

Genetics, BSc, University of Helsinki

External positions

Visiting Scientist, Garvan Institute of Medical Research

Senior Visiting Fellow, UNSW Sydney, Microbiome Research Centre

Conjoint Professor, Western Sydney University, School of Medicine

Head, Woolcock Institute of Medical Research

Research Leader, Woolcock Institute of Medical Research, Macquarie University

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  • A STAT3 protein complex required for mitochondrial mRNA stability and cancer

    Fernando, C. D., Jayasekara, W. S. N., Inampudi, C., Kohonen-Corish, M. R. J., Cooper, W. A., Beilharz, T. H., Josephs, T. M., Garama, D. J. & Gough, D. J., 26 Sept 2023, In: Cell Reports. 42, 9, p. 1-14 15 p., 113033.

    Research output: Contribution to journalArticlepeer-review

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    6 Citations (Scopus)
    58 Downloads (Pure)
  • Antibiotic exposure within six months before systemic therapy was associated with lower cancer survival

    Morrell, S., Kohonen-Corish, M. R. J., Ward, R. L., Sorrell, T. C., Roder, D. & Currow, D. C., Jul 2022, In: Journal of Clinical Epidemiology. 147, p. 122-131 10 p.

    Research output: Contribution to journalArticlepeer-review

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    6 Citations (Scopus)
    66 Downloads (Pure)
  • Colorectal cancer incidences in Lynch syndrome: a comparison of results from the prospective lynch syndrome database and the international mismatch repair consortium

    Møller, P., Seppälä, T., Dowty, J. G., Haupt, S., Dominguez-Valentin, M., Sunde, L., Bernstein, I., Engel, C., Aretz, S., Nielsen, M., Capella, G., Evans, D. G., Burn, J., Holinski-Feder, E., Bertario, L., Bonanni, B., Lindblom, A., Levi, Z., Macrae, F., Winship, I., & 138 othersPlazzer, J. P., Sijmons, R., Laghi, L., Valle, A. D., Heinimann, K., Half, E., Lopez-Koestner, F., Alvarez-Valenzuela, K., Scott, R. J., Katz, L., Laish, I., Vainer, E., Vaccaro, C. A., Carraro, D. M., Gluck, N., Abu-Freha, N., Stakelum, A., Kennelly, R., Winter, D., Rossi, B. M., Greenblatt, M., Bohorquez, M., Sheth, H., Tibiletti, M. G., Lino-Silva, L. S., Horisberger, K., Portenkirchner, C., Nascimento, I., Rossi, N. T., da Silva, L. A., Thomas, H., Zaránd, A., Mecklin, J. P., Pylvänäinen, K., Renkonen-Sinisalo, L., Lepisto, A., Peltomäki, P., Therkildsen, C., Lindberg, L. J., Thorlacius-Ussing, O., von Knebel Doeberitz, M., Loeffler, M., Rahner, N., Steinke-Lange, V., Schmiegel, W., Vangala, D., Perne, C., Hüneburg, R., de Vargas, A. F., Latchford, A., Gerdes, A. M., Backman, A. S., Guillén-Ponce, C., Snyder, C., Lautrup, C. K., Amor, D., Palmero, E., Stoffel, E., Duijkers, F., Hall, M. J., Hampel, H., Williams, H., Okkels, H., Lubiński, J., Reece, J., Ngeow, J., Guillem, J. G., Arnold, J., Wadt, K., Monahan, K., Senter, L., Rasmussen, L. J., van Hest, L. P., Ricciardiello, L., Kohonen-Corish, M. R. J., Ligtenberg, M. J. L., Southey, M., Aronson, M., Zahary, M. N., Samadder, N. J., Poplawski, N., Hoogerbrugge, N., Morrison, P. J., James, P., Lee, G., Chen-Shtoyerman, R., Ankathil, R., Pai, R., Ward, R., Parry, S., Dębniak, T., John, T., van Overeem Hansen, T., Caldés, T., Yamaguchi, T., Barca-Tierno, V., Garre, P., Cavestro, G. M., Weitz, J., Redler, S., Büttner, R., Heuveline, V., Hopper, J. L., Win, A. K., Lindor, N., Gallinger, S., Le Marchand, L., Newcomb, P. A., Figueiredo, J., Buchanan, D. D., Thibodeau, S. N., ten Broeke, S. W., Hovig, E., Nakken, S., Pineda, M., Dueñas, N., Brunet, J., Green, K., Lalloo, F., Newton, K., Crosbie, E. J., Mints, M., Tjandra, D., Neffa, F., Esperon, P., Kariv, R., Rosner, G., Pavicic, W. H., Kalfayan, P., Torrezan, G. T., Bassaneze, T., Martin, C., Moslein, G., Ahadova, A., Kloor, M., Sampson, J. R., Jenkins, M. A. & The European Hereditary Tumour Group (EHTG) and the International Mismatch Repair Consortium (IMRC), 1 Oct 2022, In: Hereditary Cancer in Clinical Practice. 20, 1, p. 1-11 11 p., 36.

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    27 Citations (Scopus)
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  • Extracellular matrix profiles determine risk and prognosis of the squamous cell carcinoma subtype of non-small cell lung carcinoma

    Parker, A. L., Bowman, E., Zingone, A., Ryan, B. M., Cooper, W. A., Kohonen-Corish, M., Harris, C. C. & Cox, T. R., 21 Nov 2022, In: Genome Medicine. 14, 1, p. 1-29 29 p., 126.

    Research output: Contribution to journalArticlepeer-review

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    27 Citations (Scopus)
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  • MCC gene silencing is a CpG island methylator phenotype-associated factor that predisposes colon cancer cells to irinotecan and Olaparib

    Jahan, Z., Benthani, F. A., Currey, N., Parker, H. W., Dahlstrom, J. E., Caldon, C. E. & Kohonen-Corish, M. R. J., 9 Jun 2022, In: Cancers. 14, 12, p. 1-14 14 p., 2859.

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    1 Citation (Scopus)
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